YNL237W / YTP1

Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL237W / YTP1

Click on Significant Values for Screen Details ID:SGTC_94|Compound:0334-0113|FD-Score:4.17|P-value:4.91E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.73|P-value:9.20E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:4.15|P-value:5.24E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:4.00|P-value:7.88E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.29|P-value:3.50E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.91|P-value:5.05E-5 ID:SGTC_317|Compound:4495-0002|FD-Score:-4.12|P-value:4.06E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.97|P-value:8.70E-4 ID:SGTC_462|Compound:ag-879|FD-Score:5.86|P-value:1.67E-6 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-4.58|P-value:1.02E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.23|P-value:4.21E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:9.35|P-value:4.80E-14 ID:SGTC_639|Compound:0833-0042|FD-Score:4.54|P-value:1.65E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.00|P-value:1.32E-8 ID:SGTC_721|Compound:1187-1332|FD-Score:5.31|P-value:1.29E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:-4.14|P-value:3.82E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.97|P-value:8.67E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:4.06|P-value:6.80E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-4.62|P-value:8.97E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:4.76|P-value:8.19E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:-4.16|P-value:3.56E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:5.71|P-value:3.01E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:4.43|P-value:2.31E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:5.36|P-value:1.07E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.87|P-value:8.16E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.75|P-value:8.53E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.24|P-value:4.06E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:6.31|P-value:2.74E-7 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.06|P-value:6.81E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-7.53|P-value:6.03E-10 ID:SGTC_1265|Compound:0819-1001|FD-Score:5.91|P-value:1.39E-6 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.32|P-value:3.18E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.68|P-value:3.34E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.81|P-value:6.99E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.04|P-value:7.19E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:-4.21|P-value:3.09E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:-3.83|P-value:9.04E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.99|P-value:8.18E-4 ID:SGTC_1523|Compound:st012844|FD-Score:5.00|P-value:3.72E-5 ID:SGTC_1672|Compound:st016598|FD-Score:4.49|P-value:1.96E-4 ID:SGTC_1687|Compound:st020778|FD-Score:7.06|P-value:1.02E-8 ID:SGTC_1750|Compound:st081859|FD-Score:3.96|P-value:8.90E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.81|P-value:2.01E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.03|P-value:8.56E-7 ID:SGTC_1897|Compound:st060201|FD-Score:8.64|P-value:3.07E-12 ID:SGTC_1912|Compound:st060209|FD-Score:5.26|P-value:1.56E-5 ID:SGTC_1941|Compound:st076221|FD-Score:12.40|P-value:3.11E-23 ID:SGTC_1949|Compound:st076024|FD-Score:5.59|P-value:4.66E-6 ID:SGTC_2036|Compound:5160441|FD-Score:5.54|P-value:5.66E-6 ID:SGTC_2118|Compound:5526350|FD-Score:4.38|P-value:2.71E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.32|P-value:3.19E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:-4.23|P-value:2.96E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:9.07|P-value:2.60E-13 ID:SGTC_2586|Compound:curcumin|FD-Score:4.25|P-value:3.99E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.66|P-value:1.14E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-4.37|P-value:1.91E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.10|P-value:5.96E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-4.08|P-value:4.60E-4 ID:SGTC_2858|Compound:9025781|FD-Score:10.90|P-value:1.60E-18 ID:SGTC_2981|Compound:9013952|FD-Score:-3.81|P-value:9.65E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.00|P-value:7.94E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.51|P-value:1.79E-4 ID:SGTC_3140|Compound:9094243|FD-Score:6.84|P-value:2.74E-8 ID:SGTC_3142|Compound:9086498|FD-Score:-4.19|P-value:3.28E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.17|P-value:4.91E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.73|P-value:9.20E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:4.15|P-value:5.24E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:4.00|P-value:7.88E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.29|P-value:3.50E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.91|P-value:5.05E-5 ID:SGTC_317|Compound:4495-0002|FD-Score:-4.12|P-value:4.06E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.97|P-value:8.70E-4 ID:SGTC_462|Compound:ag-879|FD-Score:5.86|P-value:1.67E-6 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-4.58|P-value:1.02E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.23|P-value:4.21E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:9.35|P-value:4.80E-14 ID:SGTC_639|Compound:0833-0042|FD-Score:4.54|P-value:1.65E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.00|P-value:1.32E-8 ID:SGTC_721|Compound:1187-1332|FD-Score:5.31|P-value:1.29E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:-4.14|P-value:3.82E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.97|P-value:8.67E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:4.06|P-value:6.80E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-4.62|P-value:8.97E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:4.76|P-value:8.19E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:-4.16|P-value:3.56E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:5.71|P-value:3.01E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:4.43|P-value:2.31E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:5.36|P-value:1.07E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.87|P-value:8.16E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:4.75|P-value:8.53E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.24|P-value:4.06E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:6.31|P-value:2.74E-7 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.06|P-value:6.81E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-7.53|P-value:6.03E-10 ID:SGTC_1265|Compound:0819-1001|FD-Score:5.91|P-value:1.39E-6 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.32|P-value:3.18E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.68|P-value:3.34E-6 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.81|P-value:6.99E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.04|P-value:7.19E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:-4.21|P-value:3.09E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:-3.83|P-value:9.04E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.99|P-value:8.18E-4 ID:SGTC_1523|Compound:st012844|FD-Score:5.00|P-value:3.72E-5 ID:SGTC_1672|Compound:st016598|FD-Score:4.49|P-value:1.96E-4 ID:SGTC_1687|Compound:st020778|FD-Score:7.06|P-value:1.02E-8 ID:SGTC_1750|Compound:st081859|FD-Score:3.96|P-value:8.90E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.81|P-value:2.01E-6 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.03|P-value:8.56E-7 ID:SGTC_1897|Compound:st060201|FD-Score:8.64|P-value:3.07E-12 ID:SGTC_1912|Compound:st060209|FD-Score:5.26|P-value:1.56E-5 ID:SGTC_1941|Compound:st076221|FD-Score:12.40|P-value:3.11E-23 ID:SGTC_1949|Compound:st076024|FD-Score:5.59|P-value:4.66E-6 ID:SGTC_2036|Compound:5160441|FD-Score:5.54|P-value:5.66E-6 ID:SGTC_2118|Compound:5526350|FD-Score:4.38|P-value:2.71E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.32|P-value:3.19E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:-4.23|P-value:2.96E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:9.07|P-value:2.60E-13 ID:SGTC_2586|Compound:curcumin|FD-Score:4.25|P-value:3.99E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.66|P-value:1.14E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-4.37|P-value:1.91E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.10|P-value:5.96E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-4.08|P-value:4.60E-4 ID:SGTC_2858|Compound:9025781|FD-Score:10.90|P-value:1.60E-18 ID:SGTC_2981|Compound:9013952|FD-Score:-3.81|P-value:9.65E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.00|P-value:7.94E-4 ID:SGTC_3062|Compound:9077494|FD-Score:4.51|P-value:1.79E-4 ID:SGTC_3140|Compound:9094243|FD-Score:6.84|P-value:2.74E-8 ID:SGTC_3142|Compound:9086498|FD-Score:-4.19|P-value:3.28E-4

Top fitness defect scores for YNL237W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1941 st076221 12.40 61.8 µM 3.11E-23 sphingolipid biosynthesis & PDR1 8 2.01E-35
2 SGTC_2858 9025781 10.90 9.0 µM 1.60E-18 sphingolipid biosynthesis & PDR1 16 4.49E-28
3 SGTC_528 3492-0019 9.35 172.0 µM 4.80E-14 calcium & mitochondrial duress 45 4.25E-21
4 SGTC_2500 5-alpha-androstan-3,17-dione 9.07 61.4 µM 2.60E-13 2 5.91E-20
5 SGTC_1897 st060201 8.64 15.0 µM 3.07E-12 mitochondrial processes 1 2.76E-18
6 SGTC_1687 st020778 7.06 55.4 µM 1.02E-8 86 8.38E-13
7 SGTC_682 0kpi-0099 7.00 17.0 µM 1.32E-8 16 1.24E-12
8 SGTC_3140 9094243 6.84 49.5 µM 2.74E-8 3 3.88E-12
9 SGTC_1193 1488-0126 6.31 41.5 µM 2.74E-7 6 1.38E-10
10 SGTC_1877 wortmannin 6.03 25.0 µM 8.56E-7 46 8.12E-10
11 SGTC_1265 0819-1001 5.91 68.8 µM 1.39E-6 2 1.71E-9
12 SGTC_462 ag-879 5.86 158.0 µM 1.67E-6 6 2.29E-9
13 SGTC_1875 nocodazole 5.81 6.0 µM 2.01E-6 tubulin folding & SWR complex 32 3.04E-9
14 SGTC_913 3487-1245 5.71 167.0 µM 3.01E-6 2 5.70E-9
15 SGTC_1287 0971-0001 5.68 34.6 µM 3.34E-6 sphingolipid biosynthesis & PDR1 23 6.72E-9
16 SGTC_1949 st076024 5.59 69.1 µM 4.66E-6 5 1.12E-8
17 SGTC_2036 5160441 5.54 105.0 µM 5.66E-6 NEO1 47 1.52E-8
18 SGTC_995 3931-2021 5.36 34.6 µM 1.07E-5 RPP1 & pyrimidine depletion 6 4.05E-8
19 SGTC_721 1187-1332 5.31 279.0 µM 1.29E-5 cell wall signaling 4 5.46E-8
20 SGTC_1912 st060209 5.26 90.8 µM 1.56E-5 15 7.30E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.375 1.78E-112 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.343 1.65E-93 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.307 3.25E-74 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.292 4.24E-67 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.287 1.97E-64 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.274 8.76E-59 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.245 5.15E-47 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.223 3.11E-39 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.212 2.11E-35 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.210 8.69E-35 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.203 1.06E-32 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.197 1.16E-30 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.196 2.47E-30 YPL265W DIP5 hom Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress
0.184 6.38E-27 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.178 2.23E-25 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication