YNL246W / VPS75

NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL246W / VPS75

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:-3.35|P-value:9.04E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.47|P-value:1.83E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:14.40|P-value:5.31E-41 ID:SGTC_149|Compound:3970-0822|FD-Score:14.50|P-value:1.57E-41 ID:SGTC_150|Compound:3970-0969|FD-Score:4.80|P-value:4.77E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:5.37|P-value:3.61E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:-5.51|P-value:1.51E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:3.61|P-value:4.42E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.75|P-value:2.75E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.49|P-value:8.51E-19 ID:SGTC_229|Compound:benomyl|FD-Score:3.83|P-value:2.06E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.65|P-value:3.88E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.62|P-value:9.92E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.89|P-value:1.65E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.70|P-value:2.81E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.40|P-value:7.66E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:5.40|P-value:3.01E-7 ID:SGTC_444|Compound:curcumin|FD-Score:-4.40|P-value:2.11E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.66|P-value:6.88E-13 ID:SGTC_447|Compound:ml7|FD-Score:3.71|P-value:3.09E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.49|P-value:1.73E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.35|P-value:2.52E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.42|P-value:7.22E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.16|P-value:6.23E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.79|P-value:2.05E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.27|P-value:4.04E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.49|P-value:6.52E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.12|P-value:1.16E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.34|P-value:9.17E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.55|P-value:1.33E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:3.72|P-value:2.99E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:6.19|P-value:5.26E-9 ID:SGTC_994|Compound:3910-0338|FD-Score:4.47|P-value:1.88E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.89|P-value:1.68E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.65|P-value:9.00E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.02|P-value:1.78E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.55|P-value:5.39E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.51|P-value:1.87E-12 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.20|P-value:5.26E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.51|P-value:1.56E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.87|P-value:3.50E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.48|P-value:6.64E-4 ID:SGTC_1712|Compound:st032288|FD-Score:9.69|P-value:1.59E-19 ID:SGTC_1781|Compound:st038725|FD-Score:3.68|P-value:3.46E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.71|P-value:3.13E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.83|P-value:1.33E-10 ID:SGTC_1991|Compound:st073000|FD-Score:4.01|P-value:1.08E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-4.01|P-value:9.31E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.26|P-value:4.23E-5 ID:SGTC_2075|Compound:5212009|FD-Score:-3.36|P-value:8.75E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.62|P-value:4.25E-4 ID:SGTC_2174|Compound:5790901|FD-Score:8.61|P-value:8.63E-16 ID:SGTC_2352|Compound:9027995|FD-Score:4.73|P-value:6.23E-6 ID:SGTC_2403|Compound:6032726|FD-Score:4.82|P-value:4.27E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.75|P-value:2.70E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.56|P-value:5.15E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.76|P-value:2.29E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.47|P-value:6.93E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.59|P-value:4.68E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.08|P-value:1.33E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.87|P-value:3.49E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.87|P-value:1.79E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.80|P-value:1.97E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.17|P-value:5.93E-5 ID:SGTC_2706|Compound:st078239|FD-Score:3.62|P-value:4.27E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-3.34|P-value:9.32E-4 ID:SGTC_2797|Compound:7859098|FD-Score:5.70|P-value:7.06E-8 ID:SGTC_2850|Compound:9015429|FD-Score:3.57|P-value:4.97E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.00|P-value:1.13E-4 ID:SGTC_2940|Compound:9060638|FD-Score:4.38|P-value:2.66E-5 ID:SGTC_2941|Compound:9056145|FD-Score:4.11|P-value:7.46E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.85|P-value:1.93E-4 ID:SGTC_3356|Compound:9151811|FD-Score:6.88|P-value:1.01E-10 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.35|P-value:9.04E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.47|P-value:1.83E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:14.40|P-value:5.31E-41 ID:SGTC_149|Compound:3970-0822|FD-Score:14.50|P-value:1.57E-41 ID:SGTC_150|Compound:3970-0969|FD-Score:4.80|P-value:4.77E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:5.37|P-value:3.61E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:-5.51|P-value:1.51E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:3.61|P-value:4.42E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.75|P-value:2.75E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.49|P-value:8.51E-19 ID:SGTC_229|Compound:benomyl|FD-Score:3.83|P-value:2.06E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.65|P-value:3.88E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.62|P-value:9.92E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.89|P-value:1.65E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.70|P-value:2.81E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.40|P-value:7.66E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:5.40|P-value:3.01E-7 ID:SGTC_444|Compound:curcumin|FD-Score:-4.40|P-value:2.11E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.66|P-value:6.88E-13 ID:SGTC_447|Compound:ml7|FD-Score:3.71|P-value:3.09E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.49|P-value:1.73E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.35|P-value:2.52E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.42|P-value:7.22E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.16|P-value:6.23E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.79|P-value:2.05E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.27|P-value:4.04E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:3.49|P-value:6.52E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.12|P-value:1.16E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.34|P-value:9.17E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.55|P-value:1.33E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:3.72|P-value:2.99E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:6.19|P-value:5.26E-9 ID:SGTC_994|Compound:3910-0338|FD-Score:4.47|P-value:1.88E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.89|P-value:1.68E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.65|P-value:9.00E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.02|P-value:1.78E-6 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.55|P-value:5.39E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.51|P-value:1.87E-12 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.20|P-value:5.26E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.51|P-value:1.56E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.87|P-value:3.50E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.48|P-value:6.64E-4 ID:SGTC_1712|Compound:st032288|FD-Score:9.69|P-value:1.59E-19 ID:SGTC_1781|Compound:st038725|FD-Score:3.68|P-value:3.46E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.71|P-value:3.13E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.83|P-value:1.33E-10 ID:SGTC_1991|Compound:st073000|FD-Score:4.01|P-value:1.08E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-4.01|P-value:9.31E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.26|P-value:4.23E-5 ID:SGTC_2075|Compound:5212009|FD-Score:-3.36|P-value:8.75E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.62|P-value:4.25E-4 ID:SGTC_2174|Compound:5790901|FD-Score:8.61|P-value:8.63E-16 ID:SGTC_2352|Compound:9027995|FD-Score:4.73|P-value:6.23E-6 ID:SGTC_2403|Compound:6032726|FD-Score:4.82|P-value:4.27E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.75|P-value:2.70E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.56|P-value:5.15E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.76|P-value:2.29E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.47|P-value:6.93E-4 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.59|P-value:4.68E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.08|P-value:1.33E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.87|P-value:3.49E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.87|P-value:1.79E-4 ID:SGTC_2698|Compound:st077697|FD-Score:-3.80|P-value:1.97E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.17|P-value:5.93E-5 ID:SGTC_2706|Compound:st078239|FD-Score:3.62|P-value:4.27E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:-3.34|P-value:9.32E-4 ID:SGTC_2797|Compound:7859098|FD-Score:5.70|P-value:7.06E-8 ID:SGTC_2850|Compound:9015429|FD-Score:3.57|P-value:4.97E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.00|P-value:1.13E-4 ID:SGTC_2940|Compound:9060638|FD-Score:4.38|P-value:2.66E-5 ID:SGTC_2941|Compound:9056145|FD-Score:4.11|P-value:7.46E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.85|P-value:1.93E-4 ID:SGTC_3356|Compound:9151811|FD-Score:6.88|P-value:1.01E-10

Top fitness defect scores for YNL246W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_149 3970-0822 14.50 46.1 µM 1.57E-41 tubulin folding & SWR complex 4 4.12E-48
2 SGTC_146 3448-8650 14.40 53.1 µM 5.31E-41 NEO1-PIK1 8 1.71E-47
3 SGTC_1712 st032288 9.69 53.4 µM 1.59E-19 calcium & mitochondrial duress 26 1.71E-22
4 SGTC_221 trifluoperazine 9.49 10.3 µM 8.51E-19 NEO1-PIK1 66 1.20E-21
5 SGTC_2174 5790901 8.61 200.0 µM 8.63E-16 tubulin folding & SWR complex 12 3.79E-18
6 SGTC_445 e6 berbamine 7.66 66.0 µM 6.88E-13 NEO1-PIK1 14 9.03E-15
7 SGTC_1306 1185-0270 7.51 9.0 µM 1.87E-12 Golgi 20 2.89E-14
8 SGTC_3356 9151811 6.88 4.5 µM 1.01E-10 cell wall 3 2.99E-12
9 SGTC_1875 nocodazole 6.83 6.0 µM 1.33E-10 tubulin folding & SWR complex 21 4.14E-12
10 SGTC_967 1306-0166 6.19 352.0 µM 5.26E-9 2 2.97E-10
11 SGTC_528 3492-0019 6.16 172.0 µM 6.23E-9 calcium & mitochondrial duress 118 3.61E-10
12 SGTC_2797 7859098 5.70 81.8 µM 7.06E-8 6 6.07E-9
13 SGTC_438 sphingosine 5.40 6.7 µM 3.01E-7 7 3.27E-8
14 SGTC_155 k072-0202 5.37 43.6 µM 3.61E-7 6 4.05E-8
15 SGTC_800 3448-7362 5.12 155.0 µM 1.16E-6 translation 83 1.56E-7
16 SGTC_2679 rapamycin 5.08 1.0 nM 1.33E-6 94 1.84E-7
17 SGTC_1130 3454-2858 5.02 15.9 µM 1.78E-6 NEO1 57 2.57E-7
18 SGTC_2688 kanamycin b 4.87 96.7 µM 3.49E-6 calcium & mitochondrial duress 256 5.65E-7
19 SGTC_1597 7-benzyloxygramine 4.87 47.5 µM 3.50E-6 calcium & mitochondrial duress 71 5.66E-7
20 SGTC_2403 6032726 4.82 181.2 µM 4.27E-6 20 7.13E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.335 6.05E-89 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.320 1.21E-80 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.291 2.43E-66 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.278 1.92E-60 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.254 1.49E-50 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.253 3.24E-50 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.244 1.47E-46 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.244 1.38E-46 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.242 5.48E-46 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.236 8.66E-44 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.231 8.97E-42 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.227 1.64E-40 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.224 2.76E-39 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.221 2.24E-38 YJL179W PFD1 hom Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
0.219 7.45E-38 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication