YNL207W / RIO2

Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL207W / RIO2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.78|P-value:1.70E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:4.04|P-value:6.41E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.83|P-value:1.45E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:4.30|P-value:2.28E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:4.54|P-value:8.29E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:4.07|P-value:5.80E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:3.46|P-value:5.34E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.35|P-value:7.63E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.89|P-value:1.13E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.41|P-value:6.32E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:5.46|P-value:1.10E-7 ID:SGTC_668|Compound:1682-0499|FD-Score:3.56|P-value:3.72E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:5.13|P-value:5.78E-7 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.69|P-value:2.06E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.81|P-value:1.55E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.23|P-value:9.77E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:5.97|P-value:7.53E-9 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.06|P-value:5.92E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:-3.34|P-value:6.81E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.44|P-value:1.28E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.50|P-value:4.03E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.98|P-value:1.17E-6 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.88|P-value:1.04E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.75|P-value:1.66E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.32|P-value:8.41E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.48|P-value:4.93E-4 ID:SGTC_2328|Compound:6201408|FD-Score:4.13|P-value:4.47E-5 ID:SGTC_2342|Compound:7990637|FD-Score:-3.32|P-value:7.48E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.50|P-value:9.92E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.95|P-value:9.12E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.29|P-value:8.02E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-4.89|P-value:1.46E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:7.30|P-value:2.08E-12 ID:SGTC_2696|Compound:st077691|FD-Score:6.33|P-value:9.59E-10 ID:SGTC_2785|Compound:7756463|FD-Score:3.36|P-value:7.26E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.53|P-value:3.61E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.25|P-value:2.77E-5 ID:SGTC_2873|Compound:9040596|FD-Score:-3.81|P-value:1.32E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.08|P-value:5.60E-5 ID:SGTC_2927|Compound:9011802|FD-Score:4.70|P-value:4.13E-6 ID:SGTC_2950|Compound:9072895|FD-Score:4.98|P-value:1.16E-6 ID:SGTC_3180|Compound:9109287|FD-Score:3.86|P-value:1.30E-4 ID:SGTC_3184|Compound:9108758|FD-Score:3.44|P-value:5.56E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.30|P-value:8.90E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.78|P-value:1.70E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:4.04|P-value:6.41E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:3.83|P-value:1.45E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:4.30|P-value:2.28E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:4.54|P-value:8.29E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:4.07|P-value:5.80E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:3.46|P-value:5.34E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.35|P-value:7.63E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.89|P-value:1.13E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.41|P-value:6.32E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:5.46|P-value:1.10E-7 ID:SGTC_668|Compound:1682-0499|FD-Score:3.56|P-value:3.72E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:5.13|P-value:5.78E-7 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.69|P-value:2.06E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.81|P-value:1.55E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.23|P-value:9.77E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:5.97|P-value:7.53E-9 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.06|P-value:5.92E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:-3.34|P-value:6.81E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.44|P-value:1.28E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.50|P-value:4.03E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.98|P-value:1.17E-6 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:-3.88|P-value:1.04E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.75|P-value:1.66E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.32|P-value:8.41E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.48|P-value:4.93E-4 ID:SGTC_2328|Compound:6201408|FD-Score:4.13|P-value:4.47E-5 ID:SGTC_2342|Compound:7990637|FD-Score:-3.32|P-value:7.48E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.50|P-value:9.92E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.95|P-value:9.12E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:-3.29|P-value:8.02E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-4.89|P-value:1.46E-6 ID:SGTC_2689|Compound:tacrolimus|FD-Score:7.30|P-value:2.08E-12 ID:SGTC_2696|Compound:st077691|FD-Score:6.33|P-value:9.59E-10 ID:SGTC_2785|Compound:7756463|FD-Score:3.36|P-value:7.26E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.53|P-value:3.61E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.25|P-value:2.77E-5 ID:SGTC_2873|Compound:9040596|FD-Score:-3.81|P-value:1.32E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.08|P-value:5.60E-5 ID:SGTC_2927|Compound:9011802|FD-Score:4.70|P-value:4.13E-6 ID:SGTC_2950|Compound:9072895|FD-Score:4.98|P-value:1.16E-6 ID:SGTC_3180|Compound:9109287|FD-Score:3.86|P-value:1.30E-4 ID:SGTC_3184|Compound:9108758|FD-Score:3.44|P-value:5.56E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.30|P-value:8.90E-4

Top fitness defect scores for YNL207W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2689 tacrolimus 7.30 100.0 µM 2.08E-12 3 1.44E-13 0.63
2 SGTC_2696 st077691 6.33 74.3 µM 9.59E-10 4 1.26E-10 0.67
3 SGTC_1063 disulfiram 5.97 1.8 µM 7.53E-9 2 1.22E-9 1.05
4 SGTC_661 1304-0007 5.46 33.6 µM 1.10E-7 1 2.36E-8 1.12
5 SGTC_747 3448-8087 5.13 38.7 µM 5.78E-7 2 1.47E-7 0.19
6 SGTC_2950 9072895 4.98 21.5 µM 1.16E-6 6 3.17E-7 0.13
7 SGTC_1456 k015-0012 4.98 13.0 µM 1.17E-6 4 3.21E-7 0.71
8 SGTC_2927 9011802 4.70 47.9 µM 4.13E-6 5 1.29E-6 0.28
9 SGTC_136 0097-0015 4.54 404.5 µM 8.29E-6 60S ribosome export 7 2.78E-6 0.27
10 SGTC_2407 paclitaxel 4.50 400.0 µM 9.92E-6 3 3.38E-6 0.43
11 SGTC_1448 4255-0083 4.44 152.0 µM 1.28E-5 ERG2 1 4.50E-6 0.42
12 SGTC_74 000s-0487 4.30 160.3 µM 2.28E-5 2 8.47E-6 0.60
13 SGTC_2830 7992007 4.25 71.4 µM 2.77E-5 10 1.05E-5 0.15
14 SGTC_2328 6201408 4.13 200.0 µM 4.47E-5 9 1.78E-5 0.07
15 SGTC_2919 7978188 4.08 46.4 µM 5.60E-5 3 2.28E-5 0.37
16 SGTC_184 1494-0393 4.07 24.7 µM 5.80E-5 27 2.37E-5 0.00
17 SGTC_1105 epirubicin 4.06 18.1 µM 5.92E-5 anthracycline transcription coupled DNA repair 10 2.43E-5 0.25
18 SGTC_14 0354-0009 4.04 295.0 µM 6.41E-5 2 2.65E-5 0.30
19 SGTC_2452 5863136 3.95 48.4 µM 9.12E-5 2 3.91E-5 0.23
20 SGTC_563 tetrahydrosecaminediol 3.89 614.0 µM 1.13E-4 amide catabolism 3 4.93E-5 0.26

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 7.87E-21 YPL233W NSL1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
0.101 3.92E-9 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.100 7.47E-9 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.095 3.69E-8 YBR043C QDR3 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin
0.091 1.39E-7 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.089 2.57E-7 YJR095W SFC1 hom Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
0.088 3.22E-7 YBR093C PHO5 hom Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
0.084 1.00E-6 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.080 3.86E-6 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.079 4.09E-6 YDR361C BCP1 het Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
0.075 1.25E-5 YMR235C RNA1 het GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
0.074 1.71E-5 YLR289W GUF1 hom Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
0.073 2.07E-5 YLR054C OSW2 hom Protein of unknown function proposed to be involved in the assembly of the spore wall
0.073 2.32E-5 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.073 2.49E-5 YPL080C_d YPL080C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data