YNL230C / ELA1

Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL230C / ELA1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:-4.39|P-value:9.43E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:3.43|P-value:4.49E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.11|P-value:3.14E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:4.29|P-value:1.66E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.24|P-value:2.00E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.61|P-value:2.17E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.05|P-value:4.40E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:3.54|P-value:3.05E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.99|P-value:5.13E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:3.39|P-value:5.28E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.33|P-value:5.80E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:4.50|P-value:6.57E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:4.17|P-value:2.71E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:4.60|P-value:4.11E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:3.24|P-value:8.51E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.20|P-value:8.93E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.66|P-value:2.02E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.60|P-value:2.46E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.33|P-value:6.29E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.79|P-value:1.24E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.26|P-value:7.31E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-3.55|P-value:2.71E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.70|P-value:1.74E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.18|P-value:2.63E-5 ID:SGTC_1814|Compound:st052110|FD-Score:3.31|P-value:6.71E-4 ID:SGTC_1867|Compound:st057372|FD-Score:4.49|P-value:6.74E-6 ID:SGTC_2050|Compound:5263056|FD-Score:-3.22|P-value:8.29E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.89|P-value:8.22E-5 ID:SGTC_2152|Compound:5568786|FD-Score:4.63|P-value:3.59E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.25|P-value:7.53E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.63|P-value:2.20E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.51|P-value:6.35E-6 ID:SGTC_2300|Compound:7976697|FD-Score:3.62|P-value:2.27E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-4.39|P-value:9.53E-6 ID:SGTC_2479|Compound:5617353|FD-Score:3.57|P-value:2.75E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.89|P-value:7.60E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.00|P-value:5.38E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.38|P-value:1.09E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.59|P-value:2.52E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.40|P-value:4.55E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.87|P-value:1.20E-6 ID:SGTC_2858|Compound:9025781|FD-Score:3.49|P-value:3.62E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.56|P-value:2.89E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-4.45|P-value:7.42E-6 ID:SGTC_3145|Compound:9085516|FD-Score:3.24|P-value:8.54E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.47|P-value:3.63E-4 ID:SGTC_3177|Compound:9107506|FD-Score:-3.76|P-value:1.25E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.64|P-value:2.14E-4 ID:SGTC_3300|Compound:9124615|FD-Score:5.59|P-value:3.06E-8 ID:SGTC_3303|Compound:9125618|FD-Score:4.41|P-value:9.85E-6 ID:SGTC_3307|Compound:9126885|FD-Score:-3.52|P-value:3.02E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:-4.39|P-value:9.43E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:3.43|P-value:4.49E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.11|P-value:3.14E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:4.29|P-value:1.66E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.24|P-value:2.00E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.61|P-value:2.17E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.05|P-value:4.40E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:3.54|P-value:3.05E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.99|P-value:5.13E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:3.39|P-value:5.28E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.33|P-value:5.80E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:4.50|P-value:6.57E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:4.17|P-value:2.71E-5 ID:SGTC_883|Compound:0850-0245|FD-Score:4.60|P-value:4.11E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:3.24|P-value:8.51E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.20|P-value:8.93E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.66|P-value:2.02E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.60|P-value:2.46E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.33|P-value:6.29E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.79|P-value:1.24E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-3.26|P-value:7.31E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:-3.55|P-value:2.71E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.70|P-value:1.74E-4 ID:SGTC_1613|Compound:st002381|FD-Score:4.18|P-value:2.63E-5 ID:SGTC_1814|Compound:st052110|FD-Score:3.31|P-value:6.71E-4 ID:SGTC_1867|Compound:st057372|FD-Score:4.49|P-value:6.74E-6 ID:SGTC_2050|Compound:5263056|FD-Score:-3.22|P-value:8.29E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.89|P-value:8.22E-5 ID:SGTC_2152|Compound:5568786|FD-Score:4.63|P-value:3.59E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.25|P-value:7.53E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.63|P-value:2.20E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.51|P-value:6.35E-6 ID:SGTC_2300|Compound:7976697|FD-Score:3.62|P-value:2.27E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-4.39|P-value:9.53E-6 ID:SGTC_2479|Compound:5617353|FD-Score:3.57|P-value:2.75E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-3.89|P-value:7.60E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.00|P-value:5.38E-5 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.38|P-value:1.09E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.59|P-value:2.52E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.40|P-value:4.55E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.87|P-value:1.20E-6 ID:SGTC_2858|Compound:9025781|FD-Score:3.49|P-value:3.62E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.56|P-value:2.89E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-4.45|P-value:7.42E-6 ID:SGTC_3145|Compound:9085516|FD-Score:3.24|P-value:8.54E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.47|P-value:3.63E-4 ID:SGTC_3177|Compound:9107506|FD-Score:-3.76|P-value:1.25E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.64|P-value:2.14E-4 ID:SGTC_3300|Compound:9124615|FD-Score:5.59|P-value:3.06E-8 ID:SGTC_3303|Compound:9125618|FD-Score:4.41|P-value:9.85E-6 ID:SGTC_3307|Compound:9126885|FD-Score:-3.52|P-value:3.02E-4

Top fitness defect scores for YNL230C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3300 9124615 5.59 50.5 µM 3.06E-8 2 1.14E-8
2 SGTC_2832 7992762 4.87 52.0 µM 1.20E-6 15 5.61E-7
3 SGTC_2152 5568786 4.63 200.0 µM 3.59E-6 5 1.79E-6
4 SGTC_883 0850-0245 4.60 24.6 µM 4.11E-6 cell wall 18 2.07E-6
5 SGTC_2297 7971671 4.51 152.3 µM 6.35E-6 RNA processing & uracil transport 16 3.28E-6
6 SGTC_787 4152-0075 4.50 138.0 µM 6.57E-6 13 3.40E-6
7 SGTC_1867 st057372 4.49 64.0 µM 6.74E-6 4 3.49E-6
8 SGTC_3303 9125618 4.41 40.6 µM 9.85E-6 32 5.23E-6
9 SGTC_2558 carylophyllene oxide 4.38 100.0 µM 1.09E-5 7 5.82E-6
10 SGTC_89 0302-0250 4.29 142.1 µM 1.66E-5 13 9.07E-6
11 SGTC_93 0109-0045 4.24 59.2 µM 2.00E-5 DNA damage response 32 1.11E-5
12 SGTC_1613 st002381 4.18 52.1 µM 2.63E-5 18 1.48E-5
13 SGTC_866 0495-0101 4.17 262.0 µM 2.71E-5 60S ribosome export 13 1.53E-5
14 SGTC_142 0335-0849 4.05 62.7 µM 4.40E-5 ubiquinone biosynthesis & proteasome 121 2.55E-5
15 SGTC_2535 4',4'-dimethoxydalbergione 4.00 51.2 µM 5.38E-5 DNA damage response 16 3.16E-5
16 SGTC_2053 5265679 3.89 138.0 µM 8.22E-5 26 4.95E-5
17 SGTC_1384 3089-0840 3.79 101.0 µM 1.24E-4 19 7.68E-5
18 SGTC_1574 spiramycin 3.70 23.7 µM 1.74E-4 34 1.10E-4
19 SGTC_1016 4226-1401 3.66 38.0 µM 2.02E-4 RNA pol III & RNase P/MRP 25 1.28E-4
20 SGTC_3255 9139072 3.64 49.5 µM 2.14E-4 24 1.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.08E-11 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.094 5.60E-8 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.091 1.11E-7 YNL281W HCH1 hom Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.088 3.54E-7 YAR027W UIP3 hom Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
0.085 7.98E-7 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.084 1.04E-6 YDL074C BRE1 hom E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
0.084 1.20E-6 YJR005C-A_p YJR005C-A_p hom Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication
0.077 8.57E-6 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.075 1.40E-5 YMR224C MRE11 hom Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress
0.074 1.89E-5 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.073 2.42E-5 YPR148C YPR148C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.072 2.79E-5 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 3.12E-5 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.072 3.29E-5 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.072 3.32E-5 YLR253W_p YLR253W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene