YNL221C / POP1

Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL221C / POP1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:5.07|P-value:1.73E-7 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.59|P-value:1.80E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:5.25|P-value:6.51E-8 ID:SGTC_89|Compound:0302-0250|FD-Score:4.74|P-value:9.25E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:3.43|P-value:2.80E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.78|P-value:7.39E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:4.13|P-value:1.65E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.19|P-value:6.83E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.11|P-value:1.77E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.69|P-value:1.02E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:17.40|P-value:2.61E-69 ID:SGTC_548|Compound:1436-0017|FD-Score:6.07|P-value:5.19E-10 ID:SGTC_600|Compound:1495-0418|FD-Score:4.21|P-value:1.16E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:4.93|P-value:3.52E-7 ID:SGTC_780|Compound:0109-0199|FD-Score:4.85|P-value:5.34E-7 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.46|P-value:2.33E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.92|P-value:4.15E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:3.08|P-value:9.75E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:5.07|P-value:1.71E-7 ID:SGTC_860|Compound:0443-0016|FD-Score:3.95|P-value:3.65E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:17.40|P-value:9.94E-69 ID:SGTC_955|Compound:1216-0110|FD-Score:3.39|P-value:3.36E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.52|P-value:2.71E-6 ID:SGTC_1016|Compound:4226-1401|FD-Score:12.60|P-value:6.41E-37 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.10|P-value:9.29E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.59|P-value:1.57E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.28|P-value:4.63E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.16|P-value:7.63E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.69|P-value:1.21E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.99|P-value:3.03E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.82|P-value:5.75E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:11.50|P-value:1.61E-31 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.74|P-value:8.68E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.53|P-value:1.79E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.26|P-value:9.46E-6 ID:SGTC_1174|Compound:0739-0097|FD-Score:7.19|P-value:2.32E-13 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.37|P-value:5.52E-6 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.63|P-value:1.32E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.24|P-value:5.70E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.39|P-value:3.25E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.13|P-value:7.75E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.15|P-value:7.77E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.48|P-value:3.37E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:8.11|P-value:1.58E-16 ID:SGTC_1554|Compound:st069299|FD-Score:3.95|P-value:3.56E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.19|P-value:6.73E-4 ID:SGTC_1643|Compound:st009866|FD-Score:12.40|P-value:6.07E-36 ID:SGTC_1843|Compound:st055809|FD-Score:3.32|P-value:4.29E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.92|P-value:4.13E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:31.70|P-value:4.02E-224 ID:SGTC_1915|Compound:st067105|FD-Score:5.24|P-value:6.87E-8 ID:SGTC_1934|Compound:st074720|FD-Score:3.63|P-value:1.32E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.48|P-value:2.32E-4 ID:SGTC_1954|Compound:st077032|FD-Score:5.71|P-value:4.76E-9 ID:SGTC_2057|Compound:5236571|FD-Score:3.72|P-value:9.16E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-3.14|P-value:7.44E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.37|P-value:3.57E-4 ID:SGTC_2067|Compound:5224629|FD-Score:5.23|P-value:7.39E-8 ID:SGTC_2078|Compound:5212016|FD-Score:3.35|P-value:3.81E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.55|P-value:1.78E-4 ID:SGTC_2110|Compound:5483698|FD-Score:5.70|P-value:4.97E-9 ID:SGTC_2188|Compound:6126565|FD-Score:4.51|P-value:2.85E-6 ID:SGTC_2373|Compound:9071805|FD-Score:-3.07|P-value:9.68E-4 ID:SGTC_2387|Compound:9077560|FD-Score:6.38|P-value:7.03E-11 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.34|P-value:3.94E-8 ID:SGTC_2411|Compound:st077133|FD-Score:38.30|P-value:0 ID:SGTC_2456|Compound:5770359|FD-Score:-3.89|P-value:4.21E-5 ID:SGTC_2458|Compound:5808907|FD-Score:-3.10|P-value:8.55E-4 ID:SGTC_2470|Compound:5664817|FD-Score:3.86|P-value:5.31E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:10.40|P-value:3.61E-26 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.14|P-value:1.62E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:23.90|P-value:4.13E-128 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:9.05|P-value:3.98E-20 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-3.28|P-value:4.54E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.73|P-value:4.14E-9 ID:SGTC_2797|Compound:7859098|FD-Score:3.57|P-value:1.67E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-4.17|P-value:1.24E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-3.15|P-value:7.21E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.41|P-value:3.09E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.61|P-value:1.44E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-4.36|P-value:5.29E-6 ID:SGTC_2894|Compound:9048625|FD-Score:-3.49|P-value:2.12E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.08|P-value:2.03E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-3.86|P-value:4.70E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:5.07|P-value:1.73E-7 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.59|P-value:1.80E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:5.25|P-value:6.51E-8 ID:SGTC_89|Compound:0302-0250|FD-Score:4.74|P-value:9.25E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:3.43|P-value:2.80E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:3.78|P-value:7.39E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:4.13|P-value:1.65E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.19|P-value:6.83E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.11|P-value:1.77E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.69|P-value:1.02E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:17.40|P-value:2.61E-69 ID:SGTC_548|Compound:1436-0017|FD-Score:6.07|P-value:5.19E-10 ID:SGTC_600|Compound:1495-0418|FD-Score:4.21|P-value:1.16E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:4.93|P-value:3.52E-7 ID:SGTC_780|Compound:0109-0199|FD-Score:4.85|P-value:5.34E-7 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.46|P-value:2.33E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.92|P-value:4.15E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:3.08|P-value:9.75E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:5.07|P-value:1.71E-7 ID:SGTC_860|Compound:0443-0016|FD-Score:3.95|P-value:3.65E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:17.40|P-value:9.94E-69 ID:SGTC_955|Compound:1216-0110|FD-Score:3.39|P-value:3.36E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.52|P-value:2.71E-6 ID:SGTC_1016|Compound:4226-1401|FD-Score:12.60|P-value:6.41E-37 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.10|P-value:9.29E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.59|P-value:1.57E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.28|P-value:4.63E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.16|P-value:7.63E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.69|P-value:1.21E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.99|P-value:3.03E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.82|P-value:5.75E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:11.50|P-value:1.61E-31 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.74|P-value:8.68E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.53|P-value:1.79E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.26|P-value:9.46E-6 ID:SGTC_1174|Compound:0739-0097|FD-Score:7.19|P-value:2.32E-13 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.37|P-value:5.52E-6 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.63|P-value:1.32E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.24|P-value:5.70E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.39|P-value:3.25E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.13|P-value:7.75E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.15|P-value:7.77E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.48|P-value:3.37E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:8.11|P-value:1.58E-16 ID:SGTC_1554|Compound:st069299|FD-Score:3.95|P-value:3.56E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.19|P-value:6.73E-4 ID:SGTC_1643|Compound:st009866|FD-Score:12.40|P-value:6.07E-36 ID:SGTC_1843|Compound:st055809|FD-Score:3.32|P-value:4.29E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.92|P-value:4.13E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:31.70|P-value:4.02E-224 ID:SGTC_1915|Compound:st067105|FD-Score:5.24|P-value:6.87E-8 ID:SGTC_1934|Compound:st074720|FD-Score:3.63|P-value:1.32E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.48|P-value:2.32E-4 ID:SGTC_1954|Compound:st077032|FD-Score:5.71|P-value:4.76E-9 ID:SGTC_2057|Compound:5236571|FD-Score:3.72|P-value:9.16E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-3.14|P-value:7.44E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.37|P-value:3.57E-4 ID:SGTC_2067|Compound:5224629|FD-Score:5.23|P-value:7.39E-8 ID:SGTC_2078|Compound:5212016|FD-Score:3.35|P-value:3.81E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.55|P-value:1.78E-4 ID:SGTC_2110|Compound:5483698|FD-Score:5.70|P-value:4.97E-9 ID:SGTC_2188|Compound:6126565|FD-Score:4.51|P-value:2.85E-6 ID:SGTC_2373|Compound:9071805|FD-Score:-3.07|P-value:9.68E-4 ID:SGTC_2387|Compound:9077560|FD-Score:6.38|P-value:7.03E-11 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.34|P-value:3.94E-8 ID:SGTC_2411|Compound:st077133|FD-Score:38.30|P-value:0 ID:SGTC_2456|Compound:5770359|FD-Score:-3.89|P-value:4.21E-5 ID:SGTC_2458|Compound:5808907|FD-Score:-3.10|P-value:8.55E-4 ID:SGTC_2470|Compound:5664817|FD-Score:3.86|P-value:5.31E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:10.40|P-value:3.61E-26 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.14|P-value:1.62E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:23.90|P-value:4.13E-128 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:9.05|P-value:3.98E-20 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-3.28|P-value:4.54E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.73|P-value:4.14E-9 ID:SGTC_2797|Compound:7859098|FD-Score:3.57|P-value:1.67E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-4.17|P-value:1.24E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-3.15|P-value:7.21E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.41|P-value:3.09E-4 ID:SGTC_2860|Compound:9025725|FD-Score:3.61|P-value:1.44E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-4.36|P-value:5.29E-6 ID:SGTC_2894|Compound:9048625|FD-Score:-3.49|P-value:2.12E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.08|P-value:2.03E-5 ID:SGTC_3031|Compound:9088762|FD-Score:-3.86|P-value:4.70E-5

Top fitness defect scores for YNL221C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2411 st077133 38.30 39.9 µM 0 RNA pol III & RNase P/MRP 1 0 14.80
2 SGTC_1872 amphotericin b 31.70 148.0 nM 4.02E-224 RNA pol III & RNase P/MRP 1 7.27E-221 14.10
3 SGTC_2612 dictamnine 23.90 15.5 µM 4.13E-128 RNA pol III & RNase P/MRP 2 2.73E-126 5.43
4 SGTC_539 4859-0462 17.40 2.5 µM 2.61E-69 RNA pol III & RNase P/MRP 1 2.33E-68 6.29
5 SGTC_919 tnp00227 17.40 403.6 nM 9.94E-69 RNA pol III & RNase P/MRP 1 8.69E-68 8.13
6 SGTC_1016 4226-1401 12.60 38.0 µM 6.41E-37 RNA pol III & RNase P/MRP 3 1.92E-36 3.43
7 SGTC_1643 st009866 12.40 20.2 µM 6.07E-36 5 1.76E-35 5.04
8 SGTC_1127 asiatic acid 11.50 681.4 nM 1.61E-31 1 4.04E-31 5.62
9 SGTC_2544 sphondin 10.40 68.5 µM 3.61E-26 RNA pol III & RNase P/MRP 5 7.60E-26 0.19
10 SGTC_2685 mycophenolic acid 9.05 18.9 µM 3.98E-20 RNA pol III & RNase P/MRP 2 6.88E-20 3.46
11 SGTC_1534 6-azauridine 8.11 81.6 µM 1.58E-16 RNA pol III & RNase P/MRP 2 2.44E-16 2.53
12 SGTC_1174 0739-0097 7.19 51.1 µM 2.32E-13 redox potentiating 1 3.23E-13 1.98
13 SGTC_2387 9077560 6.38 195.1 µM 7.03E-11 4 9.06E-11 0.64
14 SGTC_548 1436-0017 6.07 110.0 µM 5.19E-10 TSC3-RPN4 2 6.50E-10 1.43
15 SGTC_2752 diclazuril 5.73 33.1 µM 4.14E-9 2 5.05E-9 0.28
16 SGTC_1954 st077032 5.71 68.9 µM 4.76E-9 1 5.80E-9 1.08
17 SGTC_2110 5483698 5.70 200.0 µM 4.97E-9 TSC3-RPN4 3 6.05E-9 0.76
18 SGTC_2408 sulbentine 5.34 18.4 µM 3.94E-8 20 4.66E-8 0.22
19 SGTC_78 0336-0123 5.25 156.8 µM 6.51E-8 5 7.66E-8 0.82
20 SGTC_1915 st067105 5.24 30.6 µM 6.87E-8 RNA pol III & RNase P/MRP 26 8.08E-8 0.17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.444 6.51E-162 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.417 4.21E-141 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.411 4.60E-137 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.397 4.73E-127 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.365 2.93E-106 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.341 4.25E-92 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.293 3.08E-67 YDR211W GCD6 het Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.259 1.53E-52 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.241 1.84E-45 YDL152W_d YDL152W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
0.237 3.62E-44 YDL150W RPC53 het RNA polymerase III subunit C53
0.226 5.09E-40 YMR283C RIT1 hom 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
0.195 6.39E-30 YHR062C RPP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.195 4.25E-30 YNL282W POP3 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.192 3.18E-29 YGR090W UTP22 het Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals
0.179 1.55E-25 YER048C CAJ1 hom Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly