YNL247W

Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL247W / YNL247W

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.36|P-value:2.92E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.47|P-value:1.88E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:5.87|P-value:8.59E-10 ID:SGTC_56|Compound:0957-0365|FD-Score:3.13|P-value:6.73E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.81|P-value:3.75E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:3.20|P-value:5.28E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:6.63|P-value:4.80E-12 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.68|P-value:6.57E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.52|P-value:1.79E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:3.72|P-value:6.81E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.99|P-value:2.14E-5 ID:SGTC_480|Compound:am 92016|FD-Score:3.69|P-value:7.89E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.64|P-value:9.72E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:3.08|P-value:8.28E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.40|P-value:2.46E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.73|P-value:6.70E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.78|P-value:5.36E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.48|P-value:1.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.77|P-value:5.58E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.93|P-value:2.82E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.50|P-value:1.72E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.12|P-value:7.08E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.84|P-value:4.10E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.86|P-value:3.06E-7 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.44|P-value:2.65E-6 ID:SGTC_1610|Compound:st001799|FD-Score:3.31|P-value:3.56E-4 ID:SGTC_1611|Compound:st001856|FD-Score:7.37|P-value:1.82E-14 ID:SGTC_1763|Compound:st044482|FD-Score:-4.40|P-value:2.52E-6 ID:SGTC_1767|Compound:st044992|FD-Score:-3.18|P-value:4.66E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.80|P-value:5.02E-5 ID:SGTC_1810|Compound:st050138|FD-Score:3.45|P-value:2.09E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.20|P-value:5.40E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.21|P-value:7.86E-6 ID:SGTC_2267|Compound:7931562|FD-Score:-3.45|P-value:1.71E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.14|P-value:5.51E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.61|P-value:9.00E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.42|P-value:1.89E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.62|P-value:1.03E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.20|P-value:5.34E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.19|P-value:5.59E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.02|P-value:8.38E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.93|P-value:2.81E-5 ID:SGTC_2823|Compound:7987624|FD-Score:4.02|P-value:1.90E-5 ID:SGTC_2828|Compound:7998861|FD-Score:5.08|P-value:9.57E-8 ID:SGTC_2916|Compound:7875993|FD-Score:3.85|P-value:4.05E-5 ID:SGTC_2938|Compound:9059746|FD-Score:-3.76|P-value:4.79E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.42|P-value:2.89E-6 ID:SGTC_2957|Compound:9076800|FD-Score:-3.61|P-value:8.85E-5 ID:SGTC_2962|Compound:9082311|FD-Score:-5.04|P-value:8.84E-8 ID:SGTC_3030|Compound:9087619|FD-Score:4.66|P-value:8.88E-7 ID:SGTC_3108|Compound:9121785|FD-Score:3.03|P-value:9.78E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.50|P-value:1.71E-4 ID:SGTC_3255|Compound:9139072|FD-Score:4.28|P-value:5.79E-6 ID:SGTC_3326|Compound:9140064|FD-Score:4.62|P-value:1.07E-6 ID:SGTC_3331|Compound:9141060|FD-Score:-4.41|P-value:2.34E-6 ID:SGTC_3333|Compound:9141820|FD-Score:3.25|P-value:4.40E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.84|P-value:4.26E-5 ID:SGTC_3343|Compound:9148379|FD-Score:3.14|P-value:6.56E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.36|P-value:2.92E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.47|P-value:1.88E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:5.87|P-value:8.59E-10 ID:SGTC_56|Compound:0957-0365|FD-Score:3.13|P-value:6.73E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.81|P-value:3.75E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:3.20|P-value:5.28E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:6.63|P-value:4.80E-12 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.68|P-value:6.57E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.52|P-value:1.79E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:3.72|P-value:6.81E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.99|P-value:2.14E-5 ID:SGTC_480|Compound:am 92016|FD-Score:3.69|P-value:7.89E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.64|P-value:9.72E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:3.08|P-value:8.28E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:3.40|P-value:2.46E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.73|P-value:6.70E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.78|P-value:5.36E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.48|P-value:1.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.77|P-value:5.58E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.93|P-value:2.82E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.50|P-value:1.72E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.12|P-value:7.08E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.84|P-value:4.10E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.86|P-value:3.06E-7 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.44|P-value:2.65E-6 ID:SGTC_1610|Compound:st001799|FD-Score:3.31|P-value:3.56E-4 ID:SGTC_1611|Compound:st001856|FD-Score:7.37|P-value:1.82E-14 ID:SGTC_1763|Compound:st044482|FD-Score:-4.40|P-value:2.52E-6 ID:SGTC_1767|Compound:st044992|FD-Score:-3.18|P-value:4.66E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.80|P-value:5.02E-5 ID:SGTC_1810|Compound:st050138|FD-Score:3.45|P-value:2.09E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.20|P-value:5.40E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.21|P-value:7.86E-6 ID:SGTC_2267|Compound:7931562|FD-Score:-3.45|P-value:1.71E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.14|P-value:5.51E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.61|P-value:9.00E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.42|P-value:1.89E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.62|P-value:1.03E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.20|P-value:5.34E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.19|P-value:5.59E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.02|P-value:8.38E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.93|P-value:2.81E-5 ID:SGTC_2823|Compound:7987624|FD-Score:4.02|P-value:1.90E-5 ID:SGTC_2828|Compound:7998861|FD-Score:5.08|P-value:9.57E-8 ID:SGTC_2916|Compound:7875993|FD-Score:3.85|P-value:4.05E-5 ID:SGTC_2938|Compound:9059746|FD-Score:-3.76|P-value:4.79E-5 ID:SGTC_2954|Compound:9074818|FD-Score:4.42|P-value:2.89E-6 ID:SGTC_2957|Compound:9076800|FD-Score:-3.61|P-value:8.85E-5 ID:SGTC_2962|Compound:9082311|FD-Score:-5.04|P-value:8.84E-8 ID:SGTC_3030|Compound:9087619|FD-Score:4.66|P-value:8.88E-7 ID:SGTC_3108|Compound:9121785|FD-Score:3.03|P-value:9.78E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.50|P-value:1.71E-4 ID:SGTC_3255|Compound:9139072|FD-Score:4.28|P-value:5.79E-6 ID:SGTC_3326|Compound:9140064|FD-Score:4.62|P-value:1.07E-6 ID:SGTC_3331|Compound:9141060|FD-Score:-4.41|P-value:2.34E-6 ID:SGTC_3333|Compound:9141820|FD-Score:3.25|P-value:4.40E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.84|P-value:4.26E-5 ID:SGTC_3343|Compound:9148379|FD-Score:3.14|P-value:6.56E-4

Top fitness defect scores for YNL247W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1611 st001856 7.37 99.4 µM 1.82E-14 1 8.60E-14 2.49
2 SGTC_101 0490-5701 6.63 117.5 µM 4.80E-12 1 1.66E-11 1.83
3 SGTC_55 0767-0285 5.87 6.6 µM 8.59E-10 1 2.24E-9 0.57
4 SGTC_2828 7998861 5.08 71.4 µM 9.57E-8 1 1.94E-7 1.13
5 SGTC_1467 k284-1082 4.86 293.0 µM 3.06E-7 1 5.82E-7 0.58
6 SGTC_3030 9087619 4.66 49.5 µM 8.88E-7 4 1.60E-6 0.13
7 SGTC_3326 9140064 4.62 16.4 µM 1.07E-6 3 1.91E-6 0.36
8 SGTC_261 5-fluorouridine 4.52 15.4 µM 1.79E-6 exosome 9 3.11E-6 0.05
9 SGTC_1495 4469-0029 4.44 237.0 µM 2.65E-6 3 4.49E-6 0.34
10 SGTC_2954 9074818 4.42 52.7 µM 2.89E-6 2 4.89E-6 0.02
11 SGTC_3255 9139072 4.28 49.5 µM 5.79E-6 2 9.44E-6 0.97
12 SGTC_2174 5790901 4.21 200.0 µM 7.86E-6 tubulin folding & SWR complex 10 1.26E-5 0.25
13 SGTC_2823 7987624 4.02 58.4 µM 1.90E-5 11 2.92E-5 0.02
14 SGTC_420 mitomycin C 3.99 81.9 mM 2.14E-5 2 3.26E-5 0.33
15 SGTC_2769 toremifene 3.93 3.7 µM 2.81E-5 7 4.22E-5 0.23
16 SGTC_1214 0358-0031 3.93 63.7 µM 2.82E-5 9 4.24E-5 0.10
17 SGTC_2916 7875993 3.85 68.8 µM 4.05E-5 6 5.97E-5 0.09
18 SGTC_1430 4049-0248 3.84 69.1 µM 4.10E-5 1 6.04E-5 0.31
19 SGTC_3337 9144342 3.84 33.5 µM 4.26E-5 13 6.26E-5 0.12
20 SGTC_1797 st048695 3.80 56.8 µM 5.02E-5 NEO1 16 7.32E-5 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 5.34E-8 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.094 5.26E-8 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.083 1.46E-6 YEL011W GLC3 hom Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.081 2.77E-6 YAL027W SAW1 hom 5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.078 5.56E-6 YHR136C SPL2 hom Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm
0.075 1.29E-5 YBR130C SHE3 hom Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
0.074 1.66E-5 YPR185W ATG13 hom Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
0.074 1.71E-5 YEL028W_d YEL028W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.073 2.03E-5 YLR099C ICT1 hom Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.069 7.04E-5 YPR004C AIM45 hom Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response
0.068 8.01E-5 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.067 9.44E-5 YFR035C_p YFR035C_p hom Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
0.067 9.65E-5 YOL155C HPF1 hom Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
0.067 1.08E-4 YPL064C CWC27 hom Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress
0.067 1.10E-4 YGL060W YBP2 hom Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication