YNL213C / RRG9

Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL213C / RRG9

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:-3.51|P-value:8.72E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.88|P-value:2.81E-10 ID:SGTC_19|Compound:0279-0214|FD-Score:5.42|P-value:5.03E-7 ID:SGTC_29|Compound:0299-0004|FD-Score:-4.26|P-value:7.00E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:5.72|P-value:1.20E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:4.30|P-value:5.10E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:6.91|P-value:2.34E-10 ID:SGTC_119|Compound:0121-0043|FD-Score:8.08|P-value:1.69E-13 ID:SGTC_134|Compound:0269-0018|FD-Score:8.14|P-value:1.08E-13 ID:SGTC_141|Compound:0443-0274|FD-Score:3.79|P-value:3.08E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.93|P-value:1.87E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.42|P-value:9.83E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:3.57|P-value:6.14E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:30.40|P-value:2.01E-165 ID:SGTC_251|Compound:melphalan|FD-Score:3.42|P-value:9.94E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:14.40|P-value:1.07E-38 ID:SGTC_305|Compound:1682-2595|FD-Score:4.68|P-value:1.16E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.34|P-value:4.38E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:3.65|P-value:4.89E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.14|P-value:1.10E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.65|P-value:4.79E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:12.60|P-value:5.84E-30 ID:SGTC_435|Compound:c-PAF|FD-Score:4.15|P-value:8.77E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-5.35|P-value:8.36E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.54|P-value:2.49E-5 ID:SGTC_462|Compound:ag-879|FD-Score:4.30|P-value:5.06E-5 ID:SGTC_564|Compound:3555-0129|FD-Score:3.49|P-value:8.07E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:4.38|P-value:3.85E-5 ID:SGTC_835|Compound:0312-0010|FD-Score:-4.10|P-value:1.23E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:4.00|P-value:1.51E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.46|P-value:8.68E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.81|P-value:7.02E-6 ID:SGTC_942|Compound:3253-1115|FD-Score:3.72|P-value:3.89E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.52|P-value:7.22E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.47|P-value:8.41E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:5.30|P-value:8.63E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.53|P-value:7.10E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-4.78|P-value:9.60E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.72|P-value:3.78E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.11|P-value:1.22E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.56|P-value:6.39E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.00|P-value:1.78E-4 ID:SGTC_1635|Compound:st007035|FD-Score:26.50|P-value:2.91E-126 ID:SGTC_1658|Compound:st012944|FD-Score:-3.75|P-value:4.01E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.99|P-value:1.57E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.57|P-value:6.17E-4 ID:SGTC_1742|Compound:st038235|FD-Score:9.22|P-value:5.00E-17 ID:SGTC_1754|Compound:st042065|FD-Score:-3.91|P-value:2.35E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.43|P-value:9.68E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.73|P-value:4.30E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-4.87|P-value:6.52E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-6.71|P-value:9.29E-10 ID:SGTC_1935|Compound:st074532|FD-Score:4.02|P-value:1.41E-4 ID:SGTC_2380|Compound:9035439|FD-Score:5.86|P-value:6.15E-8 ID:SGTC_2482|Compound:5981709|FD-Score:-3.70|P-value:4.76E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.32|P-value:4.80E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:6.25|P-value:8.63E-9 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.65|P-value:4.81E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.56|P-value:7.45E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.02|P-value:1.41E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.96|P-value:4.55E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.26|P-value:1.02E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.69|P-value:1.37E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.50|P-value:7.70E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-4.06|P-value:1.43E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.45|P-value:9.04E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.10|P-value:1.05E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-4.35|P-value:5.06E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-6.15|P-value:1.82E-8 ID:SGTC_3055|Compound:9094636|FD-Score:-3.54|P-value:7.85E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.73|P-value:4.30E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.50|P-value:8.95E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:-3.51|P-value:8.72E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.88|P-value:2.81E-10 ID:SGTC_19|Compound:0279-0214|FD-Score:5.42|P-value:5.03E-7 ID:SGTC_29|Compound:0299-0004|FD-Score:-4.26|P-value:7.00E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:5.72|P-value:1.20E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:4.30|P-value:5.10E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:6.91|P-value:2.34E-10 ID:SGTC_119|Compound:0121-0043|FD-Score:8.08|P-value:1.69E-13 ID:SGTC_134|Compound:0269-0018|FD-Score:8.14|P-value:1.08E-13 ID:SGTC_141|Compound:0443-0274|FD-Score:3.79|P-value:3.08E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.93|P-value:1.87E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.42|P-value:9.83E-4 ID:SGTC_186|Compound:3455-3465|FD-Score:3.57|P-value:6.14E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:30.40|P-value:2.01E-165 ID:SGTC_251|Compound:melphalan|FD-Score:3.42|P-value:9.94E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:14.40|P-value:1.07E-38 ID:SGTC_305|Compound:1682-2595|FD-Score:4.68|P-value:1.16E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.34|P-value:4.38E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:3.65|P-value:4.89E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.14|P-value:1.10E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.65|P-value:4.79E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:12.60|P-value:5.84E-30 ID:SGTC_435|Compound:c-PAF|FD-Score:4.15|P-value:8.77E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-5.35|P-value:8.36E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.54|P-value:2.49E-5 ID:SGTC_462|Compound:ag-879|FD-Score:4.30|P-value:5.06E-5 ID:SGTC_564|Compound:3555-0129|FD-Score:3.49|P-value:8.07E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:4.38|P-value:3.85E-5 ID:SGTC_835|Compound:0312-0010|FD-Score:-4.10|P-value:1.23E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:4.00|P-value:1.51E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.46|P-value:8.68E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.81|P-value:7.02E-6 ID:SGTC_942|Compound:3253-1115|FD-Score:3.72|P-value:3.89E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.52|P-value:7.22E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.47|P-value:8.41E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:5.30|P-value:8.63E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.53|P-value:7.10E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-4.78|P-value:9.60E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.72|P-value:3.78E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.11|P-value:1.22E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.56|P-value:6.39E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.00|P-value:1.78E-4 ID:SGTC_1635|Compound:st007035|FD-Score:26.50|P-value:2.91E-126 ID:SGTC_1658|Compound:st012944|FD-Score:-3.75|P-value:4.01E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.99|P-value:1.57E-4 ID:SGTC_1702|Compound:st027038|FD-Score:3.57|P-value:6.17E-4 ID:SGTC_1742|Compound:st038235|FD-Score:9.22|P-value:5.00E-17 ID:SGTC_1754|Compound:st042065|FD-Score:-3.91|P-value:2.35E-4 ID:SGTC_1759|Compound:st043059|FD-Score:3.43|P-value:9.68E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.73|P-value:4.30E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-4.87|P-value:6.52E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-6.71|P-value:9.29E-10 ID:SGTC_1935|Compound:st074532|FD-Score:4.02|P-value:1.41E-4 ID:SGTC_2380|Compound:9035439|FD-Score:5.86|P-value:6.15E-8 ID:SGTC_2482|Compound:5981709|FD-Score:-3.70|P-value:4.76E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.32|P-value:4.80E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:6.25|P-value:8.63E-9 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.65|P-value:4.81E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.56|P-value:7.45E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.02|P-value:1.41E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.96|P-value:4.55E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.26|P-value:1.02E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.69|P-value:1.37E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.50|P-value:7.70E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-4.06|P-value:1.43E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.45|P-value:9.04E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.10|P-value:1.05E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-4.35|P-value:5.06E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-6.15|P-value:1.82E-8 ID:SGTC_3055|Compound:9094636|FD-Score:-3.54|P-value:7.85E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.73|P-value:4.30E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.50|P-value:8.95E-4

Top fitness defect scores for YNL213C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 30.40 5.3 µM 2.01E-165 13 6.05E-204
2 SGTC_1635 st007035 26.50 42.4 µM 2.91E-126 11 1.64E-155
3 SGTC_275 trichlorophene 14.40 5.7 µM 1.07E-38 mitochondrial stress 9 2.81E-47
4 SGTC_386 1509-0011 12.60 3.1 µM 5.84E-30 32 1.72E-36
5 SGTC_1742 st038235 9.22 28.9 µM 5.00E-17 mitochondrial stress 15 1.52E-20
6 SGTC_134 0269-0018 8.14 6.9 µM 1.08E-13 61 1.95E-16
7 SGTC_119 0121-0043 8.08 24.8 µM 1.69E-13 mitochondrial stress 10 3.36E-16
8 SGTC_116 0155-0182 6.91 31.8 µM 2.34E-10 mitochondrial response to ROS 15 2.46E-12
9 SGTC_10 0279-0212 6.88 42.6 µM 2.81E-10 TRP & mitochondrial translation 14 3.07E-12
10 SGTC_2573 2',4'-dihydroxychalcone 6.25 15.0 µM 8.63E-9 11 2.06E-10
11 SGTC_2380 9035439 5.86 200.0 µM 6.15E-8 endomembrane recycling 4 2.29E-9
12 SGTC_70 0141-0289 5.72 43.3 µM 1.20E-7 mitochondrial stress 90 5.22E-9
13 SGTC_19 0279-0214 5.42 38.4 µM 5.03E-7 TRP & mitochondrial translation 15 3.01E-8
14 SGTC_1063 disulfiram 5.30 1.8 µM 8.63E-7 5 5.83E-8
15 SGTC_2582 agaric acid 5.26 100.0 µM 1.02E-6 redox potentiating 206 7.19E-8
16 SGTC_908 3448-7491 4.81 47.7 µM 7.02E-6 mitochondrial stress 86 7.57E-7
17 SGTC_305 1682-2595 4.68 20.8 µM 1.16E-5 RNA processing & uracil transport 13 1.41E-6
18 SGTC_567 1080-0542 4.38 68.4 µM 3.85E-5 8 6.06E-6
19 SGTC_310 1273-0058 4.34 1.1 µM 4.38E-5 mitochondrial stress 222 7.10E-6
20 SGTC_2572 astragaloside iv 4.32 100.0 µM 4.80E-5 16 7.93E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.709 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.668 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.659 0 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.644 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.643 0 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.630 0 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.628 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.613 0 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.611 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.611 0 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.611 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.609 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.609 0 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.605 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.603 0 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit