YNL232W / CSL4

Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL232W / CSL4

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:3.74|P-value:1.51E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.46|P-value:3.24E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.82|P-value:8.56E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.71|P-value:1.54E-8 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.22|P-value:9.57E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.35|P-value:6.12E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.24|P-value:8.71E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.63|P-value:3.73E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.41|P-value:3.93E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.32|P-value:6.72E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.92|P-value:7.50E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:7.84|P-value:1.34E-14 ID:SGTC_618|Compound:k072-0232|FD-Score:-4.90|P-value:7.49E-7 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.72|P-value:1.23E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.48|P-value:7.12E-6 ID:SGTC_796|Compound:1234-0020|FD-Score:-4.37|P-value:8.70E-6 ID:SGTC_797|Compound:k781-0471|FD-Score:3.38|P-value:5.48E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.24|P-value:8.93E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:4.03|P-value:4.82E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.37|P-value:4.49E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:4.09|P-value:3.80E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.53|P-value:5.65E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:3.38|P-value:5.50E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:11.00|P-value:4.14E-27 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.65|P-value:1.61E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.39|P-value:4.17E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.22|P-value:9.45E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.77|P-value:1.87E-6 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:8.86|P-value:3.73E-18 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.91|P-value:7.68E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.86|P-value:9.54E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.42|P-value:4.75E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.40|P-value:5.10E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.59|P-value:4.31E-6 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:5.95|P-value:3.90E-9 ID:SGTC_1841|Compound:st054148|FD-Score:3.96|P-value:6.46E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.66|P-value:1.99E-4 ID:SGTC_2193|Compound:5925765|FD-Score:-3.19|P-value:8.36E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.60|P-value:2.49E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.18|P-value:8.57E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.21|P-value:9.79E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.28|P-value:1.71E-5 ID:SGTC_2556|Compound:citropten|FD-Score:4.95|P-value:8.25E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.14|P-value:9.75E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.47|P-value:3.12E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.70|P-value:1.32E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-4.29|P-value:1.20E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.74|P-value:1.51E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.46|P-value:3.24E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.82|P-value:8.56E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.71|P-value:1.54E-8 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.22|P-value:9.57E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.35|P-value:6.12E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.24|P-value:8.71E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.63|P-value:3.73E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.41|P-value:3.93E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.32|P-value:6.72E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.92|P-value:7.50E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:7.84|P-value:1.34E-14 ID:SGTC_618|Compound:k072-0232|FD-Score:-4.90|P-value:7.49E-7 ID:SGTC_623|Compound:k072-0108|FD-Score:-3.72|P-value:1.23E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.48|P-value:7.12E-6 ID:SGTC_796|Compound:1234-0020|FD-Score:-4.37|P-value:8.70E-6 ID:SGTC_797|Compound:k781-0471|FD-Score:3.38|P-value:5.48E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.24|P-value:8.93E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:4.03|P-value:4.82E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.37|P-value:4.49E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:4.09|P-value:3.80E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.53|P-value:5.65E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:3.38|P-value:5.50E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:11.00|P-value:4.14E-27 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.65|P-value:1.61E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.39|P-value:4.17E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.22|P-value:9.45E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.77|P-value:1.87E-6 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:8.86|P-value:3.73E-18 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.91|P-value:7.68E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.86|P-value:9.54E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.42|P-value:4.75E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.40|P-value:5.10E-4 ID:SGTC_1602|Compound:st001878|FD-Score:4.59|P-value:4.31E-6 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:5.95|P-value:3.90E-9 ID:SGTC_1841|Compound:st054148|FD-Score:3.96|P-value:6.46E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.66|P-value:1.99E-4 ID:SGTC_2193|Compound:5925765|FD-Score:-3.19|P-value:8.36E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.60|P-value:2.49E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.18|P-value:8.57E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.21|P-value:9.79E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.28|P-value:1.71E-5 ID:SGTC_2556|Compound:citropten|FD-Score:4.95|P-value:8.25E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.14|P-value:9.75E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.47|P-value:3.12E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-3.70|P-value:1.32E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-4.29|P-value:1.20E-5

Top fitness defect scores for YNL232W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_879 0831-1030 11.00 162.0 µM 4.14E-27 2 1.55E-28 2.96
2 SGTC_1077 5-fluorocytosine 8.86 377.0 nM 3.73E-18 exosome 7 4.17E-19 1.07
3 SGTC_617 3770-0098 7.84 35.0 µM 1.34E-14 exosome 10 2.33E-15 0.26
4 SGTC_1698 5-fluorocytosine 5.95 1.1 µM 3.90E-9 exosome 10 1.34E-9 0.34
5 SGTC_423 5-fluorouracil 5.71 457.0 µM 1.54E-8 exosome 14 5.69E-9 0.04
6 SGTC_2556 citropten 4.95 84.6 µM 8.25E-7 2 3.79E-7 0.74
7 SGTC_1074 carmofur 4.77 3.8 µM 1.87E-6 exosome 20 9.00E-7 0.00
8 SGTC_504 lovastatin 4.63 124.0 µM 3.73E-6 2 1.87E-6 0.15
9 SGTC_1602 st001878 4.59 87.6 µM 4.31E-6 3 2.17E-6 0.15
10 SGTC_832 4083-0019 4.53 164.0 µM 5.65E-6 translation 19 2.89E-6 0.06
11 SGTC_770 0389-1121 4.48 67.2 µM 7.12E-6 RPP1 & pyrimidine depletion 7 3.69E-6 0.17
12 SGTC_2479 5617353 4.28 43.9 µM 1.71E-5 5 9.30E-6 0.25
13 SGTC_828 2074-0507 4.09 139.0 µM 3.80E-5 RPP1 & pyrimidine depletion 7 2.16E-5 0.23
14 SGTC_812 4251-0442 4.03 148.0 µM 4.82E-5 2 2.78E-5 0.11
15 SGTC_1841 st054148 3.96 70.0 µM 6.46E-5 4 3.78E-5 0.34
16 SGTC_581 0958-0271 3.92 211.0 µM 7.50E-5 6 4.43E-5 0.13
17 SGTC_1144 3486-0183 3.91 12.5 µM 7.68E-5 2 4.54E-5 0.02
18 SGTC_1147 3809-1045 3.86 12.3 µM 9.54E-5 3 5.71E-5 0.08
19 SGTC_118 0083-0097 3.74 135.3 µM 1.51E-4 translation 25 9.27E-5 0.09
20 SGTC_2003 4023581 3.66 200.0 µM 1.99E-4 cell wall signaling 10 1.24E-4 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.345 2.52E-94 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.330 6.06E-86 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.324 7.05E-83 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.268 2.22E-56 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.240 3.98E-45 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.223 3.81E-39 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.223 6.87E-39 YNL002C RLP7 het Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
0.223 7.49E-39 YHR069C RRP4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.208 3.22E-34 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.207 1.04E-33 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.201 8.57E-32 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.179 1.48E-25 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.171 1.80E-23 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.166 3.52E-22 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.126 3.01E-13 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats