YNL228W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL228W / YNL228W

Click on Significant Values for Screen Details ID:SGTC_97|Compound:0535-0701|FD-Score:4.80|P-value:4.61E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:5.33|P-value:4.15E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:5.18|P-value:8.11E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.77|P-value:2.17E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:4.33|P-value:3.11E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:4.44|P-value:2.00E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:5.07|P-value:1.36E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:5.46|P-value:2.21E-7 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.46|P-value:6.96E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.97|P-value:1.23E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.44|P-value:7.57E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.45|P-value:6.43E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.99|P-value:1.13E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:4.75|P-value:5.71E-6 ID:SGTC_782|Compound:0083-0095|FD-Score:4.24|P-value:4.49E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:5.78|P-value:4.36E-8 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.93|P-value:2.55E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.92|P-value:2.29E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:7.18|P-value:1.43E-11 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.67|P-value:3.50E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:5.16|P-value:9.08E-7 ID:SGTC_1206|Compound:3978-0017|FD-Score:5.44|P-value:2.38E-7 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.81|P-value:2.14E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:5.07|P-value:1.36E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.54|P-value:1.47E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.44|P-value:7.49E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.68|P-value:3.39E-4 ID:SGTC_1734|Compound:st037168|FD-Score:5.66|P-value:8.21E-8 ID:SGTC_1863|Compound:st057641|FD-Score:3.59|P-value:4.52E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.51|P-value:1.56E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.43|P-value:7.68E-4 ID:SGTC_2121|Compound:5257820|FD-Score:4.32|P-value:3.30E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.69|P-value:3.26E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.82|P-value:1.83E-4 ID:SGTC_2203|Compound:7227154|FD-Score:4.05|P-value:9.09E-5 ID:SGTC_2270|Compound:7924575|FD-Score:3.94|P-value:1.35E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.00|P-value:1.09E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.76|P-value:2.55E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.49|P-value:5.57E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:4.51|P-value:1.51E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.53|P-value:5.67E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.55|P-value:1.30E-5 ID:SGTC_2783|Compound:7738165|FD-Score:4.12|P-value:6.91E-5 ID:SGTC_2786|Compound:7743617|FD-Score:6.90|P-value:8.46E-11 ID:SGTC_2795|Compound:7780010|FD-Score:4.41|P-value:2.25E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.59|P-value:1.10E-5 ID:SGTC_2818|Compound:7996756|FD-Score:4.45|P-value:1.95E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.97|P-value:1.21E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.93|P-value:1.39E-4 ID:SGTC_3019|Compound:9081971|FD-Score:4.29|P-value:3.61E-5 ID:SGTC_3072|Compound:9116419|FD-Score:4.60|P-value:1.06E-5 ID:SGTC_3075|Compound:9116269|FD-Score:5.30|P-value:4.62E-7 ID:SGTC_3081|Compound:9117243|FD-Score:3.71|P-value:3.04E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.47|P-value:6.80E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.55|P-value:5.19E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:4.80|P-value:4.61E-6 ID:SGTC_100|Compound:0086-0128|FD-Score:5.33|P-value:4.15E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:5.18|P-value:8.11E-7 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.77|P-value:2.17E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:4.33|P-value:3.11E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:4.44|P-value:2.00E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:5.07|P-value:1.36E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:5.46|P-value:2.21E-7 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.46|P-value:6.96E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.97|P-value:1.23E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.44|P-value:7.57E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.45|P-value:6.43E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.99|P-value:1.13E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:4.75|P-value:5.71E-6 ID:SGTC_782|Compound:0083-0095|FD-Score:4.24|P-value:4.49E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:5.78|P-value:4.36E-8 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.93|P-value:2.55E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.92|P-value:2.29E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:7.18|P-value:1.43E-11 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.67|P-value:3.50E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:5.16|P-value:9.08E-7 ID:SGTC_1206|Compound:3978-0017|FD-Score:5.44|P-value:2.38E-7 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.81|P-value:2.14E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:5.07|P-value:1.36E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.54|P-value:1.47E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.44|P-value:7.49E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.68|P-value:3.39E-4 ID:SGTC_1734|Compound:st037168|FD-Score:5.66|P-value:8.21E-8 ID:SGTC_1863|Compound:st057641|FD-Score:3.59|P-value:4.52E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.51|P-value:1.56E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.43|P-value:7.68E-4 ID:SGTC_2121|Compound:5257820|FD-Score:4.32|P-value:3.30E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.69|P-value:3.26E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.82|P-value:1.83E-4 ID:SGTC_2203|Compound:7227154|FD-Score:4.05|P-value:9.09E-5 ID:SGTC_2270|Compound:7924575|FD-Score:3.94|P-value:1.35E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.00|P-value:1.09E-4 ID:SGTC_2511|Compound:berberine|FD-Score:3.76|P-value:2.55E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.49|P-value:5.57E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:4.51|P-value:1.51E-5 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.53|P-value:5.67E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.55|P-value:1.30E-5 ID:SGTC_2783|Compound:7738165|FD-Score:4.12|P-value:6.91E-5 ID:SGTC_2786|Compound:7743617|FD-Score:6.90|P-value:8.46E-11 ID:SGTC_2795|Compound:7780010|FD-Score:4.41|P-value:2.25E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.59|P-value:1.10E-5 ID:SGTC_2818|Compound:7996756|FD-Score:4.45|P-value:1.95E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.97|P-value:1.21E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.93|P-value:1.39E-4 ID:SGTC_3019|Compound:9081971|FD-Score:4.29|P-value:3.61E-5 ID:SGTC_3072|Compound:9116419|FD-Score:4.60|P-value:1.06E-5 ID:SGTC_3075|Compound:9116269|FD-Score:5.30|P-value:4.62E-7 ID:SGTC_3081|Compound:9117243|FD-Score:3.71|P-value:3.04E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.47|P-value:6.80E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.55|P-value:5.19E-4

Top fitness defect scores for YNL228W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1123 mangostin 7.18 811.3 nM 1.43E-11 mitochondrial response to ROS 7 3.36E-13
2 SGTC_2786 7743617 6.90 45.5 µM 8.46E-11 1 2.64E-12
3 SGTC_1043 0916-0009 5.78 19.3 µM 4.36E-8 2 3.68E-9
4 SGTC_1734 st037168 5.66 69.4 µM 8.21E-8 6 7.65E-9
5 SGTC_1375 2910-0797 5.54 186.0 µM 1.47E-7 8 1.50E-8
6 SGTC_530 4358-1714 5.46 28.0 µM 2.21E-7 11 2.41E-8
7 SGTC_1206 3978-0017 5.44 132.0 µM 2.38E-7 ERG2 12 2.63E-8
8 SGTC_100 0086-0128 5.33 49.6 µM 4.15E-7 copper-dependent oxidative stress 18 4.99E-8
9 SGTC_3075 9116269 5.30 49.5 µM 4.62E-7 5 5.65E-8
10 SGTC_118 0083-0097 5.18 135.3 µM 8.11E-7 translation 48 1.09E-7
11 SGTC_1136 pergolide 5.16 1.1 µM 9.08E-7 11 1.24E-7
12 SGTC_529 4076-0302 5.07 30.3 µM 1.36E-6 mitochondrial processes 6 1.97E-7
13 SGTC_1281 0884-0031 5.07 11.8 µM 1.36E-6 fatty acid desaturase (OLE1) 11 1.98E-7
14 SGTC_1065 prochlorperazine maleate 4.93 2.5 µM 2.55E-6 3 4.08E-7
15 SGTC_97 0535-0701 4.80 19.1 µM 4.61E-6 60S ribosome export 6 8.12E-7
16 SGTC_760 0568-0725 4.75 82.9 µM 5.71E-6 2 1.04E-6
17 SGTC_3072 9116419 4.60 49.5 µM 1.06E-5 ERG2 7 2.13E-6
18 SGTC_2800 7887935 4.59 81.8 µM 1.10E-5 RPP1 & pyrimidine depletion 11 2.22E-6
19 SGTC_2688 kanamycin b 4.55 96.7 µM 1.30E-5 calcium & mitochondrial duress 293 2.70E-6
20 SGTC_2649 anisomycin 4.51 9.6 µM 1.51E-5 4 3.19E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 1.04E-12 YNL226W_d YNL226W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C
0.117 1.27E-11 YKR081C RPF2 het Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
0.107 5.79E-10 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.106 7.57E-10 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.101 3.92E-9 YPR170C_d YPR170C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
0.092 8.48E-8 YMR163C INP2 hom Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene
0.090 1.60E-7 YML009W-B_d YML009W-B_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
0.090 1.68E-7 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.088 2.83E-7 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.088 3.65E-7 YPL093W NOG1 het Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
0.086 5.35E-7 YGL030W RPL30 het Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
0.086 5.62E-7 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.086 7.03E-7 YOR021C SFM1 hom SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
0.085 7.84E-7 YBR267W REI1 hom Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
0.085 8.52E-7 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p