HIPHOP chemogenomics database
YNL240C / NAR1 
Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YNL240C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.113 | 4.53E-11 | YKR028W | SAP190 | hom | Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication |
| 0.106 | 8.52E-10 | YOL013C | HRD1 | hom | Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon |
| 0.087 | 3.90E-7 | YHL046C | PAU13 | hom | Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock |
| 0.085 | 9.45E-7 | YPR079W | MRL1 | hom | Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress |
| 0.083 | 1.39E-6 | YML065W | ORC1 | het | Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity |
| 0.083 | 1.64E-6 | YHR038W | RRF1 | hom | Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria |
| 0.080 | 3.61E-6 | YOR079C | ATX2 | hom | Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation |
| 0.076 | 1.03E-5 | YOR243C | PUS7 | hom | Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria |
| 0.073 | 2.34E-5 | YML069W | POB3 | het | Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress |
| 0.072 | 3.05E-5 | YNR004W_p | SWM2_p | hom | Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds |
| 0.070 | 4.68E-5 | YBR019C | GAL10 | hom | UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers |
| 0.069 | 6.22E-5 | YIR026C | YVH1 | hom | Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases |
| 0.069 | 6.31E-5 | YOR302W | YOR302W | hom | CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA |
| 0.068 | 7.91E-5 | YDL076C | RXT3 | hom | Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress |
| 0.068 | 8.16E-5 | YKL021C | MAK11 | het | Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats |