YNL226W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL226W / YNL226W

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:3.67|P-value:1.69E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.97|P-value:5.21E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:4.62|P-value:3.27E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:5.79|P-value:8.24E-9 ID:SGTC_397|Compound:arbidol|FD-Score:3.22|P-value:8.23E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.28|P-value:1.43E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.38|P-value:9.24E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.40|P-value:5.19E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:5.70|P-value:1.35E-8 ID:SGTC_611|Compound:3453-1652|FD-Score:3.24|P-value:7.63E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.82|P-value:9.25E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.49|P-value:3.77E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-5.25|P-value:1.86E-7 ID:SGTC_665|Compound:3914-0008|FD-Score:4.27|P-value:1.50E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:4.48|P-value:6.17E-6 ID:SGTC_836|Compound:0330-0104|FD-Score:5.10|P-value:3.19E-7 ID:SGTC_899|Compound:1083-0020|FD-Score:3.51|P-value:3.03E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.24|P-value:7.61E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.38|P-value:4.65E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.69|P-value:1.54E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:6.42|P-value:1.95E-10 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.89|P-value:7.11E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.61|P-value:2.09E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:6.21|P-value:6.97E-10 ID:SGTC_1483|Compound:3453-0561|FD-Score:6.11|P-value:1.27E-9 ID:SGTC_1490|Compound:4089-0339|FD-Score:-3.83|P-value:1.06E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:-3.42|P-value:4.74E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.66|P-value:1.71E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.25|P-value:7.37E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.63|P-value:2.26E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.01|P-value:4.40E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.27|P-value:6.79E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.39|P-value:4.54E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.53|P-value:2.77E-4 ID:SGTC_1866|Compound:st057638|FD-Score:3.31|P-value:6.08E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.53|P-value:3.21E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.39|P-value:5.25E-4 ID:SGTC_1963|Compound:st076565|FD-Score:4.66|P-value:2.64E-6 ID:SGTC_2056|Compound:5235370|FD-Score:4.17|P-value:2.34E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.60|P-value:2.16E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.61|P-value:2.07E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.29|P-value:1.23E-7 ID:SGTC_2151|Compound:5563267|FD-Score:5.49|P-value:4.29E-8 ID:SGTC_2156|Compound:5649887|FD-Score:3.31|P-value:5.95E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.83|P-value:9.07E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.20|P-value:8.65E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.47|P-value:4.06E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.20|P-value:8.69E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.94|P-value:7.02E-7 ID:SGTC_2712|Compound:st079126|FD-Score:3.80|P-value:1.01E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.47|P-value:3.46E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.06|P-value:3.69E-5 ID:SGTC_2818|Compound:7996756|FD-Score:5.66|P-value:1.69E-8 ID:SGTC_2823|Compound:7987624|FD-Score:3.20|P-value:8.70E-4 ID:SGTC_2908|Compound:7930301|FD-Score:5.57|P-value:2.66E-8 ID:SGTC_2937|Compound:9044753|FD-Score:8.89|P-value:2.24E-18 ID:SGTC_3152|Compound:9099253|FD-Score:-4.75|P-value:2.15E-6 ID:SGTC_3225|Compound:9130819|FD-Score:-4.47|P-value:7.66E-6 ID:SGTC_3246|Compound:9135460|FD-Score:3.17|P-value:9.66E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.91|P-value:7.89E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:3.67|P-value:1.69E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.97|P-value:5.21E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:4.62|P-value:3.27E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:5.79|P-value:8.24E-9 ID:SGTC_397|Compound:arbidol|FD-Score:3.22|P-value:8.23E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.28|P-value:1.43E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.38|P-value:9.24E-6 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.40|P-value:5.19E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:5.70|P-value:1.35E-8 ID:SGTC_611|Compound:3453-1652|FD-Score:3.24|P-value:7.63E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.82|P-value:9.25E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:-3.49|P-value:3.77E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-5.25|P-value:1.86E-7 ID:SGTC_665|Compound:3914-0008|FD-Score:4.27|P-value:1.50E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:4.48|P-value:6.17E-6 ID:SGTC_836|Compound:0330-0104|FD-Score:5.10|P-value:3.19E-7 ID:SGTC_899|Compound:1083-0020|FD-Score:3.51|P-value:3.03E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.24|P-value:7.61E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.38|P-value:4.65E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.69|P-value:1.54E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:6.42|P-value:1.95E-10 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.89|P-value:7.11E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.61|P-value:2.09E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:6.21|P-value:6.97E-10 ID:SGTC_1483|Compound:3453-0561|FD-Score:6.11|P-value:1.27E-9 ID:SGTC_1490|Compound:4089-0339|FD-Score:-3.83|P-value:1.06E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:-3.42|P-value:4.74E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.66|P-value:1.71E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.25|P-value:7.37E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.63|P-value:2.26E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.01|P-value:4.40E-5 ID:SGTC_1769|Compound:st044406|FD-Score:3.27|P-value:6.79E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.39|P-value:4.54E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.53|P-value:2.77E-4 ID:SGTC_1866|Compound:st057638|FD-Score:3.31|P-value:6.08E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.53|P-value:3.21E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.39|P-value:5.25E-4 ID:SGTC_1963|Compound:st076565|FD-Score:4.66|P-value:2.64E-6 ID:SGTC_2056|Compound:5235370|FD-Score:4.17|P-value:2.34E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.60|P-value:2.16E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.61|P-value:2.07E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:5.29|P-value:1.23E-7 ID:SGTC_2151|Compound:5563267|FD-Score:5.49|P-value:4.29E-8 ID:SGTC_2156|Compound:5649887|FD-Score:3.31|P-value:5.95E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.83|P-value:9.07E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.20|P-value:8.65E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.47|P-value:4.06E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.20|P-value:8.69E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.94|P-value:7.02E-7 ID:SGTC_2712|Compound:st079126|FD-Score:3.80|P-value:1.01E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.47|P-value:3.46E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.06|P-value:3.69E-5 ID:SGTC_2818|Compound:7996756|FD-Score:5.66|P-value:1.69E-8 ID:SGTC_2823|Compound:7987624|FD-Score:3.20|P-value:8.70E-4 ID:SGTC_2908|Compound:7930301|FD-Score:5.57|P-value:2.66E-8 ID:SGTC_2937|Compound:9044753|FD-Score:8.89|P-value:2.24E-18 ID:SGTC_3152|Compound:9099253|FD-Score:-4.75|P-value:2.15E-6 ID:SGTC_3225|Compound:9130819|FD-Score:-4.47|P-value:7.66E-6 ID:SGTC_3246|Compound:9135460|FD-Score:3.17|P-value:9.66E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-3.91|P-value:7.89E-5

Top fitness defect scores for YNL226W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2937 9044753 8.89 11.3 µM 2.24E-18 60S ribosome export 1 2.98E-19
2 SGTC_1314 1222-0010 6.42 41.1 µM 1.95E-10 1 7.01E-11
3 SGTC_1479 0549-0158 6.21 134.0 µM 6.97E-10 2 2.68E-10
4 SGTC_1483 3453-0561 6.11 55.9 µM 1.27E-9 1 5.05E-10
5 SGTC_118 0083-0097 5.79 135.3 µM 8.24E-9 translation 30 3.62E-9
6 SGTC_561 1550-0330 5.70 72.9 µM 1.35E-8 3 6.10E-9
7 SGTC_2818 7996756 5.66 13.0 µM 1.69E-8 4 7.69E-9
8 SGTC_2908 7930301 5.57 100.0 µM 2.66E-8 5 1.24E-8
9 SGTC_2151 5563267 5.49 85.4 µM 4.29E-8 6 2.05E-8
10 SGTC_2129 girgensonine 5.29 121.0 µM 1.23E-7 heme biosynthesis & mitochondrial translocase 15 6.20E-8
11 SGTC_836 0330-0104 5.10 1.4 µM 3.19E-7 6 1.69E-7
12 SGTC_2688 kanamycin b 4.94 96.7 µM 7.02E-7 calcium & mitochondrial duress 250 3.89E-7
13 SGTC_1963 st076565 4.66 50.3 µM 2.64E-6 3 1.57E-6
14 SGTC_97 0535-0701 4.62 19.1 µM 3.27E-6 60S ribosome export 8 1.96E-6
15 SGTC_679 0422-0091 4.48 41.4 µM 6.17E-6 Golgi 18 3.82E-6
16 SGTC_545 4218-0007 4.38 221.0 µM 9.24E-6 16 5.84E-6
17 SGTC_518 1021-0119 4.28 62.6 µM 1.43E-5 ERG2 28 9.26E-6
18 SGTC_665 3914-0008 4.27 307.0 µM 1.50E-5 14 9.73E-6
19 SGTC_2056 5235370 4.17 200.0 µM 2.34E-5 31 1.55E-5
20 SGTC_2814 7977482 4.06 43.0 µM 3.69E-5 47 2.50E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 1.04E-12 YNL228W_d YNL228W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1
0.120 3.52E-12 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.117 9.15E-12 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.114 3.05E-11 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.112 9.06E-11 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.105 1.29E-9 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.100 6.53E-9 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.099 9.81E-9 YHL033C RPL8A hom Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.095 3.11E-8 YHR136C SPL2 hom Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm
0.094 5.13E-8 YBR267W REI1 hom Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
0.093 7.42E-8 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.089 2.61E-7 YMR193C-A_d YMR193C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.71E-7 YPR150W_d YPR150W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
0.087 5.17E-7 YDR161W_p YDR161W_p hom Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
0.086 6.45E-7 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases