YNL215W / IES2

Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL215W / IES2

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:-3.76|P-value:2.61E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:13.90|P-value:7.29E-38 ID:SGTC_13|Compound:0199-0087|FD-Score:3.46|P-value:6.79E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:4.30|P-value:3.47E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:-3.48|P-value:6.64E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:4.16|P-value:5.99E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.88|P-value:1.73E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:22.10|P-value:4.57E-93 ID:SGTC_90|Compound:0870-0863|FD-Score:3.39|P-value:8.54E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.41|P-value:8.01E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.88|P-value:1.71E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-5.93|P-value:2.25E-8 ID:SGTC_266|Compound:formosanin C|FD-Score:4.23|P-value:4.57E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:4.45|P-value:1.96E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:7.44|P-value:3.09E-12 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.54|P-value:5.43E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:5.00|P-value:1.87E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:5.13|P-value:1.05E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.73|P-value:6.03E-8 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.43|P-value:7.80E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.92|P-value:2.67E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:3.97|P-value:1.23E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.17|P-value:5.81E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:5.09|P-value:1.29E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.47|P-value:6.84E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.63|P-value:4.10E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.66|P-value:9.06E-8 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.64|P-value:8.78E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.03|P-value:9.74E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:-4.20|P-value:5.38E-5 ID:SGTC_1322|Compound:1348-1070|FD-Score:-3.53|P-value:5.73E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:-3.47|P-value:6.88E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.42|P-value:2.16E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.68|P-value:3.32E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.76|P-value:2.63E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.81|P-value:2.23E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.66|P-value:3.68E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-4.89|P-value:3.26E-6 ID:SGTC_2006|Compound:4011487|FD-Score:-3.56|P-value:5.12E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.52|P-value:5.72E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-4.07|P-value:8.73E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.15|P-value:9.51E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.66|P-value:3.72E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.19|P-value:5.43E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:16.40|P-value:2.91E-52 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.59|P-value:4.48E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.77|P-value:2.51E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.12|P-value:6.94E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.39|P-value:2.56E-5 ID:SGTC_2691|Compound:st077356|FD-Score:3.62|P-value:4.05E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.47|P-value:1.82E-5 ID:SGTC_2780|Compound:5215298|FD-Score:6.27|P-value:3.39E-9 ID:SGTC_2825|Compound:7998094|FD-Score:3.71|P-value:3.02E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.21|P-value:4.90E-5 ID:SGTC_2866|Compound:9034245|FD-Score:3.46|P-value:6.80E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.34|P-value:4.15E-7 ID:SGTC_3009|Compound:9080819|FD-Score:3.80|P-value:2.23E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.89|P-value:3.13E-6 ID:SGTC_3029|Compound:9088683|FD-Score:-3.58|P-value:4.80E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-4.85|P-value:3.83E-6 ID:SGTC_3182|Compound:9108849|FD-Score:4.54|P-value:1.38E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.39|P-value:8.57E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:-3.76|P-value:2.61E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:13.90|P-value:7.29E-38 ID:SGTC_13|Compound:0199-0087|FD-Score:3.46|P-value:6.79E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:4.30|P-value:3.47E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:-3.48|P-value:6.64E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:4.16|P-value:5.99E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.88|P-value:1.73E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:22.10|P-value:4.57E-93 ID:SGTC_90|Compound:0870-0863|FD-Score:3.39|P-value:8.54E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.41|P-value:8.01E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.88|P-value:1.71E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-5.93|P-value:2.25E-8 ID:SGTC_266|Compound:formosanin C|FD-Score:4.23|P-value:4.57E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:4.45|P-value:1.96E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:7.44|P-value:3.09E-12 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.54|P-value:5.43E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:5.00|P-value:1.87E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:5.13|P-value:1.05E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.73|P-value:6.03E-8 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.43|P-value:7.80E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.92|P-value:2.67E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:3.97|P-value:1.23E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.17|P-value:5.81E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:5.09|P-value:1.29E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.47|P-value:6.84E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.63|P-value:4.10E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.66|P-value:9.06E-8 ID:SGTC_1191|Compound:1487-1166|FD-Score:4.64|P-value:8.78E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.03|P-value:9.74E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:-4.20|P-value:5.38E-5 ID:SGTC_1322|Compound:1348-1070|FD-Score:-3.53|P-value:5.73E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:-3.47|P-value:6.88E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:4.42|P-value:2.16E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.68|P-value:3.32E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-3.76|P-value:2.63E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.81|P-value:2.23E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.66|P-value:3.68E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-4.89|P-value:3.26E-6 ID:SGTC_2006|Compound:4011487|FD-Score:-3.56|P-value:5.12E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.52|P-value:5.72E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-4.07|P-value:8.73E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.15|P-value:9.51E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.66|P-value:3.72E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.19|P-value:5.43E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:16.40|P-value:2.91E-52 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.59|P-value:4.48E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.77|P-value:2.51E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.12|P-value:6.94E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.39|P-value:2.56E-5 ID:SGTC_2691|Compound:st077356|FD-Score:3.62|P-value:4.05E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.47|P-value:1.82E-5 ID:SGTC_2780|Compound:5215298|FD-Score:6.27|P-value:3.39E-9 ID:SGTC_2825|Compound:7998094|FD-Score:3.71|P-value:3.02E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.21|P-value:4.90E-5 ID:SGTC_2866|Compound:9034245|FD-Score:3.46|P-value:6.80E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.34|P-value:4.15E-7 ID:SGTC_3009|Compound:9080819|FD-Score:3.80|P-value:2.23E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.89|P-value:3.13E-6 ID:SGTC_3029|Compound:9088683|FD-Score:-3.58|P-value:4.80E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-4.85|P-value:3.83E-6 ID:SGTC_3182|Compound:9108849|FD-Score:4.54|P-value:1.38E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.39|P-value:8.57E-4

Top fitness defect scores for YNL215W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 22.10 9.0 µM 4.57E-93 cell wall 6 1.00E-108
2 SGTC_2582 agaric acid 16.40 100.0 µM 2.91E-52 redox potentiating 6 6.72E-61
3 SGTC_7 0192-1582 13.90 4.2 µM 7.29E-38 3 5.00E-44
4 SGTC_359 0081-0058 7.44 15.9 µM 3.09E-12 60S ribosome export 5 5.01E-14
5 SGTC_2780 5215298 6.27 71.4 µM 3.39E-9 6 1.78E-10
6 SGTC_453 enantio-paf c16 5.73 10.0 µM 6.03E-8 61 5.13E-9
7 SGTC_2489 cantharidin 5.15 73.4 µM 9.51E-7 cell wall signaling 17 1.28E-7
8 SGTC_435 c-PAF 5.13 6.7 µM 1.05E-6 15 1.44E-7
9 SGTC_853 0419-0306 5.09 21.0 µM 1.29E-6 3 1.82E-7
10 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 5.00 8.0 µM 1.87E-6 12 2.81E-7
11 SGTC_513 4245-1575 4.92 41.7 µM 2.67E-6 unfolded protein response 76 4.27E-7
12 SGTC_3027 9089541 4.89 49.5 µM 3.13E-6 fatty acid desaturase (OLE1) 7 5.12E-7
13 SGTC_1191 1487-1166 4.64 10.6 µM 8.78E-6 azole & statin 23 1.70E-6
14 SGTC_3182 9108849 4.54 49.5 µM 1.38E-5 RPP1 & pyrimidine depletion 6 2.88E-6
15 SGTC_2741 miltefosine 4.47 3.0 µM 1.82E-5 32 3.99E-6
16 SGTC_304 1310-0298 4.45 97.0 µM 1.96E-5 cell wall 44 4.35E-6
17 SGTC_1476 4112-3294 4.42 3.3 µM 2.16E-5 60S ribosome export 10 4.86E-6
18 SGTC_14 0354-0009 4.30 295.0 µM 3.47E-5 22 8.41E-6
19 SGTC_266 formosanin C 4.23 406.0 nM 4.57E-5 sphingolipid biosynthesis & PDR1 57 1.16E-5
20 SGTC_2858 9025781 4.21 9.0 µM 4.90E-5 sphingolipid biosynthesis & PDR1 86 1.26E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.424 7.84E-146 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.375 5.33E-112 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.353 1.06E-98 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.347 2.17E-95 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.331 1.91E-86 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.322 2.53E-81 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.321 4.11E-81 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.309 3.58E-75 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.300 1.53E-70 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.289 2.07E-65 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.279 6.92E-61 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.278 2.52E-60 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.277 8.28E-60 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.275 3.31E-59 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.267 1.14E-55 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly