YNL211C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL211C / YNL211C

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:4.12|P-value:1.08E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:12.60|P-value:5.21E-39 ID:SGTC_65|Compound:0798-0905|FD-Score:3.98|P-value:2.06E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.57|P-value:1.16E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.38|P-value:2.50E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.74|P-value:5.92E-5 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.42|P-value:2.02E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.36|P-value:2.68E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.72|P-value:6.49E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.39|P-value:3.01E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.34|P-value:3.76E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.44|P-value:1.87E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.80|P-value:4.60E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.00|P-value:9.50E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.44|P-value:2.01E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.63|P-value:9.40E-7 ID:SGTC_525|Compound:k781-2675|FD-Score:4.36|P-value:3.55E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:4.22|P-value:7.05E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.43|P-value:2.00E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.72|P-value:6.08E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.36|P-value:2.61E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.67|P-value:7.86E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.73|P-value:6.05E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:3.61|P-value:1.03E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.81|P-value:3.61E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:4.41|P-value:2.79E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.38|P-value:2.51E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.42|P-value:2.14E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.04|P-value:8.78E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.32|P-value:3.10E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:5.25|P-value:3.19E-8 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.01|P-value:9.89E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.02|P-value:9.38E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.65|P-value:8.37E-5 ID:SGTC_1902|Compound:st060212|FD-Score:3.06|P-value:8.25E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.58|P-value:1.12E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.14|P-value:9.86E-6 ID:SGTC_2339|Compound:9000433|FD-Score:3.52|P-value:1.45E-4 ID:SGTC_2439|Compound:5492030|FD-Score:5.96|P-value:4.20E-10 ID:SGTC_2570|Compound:licareol|FD-Score:3.46|P-value:1.82E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.81|P-value:3.60E-7 ID:SGTC_2602|Compound:kawain|FD-Score:3.35|P-value:2.84E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:4.65|P-value:8.32E-7 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.16|P-value:5.70E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.42|P-value:2.17E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.95|P-value:1.70E-7 ID:SGTC_2880|Compound:9042983|FD-Score:3.18|P-value:5.27E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.22|P-value:4.53E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.78|P-value:4.94E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.36|P-value:2.71E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.41|P-value:2.25E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.05|P-value:8.35E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:4.12|P-value:1.08E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:12.60|P-value:5.21E-39 ID:SGTC_65|Compound:0798-0905|FD-Score:3.98|P-value:2.06E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.57|P-value:1.16E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.38|P-value:2.50E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.74|P-value:5.92E-5 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.42|P-value:2.02E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.36|P-value:2.68E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.72|P-value:6.49E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.39|P-value:3.01E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:-4.34|P-value:3.76E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.44|P-value:1.87E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.80|P-value:4.60E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.00|P-value:9.50E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.44|P-value:2.01E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.63|P-value:9.40E-7 ID:SGTC_525|Compound:k781-2675|FD-Score:4.36|P-value:3.55E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:4.22|P-value:7.05E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.43|P-value:2.00E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.72|P-value:6.08E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.36|P-value:2.61E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.67|P-value:7.86E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.73|P-value:6.05E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:3.61|P-value:1.03E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:4.81|P-value:3.61E-7 ID:SGTC_841|Compound:0251-0215|FD-Score:4.41|P-value:2.79E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.38|P-value:2.51E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.42|P-value:2.14E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.04|P-value:8.78E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.32|P-value:3.10E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:5.25|P-value:3.19E-8 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.01|P-value:9.89E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.02|P-value:9.38E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.65|P-value:8.37E-5 ID:SGTC_1902|Compound:st060212|FD-Score:3.06|P-value:8.25E-4 ID:SGTC_1974|Compound:st069448|FD-Score:3.58|P-value:1.12E-4 ID:SGTC_2157|Compound:5649910|FD-Score:4.14|P-value:9.86E-6 ID:SGTC_2339|Compound:9000433|FD-Score:3.52|P-value:1.45E-4 ID:SGTC_2439|Compound:5492030|FD-Score:5.96|P-value:4.20E-10 ID:SGTC_2570|Compound:licareol|FD-Score:3.46|P-value:1.82E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.81|P-value:3.60E-7 ID:SGTC_2602|Compound:kawain|FD-Score:3.35|P-value:2.84E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:4.65|P-value:8.32E-7 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.16|P-value:5.70E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.42|P-value:2.17E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.95|P-value:1.70E-7 ID:SGTC_2880|Compound:9042983|FD-Score:3.18|P-value:5.27E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.22|P-value:4.53E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.78|P-value:4.94E-5 ID:SGTC_3104|Compound:9120930|FD-Score:3.36|P-value:2.71E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.41|P-value:2.25E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.05|P-value:8.35E-4

Top fitness defect scores for YNL211C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 12.60 9.0 µM 5.21E-39 cell wall 43 8.13E-37
2 SGTC_2439 5492030 5.96 7.2 µM 4.20E-10 2 1.30E-9
3 SGTC_1162 k048-0130 5.25 20.1 µM 3.19E-8 Golgi 9 7.65E-8
4 SGTC_2850 9015429 4.95 58.4 µM 1.70E-7 4 3.72E-7
5 SGTC_2575 plumbagin 4.81 510.0 nM 3.60E-7 superoxide 23 7.52E-7
6 SGTC_820 1582-0060 4.81 59.9 µM 3.61E-7 13 7.54E-7
7 SGTC_2718 lomofungin 4.65 53.0 µM 8.32E-7 mitochondrial processes 2 1.66E-6
8 SGTC_518 1021-0119 4.63 62.6 µM 9.40E-7 ERG2 20 1.86E-6
9 SGTC_841 0251-0215 4.41 91.2 µM 2.79E-6 63 5.19E-6
10 SGTC_221 trifluoperazine 4.39 10.3 µM 3.01E-6 NEO1-PIK1 187 5.57E-6
11 SGTC_525 k781-2675 4.36 26.7 µM 3.55E-6 redox potentiating 43 6.51E-6
12 SGTC_527 4476-4215 4.22 268.0 µM 7.05E-6 PDR1 26 1.24E-5
13 SGTC_2157 5649910 4.14 96.4 µM 9.86E-6 20 1.71E-5
14 SGTC_50 0929-0078 4.12 56.4 µM 1.08E-5 41 1.87E-5
15 SGTC_65 0798-0905 3.98 35.0 µM 2.06E-5 calcium & mitochondrial duress 84 3.42E-5
16 SGTC_433 pimozide 3.80 108.0 µM 4.60E-5 19 7.31E-5
17 SGTC_3067 9117431 3.78 49.5 µM 4.94E-5 15 7.82E-5
18 SGTC_146 3448-8650 3.74 53.1 µM 5.92E-5 NEO1-PIK1 153 9.28E-5
19 SGTC_722 3534-0461 3.73 190.0 µM 6.05E-5 PDR1 45 9.47E-5
20 SGTC_212 3807-4682 3.72 38.8 µM 6.49E-5 tubulin folding & SWR complex 83 1.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.317 2.07E-79 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.312 1.83E-76 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.303 3.83E-72 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.302 9.95E-72 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.289 1.54E-65 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.253 2.43E-50 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.246 1.87E-47 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.245 2.88E-47 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.243 2.32E-46 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.241 1.11E-45 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.239 1.19E-44 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.238 1.88E-44 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.228 9.66E-41 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.228 1.05E-40 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.218 2.38E-37 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1