YNL217W_p

Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL217W / YNL217W

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:-2.88|P-value:9.60E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.64|P-value:4.90E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.86|P-value:1.80E-5 ID:SGTC_276|Compound:colchicine|FD-Score:3.47|P-value:1.03E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.52|P-value:6.79E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.14|P-value:3.63E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.15|P-value:3.85E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:-3.10|P-value:4.20E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.35|P-value:1.65E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:2.97|P-value:7.47E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.17|P-value:3.56E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:-2.98|P-value:6.55E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.10|P-value:5.65E-6 ID:SGTC_1442|Compound:4112-3290|FD-Score:-3.25|P-value:2.34E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.14|P-value:3.93E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-2.92|P-value:8.21E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.21|P-value:3.01E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.40|P-value:1.26E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.29|P-value:2.15E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-2.97|P-value:6.82E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-2.99|P-value:6.29E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.36|P-value:1.67E-4 ID:SGTC_2056|Compound:5235370|FD-Score:4.09|P-value:5.93E-6 ID:SGTC_2313|Compound:7726885|FD-Score:3.39|P-value:1.44E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.12|P-value:4.30E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-2.87|P-value:9.74E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:2.96|P-value:7.95E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.22|P-value:2.92E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-4.03|P-value:7.13E-6 ID:SGTC_2479|Compound:5617353|FD-Score:3.57|P-value:6.67E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.22|P-value:2.90E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:2.94|P-value:8.48E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.90|P-value:8.74E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.10|P-value:4.23E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.71|P-value:3.18E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.84|P-value:1.98E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.32|P-value:1.95E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.41|P-value:1.32E-4 ID:SGTC_2891|Compound:9063876|FD-Score:4.10|P-value:5.86E-6 ID:SGTC_2894|Compound:9048625|FD-Score:5.20|P-value:1.27E-8 ID:SGTC_3031|Compound:9088762|FD-Score:4.03|P-value:8.22E-6 ID:SGTC_3101|Compound:9120531|FD-Score:3.18|P-value:3.34E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.69|P-value:3.99E-5 ID:SGTC_26|Compound:0302-0163|FD-Score:-2.88|P-value:9.60E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.64|P-value:4.90E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.86|P-value:1.80E-5 ID:SGTC_276|Compound:colchicine|FD-Score:3.47|P-value:1.03E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:4.52|P-value:6.79E-7 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.14|P-value:3.63E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.15|P-value:3.85E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:-3.10|P-value:4.20E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.35|P-value:1.65E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:2.97|P-value:7.47E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.17|P-value:3.56E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:-2.98|P-value:6.55E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.10|P-value:5.65E-6 ID:SGTC_1442|Compound:4112-3290|FD-Score:-3.25|P-value:2.34E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.14|P-value:3.93E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-2.92|P-value:8.21E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.21|P-value:3.01E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.40|P-value:1.26E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.29|P-value:2.15E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-2.97|P-value:6.82E-4 ID:SGTC_1905|Compound:st060207|FD-Score:-2.99|P-value:6.29E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.36|P-value:1.67E-4 ID:SGTC_2056|Compound:5235370|FD-Score:4.09|P-value:5.93E-6 ID:SGTC_2313|Compound:7726885|FD-Score:3.39|P-value:1.44E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.12|P-value:4.30E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-2.87|P-value:9.74E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:2.96|P-value:7.95E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.22|P-value:2.92E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-4.03|P-value:7.13E-6 ID:SGTC_2479|Compound:5617353|FD-Score:3.57|P-value:6.67E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.22|P-value:2.90E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:2.94|P-value:8.48E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.90|P-value:8.74E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.10|P-value:4.23E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.71|P-value:3.18E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.84|P-value:1.98E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.32|P-value:1.95E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.41|P-value:1.32E-4 ID:SGTC_2891|Compound:9063876|FD-Score:4.10|P-value:5.86E-6 ID:SGTC_2894|Compound:9048625|FD-Score:5.20|P-value:1.27E-8 ID:SGTC_3031|Compound:9088762|FD-Score:4.03|P-value:8.22E-6 ID:SGTC_3101|Compound:9120531|FD-Score:3.18|P-value:3.34E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.69|P-value:3.99E-5

Top fitness defect scores for YNL217W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2894 9048625 5.20 32.5 µM 1.27E-8 3 9.75E-8
2 SGTC_536 3852-0578 4.52 10.6 µM 6.79E-7 16 3.16E-6
3 SGTC_907 3448-6986 4.35 75.5 µM 1.65E-6 19 6.90E-6
4 SGTC_1418 3966-3099 4.10 2.4 µM 5.65E-6 14 2.02E-5
5 SGTC_2891 9063876 4.10 19.5 µM 5.86E-6 5 2.09E-5
6 SGTC_2056 5235370 4.09 200.0 µM 5.93E-6 35 2.11E-5
7 SGTC_3031 9088762 4.03 49.5 µM 8.22E-6 16 2.81E-5
8 SGTC_265 mycophenolic acid 3.86 32.9 µM 1.80E-5 RPP1 & pyrimidine depletion 20 5.58E-5
9 SGTC_2613 3',4'-dimethoxydalbergione 3.84 24.6 µM 1.98E-5 27 6.08E-5
10 SGTC_3292 9120825 3.69 59.8 µM 3.99E-5 16 1.13E-4
11 SGTC_182 3448-4371 3.64 550.5 µM 4.90E-5 27 1.35E-4
12 SGTC_2479 5617353 3.57 43.9 µM 6.67E-5 53 1.76E-4
13 SGTC_276 colchicine 3.47 750.0 µM 1.03E-4 29 2.59E-4
14 SGTC_2882 9058044 3.41 58.4 µM 1.32E-4 28 3.22E-4
15 SGTC_2313 7726885 3.39 200.0 µM 1.44E-4 RPP1 & pyrimidine depletion 54 3.48E-4
16 SGTC_2042 p-Dimethylaminoacetophenone 3.36 200.0 µM 1.67E-4 43 3.95E-4
17 SGTC_2623 humulene 3.32 100.0 µM 1.95E-4 43 4.52E-4
18 SGTC_1733 st037357 3.29 54.9 µM 2.15E-4 60S ribosome export 70 4.94E-4
19 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.22 92.6 µM 2.90E-4 55 6.42E-4
20 SGTC_2414 st077232 3.22 92.9 µM 2.92E-4 48 6.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.089 2.25E-7 YGR205W TDA10 hom ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
0.089 2.30E-7 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.087 4.65E-7 YMR018W_p YMR018W_p hom Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene
0.083 1.64E-6 YPR178W PRP4 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.081 2.79E-6 YNL277W-A_p YNL277W-A_p hom Putative protein of unknown function
0.080 3.80E-6 YGL098W USE1 het Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
0.078 6.55E-6 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.075 1.21E-5 YDL212W SHR3 het Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
0.070 5.11E-5 YMR049C ERB1 het Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1
0.068 8.55E-5 YLR285W NNT1 hom S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination
0.067 9.89E-5 YFL040W_p YFL040W_p hom Putative transporter, member of the sugar porter family; YFL040W is not an essential gene
0.066 1.25E-4 YAR028W_p YAR028W_p hom Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.066 1.49E-4 YNL145W MFA2 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1
0.065 1.61E-4 YDR193W_d YDR193W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.065 1.78E-4 YLR141W RRN5 het Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p