YNL229C / URE2

Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL229C / URE2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.33|P-value:3.46E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:5.18|P-value:2.48E-5 ID:SGTC_13|Compound:0199-0087|FD-Score:4.91|P-value:5.96E-5 ID:SGTC_14|Compound:0354-0009|FD-Score:5.29|P-value:1.66E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:6.20|P-value:5.80E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:4.23|P-value:4.59E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:8.82|P-value:2.11E-12 ID:SGTC_55|Compound:0767-0285|FD-Score:7.33|P-value:4.23E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:4.84|P-value:7.46E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:13.70|P-value:1.77E-27 ID:SGTC_64|Compound:000l-0018|FD-Score:10.10|P-value:9.07E-16 ID:SGTC_87|Compound:0100-0052|FD-Score:5.02|P-value:4.22E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:11.70|P-value:1.54E-20 ID:SGTC_121|Compound:0557-0495|FD-Score:-4.37|P-value:2.62E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.01|P-value:8.48E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:16.20|P-value:1.31E-37 ID:SGTC_164|Compound:4100-3994|FD-Score:4.69|P-value:1.19E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.46|P-value:2.40E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:4.24|P-value:4.52E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:6.09|P-value:8.74E-7 ID:SGTC_216|Compound:k038-0035|FD-Score:6.04|P-value:1.06E-6 ID:SGTC_237|Compound:nikkomycin|FD-Score:7.14|P-value:1.03E-8 ID:SGTC_266|Compound:formosanin C|FD-Score:17.00|P-value:2.36E-41 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.30|P-value:3.77E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.69|P-value:9.94E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:16.20|P-value:1.17E-37 ID:SGTC_377|Compound:3970-0964|FD-Score:6.89|P-value:3.22E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.84|P-value:2.35E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:5.62|P-value:5.30E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:4.14|P-value:6.02E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.86|P-value:2.15E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:4.54|P-value:1.89E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.97|P-value:9.59E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.49|P-value:2.16E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:12.90|P-value:1.19E-24 ID:SGTC_682|Compound:0kpi-0099|FD-Score:9.41|P-value:6.89E-14 ID:SGTC_683|Compound:panaxydol|FD-Score:16.30|P-value:7.45E-38 ID:SGTC_686|Compound:1319-0111|FD-Score:4.19|P-value:5.12E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:21.30|P-value:1.57E-63 ID:SGTC_748|Compound:0136-0228|FD-Score:4.51|P-value:2.06E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.47|P-value:2.35E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:11.10|P-value:1.17E-18 ID:SGTC_845|Compound:0330-0138|FD-Score:3.99|P-value:9.03E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:12.00|P-value:1.57E-21 ID:SGTC_897|Compound:1000-0139|FD-Score:4.14|P-value:5.90E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:13.30|P-value:6.99E-26 ID:SGTC_984|Compound:1492-0255|FD-Score:5.62|P-value:5.13E-6 ID:SGTC_985|Compound:1493-0307|FD-Score:4.39|P-value:2.92E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.10|P-value:6.59E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.67|P-value:1.28E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.25|P-value:4.37E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.71|P-value:3.69E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.45|P-value:9.49E-6 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.99|P-value:8.93E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.53|P-value:1.46E-7 ID:SGTC_1346|Compound:1488-2224|FD-Score:12.00|P-value:2.06E-21 ID:SGTC_1357|Compound:1503-1303|FD-Score:7.05|P-value:1.55E-8 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.98|P-value:9.32E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.88|P-value:6.53E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:9.14|P-value:3.47E-13 ID:SGTC_1636|Compound:st007707|FD-Score:4.97|P-value:4.99E-5 ID:SGTC_1685|Compound:st024049|FD-Score:4.09|P-value:6.91E-4 ID:SGTC_1687|Compound:st020778|FD-Score:21.60|P-value:1.79E-65 ID:SGTC_1691|Compound:st019933|FD-Score:6.46|P-value:1.98E-7 ID:SGTC_1706|Compound:st031321|FD-Score:6.50|P-value:1.67E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-7.88|P-value:2.19E-10 ID:SGTC_1726|Compound:st035556|FD-Score:11.40|P-value:1.38E-19 ID:SGTC_1775|Compound:st081588|FD-Score:-5.40|P-value:9.13E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.62|P-value:4.17E-6 ID:SGTC_1795|Compound:st049545|FD-Score:4.36|P-value:3.23E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.99|P-value:4.61E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:9.95|P-value:2.55E-15 ID:SGTC_1941|Compound:st076221|FD-Score:8.88|P-value:1.51E-12 ID:SGTC_2077|Compound:5212015|FD-Score:6.01|P-value:1.21E-6 ID:SGTC_2132|Compound:5317594|FD-Score:5.88|P-value:1.97E-6 ID:SGTC_2135|Compound:5326629|FD-Score:7.73|P-value:6.40E-10 ID:SGTC_2200|Compound:6600604|FD-Score:5.37|P-value:1.27E-5 ID:SGTC_2248|Compound:tofa|FD-Score:5.71|P-value:3.82E-6 ID:SGTC_2349|Compound:9023730|FD-Score:7.32|P-value:4.57E-9 ID:SGTC_2416|Compound:tofa|FD-Score:6.88|P-value:3.34E-8 ID:SGTC_2429|Compound:5902844|FD-Score:4.18|P-value:5.33E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.98|P-value:9.34E-4 ID:SGTC_2462|Compound:5162487|FD-Score:-4.58|P-value:1.38E-4 ID:SGTC_2469|Compound:5655019|FD-Score:5.40|P-value:1.15E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:5.21|P-value:2.21E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.56|P-value:1.75E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.13|P-value:2.89E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:14.40|P-value:3.27E-30 ID:SGTC_2619|Compound:obliquin|FD-Score:27.80|P-value:1.44E-106 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.26|P-value:4.30E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.71|P-value:1.14E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.53|P-value:1.51E-7 ID:SGTC_2659|Compound:sanguinarine|FD-Score:6.91|P-value:2.88E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:8.08|P-value:1.10E-10 ID:SGTC_2787|Compound:5284540|FD-Score:-4.11|P-value:5.45E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-5.35|P-value:1.11E-5 ID:SGTC_2833|Compound:9001315|FD-Score:5.50|P-value:8.06E-6 ID:SGTC_2845|Compound:9003024|FD-Score:4.82|P-value:7.83E-5 ID:SGTC_2858|Compound:9025781|FD-Score:14.00|P-value:2.16E-28 ID:SGTC_2890|Compound:9046729|FD-Score:-4.37|P-value:2.62E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-4.01|P-value:7.22E-4 ID:SGTC_2912|Compound:7964298|FD-Score:9.51|P-value:3.86E-14 ID:SGTC_3059|Compound:1327-0034|FD-Score:8.44|P-value:1.62E-11 ID:SGTC_3060|Compound:1327-0027|FD-Score:11.00|P-value:2.53E-18 ID:SGTC_3063|Compound:1327-0034|FD-Score:7.16|P-value:9.23E-9 ID:SGTC_3083|Compound:9117465|FD-Score:5.02|P-value:4.18E-5 ID:SGTC_3084|Compound:9116877|FD-Score:6.35|P-value:3.15E-7 ID:SGTC_3090|Compound:9117696|FD-Score:5.17|P-value:2.57E-5 ID:SGTC_3128|Compound:9127691|FD-Score:-4.23|P-value:3.87E-4 ID:SGTC_3266|Compound:9136860|FD-Score:13.00|P-value:6.84E-25 ID:SGTC_3285|Compound:9112818|FD-Score:4.61|P-value:1.54E-4 ID:SGTC_3311|Compound:9131146|FD-Score:15.50|P-value:2.20E-34 ID:SGTC_3321|Compound:9137793|FD-Score:7.54|P-value:1.58E-9 ID:SGTC_3322|Compound:9139058|FD-Score:7.70|P-value:7.18E-10 ID:SGTC_3331|Compound:9141060|FD-Score:9.60|P-value:2.24E-14 ID:SGTC_3350|Compound:9150499|FD-Score:8.92|P-value:1.20E-12 ID:SGTC_3351|Compound:9150312|FD-Score:4.49|P-value:2.17E-4 ID:SGTC_3356|Compound:9151811|FD-Score:4.70|P-value:1.17E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.33|P-value:3.46E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:5.18|P-value:2.48E-5 ID:SGTC_13|Compound:0199-0087|FD-Score:4.91|P-value:5.96E-5 ID:SGTC_14|Compound:0354-0009|FD-Score:5.29|P-value:1.66E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:6.20|P-value:5.80E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:4.23|P-value:4.59E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:8.82|P-value:2.11E-12 ID:SGTC_55|Compound:0767-0285|FD-Score:7.33|P-value:4.23E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:4.84|P-value:7.46E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:13.70|P-value:1.77E-27 ID:SGTC_64|Compound:000l-0018|FD-Score:10.10|P-value:9.07E-16 ID:SGTC_87|Compound:0100-0052|FD-Score:5.02|P-value:4.22E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:11.70|P-value:1.54E-20 ID:SGTC_121|Compound:0557-0495|FD-Score:-4.37|P-value:2.62E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.01|P-value:8.48E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:16.20|P-value:1.31E-37 ID:SGTC_164|Compound:4100-3994|FD-Score:4.69|P-value:1.19E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.46|P-value:2.40E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:4.24|P-value:4.52E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:6.09|P-value:8.74E-7 ID:SGTC_216|Compound:k038-0035|FD-Score:6.04|P-value:1.06E-6 ID:SGTC_237|Compound:nikkomycin|FD-Score:7.14|P-value:1.03E-8 ID:SGTC_266|Compound:formosanin C|FD-Score:17.00|P-value:2.36E-41 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.30|P-value:3.77E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.69|P-value:9.94E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:16.20|P-value:1.17E-37 ID:SGTC_377|Compound:3970-0964|FD-Score:6.89|P-value:3.22E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.84|P-value:2.35E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:5.62|P-value:5.30E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:4.14|P-value:6.02E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.86|P-value:2.15E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:4.54|P-value:1.89E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.97|P-value:9.59E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.49|P-value:2.16E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:12.90|P-value:1.19E-24 ID:SGTC_682|Compound:0kpi-0099|FD-Score:9.41|P-value:6.89E-14 ID:SGTC_683|Compound:panaxydol|FD-Score:16.30|P-value:7.45E-38 ID:SGTC_686|Compound:1319-0111|FD-Score:4.19|P-value:5.12E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:21.30|P-value:1.57E-63 ID:SGTC_748|Compound:0136-0228|FD-Score:4.51|P-value:2.06E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.47|P-value:2.35E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:11.10|P-value:1.17E-18 ID:SGTC_845|Compound:0330-0138|FD-Score:3.99|P-value:9.03E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:12.00|P-value:1.57E-21 ID:SGTC_897|Compound:1000-0139|FD-Score:4.14|P-value:5.90E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:13.30|P-value:6.99E-26 ID:SGTC_984|Compound:1492-0255|FD-Score:5.62|P-value:5.13E-6 ID:SGTC_985|Compound:1493-0307|FD-Score:4.39|P-value:2.92E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.10|P-value:6.59E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.67|P-value:1.28E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.25|P-value:4.37E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.71|P-value:3.69E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.45|P-value:9.49E-6 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.99|P-value:8.93E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.53|P-value:1.46E-7 ID:SGTC_1346|Compound:1488-2224|FD-Score:12.00|P-value:2.06E-21 ID:SGTC_1357|Compound:1503-1303|FD-Score:7.05|P-value:1.55E-8 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.98|P-value:9.32E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.88|P-value:6.53E-5 ID:SGTC_1506|Compound:4226-2149|FD-Score:9.14|P-value:3.47E-13 ID:SGTC_1636|Compound:st007707|FD-Score:4.97|P-value:4.99E-5 ID:SGTC_1685|Compound:st024049|FD-Score:4.09|P-value:6.91E-4 ID:SGTC_1687|Compound:st020778|FD-Score:21.60|P-value:1.79E-65 ID:SGTC_1691|Compound:st019933|FD-Score:6.46|P-value:1.98E-7 ID:SGTC_1706|Compound:st031321|FD-Score:6.50|P-value:1.67E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-7.88|P-value:2.19E-10 ID:SGTC_1726|Compound:st035556|FD-Score:11.40|P-value:1.38E-19 ID:SGTC_1775|Compound:st081588|FD-Score:-5.40|P-value:9.13E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.62|P-value:4.17E-6 ID:SGTC_1795|Compound:st049545|FD-Score:4.36|P-value:3.23E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.99|P-value:4.61E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:9.95|P-value:2.55E-15 ID:SGTC_1941|Compound:st076221|FD-Score:8.88|P-value:1.51E-12 ID:SGTC_2077|Compound:5212015|FD-Score:6.01|P-value:1.21E-6 ID:SGTC_2132|Compound:5317594|FD-Score:5.88|P-value:1.97E-6 ID:SGTC_2135|Compound:5326629|FD-Score:7.73|P-value:6.40E-10 ID:SGTC_2200|Compound:6600604|FD-Score:5.37|P-value:1.27E-5 ID:SGTC_2248|Compound:tofa|FD-Score:5.71|P-value:3.82E-6 ID:SGTC_2349|Compound:9023730|FD-Score:7.32|P-value:4.57E-9 ID:SGTC_2416|Compound:tofa|FD-Score:6.88|P-value:3.34E-8 ID:SGTC_2429|Compound:5902844|FD-Score:4.18|P-value:5.33E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.98|P-value:9.34E-4 ID:SGTC_2462|Compound:5162487|FD-Score:-4.58|P-value:1.38E-4 ID:SGTC_2469|Compound:5655019|FD-Score:5.40|P-value:1.15E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:5.21|P-value:2.21E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:4.56|P-value:1.75E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.13|P-value:2.89E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:14.40|P-value:3.27E-30 ID:SGTC_2619|Compound:obliquin|FD-Score:27.80|P-value:1.44E-106 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.26|P-value:4.30E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.71|P-value:1.14E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.53|P-value:1.51E-7 ID:SGTC_2659|Compound:sanguinarine|FD-Score:6.91|P-value:2.88E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:8.08|P-value:1.10E-10 ID:SGTC_2787|Compound:5284540|FD-Score:-4.11|P-value:5.45E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-5.35|P-value:1.11E-5 ID:SGTC_2833|Compound:9001315|FD-Score:5.50|P-value:8.06E-6 ID:SGTC_2845|Compound:9003024|FD-Score:4.82|P-value:7.83E-5 ID:SGTC_2858|Compound:9025781|FD-Score:14.00|P-value:2.16E-28 ID:SGTC_2890|Compound:9046729|FD-Score:-4.37|P-value:2.62E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-4.01|P-value:7.22E-4 ID:SGTC_2912|Compound:7964298|FD-Score:9.51|P-value:3.86E-14 ID:SGTC_3059|Compound:1327-0034|FD-Score:8.44|P-value:1.62E-11 ID:SGTC_3060|Compound:1327-0027|FD-Score:11.00|P-value:2.53E-18 ID:SGTC_3063|Compound:1327-0034|FD-Score:7.16|P-value:9.23E-9 ID:SGTC_3083|Compound:9117465|FD-Score:5.02|P-value:4.18E-5 ID:SGTC_3084|Compound:9116877|FD-Score:6.35|P-value:3.15E-7 ID:SGTC_3090|Compound:9117696|FD-Score:5.17|P-value:2.57E-5 ID:SGTC_3128|Compound:9127691|FD-Score:-4.23|P-value:3.87E-4 ID:SGTC_3266|Compound:9136860|FD-Score:13.00|P-value:6.84E-25 ID:SGTC_3285|Compound:9112818|FD-Score:4.61|P-value:1.54E-4 ID:SGTC_3311|Compound:9131146|FD-Score:15.50|P-value:2.20E-34 ID:SGTC_3321|Compound:9137793|FD-Score:7.54|P-value:1.58E-9 ID:SGTC_3322|Compound:9139058|FD-Score:7.70|P-value:7.18E-10 ID:SGTC_3331|Compound:9141060|FD-Score:9.60|P-value:2.24E-14 ID:SGTC_3350|Compound:9150499|FD-Score:8.92|P-value:1.20E-12 ID:SGTC_3351|Compound:9150312|FD-Score:4.49|P-value:2.17E-4 ID:SGTC_3356|Compound:9151811|FD-Score:4.70|P-value:1.17E-4

Top fitness defect scores for YNL229C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2619 obliquin 27.80 87.9 µM 1.44E-106 cell wall 2 2.49E-170
2 SGTC_1687 st020778 21.60 55.4 µM 1.79E-65 6 3.09E-104
3 SGTC_690 glyoxal 21.30 20.3 µM 1.57E-63 1 4.12E-101
4 SGTC_266 formosanin C 17.00 406.0 nM 2.36E-41 sphingolipid biosynthesis & PDR1 6 1.87E-65
5 SGTC_683 panaxydol 16.30 45.0 µM 7.45E-38 sphingolipid biosynthesis & PDR1 1 7.89E-60
6 SGTC_315 k915-0449 16.20 187.0 µM 1.17E-37 4 1.62E-59
7 SGTC_163 1327-0036 16.20 7.5 µM 1.31E-37 6 1.95E-59
8 SGTC_3311 9131146 15.50 2.9 µM 2.20E-34 cell wall 5 2.97E-54
9 SGTC_2584 androsterone 14.40 48.7 µM 3.27E-30 cell wall 4 1.51E-47
10 SGTC_2858 9025781 14.00 9.0 µM 2.16E-28 sphingolipid biosynthesis & PDR1 13 1.26E-44
11 SGTC_59 0330-0160 13.70 1.3 µM 1.77E-27 5 3.70E-43
12 SGTC_955 1216-0110 13.30 33.0 µM 6.99E-26 sphingolipid biosynthesis & PDR1 8 1.36E-40
13 SGTC_3266 9136860 13.00 49.5 µM 6.84E-25 cell wall 3 5.32E-39
14 SGTC_664 1222-0054 12.90 14.9 µM 1.19E-24 sphingolipid biosynthesis & PDR1 5 1.29E-38
15 SGTC_863 0466-0191 12.00 129.0 µM 1.57E-21 cell wall 6 1.33E-33
16 SGTC_1346 1488-2224 12.00 62.4 µM 2.06E-21 1 2.06E-33
17 SGTC_90 0870-0863 11.70 4.6 µM 1.54E-20 5 5.19E-32
18 SGTC_1726 st035556 11.40 14.6 µM 1.38E-19 4 1.76E-30
19 SGTC_804 1595-0054 11.10 20.9 µM 1.17E-18 sphingolipid biosynthesis & PDR1 1 5.39E-29
20 SGTC_3060 1327-0027 11.00 12.5 µM 2.53E-18 6 1.87E-28

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.341 2.44E-92 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.307 3.37E-74 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.305 4.65E-73 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.303 4.73E-72 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.302 8.50E-72 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.264 2.19E-54 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.258 3.71E-52 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.256 2.31E-51 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.256 2.82E-51 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.256 3.79E-51 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.249 1.81E-48 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.245 4.13E-47 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.245 5.04E-47 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.245 5.35E-47 YNL307C MCK1 hom Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
0.245 6.01E-47 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication