YNL204C / SPS18

Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL204C / SPS18

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:6.94|P-value:1.31E-11 ID:SGTC_94|Compound:0334-0113|FD-Score:3.30|P-value:7.97E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.38|P-value:6.15E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.30|P-value:6.90E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.56|P-value:2.84E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.88|P-value:1.44E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.45|P-value:4.81E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.95|P-value:6.69E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:4.75|P-value:2.57E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:3.80|P-value:1.34E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.98|P-value:6.89E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.65|P-value:2.34E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:4.91|P-value:1.27E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:3.60|P-value:2.85E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.48|P-value:4.28E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.76|P-value:2.54E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.31|P-value:7.62E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.46|P-value:4.63E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:-3.40|P-value:5.07E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.27|P-value:8.84E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.44|P-value:4.98E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.98|P-value:8.73E-7 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.93|P-value:7.07E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.59|P-value:2.96E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.54|P-value:6.73E-6 ID:SGTC_1727|Compound:st034309|FD-Score:3.56|P-value:3.21E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.32|P-value:7.50E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.25|P-value:9.22E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.56|P-value:3.26E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.35|P-value:6.63E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.42|P-value:5.30E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.28|P-value:8.38E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.72|P-value:1.81E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.66|P-value:2.24E-4 ID:SGTC_2159|Compound:5658611|FD-Score:4.14|P-value:3.70E-5 ID:SGTC_2284|Compound:7945075|FD-Score:4.40|P-value:1.24E-5 ID:SGTC_2453|Compound:5731132|FD-Score:4.01|P-value:6.16E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.24|P-value:8.47E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.26|P-value:9.01E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:5.73|P-value:1.94E-8 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.59|P-value:2.96E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-3.40|P-value:4.92E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.41|P-value:5.45E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.79|P-value:2.21E-6 ID:SGTC_3329|Compound:9141233|FD-Score:3.89|P-value:9.83E-5 ID:SGTC_3336|Compound:9143619|FD-Score:-3.78|P-value:1.26E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.29|P-value:8.19E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.94|P-value:1.31E-11 ID:SGTC_94|Compound:0334-0113|FD-Score:3.30|P-value:7.97E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.38|P-value:6.15E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.30|P-value:6.90E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.56|P-value:2.84E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.88|P-value:1.44E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.45|P-value:4.81E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.95|P-value:6.69E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:4.75|P-value:2.57E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:3.80|P-value:1.34E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.98|P-value:6.89E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.65|P-value:2.34E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:4.91|P-value:1.27E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:3.60|P-value:2.85E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.48|P-value:4.28E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.76|P-value:2.54E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.31|P-value:7.62E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.46|P-value:4.63E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:-3.40|P-value:5.07E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.27|P-value:8.84E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.44|P-value:4.98E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.98|P-value:8.73E-7 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.93|P-value:7.07E-5 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.59|P-value:2.96E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.54|P-value:6.73E-6 ID:SGTC_1727|Compound:st034309|FD-Score:3.56|P-value:3.21E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.32|P-value:7.50E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.25|P-value:9.22E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.56|P-value:3.26E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.35|P-value:6.63E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.42|P-value:5.30E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.28|P-value:8.38E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.72|P-value:1.81E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.66|P-value:2.24E-4 ID:SGTC_2159|Compound:5658611|FD-Score:4.14|P-value:3.70E-5 ID:SGTC_2284|Compound:7945075|FD-Score:4.40|P-value:1.24E-5 ID:SGTC_2453|Compound:5731132|FD-Score:4.01|P-value:6.16E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.24|P-value:8.47E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.26|P-value:9.01E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:5.73|P-value:1.94E-8 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.59|P-value:2.96E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-3.40|P-value:4.92E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.41|P-value:5.45E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.79|P-value:2.21E-6 ID:SGTC_3329|Compound:9141233|FD-Score:3.89|P-value:9.83E-5 ID:SGTC_3336|Compound:9143619|FD-Score:-3.78|P-value:1.26E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.29|P-value:8.19E-4

Top fitness defect scores for YNL204C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 6.94 9.0 µM 1.31E-11 cell wall 164 1.91E-12
2 SGTC_2761 levamisole 5.73 97.9 µM 1.94E-8 1 5.08E-9
3 SGTC_1447 4239-0816 4.98 81.9 µM 8.73E-7 11 3.10E-7
4 SGTC_896 0964-0007 4.91 44.5 µM 1.27E-6 7 4.66E-7
5 SGTC_221 trifluoperazine 4.88 10.3 µM 1.44E-6 NEO1-PIK1 167 5.31E-7
6 SGTC_3325 9138760 4.79 55.2 µM 2.21E-6 Golgi 14 8.47E-7
7 SGTC_1022 4477-0945 4.76 21.3 µM 2.54E-6 9 9.81E-7
8 SGTC_524 r073-0010 4.75 27.8 µM 2.57E-6 33 9.96E-7
9 SGTC_1522 st012842 4.54 45.6 µM 6.73E-6 RNA pol III & RNase P/MRP 15 2.81E-6
10 SGTC_2284 7945075 4.40 39.2 µM 1.24E-5 mitochondrial processes 17 5.42E-6
11 SGTC_2159 5658611 4.14 73.8 µM 3.70E-5 8 1.77E-5
12 SGTC_2453 5731132 4.01 22.2 µM 6.16E-5 20 3.07E-5
13 SGTC_554 4483-2211 3.98 187.0 µM 6.89E-5 17 3.47E-5
14 SGTC_3329 9141233 3.89 27.6 µM 9.83E-5 16 5.09E-5
15 SGTC_533 1222-0222 3.80 6.7 µM 1.34E-4 PDR1 33 7.13E-5
16 SGTC_2053 5265679 3.72 138.0 µM 1.81E-4 30 9.84E-5
17 SGTC_2154 5570129 3.66 200.0 µM 2.24E-4 24 1.24E-4
18 SGTC_669 0108-0021 3.65 26.2 µM 2.34E-4 fatty acid desaturase (OLE1) 99 1.30E-4
19 SGTC_902 1120-0002 3.60 2.1 µM 2.85E-4 azole & statin 59 1.60E-4
20 SGTC_1460 k062-0059 3.59 9.2 µM 2.96E-4 Golgi 21 1.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 9.43E-22 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.158 2.82E-20 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.158 2.95E-20 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.153 5.92E-19 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.152 8.83E-19 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.148 5.51E-18 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.141 2.36E-16 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.141 2.54E-16 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.139 6.48E-16 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.139 7.52E-16 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.138 9.87E-16 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.136 2.55E-15 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.135 3.71E-15 YHL009C YAP3 hom Basic leucine zipper (bZIP) transcription factor
0.131 2.35E-14 YBR286W APE3 hom Vacuolar aminopeptidase Y, processed to mature form by Prb1p
0.131 2.36E-14 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress