YNL222W / SSU72

Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL222W / SSU72

Click on Significant Values for Screen Details ID:SGTC_195|Compound:4234-0266|FD-Score:-3.10|P-value:1.72E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:-2.71|P-value:8.82E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-2.89|P-value:4.27E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:-4.52|P-value:7.75E-8 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.13|P-value:1.52E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.95|P-value:2.71E-9 ID:SGTC_657|Compound:3534-0529|FD-Score:3.67|P-value:7.11E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:2.99|P-value:1.94E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:2.89|P-value:3.00E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.02|P-value:1.64E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.64|P-value:1.23E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:2.63|P-value:8.96E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:2.78|P-value:4.94E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.79|P-value:3.73E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.60|P-value:9.88E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-2.90|P-value:4.05E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.75|P-value:5.49E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.20|P-value:4.26E-10 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.61|P-value:9.97E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.03|P-value:1.67E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:2.70|P-value:6.62E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.29|P-value:4.95E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:2.90|P-value:2.92E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:2.72|P-value:6.21E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.47|P-value:2.05E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.52|P-value:1.60E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.46|P-value:2.14E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.90|P-value:1.97E-6 ID:SGTC_1738|Compound:st035555|FD-Score:4.44|P-value:7.95E-8 ID:SGTC_1749|Compound:st037932|FD-Score:-2.99|P-value:2.81E-4 ID:SGTC_1773|Compound:st048542|FD-Score:2.61|P-value:9.79E-4 ID:SGTC_1871|Compound:st057448|FD-Score:2.93|P-value:2.52E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.73|P-value:7.85E-6 ID:SGTC_1914|Compound:st062367|FD-Score:3.41|P-value:2.66E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-3.24|P-value:9.10E-5 ID:SGTC_1936|Compound:st074407|FD-Score:2.98|P-value:2.10E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-2.84|P-value:5.19E-4 ID:SGTC_2186|Compound:6124449|FD-Score:2.87|P-value:3.30E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.17|P-value:8.63E-5 ID:SGTC_2255|Compound:7941087|FD-Score:2.83|P-value:3.96E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-2.85|P-value:5.05E-4 ID:SGTC_2279|Compound:7948423|FD-Score:2.83|P-value:4.02E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.04|P-value:1.60E-4 ID:SGTC_2318|Compound:6029776|FD-Score:2.80|P-value:4.41E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-2.99|P-value:2.84E-4 ID:SGTC_2369|Compound:9071472|FD-Score:2.84|P-value:3.76E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.02|P-value:1.69E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:2.68|P-value:7.44E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:2.90|P-value:2.93E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.89|P-value:2.10E-6 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-3.00|P-value:2.63E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.50|P-value:1.73E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.50|P-value:1.76E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-2.85|P-value:4.96E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.38|P-value:3.10E-5 ID:SGTC_2973|Compound:9094665|FD-Score:4.48|P-value:6.28E-8 ID:SGTC_3094|Compound:9117742|FD-Score:2.87|P-value:3.31E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.60|P-value:1.55E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-2.84|P-value:5.18E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.32|P-value:6.20E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:-3.10|P-value:1.72E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:-2.71|P-value:8.82E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-2.89|P-value:4.27E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:-4.52|P-value:7.75E-8 ID:SGTC_628|Compound:1636-0253|FD-Score:-3.13|P-value:1.52E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.95|P-value:2.71E-9 ID:SGTC_657|Compound:3534-0529|FD-Score:3.67|P-value:7.11E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:2.99|P-value:1.94E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:2.89|P-value:3.00E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-4.02|P-value:1.64E-6 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.64|P-value:1.23E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:2.63|P-value:8.96E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:2.78|P-value:4.94E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.79|P-value:3.73E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.60|P-value:9.88E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-2.90|P-value:4.05E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.75|P-value:5.49E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.20|P-value:4.26E-10 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.61|P-value:9.97E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.03|P-value:1.67E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:2.70|P-value:6.62E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.29|P-value:4.95E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:2.90|P-value:2.92E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:2.72|P-value:6.21E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.47|P-value:2.05E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.52|P-value:1.60E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.46|P-value:2.14E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.90|P-value:1.97E-6 ID:SGTC_1738|Compound:st035555|FD-Score:4.44|P-value:7.95E-8 ID:SGTC_1749|Compound:st037932|FD-Score:-2.99|P-value:2.81E-4 ID:SGTC_1773|Compound:st048542|FD-Score:2.61|P-value:9.79E-4 ID:SGTC_1871|Compound:st057448|FD-Score:2.93|P-value:2.52E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.73|P-value:7.85E-6 ID:SGTC_1914|Compound:st062367|FD-Score:3.41|P-value:2.66E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-3.24|P-value:9.10E-5 ID:SGTC_1936|Compound:st074407|FD-Score:2.98|P-value:2.10E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-2.84|P-value:5.19E-4 ID:SGTC_2186|Compound:6124449|FD-Score:2.87|P-value:3.30E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.17|P-value:8.63E-5 ID:SGTC_2255|Compound:7941087|FD-Score:2.83|P-value:3.96E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-2.85|P-value:5.05E-4 ID:SGTC_2279|Compound:7948423|FD-Score:2.83|P-value:4.02E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.04|P-value:1.60E-4 ID:SGTC_2318|Compound:6029776|FD-Score:2.80|P-value:4.41E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-2.99|P-value:2.84E-4 ID:SGTC_2369|Compound:9071472|FD-Score:2.84|P-value:3.76E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.02|P-value:1.69E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:2.68|P-value:7.44E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:2.90|P-value:2.93E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.89|P-value:2.10E-6 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-3.00|P-value:2.63E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.50|P-value:1.73E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.50|P-value:1.76E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-2.85|P-value:4.96E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.38|P-value:3.10E-5 ID:SGTC_2973|Compound:9094665|FD-Score:4.48|P-value:6.28E-8 ID:SGTC_3094|Compound:9117742|FD-Score:2.87|P-value:3.31E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-3.60|P-value:1.55E-5 ID:SGTC_3203|Compound:9113543|FD-Score:-2.84|P-value:5.18E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.32|P-value:6.20E-5

Top fitness defect scores for YNL222W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1346 1488-2224 5.20 62.4 µM 4.26E-10 4 9.75E-8 0.60
2 SGTC_644 1498-1197 4.95 63.3 µM 2.71E-9 4 3.78E-7 0.06
3 SGTC_2973 9094665 4.48 18.0 µM 6.28E-8 NEO1 14 3.77E-6 0.06
4 SGTC_1738 st035555 4.44 74.0 µM 7.95E-8 TSC3-RPN4 2 4.48E-6 0.35
5 SGTC_1736 st036774 3.90 51.0 µM 1.97E-6 2 4.72E-5 0.05
6 SGTC_2565 isoliquiritigenin 3.89 100.0 µM 2.10E-6 12 4.94E-5 0.21
7 SGTC_1200 1643-0193 3.79 18.4 µM 3.73E-6 5 7.55E-5 0.00
8 SGTC_657 3534-0529 3.67 86.7 µM 7.11E-6 6 1.21E-4 0.21
9 SGTC_1358 1509-0022 3.61 2.5 µM 9.97E-6 7 1.55E-4 0.13
10 SGTC_1585 2',4'-dihydroxychalcone 3.52 10.4 µM 1.60E-5 15 2.20E-4 0.06
11 SGTC_2687 chenodiol 3.50 100.0 µM 1.73E-5 8 2.33E-4 0.06
12 SGTC_2851 9015922 3.50 71.4 µM 1.76E-5 11 2.35E-4 0.13
13 SGTC_1508 1080-0625 3.47 72.9 µM 2.05E-5 3 2.64E-4 0.01
14 SGTC_1691 st019933 3.46 84.6 µM 2.14E-5 2 2.72E-4 0.09
15 SGTC_1914 st062367 3.41 72.6 µM 2.66E-5 8 3.19E-4 0.12
16 SGTC_2935 9038016 3.38 30.0 µM 3.10E-5 12 3.58E-4 0.19
17 SGTC_1475 4092-1048 3.29 11.7 µM 4.95E-5 plasma membrane duress 14 5.04E-4 0.10
18 SGTC_2254 7938975 3.17 95.2 µM 8.63E-5 18 7.60E-4 0.07
19 SGTC_2307 7538926 3.04 6.3 µM 1.60E-4 41 0.00120 0.06
20 SGTC_1375 2910-0797 3.03 186.0 µM 1.67E-4 14 0.00124 0.17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.04E-10 YJR124C_p YJR124C_p hom Putative protein of unknown function; expression induced under calcium shortage
0.098 1.45E-8 YIR042C_p YIR042C_p hom Putative protein of unknown function; YIR042C is a non-essential gene
0.097 1.69E-8 YIL087C AIM19 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
0.093 6.85E-8 YBR263W SHM1 hom Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
0.092 9.97E-8 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.090 2.02E-7 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.086 6.36E-7 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.083 1.65E-6 YER053C PIC2 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
0.080 3.75E-6 YIL130W ASG1 hom Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
0.078 6.66E-6 YNR054C ESF2 het Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
0.076 9.91E-6 YBR056W YBR056W hom Putative glycoside hydrolase of the mitochondrial intermembrane space
0.075 1.22E-5 YOL056W GPM3 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.075 1.36E-5 YOR344C TYE7 hom Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
0.074 1.56E-5 YDR006C SOK1 hom Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
0.074 1.82E-5 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock