YNL241C / ZWF1

Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL241C / ZWF1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.12|P-value:7.54E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.24|P-value:5.05E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:7.98|P-value:4.91E-16 ID:SGTC_34|Compound:0469-0683|FD-Score:7.47|P-value:2.70E-14 ID:SGTC_58|Compound:0957-0393|FD-Score:12.00|P-value:1.56E-33 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.54|P-value:2.36E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.19|P-value:6.05E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:3.40|P-value:2.77E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.84|P-value:5.08E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.09|P-value:8.41E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.16|P-value:6.65E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:3.19|P-value:5.91E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.54|P-value:1.67E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:6.73|P-value:6.00E-12 ID:SGTC_362|Compound:0310-0100|FD-Score:3.49|P-value:1.97E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:4.13|P-value:1.47E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:4.20|P-value:1.08E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.09|P-value:8.46E-4 ID:SGTC_394|Compound:menadione|FD-Score:8.37|P-value:1.78E-17 ID:SGTC_444|Compound:curcumin|FD-Score:3.18|P-value:6.11E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:7.24|P-value:1.49E-13 ID:SGTC_470|Compound:aa-861|FD-Score:4.00|P-value:2.59E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.89|P-value:3.83E-7 ID:SGTC_626|Compound:0214-0009|FD-Score:3.74|P-value:7.61E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.79|P-value:6.15E-5 ID:SGTC_709|Compound:3807-1509|FD-Score:-3.28|P-value:6.22E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.46|P-value:3.16E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:3.67|P-value:9.85E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.28|P-value:4.31E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.07|P-value:9.17E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.42|P-value:2.63E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.17|P-value:8.85E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.96|P-value:2.97E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.63|P-value:1.16E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:8.44|P-value:1.06E-17 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.35|P-value:3.39E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.06|P-value:1.97E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.36|P-value:3.27E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:7.46|P-value:3.00E-14 ID:SGTC_1635|Compound:st007035|FD-Score:3.27|P-value:4.51E-4 ID:SGTC_1689|Compound:st020265|FD-Score:5.25|P-value:5.86E-8 ID:SGTC_1716|Compound:st033144|FD-Score:3.93|P-value:3.47E-5 ID:SGTC_1720|Compound:st037298|FD-Score:4.27|P-value:7.88E-6 ID:SGTC_1739|Compound:st037196|FD-Score:4.53|P-value:2.34E-6 ID:SGTC_2001|Compound:4023502|FD-Score:4.14|P-value:1.41E-5 ID:SGTC_2002|Compound:4023503|FD-Score:6.05|P-value:5.14E-10 ID:SGTC_2012|Compound:4023501|FD-Score:3.99|P-value:2.70E-5 ID:SGTC_2022|Compound:5136654|FD-Score:8.85|P-value:2.67E-19 ID:SGTC_2040|Compound:5100729|FD-Score:4.87|P-value:4.36E-7 ID:SGTC_2066|Compound:5222451|FD-Score:3.17|P-value:6.36E-4 ID:SGTC_2068|Compound:5226020|FD-Score:4.13|P-value:1.47E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.36|P-value:3.19E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.26|P-value:4.62E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.52|P-value:1.78E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.16|P-value:1.28E-5 ID:SGTC_2325|Compound:6158266|FD-Score:6.52|P-value:2.58E-11 ID:SGTC_2398|Compound:5228213|FD-Score:3.34|P-value:3.46E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.14|P-value:7.12E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.53|P-value:2.28E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.27|P-value:6.38E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.45|P-value:5.43E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.35|P-value:4.88E-4 ID:SGTC_2681|Compound:menadione|FD-Score:14.00|P-value:1.86E-45 ID:SGTC_2781|Compound:5567276|FD-Score:3.29|P-value:4.15E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.88|P-value:6.40E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.40|P-value:2.82E-4 ID:SGTC_2982|Compound:9019404|FD-Score:5.28|P-value:4.88E-8 ID:SGTC_2985|Compound:9022375|FD-Score:3.33|P-value:3.66E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.19|P-value:6.07E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.18|P-value:6.29E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.29|P-value:7.12E-6 ID:SGTC_3061|Compound:glucosamine|FD-Score:4.07|P-value:1.88E-5 ID:SGTC_3337|Compound:9144342|FD-Score:3.22|P-value:5.45E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.12|P-value:7.54E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.24|P-value:5.05E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:7.98|P-value:4.91E-16 ID:SGTC_34|Compound:0469-0683|FD-Score:7.47|P-value:2.70E-14 ID:SGTC_58|Compound:0957-0393|FD-Score:12.00|P-value:1.56E-33 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.54|P-value:2.36E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.19|P-value:6.05E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:3.40|P-value:2.77E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.84|P-value:5.08E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.09|P-value:8.41E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.16|P-value:6.65E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:3.19|P-value:5.91E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.54|P-value:1.67E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:6.73|P-value:6.00E-12 ID:SGTC_362|Compound:0310-0100|FD-Score:3.49|P-value:1.97E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:4.13|P-value:1.47E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:4.20|P-value:1.08E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.09|P-value:8.46E-4 ID:SGTC_394|Compound:menadione|FD-Score:8.37|P-value:1.78E-17 ID:SGTC_444|Compound:curcumin|FD-Score:3.18|P-value:6.11E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:7.24|P-value:1.49E-13 ID:SGTC_470|Compound:aa-861|FD-Score:4.00|P-value:2.59E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.89|P-value:3.83E-7 ID:SGTC_626|Compound:0214-0009|FD-Score:3.74|P-value:7.61E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.79|P-value:6.15E-5 ID:SGTC_709|Compound:3807-1509|FD-Score:-3.28|P-value:6.22E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:4.46|P-value:3.16E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:3.67|P-value:9.85E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.28|P-value:4.31E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.07|P-value:9.17E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.42|P-value:2.63E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.17|P-value:8.85E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.96|P-value:2.97E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.63|P-value:1.16E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:8.44|P-value:1.06E-17 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.35|P-value:3.39E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.06|P-value:1.97E-5 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.36|P-value:3.27E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:7.46|P-value:3.00E-14 ID:SGTC_1635|Compound:st007035|FD-Score:3.27|P-value:4.51E-4 ID:SGTC_1689|Compound:st020265|FD-Score:5.25|P-value:5.86E-8 ID:SGTC_1716|Compound:st033144|FD-Score:3.93|P-value:3.47E-5 ID:SGTC_1720|Compound:st037298|FD-Score:4.27|P-value:7.88E-6 ID:SGTC_1739|Compound:st037196|FD-Score:4.53|P-value:2.34E-6 ID:SGTC_2001|Compound:4023502|FD-Score:4.14|P-value:1.41E-5 ID:SGTC_2002|Compound:4023503|FD-Score:6.05|P-value:5.14E-10 ID:SGTC_2012|Compound:4023501|FD-Score:3.99|P-value:2.70E-5 ID:SGTC_2022|Compound:5136654|FD-Score:8.85|P-value:2.67E-19 ID:SGTC_2040|Compound:5100729|FD-Score:4.87|P-value:4.36E-7 ID:SGTC_2066|Compound:5222451|FD-Score:3.17|P-value:6.36E-4 ID:SGTC_2068|Compound:5226020|FD-Score:4.13|P-value:1.47E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.36|P-value:3.19E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.26|P-value:4.62E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.52|P-value:1.78E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.16|P-value:1.28E-5 ID:SGTC_2325|Compound:6158266|FD-Score:6.52|P-value:2.58E-11 ID:SGTC_2398|Compound:5228213|FD-Score:3.34|P-value:3.46E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.14|P-value:7.12E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.53|P-value:2.28E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.27|P-value:6.38E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.45|P-value:5.43E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-3.35|P-value:4.88E-4 ID:SGTC_2681|Compound:menadione|FD-Score:14.00|P-value:1.86E-45 ID:SGTC_2781|Compound:5567276|FD-Score:3.29|P-value:4.15E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.88|P-value:6.40E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.40|P-value:2.82E-4 ID:SGTC_2982|Compound:9019404|FD-Score:5.28|P-value:4.88E-8 ID:SGTC_2985|Compound:9022375|FD-Score:3.33|P-value:3.66E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.19|P-value:6.07E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.18|P-value:6.29E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.29|P-value:7.12E-6 ID:SGTC_3061|Compound:glucosamine|FD-Score:4.07|P-value:1.88E-5 ID:SGTC_3337|Compound:9144342|FD-Score:3.22|P-value:5.45E-4

Top fitness defect scores for YNL241C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2681 menadione 14.00 3.2 µM 1.86E-45 superoxide 3 4.00E-45
2 SGTC_58 0957-0393 12.00 9.0 µM 1.56E-33 cell wall 53 2.97E-33
3 SGTC_2022 5136654 8.85 200.0 µM 2.67E-19 2 4.27E-19
4 SGTC_1083 didemethylchlorpromazine sulfoxide 8.44 707.4 nM 1.06E-17 redox potentiating 11 1.65E-17
5 SGTC_394 menadione 8.37 8.3 µM 1.78E-17 superoxide 5 2.77E-17
6 SGTC_29 0299-0004 7.98 13.0 µM 4.91E-16 7 7.48E-16
7 SGTC_34 0469-0683 7.47 81.8 µM 2.70E-14 SWF1 & branched chain AA biosynthesis 4 4.00E-14
8 SGTC_1556 plumbagin 7.46 1.5 µM 3.00E-14 superoxide 10 4.45E-14
9 SGTC_451 chloral hydrate 7.24 100.0 µM 1.49E-13 9 2.19E-13
10 SGTC_318 1488-0629 6.73 67.2 µM 6.00E-12 copper-dependent oxidative stress 9 8.55E-12
11 SGTC_2325 6158266 6.52 200.0 µM 2.58E-11 3 3.63E-11
12 SGTC_2002 4023503 6.05 131.0 µM 5.14E-10 mitochondrial processes 7 7.07E-10
13 SGTC_2982 9019404 5.28 26.0 µM 4.88E-8 11 6.45E-8
14 SGTC_1689 st020265 5.25 53.5 µM 5.86E-8 4 7.73E-8
15 SGTC_513 4245-1575 4.89 41.7 µM 3.83E-7 unfolded protein response 77 4.96E-7
16 SGTC_2040 5100729 4.87 123.0 µM 4.36E-7 25 5.64E-7
17 SGTC_2582 agaric acid 4.53 100.0 µM 2.28E-6 redox potentiating 251 2.90E-6
18 SGTC_1739 st037196 4.53 92.5 µM 2.34E-6 12 2.98E-6
19 SGTC_740 k014-0057 4.46 261.0 µM 3.16E-6 15 4.01E-6
20 SGTC_3049 9092223 4.29 49.5 µM 7.12E-6 15 8.95E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.293 1.98E-67 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.285 5.43E-64 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.271 1.27E-57 YHR206W SKN7 hom Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication
0.255 4.82E-51 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.222 1.47E-38 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
0.203 1.07E-32 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.199 2.30E-31 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.188 6.43E-28 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.182 2.18E-26 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.179 1.63E-25 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.178 3.50E-25 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.177 6.06E-25 YDL162C_d YDL162C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
0.173 5.16E-24 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.170 3.73E-23 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.167 3.09E-22 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress