YNL205C_d

Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL205C / YNL205C

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:-4.25|P-value:1.35E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.84|P-value:7.61E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:4.80|P-value:1.12E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.15|P-value:9.08E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-4.26|P-value:1.28E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.93|P-value:2.39E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.55|P-value:2.22E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.82|P-value:8.15E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.22|P-value:7.30E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.16|P-value:9.19E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:6.67|P-value:2.39E-11 ID:SGTC_288|Compound:1315-0019|FD-Score:3.51|P-value:2.72E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.60|P-value:1.95E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.16|P-value:8.95E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.25|P-value:1.40E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:3.71|P-value:1.26E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.51|P-value:2.67E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.51|P-value:2.67E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.06|P-value:3.12E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.61|P-value:1.83E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.06|P-value:2.98E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.38|P-value:4.23E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.38|P-value:4.32E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.29|P-value:5.96E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.48|P-value:2.95E-4 ID:SGTC_1618|Compound:st003135|FD-Score:-3.16|P-value:8.94E-4 ID:SGTC_1642|Compound:st009582|FD-Score:4.05|P-value:3.17E-5 ID:SGTC_1705|Compound:st027868|FD-Score:3.45|P-value:3.32E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.33|P-value:4.92E-4 ID:SGTC_1849|Compound:st056239|FD-Score:5.83|P-value:4.34E-9 ID:SGTC_2013|Compound:4024628|FD-Score:-3.47|P-value:2.97E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.26|P-value:6.29E-4 ID:SGTC_2021|Compound:4019055|FD-Score:6.26|P-value:3.35E-10 ID:SGTC_2028|Compound:5153890|FD-Score:3.73|P-value:1.18E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.46|P-value:3.25E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.79|P-value:9.36E-5 ID:SGTC_2167|Compound:5876490|FD-Score:4.09|P-value:2.76E-5 ID:SGTC_2175|Compound:5807670|FD-Score:3.46|P-value:3.22E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.14|P-value:9.89E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.62|P-value:1.76E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.37|P-value:4.26E-4 ID:SGTC_2280|Compound:7785178|FD-Score:4.48|P-value:4.86E-6 ID:SGTC_2350|Compound:9023895|FD-Score:5.88|P-value:3.25E-9 ID:SGTC_2391|Compound:6285546|FD-Score:3.22|P-value:7.56E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.23|P-value:1.43E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.32|P-value:5.39E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.44|P-value:3.45E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.82|P-value:8.12E-5 ID:SGTC_2517|Compound:totarol|FD-Score:4.80|P-value:1.10E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.14|P-value:9.81E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.74|P-value:1.11E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-5.54|P-value:2.13E-8 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.40|P-value:4.00E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.41|P-value:3.85E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.54|P-value:2.34E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.17|P-value:9.01E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.67|P-value:2.02E-6 ID:SGTC_3017|Compound:9080681|FD-Score:-3.29|P-value:5.64E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.23|P-value:1.42E-5 ID:SGTC_3089|Compound:9117425|FD-Score:3.38|P-value:4.30E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.49|P-value:2.84E-4 ID:SGTC_3327|Compound:9140648|FD-Score:4.37|P-value:8.24E-6 ID:SGTC_3333|Compound:9141820|FD-Score:3.55|P-value:2.30E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:-4.25|P-value:1.35E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.84|P-value:7.61E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:4.80|P-value:1.12E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.15|P-value:9.08E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-4.26|P-value:1.28E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.93|P-value:2.39E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.55|P-value:2.22E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.82|P-value:8.15E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.22|P-value:7.30E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.16|P-value:9.19E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:6.67|P-value:2.39E-11 ID:SGTC_288|Compound:1315-0019|FD-Score:3.51|P-value:2.72E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.60|P-value:1.95E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.16|P-value:8.95E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.25|P-value:1.40E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:3.71|P-value:1.26E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.51|P-value:2.67E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.51|P-value:2.67E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.06|P-value:3.12E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.61|P-value:1.83E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.06|P-value:2.98E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.38|P-value:4.23E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.38|P-value:4.32E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.29|P-value:5.96E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.48|P-value:2.95E-4 ID:SGTC_1618|Compound:st003135|FD-Score:-3.16|P-value:8.94E-4 ID:SGTC_1642|Compound:st009582|FD-Score:4.05|P-value:3.17E-5 ID:SGTC_1705|Compound:st027868|FD-Score:3.45|P-value:3.32E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.33|P-value:4.92E-4 ID:SGTC_1849|Compound:st056239|FD-Score:5.83|P-value:4.34E-9 ID:SGTC_2013|Compound:4024628|FD-Score:-3.47|P-value:2.97E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.26|P-value:6.29E-4 ID:SGTC_2021|Compound:4019055|FD-Score:6.26|P-value:3.35E-10 ID:SGTC_2028|Compound:5153890|FD-Score:3.73|P-value:1.18E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.46|P-value:3.25E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.79|P-value:9.36E-5 ID:SGTC_2167|Compound:5876490|FD-Score:4.09|P-value:2.76E-5 ID:SGTC_2175|Compound:5807670|FD-Score:3.46|P-value:3.22E-4 ID:SGTC_2199|Compound:6590217|FD-Score:3.14|P-value:9.89E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.62|P-value:1.76E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.37|P-value:4.26E-4 ID:SGTC_2280|Compound:7785178|FD-Score:4.48|P-value:4.86E-6 ID:SGTC_2350|Compound:9023895|FD-Score:5.88|P-value:3.25E-9 ID:SGTC_2391|Compound:6285546|FD-Score:3.22|P-value:7.56E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.23|P-value:1.43E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.32|P-value:5.39E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.44|P-value:3.45E-4 ID:SGTC_2476|Compound:5806916|FD-Score:3.82|P-value:8.12E-5 ID:SGTC_2517|Compound:totarol|FD-Score:4.80|P-value:1.10E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.14|P-value:9.81E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.74|P-value:1.11E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-5.54|P-value:2.13E-8 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.40|P-value:4.00E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.41|P-value:3.85E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.54|P-value:2.34E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.17|P-value:9.01E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.67|P-value:2.02E-6 ID:SGTC_3017|Compound:9080681|FD-Score:-3.29|P-value:5.64E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.23|P-value:1.42E-5 ID:SGTC_3089|Compound:9117425|FD-Score:3.38|P-value:4.30E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.49|P-value:2.84E-4 ID:SGTC_3327|Compound:9140648|FD-Score:4.37|P-value:8.24E-6 ID:SGTC_3333|Compound:9141820|FD-Score:3.55|P-value:2.30E-4

Top fitness defect scores for YNL205C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_261 5-fluorouridine 6.67 15.4 µM 2.39E-11 exosome 2 1.32E-11
2 SGTC_2021 4019055 6.26 173.0 µM 3.35E-10 endomembrane recycling 37 1.98E-10
3 SGTC_58 0957-0393 5.93 9.0 µM 2.39E-9 cell wall 216 1.49E-9
4 SGTC_2350 9023895 5.88 38.9 µM 3.25E-9 ergosterol biosynthesis 12 2.04E-9
5 SGTC_1849 st056239 5.83 19.2 µM 4.34E-9 RPP1 & pyrimidine depletion 2 2.74E-9
6 SGTC_2517 totarol 4.80 10.0 µM 1.10E-6 9 7.99E-7
7 SGTC_16 erodoxin 4.80 22.8 µM 1.12E-6 unfolded protein response 40 8.13E-7
8 SGTC_2783 7738165 4.67 71.4 µM 2.02E-6 15 1.49E-6
9 SGTC_2280 7785178 4.48 200.0 µM 4.86E-6 7 3.67E-6
10 SGTC_3327 9140648 4.37 26.9 µM 8.24E-6 7 6.31E-6
11 SGTC_632 0781-2353 4.25 4.7 µM 1.40E-5 Golgi 33 1.09E-5
12 SGTC_2167 5876490 4.09 200.0 µM 2.76E-5 27 2.18E-5
13 SGTC_931 2812-0076 4.06 566.0 µM 3.12E-5 22 2.47E-5
14 SGTC_1642 st009582 4.05 77.7 µM 3.17E-5 RPP1 & pyrimidine depletion 14 2.51E-5
15 SGTC_15 0266-0086 3.84 27.1 µM 7.61E-5 endomembrane recycling 67 6.16E-5
16 SGTC_2476 5806916 3.82 10.5 µM 8.12E-5 17 6.58E-5
17 SGTC_114 0364-0001 3.82 490.3 µM 8.15E-5 56 6.60E-5
18 SGTC_2065 5221596 3.79 34.3 µM 9.36E-5 19 7.62E-5
19 SGTC_2572 astragaloside iv 3.74 100.0 µM 1.11E-4 36 9.08E-5
20 SGTC_2028 5153890 3.73 36.4 µM 1.18E-4 cell wall signaling 37 9.67E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 6.04E-19 YBR300C_d YBR300C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
0.149 3.27E-18 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.145 3.15E-17 YOR179C SYC1 hom Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication
0.144 4.20E-17 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.140 4.09E-16 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.139 6.24E-16 YCR085W_d YCR085W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.138 1.03E-15 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.127 1.87E-13 YDR317W HIM1 hom Protein of unknown function involved in DNA repair
0.125 4.04E-13 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.125 4.25E-13 YCR087W_d YCR087W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene
0.123 9.17E-13 YBR297W MAL33 hom MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
0.118 6.04E-12 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.117 1.11E-11 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.117 1.17E-11 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.117 1.30E-11 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency