YNL244C / SUI1

Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL244C / SUI1

Click on Significant Values for Screen Details ID:SGTC_157|Compound:1348-1695|FD-Score:3.51|P-value:1.54E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.35|P-value:2.94E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.75|P-value:5.85E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:-3.02|P-value:9.51E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.53|P-value:9.49E-12 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.95|P-value:2.44E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:7.78|P-value:6.65E-16 ID:SGTC_692|Compound:k241-0027|FD-Score:6.72|P-value:2.44E-12 ID:SGTC_766|Compound:1391-0721|FD-Score:3.19|P-value:5.27E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.21|P-value:4.84E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.71|P-value:6.59E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.29|P-value:3.64E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:6.33|P-value:3.88E-11 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.40|P-value:3.13E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-5.09|P-value:8.35E-8 ID:SGTC_1377|Compound:2944-0135|FD-Score:-4.22|P-value:7.12E-6 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.35|P-value:3.99E-6 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.41|P-value:2.30E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.40|P-value:3.09E-6 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.11|P-value:6.98E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:-3.89|P-value:3.15E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:6.62|P-value:5.07E-12 ID:SGTC_1568|Compound:digitonin|FD-Score:3.19|P-value:5.18E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.05|P-value:8.51E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.03|P-value:9.29E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.79|P-value:5.00E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.29|P-value:3.60E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.49|P-value:1.69E-4 ID:SGTC_2066|Compound:5222451|FD-Score:5.64|P-value:3.40E-9 ID:SGTC_2072|Compound:5231554|FD-Score:-3.90|P-value:3.05E-5 ID:SGTC_2081|Compound:5214970|FD-Score:-3.61|P-value:1.01E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-3.68|P-value:7.69E-5 ID:SGTC_2095|Compound:5432005|FD-Score:4.48|P-value:2.10E-6 ID:SGTC_2153|Compound:5569715|FD-Score:3.84|P-value:4.08E-5 ID:SGTC_2216|Compound:7189485|FD-Score:3.04|P-value:8.95E-4 ID:SGTC_2248|Compound:tofa|FD-Score:7.06|P-value:2.06E-13 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.43|P-value:2.59E-6 ID:SGTC_2254|Compound:7938975|FD-Score:4.28|P-value:5.44E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-3.92|P-value:2.76E-5 ID:SGTC_2391|Compound:6285546|FD-Score:3.05|P-value:8.60E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.55|P-value:1.34E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.03|P-value:9.33E-4 ID:SGTC_2471|Compound:5466956|FD-Score:4.12|P-value:1.18E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.86|P-value:3.72E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.11|P-value:1.18E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:4.29|P-value:5.16E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.04|P-value:9.09E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.03|P-value:9.25E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.71|P-value:6.78E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.02|P-value:9.57E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.59|P-value:1.14E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-4.03|P-value:1.71E-5 ID:SGTC_2805|Compound:7950783|FD-Score:4.49|P-value:2.01E-6 ID:SGTC_2831|Compound:7999036|FD-Score:3.03|P-value:9.23E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.41|P-value:2.30E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.11|P-value:1.23E-5 ID:SGTC_3075|Compound:9116269|FD-Score:30.10|P-value:5.75E-211 ID:SGTC_157|Compound:1348-1695|FD-Score:3.51|P-value:1.54E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.35|P-value:2.94E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.75|P-value:5.85E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:-3.02|P-value:9.51E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.53|P-value:9.49E-12 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.95|P-value:2.44E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:7.78|P-value:6.65E-16 ID:SGTC_692|Compound:k241-0027|FD-Score:6.72|P-value:2.44E-12 ID:SGTC_766|Compound:1391-0721|FD-Score:3.19|P-value:5.27E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.21|P-value:4.84E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.71|P-value:6.59E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.29|P-value:3.64E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:6.33|P-value:3.88E-11 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.40|P-value:3.13E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-5.09|P-value:8.35E-8 ID:SGTC_1377|Compound:2944-0135|FD-Score:-4.22|P-value:7.12E-6 ID:SGTC_1404|Compound:3909-7820|FD-Score:4.35|P-value:3.99E-6 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.41|P-value:2.30E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:4.40|P-value:3.09E-6 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.11|P-value:6.98E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:-3.89|P-value:3.15E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:6.62|P-value:5.07E-12 ID:SGTC_1568|Compound:digitonin|FD-Score:3.19|P-value:5.18E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.05|P-value:8.51E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.03|P-value:9.29E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.79|P-value:5.00E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.29|P-value:3.60E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.49|P-value:1.69E-4 ID:SGTC_2066|Compound:5222451|FD-Score:5.64|P-value:3.40E-9 ID:SGTC_2072|Compound:5231554|FD-Score:-3.90|P-value:3.05E-5 ID:SGTC_2081|Compound:5214970|FD-Score:-3.61|P-value:1.01E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-3.68|P-value:7.69E-5 ID:SGTC_2095|Compound:5432005|FD-Score:4.48|P-value:2.10E-6 ID:SGTC_2153|Compound:5569715|FD-Score:3.84|P-value:4.08E-5 ID:SGTC_2216|Compound:7189485|FD-Score:3.04|P-value:8.95E-4 ID:SGTC_2248|Compound:tofa|FD-Score:7.06|P-value:2.06E-13 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.43|P-value:2.59E-6 ID:SGTC_2254|Compound:7938975|FD-Score:4.28|P-value:5.44E-6 ID:SGTC_2313|Compound:7726885|FD-Score:-3.92|P-value:2.76E-5 ID:SGTC_2391|Compound:6285546|FD-Score:3.05|P-value:8.60E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.55|P-value:1.34E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.03|P-value:9.33E-4 ID:SGTC_2471|Compound:5466956|FD-Score:4.12|P-value:1.18E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.86|P-value:3.72E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:-4.11|P-value:1.18E-5 ID:SGTC_2490|Compound:carminic acid|FD-Score:4.29|P-value:5.16E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.04|P-value:9.09E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.03|P-value:9.25E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.71|P-value:6.78E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.02|P-value:9.57E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.59|P-value:1.14E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-4.03|P-value:1.71E-5 ID:SGTC_2805|Compound:7950783|FD-Score:4.49|P-value:2.01E-6 ID:SGTC_2831|Compound:7999036|FD-Score:3.03|P-value:9.23E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.41|P-value:2.30E-4 ID:SGTC_2989|Compound:9073649|FD-Score:4.11|P-value:1.23E-5 ID:SGTC_3075|Compound:9116269|FD-Score:30.10|P-value:5.75E-211

Top fitness defect scores for YNL244C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3075 9116269 30.10 49.5 µM 5.75E-211 1 6.49E-200 17.70
2 SGTC_690 glyoxal 7.78 20.3 µM 6.65E-16 7 3.68E-15 0.05
3 SGTC_2248 tofa 7.06 1.1 µM 2.06E-13 sphingolipid biosynthesis & PDR1 12 8.45E-13 0.29
4 SGTC_692 k241-0027 6.72 77.8 µM 2.44E-12 1 8.80E-12 1.91
5 SGTC_1453 4237-0541 6.62 195.0 µM 5.07E-12 heme biosynthesis & mitochondrial translocase 5 1.76E-11 0.03
6 SGTC_1255 0566-0045 6.33 221.0 µM 3.88E-11 excess fatty acid 4 1.21E-10 0.15
7 SGTC_2066 5222451 5.64 176.0 µM 3.40E-9 heme biosynthesis & mitochondrial translocase 9 8.42E-9 0.12
8 SGTC_1044 1222-0021 4.71 1.8 µM 6.59E-7 heme biosynthesis & mitochondrial translocase 28 1.25E-6 0.00
9 SGTC_2805 7950783 4.49 58.4 µM 2.01E-6 6 3.60E-6 0.21
10 SGTC_2095 5432005 4.48 200.0 µM 2.10E-6 2 3.75E-6 0.40
11 SGTC_1407 3909-7909 4.40 12.3 µM 3.09E-6 60S ribosome export 3 5.42E-6 0.52
12 SGTC_1360 1598-0022 4.40 39.8 µM 3.13E-6 ERG2 4 5.48E-6 0.02
13 SGTC_1404 3909-7820 4.35 48.3 µM 3.99E-6 60S ribosome export 3 6.90E-6 0.10
14 SGTC_2490 carminic acid 4.29 95.4 µM 5.16E-6 6 8.81E-6 0.14
15 SGTC_2254 7938975 4.28 95.2 µM 5.44E-6 6 9.25E-6 0.16
16 SGTC_2471 5466956 4.12 24.8 µM 1.18E-5 mitochondrial processes 15 1.93E-5 0.01
17 SGTC_2989 9073649 4.11 71.4 µM 1.23E-5 5 2.00E-5 0.06
18 SGTC_2483 5729050 3.86 27.2 µM 3.72E-5 11 5.75E-5 0.09
19 SGTC_2153 5569715 3.84 200.0 µM 4.08E-5 iron homeostasis 4 6.27E-5 0.12
20 SGTC_1733 st037357 3.79 54.9 µM 5.00E-5 60S ribosome export 9 7.61E-5 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.254 1.60E-50 YML060W OGG1 hom Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
0.217 7.20E-37 YEL057C_p YEL057C_p hom Protein of unknown function involved in telomere maintenance; target of UME6 regulation
0.192 4.51E-29 YAL067C SEO1 hom Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
0.168 1.46E-22 YPL273W SAM4 hom S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.158 3.39E-20 YPL090C RPS6A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication
0.148 5.64E-18 YHR016C YSC84 hom Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication
0.141 2.97E-16 YFL017W-A SMX2 het Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
0.129 6.22E-14 YDL219W DTD1 hom D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
0.129 7.57E-14 YHL044W_p YHL044W_p hom Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern
0.126 3.78E-13 YHR178W STB5 hom Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro
0.125 4.14E-13 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.121 1.70E-12 YLR238W FAR10 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
0.121 2.10E-12 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.118 7.75E-12 YDL034W_d YDL034W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene
0.116 1.78E-11 YBR136W MEC1 het Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres