YNL231C / PDR16

Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL231C / PDR16

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.69|P-value:6.82E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:4.08|P-value:7.77E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.93|P-value:2.42E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:4.68|P-value:7.00E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:3.65|P-value:3.58E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:7.72|P-value:3.76E-13 ID:SGTC_86|Compound:0417-1630|FD-Score:11.40|P-value:2.66E-26 ID:SGTC_137|Compound:0438-0332|FD-Score:6.22|P-value:3.90E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:18.20|P-value:1.76E-64 ID:SGTC_146|Compound:3448-8650|FD-Score:6.89|P-value:8.24E-11 ID:SGTC_158|Compound:k038-0087|FD-Score:8.87|P-value:9.11E-17 ID:SGTC_164|Compound:4100-3994|FD-Score:5.87|P-value:2.61E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:10.00|P-value:6.62E-21 ID:SGTC_200|Compound:k038-0079|FD-Score:3.35|P-value:9.60E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:9.95|P-value:1.31E-20 ID:SGTC_227|Compound:fluconazole|FD-Score:8.19|P-value:1.43E-14 ID:SGTC_294|Compound:k038-0071|FD-Score:3.65|P-value:3.59E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.74|P-value:2.65E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.71|P-value:5.65E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:5.31|P-value:4.26E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:6.32|P-value:2.30E-9 ID:SGTC_376|Compound:3970-0862|FD-Score:4.66|P-value:7.78E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.65|P-value:3.37E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:7.31|P-value:5.76E-12 ID:SGTC_526|Compound:4469-0568|FD-Score:5.63|P-value:8.67E-8 ID:SGTC_542|Compound:3381-0244|FD-Score:4.55|P-value:1.23E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:10.10|P-value:3.10E-21 ID:SGTC_562|Compound:3772-2733|FD-Score:6.16|P-value:5.46E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:10.40|P-value:3.52E-22 ID:SGTC_584|Compound:0986-0246|FD-Score:3.36|P-value:9.24E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.74|P-value:2.66E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.34|P-value:2.91E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:5.09|P-value:1.18E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:4.16|P-value:5.71E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:-5.44|P-value:2.01E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:3.61|P-value:4.17E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.96|P-value:1.62E-8 ID:SGTC_735|Compound:3076-0345|FD-Score:3.81|P-value:2.06E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:15.80|P-value:8.05E-49 ID:SGTC_779|Compound:1360-0071|FD-Score:3.45|P-value:7.06E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:11.90|P-value:1.05E-28 ID:SGTC_813|Compound:k007-0158|FD-Score:4.28|P-value:3.57E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.39|P-value:8.31E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.37|P-value:8.86E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.90|P-value:1.99E-8 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.49|P-value:5.60E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:10.90|P-value:2.29E-24 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.96|P-value:2.08E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.27|P-value:3.75E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.54|P-value:5.16E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.76|P-value:2.29E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.54|P-value:1.36E-7 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.68|P-value:7.06E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.05|P-value:8.80E-5 ID:SGTC_1521|Compound:st012942|FD-Score:6.26|P-value:3.16E-9 ID:SGTC_1522|Compound:st012842|FD-Score:4.30|P-value:3.39E-5 ID:SGTC_1530|Compound:rhein|FD-Score:3.49|P-value:6.04E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.66|P-value:6.99E-6 ID:SGTC_1606|Compound:st000094|FD-Score:3.68|P-value:3.25E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.12|P-value:6.58E-5 ID:SGTC_1778|Compound:st046819|FD-Score:3.83|P-value:1.93E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.59|P-value:9.36E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:8.18|P-value:1.53E-14 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.76|P-value:2.49E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.63|P-value:3.56E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.57|P-value:4.38E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-5.86|P-value:2.45E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.90|P-value:1.96E-8 ID:SGTC_2271|Compound:7849410|FD-Score:-5.04|P-value:1.36E-6 ID:SGTC_2273|Compound:7815444|FD-Score:-3.77|P-value:2.23E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.38|P-value:8.04E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.94|P-value:1.30E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.36|P-value:9.35E-4 ID:SGTC_2322|Compound:7413319|FD-Score:6.83|P-value:1.15E-10 ID:SGTC_2376|Compound:9072922|FD-Score:3.35|P-value:9.53E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.42|P-value:7.25E-4 ID:SGTC_2471|Compound:5466956|FD-Score:-3.59|P-value:4.15E-4 ID:SGTC_2517|Compound:totarol|FD-Score:5.04|P-value:1.47E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.01|P-value:1.66E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:3.95|P-value:1.26E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.57|P-value:5.50E-10 ID:SGTC_2687|Compound:chenodiol|FD-Score:5.27|P-value:5.11E-7 ID:SGTC_2752|Compound:diclazuril|FD-Score:10.10|P-value:3.87E-21 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.41|P-value:7.95E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.24|P-value:4.25E-5 ID:SGTC_2816|Compound:7982706|FD-Score:11.60|P-value:2.94E-27 ID:SGTC_2829|Compound:7992743|FD-Score:3.95|P-value:1.24E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.07|P-value:8.84E-9 ID:SGTC_2972|Compound:9093619|FD-Score:4.22|P-value:4.51E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-3.40|P-value:7.57E-4 ID:SGTC_2982|Compound:9019404|FD-Score:7.39|P-value:3.38E-12 ID:SGTC_2984|Compound:9022109|FD-Score:3.47|P-value:6.46E-4 ID:SGTC_3025|Compound:9087895|FD-Score:5.45|P-value:2.19E-7 ID:SGTC_3033|Compound:9090887|FD-Score:8.96|P-value:4.53E-17 ID:SGTC_3054|Compound:9094397|FD-Score:3.75|P-value:2.58E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.53|P-value:5.28E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.72|P-value:2.87E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.86|P-value:1.59E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.82|P-value:3.88E-6 ID:SGTC_3210|Compound:9128157|FD-Score:-4.04|P-value:8.35E-5 ID:SGTC_3252|Compound:9135871|FD-Score:3.44|P-value:7.27E-4 ID:SGTC_3279|Compound:9140807|FD-Score:4.29|P-value:3.45E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.74|P-value:2.65E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:4.69|P-value:6.82E-6 ID:SGTC_22|Compound:0964-0034|FD-Score:4.08|P-value:7.77E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.93|P-value:2.42E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:4.68|P-value:7.00E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:3.65|P-value:3.58E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:7.72|P-value:3.76E-13 ID:SGTC_86|Compound:0417-1630|FD-Score:11.40|P-value:2.66E-26 ID:SGTC_137|Compound:0438-0332|FD-Score:6.22|P-value:3.90E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:18.20|P-value:1.76E-64 ID:SGTC_146|Compound:3448-8650|FD-Score:6.89|P-value:8.24E-11 ID:SGTC_158|Compound:k038-0087|FD-Score:8.87|P-value:9.11E-17 ID:SGTC_164|Compound:4100-3994|FD-Score:5.87|P-value:2.61E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:10.00|P-value:6.62E-21 ID:SGTC_200|Compound:k038-0079|FD-Score:3.35|P-value:9.60E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:9.95|P-value:1.31E-20 ID:SGTC_227|Compound:fluconazole|FD-Score:8.19|P-value:1.43E-14 ID:SGTC_294|Compound:k038-0071|FD-Score:3.65|P-value:3.59E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.74|P-value:2.65E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.71|P-value:5.65E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:5.31|P-value:4.26E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:6.32|P-value:2.30E-9 ID:SGTC_376|Compound:3970-0862|FD-Score:4.66|P-value:7.78E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.65|P-value:3.37E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:7.31|P-value:5.76E-12 ID:SGTC_526|Compound:4469-0568|FD-Score:5.63|P-value:8.67E-8 ID:SGTC_542|Compound:3381-0244|FD-Score:4.55|P-value:1.23E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:10.10|P-value:3.10E-21 ID:SGTC_562|Compound:3772-2733|FD-Score:6.16|P-value:5.46E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:10.40|P-value:3.52E-22 ID:SGTC_584|Compound:0986-0246|FD-Score:3.36|P-value:9.24E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.74|P-value:2.66E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.34|P-value:2.91E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:5.09|P-value:1.18E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:4.16|P-value:5.71E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:-5.44|P-value:2.01E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:3.61|P-value:4.17E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.96|P-value:1.62E-8 ID:SGTC_735|Compound:3076-0345|FD-Score:3.81|P-value:2.06E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:15.80|P-value:8.05E-49 ID:SGTC_779|Compound:1360-0071|FD-Score:3.45|P-value:7.06E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:11.90|P-value:1.05E-28 ID:SGTC_813|Compound:k007-0158|FD-Score:4.28|P-value:3.57E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.39|P-value:8.31E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.37|P-value:8.86E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.90|P-value:1.99E-8 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.49|P-value:5.60E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:10.90|P-value:2.29E-24 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.96|P-value:2.08E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.27|P-value:3.75E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.54|P-value:5.16E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-3.76|P-value:2.29E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.54|P-value:1.36E-7 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.68|P-value:7.06E-6 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.05|P-value:8.80E-5 ID:SGTC_1521|Compound:st012942|FD-Score:6.26|P-value:3.16E-9 ID:SGTC_1522|Compound:st012842|FD-Score:4.30|P-value:3.39E-5 ID:SGTC_1530|Compound:rhein|FD-Score:3.49|P-value:6.04E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.66|P-value:6.99E-6 ID:SGTC_1606|Compound:st000094|FD-Score:3.68|P-value:3.25E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.12|P-value:6.58E-5 ID:SGTC_1778|Compound:st046819|FD-Score:3.83|P-value:1.93E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.59|P-value:9.36E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:8.18|P-value:1.53E-14 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.76|P-value:2.49E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.63|P-value:3.56E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.57|P-value:4.38E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-5.86|P-value:2.45E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-5.90|P-value:1.96E-8 ID:SGTC_2271|Compound:7849410|FD-Score:-5.04|P-value:1.36E-6 ID:SGTC_2273|Compound:7815444|FD-Score:-3.77|P-value:2.23E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.38|P-value:8.04E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.94|P-value:1.30E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.36|P-value:9.35E-4 ID:SGTC_2322|Compound:7413319|FD-Score:6.83|P-value:1.15E-10 ID:SGTC_2376|Compound:9072922|FD-Score:3.35|P-value:9.53E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.42|P-value:7.25E-4 ID:SGTC_2471|Compound:5466956|FD-Score:-3.59|P-value:4.15E-4 ID:SGTC_2517|Compound:totarol|FD-Score:5.04|P-value:1.47E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.01|P-value:1.66E-6 ID:SGTC_2645|Compound:abamectin|FD-Score:3.95|P-value:1.26E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.57|P-value:5.50E-10 ID:SGTC_2687|Compound:chenodiol|FD-Score:5.27|P-value:5.11E-7 ID:SGTC_2752|Compound:diclazuril|FD-Score:10.10|P-value:3.87E-21 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.41|P-value:7.95E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.24|P-value:4.25E-5 ID:SGTC_2816|Compound:7982706|FD-Score:11.60|P-value:2.94E-27 ID:SGTC_2829|Compound:7992743|FD-Score:3.95|P-value:1.24E-4 ID:SGTC_2896|Compound:9052656|FD-Score:6.07|P-value:8.84E-9 ID:SGTC_2972|Compound:9093619|FD-Score:4.22|P-value:4.51E-5 ID:SGTC_2978|Compound:9011784|FD-Score:-3.40|P-value:7.57E-4 ID:SGTC_2982|Compound:9019404|FD-Score:7.39|P-value:3.38E-12 ID:SGTC_2984|Compound:9022109|FD-Score:3.47|P-value:6.46E-4 ID:SGTC_3025|Compound:9087895|FD-Score:5.45|P-value:2.19E-7 ID:SGTC_3033|Compound:9090887|FD-Score:8.96|P-value:4.53E-17 ID:SGTC_3054|Compound:9094397|FD-Score:3.75|P-value:2.58E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.53|P-value:5.28E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.72|P-value:2.87E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.86|P-value:1.59E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.82|P-value:3.88E-6 ID:SGTC_3210|Compound:9128157|FD-Score:-4.04|P-value:8.35E-5 ID:SGTC_3252|Compound:9135871|FD-Score:3.44|P-value:7.27E-4 ID:SGTC_3279|Compound:9140807|FD-Score:4.29|P-value:3.45E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.74|P-value:2.65E-4

Top fitness defect scores for YNL231C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_142 0335-0849 18.20 62.7 µM 1.76E-64 ubiquinone biosynthesis & proteasome 10 2.18E-74
2 SGTC_768 0384-0033 15.80 77.3 µM 8.05E-49 fatty acid desaturase (OLE1) 8 2.93E-56
3 SGTC_781 4335-2806 11.90 94.4 µM 1.05E-28 2 5.67E-33
4 SGTC_2816 7982706 11.60 58.4 µM 2.94E-27 azole & statin 1 2.67E-31
5 SGTC_86 0417-1630 11.40 471.9 µM 2.66E-26 ubiquinone biosynthesis & proteasome 31 3.42E-30
6 SGTC_1055 3448-0672 10.90 86.0 µM 2.29E-24 3 5.92E-28
7 SGTC_568 1193-0097 10.40 7.5 µM 3.52E-22 ERAD & cell cycle 23 2.01E-25
8 SGTC_543 3844-1095 10.10 191.0 µM 3.10E-21 ERG2 3 2.49E-24
9 SGTC_2752 diclazuril 10.10 33.1 µM 3.87E-21 24 3.22E-24
10 SGTC_167 3672-0051 10.00 66.2 µM 6.62E-21 2 5.99E-24
11 SGTC_207 4185-0010 9.95 4.5 µM 1.31E-20 endomembrane recycling 20 1.33E-23
12 SGTC_3033 9090887 8.96 49.5 µM 4.53E-17 fatty acid desaturase (OLE1) 3 1.64E-19
13 SGTC_158 k038-0087 8.87 26.4 µM 9.11E-17 ubiquinone biosynthesis & proteasome 36 3.68E-19
14 SGTC_227 fluconazole 8.19 33.5 µM 1.43E-14 azole & statin 23 1.27E-16
15 SGTC_1788 fluconazole 8.18 20.0 µM 1.53E-14 azole & statin 18 1.38E-16
16 SGTC_85 0868-0259 7.72 160.1 µM 3.76E-13 60S ribosome export 1 5.60E-15
17 SGTC_2982 9019404 7.39 26.0 µM 3.38E-12 2 7.10E-14
18 SGTC_410 α-linolenic acid 7.31 100.0 µM 5.76E-12 excess fatty acid 8 1.31E-13
19 SGTC_146 3448-8650 6.89 53.1 µM 8.24E-11 NEO1-PIK1 39 2.84E-12
20 SGTC_2322 7413319 6.83 38.2 µM 1.15E-10 ERAD & cell cycle 53 4.16E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.266 1.52E-55 YMR015C ERG5 hom C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.260 6.35E-53 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.254 1.30E-50 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.244 1.33E-46 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.234 1.00E-42 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.219 1.11E-37 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.218 2.24E-37 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.216 9.78E-37 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.215 2.55E-36 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.215 3.59E-36 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.214 5.64E-36 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.214 7.16E-36 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.211 4.20E-35 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
0.211 4.69E-35 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.208 5.81E-34 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance