YNL235C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL235C / YNL235C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.26|P-value:1.07E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:7.01|P-value:1.27E-10 ID:SGTC_89|Compound:0302-0250|FD-Score:3.57|P-value:6.58E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.48|P-value:8.79E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.30|P-value:5.46E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:3.53|P-value:7.42E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.05|P-value:2.63E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:4.88|P-value:5.44E-6 ID:SGTC_185|Compound:k048-0037|FD-Score:4.61|P-value:1.65E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.67|P-value:4.31E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.63|P-value:1.53E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:3.90|P-value:2.20E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.00|P-value:1.38E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:6.66|P-value:9.28E-10 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.97|P-value:1.54E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.78|P-value:3.34E-4 ID:SGTC_389|Compound:tpck|FD-Score:3.52|P-value:7.65E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.88|P-value:5.65E-8 ID:SGTC_505|Compound:gw-5074|FD-Score:4.10|P-value:1.09E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:9.96|P-value:1.23E-19 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.94|P-value:3.67E-6 ID:SGTC_537|Compound:1334-0398|FD-Score:4.40|P-value:3.65E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.06|P-value:1.27E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.11|P-value:1.06E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:4.79|P-value:8.05E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:4.11|P-value:1.07E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.98|P-value:3.63E-6 ID:SGTC_845|Compound:0330-0138|FD-Score:3.90|P-value:2.26E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.67|P-value:4.24E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.73|P-value:3.95E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:11.10|P-value:7.29E-24 ID:SGTC_1304|Compound:1165-0502|FD-Score:7.03|P-value:1.15E-10 ID:SGTC_1305|Compound:1181-0477|FD-Score:4.94|P-value:4.23E-6 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.18|P-value:8.37E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:-3.66|P-value:4.45E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:-4.02|P-value:1.32E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.98|P-value:1.72E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.95|P-value:1.88E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.09|P-value:2.01E-8 ID:SGTC_1764|Compound:st044502|FD-Score:4.24|P-value:6.67E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.64|P-value:1.45E-5 ID:SGTC_1914|Compound:st062367|FD-Score:5.42|P-value:5.17E-7 ID:SGTC_1919|Compound:st067113|FD-Score:-3.54|P-value:6.45E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.41|P-value:3.57E-5 ID:SGTC_1970|Compound:st070122|FD-Score:5.82|P-value:7.58E-8 ID:SGTC_2009|Compound:4012297|FD-Score:3.46|P-value:9.32E-4 ID:SGTC_2123|Compound:5259487|FD-Score:4.84|P-value:6.46E-6 ID:SGTC_2156|Compound:5649887|FD-Score:3.84|P-value:2.77E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-4.57|P-value:1.69E-5 ID:SGTC_2175|Compound:5807670|FD-Score:4.79|P-value:7.90E-6 ID:SGTC_2304|Compound:7443016|FD-Score:-4.35|P-value:3.87E-5 ID:SGTC_2306|Compound:7482397|FD-Score:-4.27|P-value:5.28E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.75|P-value:3.69E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.58|P-value:1.85E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:6.26|P-value:8.23E-9 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:6.66|P-value:9.34E-10 ID:SGTC_2556|Compound:citropten|FD-Score:4.55|P-value:2.04E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.59|P-value:6.11E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.71|P-value:4.21E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:12.50|P-value:5.85E-30 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.68|P-value:1.08E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:4.70|P-value:1.16E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.94|P-value:3.82E-13 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.78|P-value:2.94E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.57|P-value:6.57E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.45|P-value:9.53E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.46|P-value:8.38E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.17|P-value:1.61E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.63|P-value:1.49E-5 ID:SGTC_3060|Compound:1327-0027|FD-Score:5.46|P-value:4.23E-7 ID:SGTC_3083|Compound:9117465|FD-Score:4.26|P-value:6.12E-5 ID:SGTC_3091|Compound:9116372|FD-Score:3.94|P-value:1.95E-4 ID:SGTC_3200|Compound:9114385|FD-Score:5.80|P-value:8.34E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:5.26|P-value:1.07E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:7.01|P-value:1.27E-10 ID:SGTC_89|Compound:0302-0250|FD-Score:3.57|P-value:6.58E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.48|P-value:8.79E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.30|P-value:5.46E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:3.53|P-value:7.42E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.05|P-value:2.63E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:4.88|P-value:5.44E-6 ID:SGTC_185|Compound:k048-0037|FD-Score:4.61|P-value:1.65E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.67|P-value:4.31E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.63|P-value:1.53E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:3.90|P-value:2.20E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-4.00|P-value:1.38E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:6.66|P-value:9.28E-10 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.97|P-value:1.54E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.78|P-value:3.34E-4 ID:SGTC_389|Compound:tpck|FD-Score:3.52|P-value:7.65E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.88|P-value:5.65E-8 ID:SGTC_505|Compound:gw-5074|FD-Score:4.10|P-value:1.09E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:9.96|P-value:1.23E-19 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.94|P-value:3.67E-6 ID:SGTC_537|Compound:1334-0398|FD-Score:4.40|P-value:3.65E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.06|P-value:1.27E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.11|P-value:1.06E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:4.79|P-value:8.05E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:4.11|P-value:1.07E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:4.98|P-value:3.63E-6 ID:SGTC_845|Compound:0330-0138|FD-Score:3.90|P-value:2.26E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.67|P-value:4.24E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.73|P-value:3.95E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:11.10|P-value:7.29E-24 ID:SGTC_1304|Compound:1165-0502|FD-Score:7.03|P-value:1.15E-10 ID:SGTC_1305|Compound:1181-0477|FD-Score:4.94|P-value:4.23E-6 ID:SGTC_1354|Compound:1498-1681|FD-Score:4.18|P-value:8.37E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:-3.66|P-value:4.45E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:-4.02|P-value:1.32E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.98|P-value:1.72E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.95|P-value:1.88E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.09|P-value:2.01E-8 ID:SGTC_1764|Compound:st044502|FD-Score:4.24|P-value:6.67E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.64|P-value:1.45E-5 ID:SGTC_1914|Compound:st062367|FD-Score:5.42|P-value:5.17E-7 ID:SGTC_1919|Compound:st067113|FD-Score:-3.54|P-value:6.45E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.41|P-value:3.57E-5 ID:SGTC_1970|Compound:st070122|FD-Score:5.82|P-value:7.58E-8 ID:SGTC_2009|Compound:4012297|FD-Score:3.46|P-value:9.32E-4 ID:SGTC_2123|Compound:5259487|FD-Score:4.84|P-value:6.46E-6 ID:SGTC_2156|Compound:5649887|FD-Score:3.84|P-value:2.77E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-4.57|P-value:1.69E-5 ID:SGTC_2175|Compound:5807670|FD-Score:4.79|P-value:7.90E-6 ID:SGTC_2304|Compound:7443016|FD-Score:-4.35|P-value:3.87E-5 ID:SGTC_2306|Compound:7482397|FD-Score:-4.27|P-value:5.28E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.75|P-value:3.69E-4 ID:SGTC_2445|Compound:5742597|FD-Score:4.58|P-value:1.85E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:6.26|P-value:8.23E-9 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:6.66|P-value:9.34E-10 ID:SGTC_2556|Compound:citropten|FD-Score:4.55|P-value:2.04E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.59|P-value:6.11E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.71|P-value:4.21E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:12.50|P-value:5.85E-30 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.68|P-value:1.08E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:4.70|P-value:1.16E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:7.94|P-value:3.82E-13 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.78|P-value:2.94E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.57|P-value:6.57E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.45|P-value:9.53E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.46|P-value:8.38E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.17|P-value:1.61E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:4.63|P-value:1.49E-5 ID:SGTC_3060|Compound:1327-0027|FD-Score:5.46|P-value:4.23E-7 ID:SGTC_3083|Compound:9117465|FD-Score:4.26|P-value:6.12E-5 ID:SGTC_3091|Compound:9116372|FD-Score:3.94|P-value:1.95E-4 ID:SGTC_3200|Compound:9114385|FD-Score:5.80|P-value:8.34E-8

Top fitness defect scores for YNL235C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2651 1327-0036 12.50 5.0 µM 5.85E-30 13 2.81E-36
2 SGTC_1287 0971-0001 11.10 34.6 µM 7.29E-24 sphingolipid biosynthesis & PDR1 8 7.94E-29
3 SGTC_513 4245-1575 9.96 41.7 µM 1.23E-19 unfolded protein response 16 1.16E-23
4 SGTC_2752 diclazuril 7.94 33.1 µM 3.82E-13 37 9.95E-16
5 SGTC_1304 1165-0502 7.03 251.0 µM 1.15E-10 20 1.05E-12
6 SGTC_66 0109-0187 7.01 42.4 µM 1.27E-10 8 1.20E-12
7 SGTC_352 k048-0007 6.66 5.1 µM 9.28E-10 ERAD & cell cycle 25 1.35E-11
8 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 6.66 54.6 µM 9.34E-10 RPP1 & pyrimidine depletion 6 1.36E-11
9 SGTC_2507 purpurin 6.26 79.7 µM 8.23E-9 copper-dependent oxidative stress 7 1.93E-10
10 SGTC_1687 st020778 6.09 55.4 µM 2.01E-8 108 5.75E-10
11 SGTC_453 enantio-paf c16 5.88 10.0 µM 5.65E-8 54 2.03E-9
12 SGTC_1970 st070122 5.82 35.8 µM 7.58E-8 TSC3-RPN4 9 2.90E-9
13 SGTC_3200 9114385 5.80 49.5 µM 8.34E-8 6 3.26E-9
14 SGTC_3060 1327-0027 5.46 12.5 µM 4.23E-7 20 2.36E-8
15 SGTC_1914 st062367 5.42 72.6 µM 5.17E-7 5 3.01E-8
16 SGTC_58 0957-0393 5.26 9.0 µM 1.07E-6 cell wall 260 7.33E-8
17 SGTC_2896 9052656 5.17 71.4 µM 1.61E-6 endomembrane recycling 55 1.20E-7
18 SGTC_173 1273-0061 5.05 2.7 µM 2.63E-6 mitochondrial stress 144 2.18E-7
19 SGTC_751 0833-0568 4.98 350.0 µM 3.63E-6 6 3.23E-7
20 SGTC_1305 1181-0477 4.94 144.0 µM 4.23E-6 8 3.89E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.282 1.90E-62 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.251 3.21E-49 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.244 9.75E-47 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.235 2.86E-43 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
0.215 1.65E-36 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.201 8.39E-32 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.199 3.32E-31 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.191 8.34E-29 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.190 1.79E-28 YNL236W SIN4 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
0.186 1.53E-27 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.172 1.16E-23 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.169 7.92E-23 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.169 8.29E-23 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.166 4.58E-22 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.162 4.51E-21 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion