YNL245C / CWC25

Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL245C / CWC25

Click on Significant Values for Screen Details ID:SGTC_84|Compound:0443-0269|FD-Score:3.16|P-value:3.75E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.43|P-value:1.14E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:3.26|P-value:2.53E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.65|P-value:4.92E-5 ID:SGTC_289|Compound:k017-0060|FD-Score:2.99|P-value:7.06E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-2.94|P-value:8.74E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.07|P-value:5.25E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.26|P-value:2.82E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.27|P-value:9.39E-9 ID:SGTC_632|Compound:0781-2353|FD-Score:3.78|P-value:2.76E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.18|P-value:3.49E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:2.99|P-value:7.08E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.30|P-value:2.22E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.11|P-value:4.55E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.67|P-value:4.51E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-4.49|P-value:8.49E-7 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.40|P-value:1.47E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.83|P-value:2.20E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.55|P-value:6.27E-7 ID:SGTC_1201|Compound:1889-3372|FD-Score:2.96|P-value:7.89E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.72|P-value:3.59E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.98|P-value:7.52E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-2.96|P-value:7.97E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-2.96|P-value:8.06E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.08|P-value:6.77E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:2.94|P-value:8.57E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.93|P-value:9.03E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.47|P-value:1.07E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.25|P-value:2.98E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.96|P-value:7.92E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.22|P-value:2.97E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.32|P-value:2.05E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.54|P-value:8.20E-5 ID:SGTC_1998|Compound:st075797|FD-Score:3.12|P-value:4.42E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-7.63|P-value:2.12E-16 ID:SGTC_2019|Compound:4016004|FD-Score:-6.63|P-value:7.58E-13 ID:SGTC_2158|Compound:5657123|FD-Score:5.74|P-value:4.62E-10 ID:SGTC_2162|Compound:5663267|FD-Score:4.01|P-value:9.45E-6 ID:SGTC_2175|Compound:5807670|FD-Score:3.61|P-value:6.05E-5 ID:SGTC_2183|Compound:6420625|FD-Score:-3.69|P-value:4.12E-5 ID:SGTC_2184|Compound:6075246|FD-Score:4.23|P-value:3.23E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.77|P-value:2.99E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.02|P-value:8.93E-6 ID:SGTC_2428|Compound:5615643|FD-Score:-3.71|P-value:3.77E-5 ID:SGTC_2434|Compound:5670830|FD-Score:5.79|P-value:3.42E-10 ID:SGTC_2435|Compound:5706476|FD-Score:2.99|P-value:7.16E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.97|P-value:1.14E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-4.45|P-value:1.06E-6 ID:SGTC_2926|Compound:9010726|FD-Score:3.30|P-value:2.18E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-5.79|P-value:3.44E-10 ID:SGTC_3348|Compound:9149464|FD-Score:-3.07|P-value:5.36E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.16|P-value:3.75E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.43|P-value:1.14E-6 ID:SGTC_150|Compound:3970-0969|FD-Score:3.26|P-value:2.53E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.65|P-value:4.92E-5 ID:SGTC_289|Compound:k017-0060|FD-Score:2.99|P-value:7.06E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-2.94|P-value:8.74E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.07|P-value:5.25E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.26|P-value:2.82E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.27|P-value:9.39E-9 ID:SGTC_632|Compound:0781-2353|FD-Score:3.78|P-value:2.76E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.18|P-value:3.49E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:2.99|P-value:7.08E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.30|P-value:2.22E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.11|P-value:4.55E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.67|P-value:4.51E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-4.49|P-value:8.49E-7 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.40|P-value:1.47E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.83|P-value:2.20E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:4.55|P-value:6.27E-7 ID:SGTC_1201|Compound:1889-3372|FD-Score:2.96|P-value:7.89E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.72|P-value:3.59E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.98|P-value:7.52E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-2.96|P-value:7.97E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-2.96|P-value:8.06E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.08|P-value:6.77E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:2.94|P-value:8.57E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.93|P-value:9.03E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.47|P-value:1.07E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.25|P-value:2.98E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.96|P-value:7.92E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.22|P-value:2.97E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.32|P-value:2.05E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.54|P-value:8.20E-5 ID:SGTC_1998|Compound:st075797|FD-Score:3.12|P-value:4.42E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-7.63|P-value:2.12E-16 ID:SGTC_2019|Compound:4016004|FD-Score:-6.63|P-value:7.58E-13 ID:SGTC_2158|Compound:5657123|FD-Score:5.74|P-value:4.62E-10 ID:SGTC_2162|Compound:5663267|FD-Score:4.01|P-value:9.45E-6 ID:SGTC_2175|Compound:5807670|FD-Score:3.61|P-value:6.05E-5 ID:SGTC_2183|Compound:6420625|FD-Score:-3.69|P-value:4.12E-5 ID:SGTC_2184|Compound:6075246|FD-Score:4.23|P-value:3.23E-6 ID:SGTC_2331|Compound:7980721|FD-Score:3.77|P-value:2.99E-5 ID:SGTC_2335|Compound:9018011|FD-Score:4.02|P-value:8.93E-6 ID:SGTC_2428|Compound:5615643|FD-Score:-3.71|P-value:3.77E-5 ID:SGTC_2434|Compound:5670830|FD-Score:5.79|P-value:3.42E-10 ID:SGTC_2435|Compound:5706476|FD-Score:2.99|P-value:7.16E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.97|P-value:1.14E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-4.45|P-value:1.06E-6 ID:SGTC_2926|Compound:9010726|FD-Score:3.30|P-value:2.18E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-5.79|P-value:3.44E-10 ID:SGTC_3348|Compound:9149464|FD-Score:-3.07|P-value:5.36E-4

Top fitness defect scores for YNL245C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2434 5670830 5.79 169.9 µM 3.42E-10 1 3.57E-9 1.45
2 SGTC_2158 5657123 5.74 3.6 µM 4.62E-10 5 4.65E-9 0.40
3 SGTC_1079 idarubicin 4.55 2.4 µM 6.27E-7 DNA damage response 5 2.72E-6 0.40
4 SGTC_130 0136-0219 4.43 337.7 µM 1.14E-6 7 4.63E-6 0.17
5 SGTC_423 5-fluorouracil 4.26 457.0 µM 2.82E-6 exosome 25 1.03E-5 0.12
6 SGTC_2184 6075246 4.23 200.0 µM 3.23E-6 2 1.16E-5 0.70
7 SGTC_1424 4048-1941 4.08 275.0 µM 6.77E-6 3 2.23E-5 0.35
8 SGTC_2335 9018011 4.02 154.2 µM 8.93E-6 9 2.85E-5 0.03
9 SGTC_2162 5663267 4.01 200.0 µM 9.45E-6 9 3.00E-5 0.08
10 SGTC_2918 7977171 3.97 22.1 µM 1.14E-5 2 3.54E-5 0.00
11 SGTC_987 1497-1013 3.83 404.0 µM 2.20E-5 3 6.34E-5 0.36
12 SGTC_632 0781-2353 3.78 4.7 µM 2.76E-5 Golgi 20 7.74E-5 0.05
13 SGTC_2331 7980721 3.77 200.0 µM 2.99E-5 14 8.31E-5 0.03
14 SGTC_159 3970-0959 3.65 50.0 µM 4.92E-5 20 1.29E-4 9.18E-4
15 SGTC_2175 5807670 3.61 165.3 µM 6.05E-5 3 1.55E-4 0.13
16 SGTC_1989 st071868 3.54 50.2 µM 8.20E-5 7 2.03E-4 0.11
17 SGTC_1984 st072354 3.32 53.1 µM 2.05E-4 4 4.57E-4 0.21
18 SGTC_2926 9010726 3.30 65.2 µM 2.18E-4 12 4.85E-4 0.07
19 SGTC_884 0851-0618 3.30 334.0 µM 2.22E-4 10 4.91E-4 0.03
20 SGTC_150 3970-0969 3.26 77.2 µM 2.53E-4 32 5.52E-4 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.205 2.53E-33 YLR146C SPE4 hom Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
0.122 1.47E-12 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.114 3.51E-11 YEL058W PCM1 het Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.109 2.13E-10 YLR106C MDN1 het Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus
0.109 2.16E-10 YGR224W AZR1 hom Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole
0.105 9.05E-10 YOR313C SPS4 hom Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
0.102 2.74E-9 YLR397C AFG2 het ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs
0.102 2.84E-9 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.097 1.91E-8 YDR104C SPO71 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.092 1.01E-7 YGR047C TFC4 het One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
0.091 1.29E-7 YCL038C ATG22 hom Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
0.091 1.38E-7 YOL036W_p YOL036W_p hom Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication
0.089 2.79E-7 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.06E-7 YKR038C KAE1 het Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription
0.087 5.17E-7 YLL039C UBI4 hom Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress