YNL214W / PEX17

Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL214W / PEX17

Click on Significant Values for Screen Details ID:SGTC_117|Compound:lucigenin|FD-Score:3.35|P-value:6.33E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:5.78|P-value:1.16E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.56|P-value:2.23E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.30|P-value:7.48E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:4.06|P-value:4.56E-5 ID:SGTC_199|Compound:4063-0024|FD-Score:3.25|P-value:8.85E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.46|P-value:3.21E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.23|P-value:9.61E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.88|P-value:9.19E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:3.85|P-value:1.05E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.36|P-value:9.05E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.30|P-value:7.49E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.74|P-value:1.17E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.94|P-value:7.31E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.79|P-value:1.31E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.29|P-value:5.97E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.26|P-value:8.81E-4 ID:SGTC_1654|Compound:st012436|FD-Score:-3.14|P-value:9.71E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.88|P-value:1.27E-6 ID:SGTC_1730|Compound:st033808|FD-Score:4.66|P-value:3.54E-6 ID:SGTC_1776|Compound:st049249|FD-Score:3.77|P-value:1.42E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.45|P-value:4.54E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.30|P-value:7.70E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.36|P-value:6.28E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.74|P-value:1.14E-4 ID:SGTC_2096|Compound:5468907|FD-Score:4.02|P-value:5.31E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.38|P-value:5.73E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.87|P-value:6.84E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-3.69|P-value:1.38E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.37|P-value:5.93E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.29|P-value:1.81E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.30|P-value:7.67E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.27|P-value:8.27E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.20|P-value:7.88E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:5.03|P-value:6.07E-7 ID:SGTC_2731|Compound:amoxapine|FD-Score:3.41|P-value:5.25E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.80|P-value:1.29E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-7.11|P-value:1.66E-12 ID:SGTC_3027|Compound:9089541|FD-Score:6.23|P-value:8.77E-10 ID:SGTC_3356|Compound:9151811|FD-Score:3.90|P-value:8.83E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.35|P-value:6.33E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:5.78|P-value:1.16E-8 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.56|P-value:2.23E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.30|P-value:7.48E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:4.06|P-value:4.56E-5 ID:SGTC_199|Compound:4063-0024|FD-Score:3.25|P-value:8.85E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.46|P-value:3.21E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.23|P-value:9.61E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.88|P-value:9.19E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:3.85|P-value:1.05E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.36|P-value:9.05E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.30|P-value:7.49E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.74|P-value:1.17E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.94|P-value:7.31E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.79|P-value:1.31E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:-3.29|P-value:5.97E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.26|P-value:8.81E-4 ID:SGTC_1654|Compound:st012436|FD-Score:-3.14|P-value:9.71E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.88|P-value:1.27E-6 ID:SGTC_1730|Compound:st033808|FD-Score:4.66|P-value:3.54E-6 ID:SGTC_1776|Compound:st049249|FD-Score:3.77|P-value:1.42E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.45|P-value:4.54E-4 ID:SGTC_1936|Compound:st074407|FD-Score:3.30|P-value:7.70E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.36|P-value:6.28E-4 ID:SGTC_1975|Compound:st070967|FD-Score:-3.74|P-value:1.14E-4 ID:SGTC_2096|Compound:5468907|FD-Score:4.02|P-value:5.31E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.38|P-value:5.73E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.87|P-value:6.84E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-3.69|P-value:1.38E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.37|P-value:5.93E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.29|P-value:1.81E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.30|P-value:7.67E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.27|P-value:8.27E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:-3.20|P-value:7.88E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:5.03|P-value:6.07E-7 ID:SGTC_2731|Compound:amoxapine|FD-Score:3.41|P-value:5.25E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.80|P-value:1.29E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-7.11|P-value:1.66E-12 ID:SGTC_3027|Compound:9089541|FD-Score:6.23|P-value:8.77E-10 ID:SGTC_3356|Compound:9151811|FD-Score:3.90|P-value:8.83E-5

Top fitness defect scores for YNL214W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_3027 9089541 6.23 49.5 µM 8.77E-10 fatty acid desaturase (OLE1) 2 2.41E-10
2 SGTC_139 0099-0334 5.78 718.6 µM 1.16E-8 5 3.71E-9
3 SGTC_2727 riluzole 5.03 51.8 µM 6.07E-7 mitochondrial processes 5 2.48E-7
4 SGTC_1682 st012968 4.88 530.0 nM 1.27E-6 6 5.43E-7
5 SGTC_1730 st033808 4.66 45.1 µM 3.54E-6 17 1.61E-6
6 SGTC_2410 aloe-emodin-8-o-glycoside 4.29 46.3 µM 1.81E-5 mitochondrial processes 22 9.12E-6
7 SGTC_190 3970-0790 4.06 3.7 µM 4.56E-5 6 2.44E-5
8 SGTC_2096 5468907 4.02 200.0 µM 5.31E-5 5 2.86E-5
9 SGTC_974 1326-0144 3.94 138.0 µM 7.31E-5 ERG2 43 4.02E-5
10 SGTC_3356 9151811 3.90 4.5 µM 8.83E-5 cell wall 21 4.91E-5
11 SGTC_436 n,n-dimethylsphingosine 3.88 3.3 µM 9.19E-5 30 5.13E-5
12 SGTC_577 r071-0003 3.85 38.6 µM 1.05E-4 fatty acid desaturase (OLE1) 60 5.89E-5
13 SGTC_2851 9015922 3.80 71.4 µM 1.29E-4 45 7.33E-5
14 SGTC_1039 k821-0043 3.79 94.0 µM 1.31E-4 Golgi 30 7.44E-5
15 SGTC_1776 st049249 3.77 45.9 µM 1.42E-4 19 8.14E-5
16 SGTC_1934 st074720 3.45 32.6 µM 4.54E-4 81 2.80E-4
17 SGTC_2731 amoxapine 3.41 43.4 µM 5.25E-4 1 3.27E-4
18 SGTC_2292 7671323 3.38 168.1 µM 5.73E-4 RNA processing & uracil transport 61 3.58E-4
19 SGTC_2407 paclitaxel 3.37 400.0 µM 5.93E-4 56 3.72E-4
20 SGTC_1942 st076330 3.36 65.2 µM 6.28E-4 45 3.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.19E-8 YHR079C-A SAE3 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
0.094 4.71E-8 YMR055C BUB2 hom Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
0.089 2.30E-7 YAR018C KIN3 hom Nonessential serine/threonine protein kinase; possible role in DNA damage response
0.085 7.92E-7 YDL184C RPL41A hom Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication
0.084 1.10E-6 YER019W ISC1 hom Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance
0.078 6.18E-6 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.078 6.61E-6 YMR194C-B CMC4 hom Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs
0.077 7.29E-6 YCR087C-A_p YCR087C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
0.077 8.39E-6 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.076 9.47E-6 YGR222W PET54 hom Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing
0.075 1.37E-5 YLR270W DCS1 hom Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress
0.075 1.38E-5 YMR290W-A_d YMR290W-A_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
0.074 1.61E-5 YGL185C_p YGL185C_p hom Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.074 1.94E-5 YPR148C YPR148C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.072 3.08E-5 YIR002C MPH1 hom 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases