YNL224C / SQS1

Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL224C / SQS1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.60|P-value:1.10E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.82|P-value:4.54E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.55|P-value:1.37E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.73|P-value:6.55E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:3.03|P-value:9.37E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.30|P-value:3.57E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-3.40|P-value:2.60E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.32|P-value:3.45E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:4.09|P-value:1.37E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.48|P-value:1.75E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.38|P-value:2.58E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.46|P-value:1.97E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:4.11|P-value:1.23E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.26|P-value:4.32E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.14|P-value:6.36E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.03|P-value:1.80E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:5.42|P-value:1.42E-8 ID:SGTC_827|Compound:3253-0474|FD-Score:-3.26|P-value:4.32E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.67|P-value:8.30E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.07|P-value:8.15E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.18|P-value:5.43E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.66|P-value:8.72E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.62|P-value:1.09E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.17|P-value:5.66E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.36|P-value:3.00E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.32|P-value:3.27E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.21|P-value:4.89E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.71|P-value:7.19E-5 ID:SGTC_1636|Compound:st007707|FD-Score:3.15|P-value:6.09E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.02|P-value:9.74E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.21|P-value:7.81E-6 ID:SGTC_1851|Compound:st056236|FD-Score:-3.79|P-value:5.34E-5 ID:SGTC_1861|Compound:st057647|FD-Score:4.18|P-value:9.03E-6 ID:SGTC_1958|Compound:st076513|FD-Score:3.55|P-value:1.36E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.07|P-value:8.04E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.98|P-value:2.21E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.91|P-value:3.00E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.66|P-value:3.22E-9 ID:SGTC_2429|Compound:5902844|FD-Score:-3.73|P-value:6.88E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.21|P-value:8.00E-6 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.12|P-value:6.77E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.13|P-value:6.71E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.31|P-value:3.41E-4 ID:SGTC_2734|Compound:clemastine|FD-Score:3.82|P-value:4.45E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-3.07|P-value:8.61E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.30|P-value:3.74E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.15|P-value:1.04E-5 ID:SGTC_2888|Compound:9058547|FD-Score:3.55|P-value:1.34E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.75|P-value:6.11E-5 ID:SGTC_2897|Compound:9048598|FD-Score:4.69|P-value:7.69E-7 ID:SGTC_3033|Compound:9090887|FD-Score:3.10|P-value:7.37E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.19|P-value:5.35E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.83|P-value:4.23E-5 ID:SGTC_3105|Compound:9121040|FD-Score:3.37|P-value:2.69E-4 ID:SGTC_3122|Compound:9126309|FD-Score:3.33|P-value:3.17E-4 ID:SGTC_3204|Compound:9114183|FD-Score:5.01|P-value:1.44E-7 ID:SGTC_49|Compound:0717-0965|FD-Score:3.60|P-value:1.10E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.82|P-value:4.54E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:3.55|P-value:1.37E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.73|P-value:6.55E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:3.03|P-value:9.37E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.30|P-value:3.57E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-3.40|P-value:2.60E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.32|P-value:3.45E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:4.09|P-value:1.37E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.48|P-value:1.75E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.38|P-value:2.58E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.46|P-value:1.97E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:4.11|P-value:1.23E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.26|P-value:4.32E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.14|P-value:6.36E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.03|P-value:1.80E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:5.42|P-value:1.42E-8 ID:SGTC_827|Compound:3253-0474|FD-Score:-3.26|P-value:4.32E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.67|P-value:8.30E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.07|P-value:8.15E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.18|P-value:5.43E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.66|P-value:8.72E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.62|P-value:1.09E-6 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.17|P-value:5.66E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.36|P-value:3.00E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.32|P-value:3.27E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.21|P-value:4.89E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.71|P-value:7.19E-5 ID:SGTC_1636|Compound:st007707|FD-Score:3.15|P-value:6.09E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.02|P-value:9.74E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.21|P-value:7.81E-6 ID:SGTC_1851|Compound:st056236|FD-Score:-3.79|P-value:5.34E-5 ID:SGTC_1861|Compound:st057647|FD-Score:4.18|P-value:9.03E-6 ID:SGTC_1958|Compound:st076513|FD-Score:3.55|P-value:1.36E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.07|P-value:8.04E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.98|P-value:2.21E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.91|P-value:3.00E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:5.66|P-value:3.22E-9 ID:SGTC_2429|Compound:5902844|FD-Score:-3.73|P-value:6.88E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.21|P-value:8.00E-6 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.12|P-value:6.77E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:3.13|P-value:6.71E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.31|P-value:3.41E-4 ID:SGTC_2734|Compound:clemastine|FD-Score:3.82|P-value:4.45E-5 ID:SGTC_2857|Compound:9024691|FD-Score:-3.07|P-value:8.61E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.30|P-value:3.74E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.15|P-value:1.04E-5 ID:SGTC_2888|Compound:9058547|FD-Score:3.55|P-value:1.34E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.75|P-value:6.11E-5 ID:SGTC_2897|Compound:9048598|FD-Score:4.69|P-value:7.69E-7 ID:SGTC_3033|Compound:9090887|FD-Score:3.10|P-value:7.37E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.19|P-value:5.35E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.83|P-value:4.23E-5 ID:SGTC_3105|Compound:9121040|FD-Score:3.37|P-value:2.69E-4 ID:SGTC_3122|Compound:9126309|FD-Score:3.33|P-value:3.17E-4 ID:SGTC_3204|Compound:9114183|FD-Score:5.01|P-value:1.44E-7

Top fitness defect scores for YNL224C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2409 alverine citrate 5.66 64.0 µM 3.22E-9 26 7.39E-9
2 SGTC_824 1304-0008 5.42 100.0 µM 1.42E-8 DNA damage response 13 3.04E-8
3 SGTC_3204 9114183 5.01 49.5 µM 1.44E-7 11 2.78E-7
4 SGTC_2897 9048598 4.69 13.0 µM 7.69E-7 6 1.38E-6
5 SGTC_1045 1348-1485 4.62 165.0 µM 1.09E-6 13 1.92E-6
6 SGTC_1786 berberine 4.21 21.6 µM 7.81E-6 60S ribosome export 22 1.26E-5
7 SGTC_2526 patulin 4.21 37.6 µM 8.00E-6 77 1.29E-5
8 SGTC_1861 st057647 4.18 17.4 µM 9.03E-6 16 1.45E-5
9 SGTC_2880 9042983 4.15 58.4 µM 1.04E-5 fatty acid desaturase (OLE1) 18 1.66E-5
10 SGTC_610 4215-0184 4.11 155.0 µM 1.23E-5 exosome 9 1.94E-5
11 SGTC_440 fluspirilene 4.09 35.1 µM 1.37E-5 10 2.15E-5
12 SGTC_796 1234-0020 4.03 70.7 µM 1.80E-5 SWF1 & branched chain AA biosynthesis 24 2.79E-5
13 SGTC_2185 6113692 3.98 200.0 µM 2.21E-5 ergosterol biosynthesis 16 3.40E-5
14 SGTC_2401 5128683 3.91 200.0 µM 3.00E-5 40 4.55E-5
15 SGTC_3102 9121669 3.83 49.5 µM 4.23E-5 12 6.32E-5
16 SGTC_2734 clemastine 3.82 41.6 µM 4.45E-5 ERG2 3 6.64E-5
17 SGTC_97 0535-0701 3.82 19.1 µM 4.54E-5 60S ribosome export 15 6.76E-5
18 SGTC_2896 9052656 3.75 71.4 µM 6.11E-5 endomembrane recycling 130 8.99E-5
19 SGTC_198 3454-2873 3.73 16.2 µM 6.55E-5 60S ribosome export 16 9.60E-5
20 SGTC_1372 2752-0194 3.71 270.0 µM 7.19E-5 23 1.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.74E-11 YJR021C REC107 hom Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation
0.108 3.37E-10 YPR094W RDS3 het Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance
0.098 1.23E-8 YMR290C HAS1 het ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
0.085 8.25E-7 YDR109C_p YDR109C_p hom Putative kinase
0.082 1.71E-6 YJR082C EAF6 hom Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
0.081 2.28E-6 YFR047C BNA6 hom Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.081 2.28E-6 YFR045W_p YFR045W_p hom Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
0.081 2.41E-6 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.081 2.47E-6 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.077 8.63E-6 YNR069C BSC5 hom Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro
0.075 1.33E-5 YBR045C GIP1 hom Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
0.073 2.43E-5 YDR142C PEX7 hom Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
0.073 2.45E-5 YDR217C RAD9 hom DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate
0.073 2.49E-5 YOL070C NBA1 hom Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate
0.071 3.60E-5 YCR032W BPH1 hom Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting