YNL239W / LAP3

Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL239W / LAP3

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.26|P-value:4.16E-6 ID:SGTC_20|Compound:0481-0013|FD-Score:5.37|P-value:1.01E-8 ID:SGTC_41|Compound:0478-0632|FD-Score:3.02|P-value:8.02E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.54|P-value:3.50E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:8.81|P-value:1.65E-20 ID:SGTC_163|Compound:1327-0036|FD-Score:11.50|P-value:1.13E-33 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.87|P-value:1.85E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:3.92|P-value:2.05E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:3.11|P-value:5.74E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.10|P-value:6.08E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.16|P-value:4.76E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.57|P-value:9.55E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.35|P-value:2.33E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.05|P-value:1.16E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:3.53|P-value:1.11E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.01|P-value:1.37E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.53|P-value:1.17E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.01|P-value:1.39E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:3.19|P-value:4.30E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.35|P-value:2.39E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-4.35|P-value:2.88E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.24|P-value:3.64E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.87|P-value:2.69E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.55|P-value:1.49E-15 ID:SGTC_1163|Compound:k060-0048|FD-Score:-3.00|P-value:8.62E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:5.50|P-value:4.36E-9 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.85|P-value:2.79E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:7.42|P-value:4.49E-15 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.19|P-value:4.22E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.83|P-value:2.19E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.48|P-value:1.42E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.26|P-value:3.39E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.16|P-value:4.68E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.17|P-value:6.49E-6 ID:SGTC_1752|Compound:st044819|FD-Score:2.98|P-value:9.16E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.21|P-value:3.99E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-3.43|P-value:1.76E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.27|P-value:4.01E-6 ID:SGTC_2059|Compound:5238311|FD-Score:-3.11|P-value:5.88E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.08|P-value:5.35E-8 ID:SGTC_2263|Compound:7948595|FD-Score:3.89|P-value:2.33E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-3.96|P-value:1.76E-5 ID:SGTC_2270|Compound:7924575|FD-Score:-4.11|P-value:8.95E-6 ID:SGTC_2322|Compound:7413319|FD-Score:2.99|P-value:8.91E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.02|P-value:1.34E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.54|P-value:1.04E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-4.36|P-value:2.74E-6 ID:SGTC_2423|Compound:st077119|FD-Score:3.56|P-value:9.87E-5 ID:SGTC_2430|Compound:5571206|FD-Score:6.48|P-value:6.29E-12 ID:SGTC_2432|Compound:5630864|FD-Score:5.75|P-value:9.23E-10 ID:SGTC_2452|Compound:5863136|FD-Score:3.01|P-value:8.24E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.81|P-value:6.32E-10 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.58|P-value:8.77E-7 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.23|P-value:3.83E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.56|P-value:9.91E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:11.50|P-value:9.92E-34 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.66|P-value:5.63E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.23|P-value:3.73E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.66|P-value:5.66E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.15|P-value:7.29E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.97|P-value:9.81E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-2.99|P-value:9.21E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.86|P-value:2.68E-5 ID:SGTC_2839|Compound:9003951|FD-Score:3.00|P-value:8.41E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.20|P-value:4.17E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.39|P-value:1.99E-4 ID:SGTC_2921|Compound:7974240|FD-Score:6.38|P-value:1.33E-11 ID:SGTC_2985|Compound:9022375|FD-Score:4.48|P-value:1.40E-6 ID:SGTC_3146|Compound:9095609|FD-Score:-3.11|P-value:5.94E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.55|P-value:1.04E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:4.26|P-value:4.16E-6 ID:SGTC_20|Compound:0481-0013|FD-Score:5.37|P-value:1.01E-8 ID:SGTC_41|Compound:0478-0632|FD-Score:3.02|P-value:8.02E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.54|P-value:3.50E-9 ID:SGTC_103|Compound:0844-0104|FD-Score:8.81|P-value:1.65E-20 ID:SGTC_163|Compound:1327-0036|FD-Score:11.50|P-value:1.13E-33 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.87|P-value:1.85E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:3.92|P-value:2.05E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:3.11|P-value:5.74E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.10|P-value:6.08E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.16|P-value:4.76E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.57|P-value:9.55E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.35|P-value:2.33E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.05|P-value:1.16E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:3.53|P-value:1.11E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.01|P-value:1.37E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:-3.53|P-value:1.17E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.01|P-value:1.39E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:3.19|P-value:4.30E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:-3.35|P-value:2.39E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:-4.35|P-value:2.88E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.24|P-value:3.64E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:-3.87|P-value:2.69E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.55|P-value:1.49E-15 ID:SGTC_1163|Compound:k060-0048|FD-Score:-3.00|P-value:8.62E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:5.50|P-value:4.36E-9 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.85|P-value:2.79E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:7.42|P-value:4.49E-15 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.19|P-value:4.22E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.83|P-value:2.19E-7 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.48|P-value:1.42E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.26|P-value:3.39E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.16|P-value:4.68E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.17|P-value:6.49E-6 ID:SGTC_1752|Compound:st044819|FD-Score:2.98|P-value:9.16E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.21|P-value:3.99E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-3.43|P-value:1.76E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.27|P-value:4.01E-6 ID:SGTC_2059|Compound:5238311|FD-Score:-3.11|P-value:5.88E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:5.08|P-value:5.35E-8 ID:SGTC_2263|Compound:7948595|FD-Score:3.89|P-value:2.33E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-3.96|P-value:1.76E-5 ID:SGTC_2270|Compound:7924575|FD-Score:-4.11|P-value:8.95E-6 ID:SGTC_2322|Compound:7413319|FD-Score:2.99|P-value:8.91E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.02|P-value:1.34E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.54|P-value:1.04E-6 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-4.36|P-value:2.74E-6 ID:SGTC_2423|Compound:st077119|FD-Score:3.56|P-value:9.87E-5 ID:SGTC_2430|Compound:5571206|FD-Score:6.48|P-value:6.29E-12 ID:SGTC_2432|Compound:5630864|FD-Score:5.75|P-value:9.23E-10 ID:SGTC_2452|Compound:5863136|FD-Score:3.01|P-value:8.24E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.81|P-value:6.32E-10 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.58|P-value:8.77E-7 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.23|P-value:3.83E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.56|P-value:9.91E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:11.50|P-value:9.92E-34 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.66|P-value:5.63E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.23|P-value:3.73E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.66|P-value:5.66E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.15|P-value:7.29E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.97|P-value:9.81E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-2.99|P-value:9.21E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.86|P-value:2.68E-5 ID:SGTC_2839|Compound:9003951|FD-Score:3.00|P-value:8.41E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.20|P-value:4.17E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.39|P-value:1.99E-4 ID:SGTC_2921|Compound:7974240|FD-Score:6.38|P-value:1.33E-11 ID:SGTC_2985|Compound:9022375|FD-Score:4.48|P-value:1.40E-6 ID:SGTC_3146|Compound:9095609|FD-Score:-3.11|P-value:5.94E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.55|P-value:1.04E-4

Top fitness defect scores for YNL239W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2651 1327-0036 11.50 5.0 µM 9.92E-34 16 4.62E-31
2 SGTC_163 1327-0036 11.50 7.5 µM 1.13E-33 10 5.22E-31
3 SGTC_103 0844-0104 8.81 51.8 µM 1.65E-20 ERAD & cell cycle 41 6.13E-19
4 SGTC_1161 k007-0610 7.55 110.0 µM 1.49E-15 ERAD & cell cycle 29 2.15E-14
5 SGTC_1375 2910-0797 7.42 186.0 µM 4.49E-15 2 5.92E-14
6 SGTC_2430 5571206 6.48 200.0 µM 6.29E-12 18 4.56E-11
7 SGTC_2921 7974240 6.38 10.7 µM 1.33E-11 13 9.07E-11
8 SGTC_2500 5-alpha-androstan-3,17-dione 5.81 61.4 µM 6.32E-10 13 3.14E-9
9 SGTC_2432 5630864 5.75 12.2 µM 9.23E-10 4 4.44E-9
10 SGTC_65 0798-0905 5.54 35.0 µM 3.50E-9 calcium & mitochondrial duress 43 1.51E-8
11 SGTC_1368 1852-0141 5.50 284.0 µM 4.36E-9 ERG2 17 1.85E-8
12 SGTC_20 0481-0013 5.37 4.9 µM 1.01E-8 8 4.01E-8
13 SGTC_2233 sulbentine 5.08 40.4 µM 5.35E-8 33 1.85E-7
14 SGTC_1562 morin hydrate 4.83 59.1 µM 2.19E-7 4 6.74E-7
15 SGTC_2679 rapamycin 4.66 1.0 nM 5.63E-7 108 1.61E-6
16 SGTC_2752 diclazuril 4.66 33.1 µM 5.66E-7 84 1.61E-6
17 SGTC_2408 sulbentine 4.54 18.4 µM 1.04E-6 35 2.83E-6
18 SGTC_2985 9022375 4.48 71.4 µM 1.40E-6 RPP1 & pyrimidine depletion 20 3.70E-6
19 SGTC_1920 st075728 4.27 45.7 µM 4.01E-6 16 9.76E-6
20 SGTC_8 0354-0001 4.26 70.0 µM 4.16E-6 65 1.01E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.355 1.50E-100 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.335 9.59E-89 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.314 7.75E-78 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.296 7.83E-69 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.292 3.75E-67 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.289 1.36E-65 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.288 3.75E-65 YMR070W MOT3 hom Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion
0.280 3.34E-61 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.268 2.65E-56 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.256 2.02E-51 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.244 1.27E-46 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.243 1.86E-46 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.229 3.36E-41 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.228 8.07E-41 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.223 4.31E-39 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway