YNL206C / RTT106

Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL206C / RTT106

Click on Significant Values for Screen Details ID:SGTC_178|Compound:4092-0806|FD-Score:-3.78|P-value:1.93E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.19|P-value:4.15E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.55|P-value:9.49E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:-5.24|P-value:4.34E-7 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-4.25|P-value:3.24E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:5.96|P-value:1.08E-8 ID:SGTC_505|Compound:gw-5074|FD-Score:4.52|P-value:1.09E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.45|P-value:1.47E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:4.69|P-value:5.37E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:3.47|P-value:5.57E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.65|P-value:3.07E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.47|P-value:5.55E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.90|P-value:1.24E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.46|P-value:5.79E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.40|P-value:7.12E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.49|P-value:5.32E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.39|P-value:1.86E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.85|P-value:1.52E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.89|P-value:1.29E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.72|P-value:2.41E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.59|P-value:3.74E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.30|P-value:9.66E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.49|P-value:5.28E-4 ID:SGTC_1790|Compound:st045711|FD-Score:4.17|P-value:4.47E-5 ID:SGTC_1795|Compound:st049545|FD-Score:3.81|P-value:1.75E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.30|P-value:9.60E-4 ID:SGTC_2004|Compound:4023728|FD-Score:6.35|P-value:1.23E-9 ID:SGTC_2208|Compound:7283366|FD-Score:4.72|P-value:4.68E-6 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.86|P-value:1.46E-4 ID:SGTC_2431|Compound:5490079|FD-Score:5.73|P-value:3.67E-8 ID:SGTC_2438|Compound:5259590|FD-Score:-4.15|P-value:4.90E-5 ID:SGTC_2441|Compound:5730946|FD-Score:-4.46|P-value:1.39E-5 ID:SGTC_2483|Compound:5729050|FD-Score:-3.63|P-value:3.24E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.71|P-value:2.45E-4 ID:SGTC_2486|Compound:5283202|FD-Score:5.32|P-value:2.94E-7 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:6.53|P-value:4.26E-10 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.42|P-value:6.54E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.69|P-value:5.39E-6 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.22|P-value:3.75E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.73|P-value:2.31E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.71|P-value:2.50E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.78|P-value:1.93E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.19|P-value:4.15E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.55|P-value:9.49E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:-5.24|P-value:4.34E-7 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-4.25|P-value:3.24E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:5.96|P-value:1.08E-8 ID:SGTC_505|Compound:gw-5074|FD-Score:4.52|P-value:1.09E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.45|P-value:1.47E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:4.69|P-value:5.37E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:3.47|P-value:5.57E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.65|P-value:3.07E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.47|P-value:5.55E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.90|P-value:1.24E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.46|P-value:5.79E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.40|P-value:7.12E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.49|P-value:5.32E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.39|P-value:1.86E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.85|P-value:1.52E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.89|P-value:1.29E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.72|P-value:2.41E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.59|P-value:3.74E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.30|P-value:9.66E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.49|P-value:5.28E-4 ID:SGTC_1790|Compound:st045711|FD-Score:4.17|P-value:4.47E-5 ID:SGTC_1795|Compound:st049545|FD-Score:3.81|P-value:1.75E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-3.30|P-value:9.60E-4 ID:SGTC_2004|Compound:4023728|FD-Score:6.35|P-value:1.23E-9 ID:SGTC_2208|Compound:7283366|FD-Score:4.72|P-value:4.68E-6 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.86|P-value:1.46E-4 ID:SGTC_2431|Compound:5490079|FD-Score:5.73|P-value:3.67E-8 ID:SGTC_2438|Compound:5259590|FD-Score:-4.15|P-value:4.90E-5 ID:SGTC_2441|Compound:5730946|FD-Score:-4.46|P-value:1.39E-5 ID:SGTC_2483|Compound:5729050|FD-Score:-3.63|P-value:3.24E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.71|P-value:2.45E-4 ID:SGTC_2486|Compound:5283202|FD-Score:5.32|P-value:2.94E-7 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:6.53|P-value:4.26E-10 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.42|P-value:6.54E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.69|P-value:5.39E-6 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.22|P-value:3.75E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.73|P-value:2.31E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.71|P-value:2.50E-4

Top fitness defect scores for YNL206C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2499 avocadenofuran 6.53 51.5 µM 4.26E-10 5 3.20E-11
2 SGTC_2004 4023728 6.35 41.9 µM 1.23E-9 5 1.06E-10
3 SGTC_495 decylubiquinone 5.96 155.0 µM 1.08E-8 copper-dependent oxidative stress 5 1.23E-9
4 SGTC_2431 5490079 5.73 200.0 µM 3.67E-8 11 4.93E-9
5 SGTC_2486 5283202 5.32 22.4 µM 2.94E-7 14 5.19E-8
6 SGTC_2208 7283366 4.72 200.0 µM 4.68E-6 6 1.18E-6
7 SGTC_697 0508-1955 4.69 564.0 µM 5.37E-6 19 1.38E-6
8 SGTC_2636 apigenin dimethyl ether 4.69 100.0 µM 5.39E-6 23 1.38E-6
9 SGTC_207 4185-0010 4.55 4.5 µM 9.49E-6 endomembrane recycling 67 2.62E-6
10 SGTC_505 gw-5074 4.52 63.9 µM 1.09E-5 43 3.06E-6
11 SGTC_1161 k007-0610 4.39 110.0 µM 1.86E-5 ERAD & cell cycle 101 5.60E-6
12 SGTC_2638 epoxomicin 4.22 18.0 µM 3.75E-5 28 1.24E-5
13 SGTC_183 3914-0051 4.19 30.6 µM 4.15E-5 60S ribosome export 20 1.38E-5
14 SGTC_1790 st045711 4.17 43.5 µM 4.47E-5 11 1.51E-5
15 SGTC_946 3434-1334 3.90 87.4 µM 1.24E-4 33 4.75E-5
16 SGTC_1277 0873-0036 3.89 22.0 µM 1.29E-4 PDR1 24 4.95E-5
17 SGTC_2252 omeprazole 3.86 400.0 µM 1.46E-4 10 5.72E-5
18 SGTC_1220 1838-0075 3.85 193.0 µM 1.52E-4 12 5.99E-5
19 SGTC_1795 st049545 3.81 62.3 µM 1.75E-4 TSC3-RPN4 14 7.01E-5
20 SGTC_2730 imipramine 3.73 71.3 µM 2.31E-4 37 9.60E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.090 2.03E-7 YHR066W SSF1 hom Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
0.089 2.10E-7 YOR021C SFM1 hom SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
0.089 2.41E-7 YHL026C_p YHL026C_p hom Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
0.086 5.23E-7 YMR247C RKR1 hom RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice
0.085 7.58E-7 YMR199W CLN1 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.083 1.39E-6 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.081 2.81E-6 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.075 1.52E-5 YFR048W RMD8 hom Cytosolic protein required for sporulation
0.074 1.79E-5 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
0.074 1.83E-5 YMR169C ALD3 hom Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
0.072 2.64E-5 YLR422W_p YLR422W_p hom Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein
0.072 2.98E-5 YBR284W_p YBR284W_p hom Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication
0.072 3.02E-5 YGR135W PRE9 hom Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform
0.070 4.40E-5 YBR006W UGA2 hom Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm
0.070 5.38E-5 YDL165W CDC36 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor