YNL248C / RPA49

RNA polymerase I subunit A49

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL248C / RPA49

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:3.68|P-value:1.77E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.23|P-value:8.14E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:3.46|P-value:3.79E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-4.68|P-value:6.62E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:5.80|P-value:1.15E-8 ID:SGTC_202|Compound:3594-0513|FD-Score:4.30|P-value:1.54E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.63|P-value:2.13E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.81|P-value:2.09E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.48|P-value:3.54E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:6.01|P-value:3.60E-9 ID:SGTC_422|Compound:cantharidin|FD-Score:9.63|P-value:1.50E-20 ID:SGTC_538|Compound:2922-0838|FD-Score:3.45|P-value:3.92E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.85|P-value:9.16E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.27|P-value:7.26E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.50|P-value:3.28E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.01|P-value:1.00E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:6.04|P-value:3.07E-9 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.81|P-value:2.07E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.67|P-value:1.84E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.97|P-value:5.82E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.90|P-value:7.82E-5 ID:SGTC_1842|Compound:st055362|FD-Score:-3.55|P-value:5.14E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-3.56|P-value:5.06E-4 ID:SGTC_1915|Compound:st067105|FD-Score:8.47|P-value:2.37E-16 ID:SGTC_1930|Compound:st074634|FD-Score:5.20|P-value:2.65E-7 ID:SGTC_2134|Compound:5324836|FD-Score:-3.94|P-value:1.29E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.49|P-value:3.45E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.30|P-value:6.52E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.37|P-value:5.13E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:9.10|P-value:1.40E-18 ID:SGTC_2556|Compound:citropten|FD-Score:3.79|P-value:1.18E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.62|P-value:4.05E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.80|P-value:2.18E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-5.90|P-value:1.84E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.59|P-value:3.51E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.57|P-value:4.96E-6 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.31|P-value:6.38E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.27|P-value:7.95E-10 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.29|P-value:6.84E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.79|P-value:2.23E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.08|P-value:3.87E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-3.78|P-value:2.36E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.36|P-value:5.34E-4 ID:SGTC_3247|Compound:9135149|FD-Score:4.21|P-value:2.23E-5 ID:SGTC_3291|Compound:9121177|FD-Score:4.05|P-value:4.30E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.79|P-value:1.18E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.68|P-value:1.77E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.23|P-value:8.14E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:3.46|P-value:3.79E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-4.68|P-value:6.62E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:5.80|P-value:1.15E-8 ID:SGTC_202|Compound:3594-0513|FD-Score:4.30|P-value:1.54E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.63|P-value:2.13E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.81|P-value:2.09E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.48|P-value:3.54E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:6.01|P-value:3.60E-9 ID:SGTC_422|Compound:cantharidin|FD-Score:9.63|P-value:1.50E-20 ID:SGTC_538|Compound:2922-0838|FD-Score:3.45|P-value:3.92E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.85|P-value:9.16E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.27|P-value:7.26E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.50|P-value:3.28E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.01|P-value:1.00E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:6.04|P-value:3.07E-9 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.81|P-value:2.07E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.67|P-value:1.84E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.97|P-value:5.82E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.90|P-value:7.82E-5 ID:SGTC_1842|Compound:st055362|FD-Score:-3.55|P-value:5.14E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-3.56|P-value:5.06E-4 ID:SGTC_1915|Compound:st067105|FD-Score:8.47|P-value:2.37E-16 ID:SGTC_1930|Compound:st074634|FD-Score:5.20|P-value:2.65E-7 ID:SGTC_2134|Compound:5324836|FD-Score:-3.94|P-value:1.29E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.49|P-value:3.45E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.30|P-value:6.52E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.37|P-value:5.13E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:9.10|P-value:1.40E-18 ID:SGTC_2556|Compound:citropten|FD-Score:3.79|P-value:1.18E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.62|P-value:4.05E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.80|P-value:2.18E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-5.90|P-value:1.84E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.59|P-value:3.51E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.57|P-value:4.96E-6 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.31|P-value:6.38E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.27|P-value:7.95E-10 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.29|P-value:6.84E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-3.79|P-value:2.23E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.08|P-value:3.87E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-3.78|P-value:2.36E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.36|P-value:5.34E-4 ID:SGTC_3247|Compound:9135149|FD-Score:4.21|P-value:2.23E-5 ID:SGTC_3291|Compound:9121177|FD-Score:4.05|P-value:4.30E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.79|P-value:1.18E-4

Top fitness defect scores for YNL248C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_422 cantharidin 9.63 155.0 µM 1.50E-20 cell wall signaling 5 2.95E-22
2 SGTC_2544 sphondin 9.10 68.5 µM 1.40E-18 RNA pol III & RNase P/MRP 2 4.34E-20
3 SGTC_1915 st067105 8.47 30.6 µM 2.37E-16 RNA pol III & RNase P/MRP 3 1.23E-17
4 SGTC_2688 kanamycin b 6.27 96.7 µM 7.95E-10 calcium & mitochondrial duress 138 1.76E-10
5 SGTC_1105 epirubicin 6.04 18.1 µM 3.07E-9 anthracycline transcription coupled DNA repair 3 7.74E-10
6 SGTC_408 cantharidin 6.01 100.0 µM 3.60E-9 cell wall signaling 8 9.20E-10
7 SGTC_118 0083-0097 5.80 135.3 µM 1.15E-8 translation 28 3.29E-9
8 SGTC_2612 dictamnine 5.59 15.5 µM 3.51E-8 RNA pol III & RNase P/MRP 14 1.11E-8
9 SGTC_1930 st074634 5.20 34.3 µM 2.65E-7 RNA pol III & RNase P/MRP 15 1.01E-7
10 SGTC_2651 1327-0036 4.57 5.0 µM 4.96E-6 131 2.44E-6
11 SGTC_202 3594-0513 4.30 34.8 µM 1.54E-5 PDR1 6 8.35E-6
12 SGTC_3247 9135149 4.21 49.5 µM 2.23E-5 DNA damage response 20 1.25E-5
13 SGTC_3050 9093513 4.08 49.5 µM 3.87E-5 16 2.27E-5
14 SGTC_3291 9121177 4.05 71.4 µM 4.30E-5 11 2.55E-5
15 SGTC_1511 0906-3109 3.97 28.5 µM 5.82E-5 excess fatty acid 48 3.54E-5
16 SGTC_1535 tetrahydropapaveroline hydrobromide 3.90 54.3 µM 7.82E-5 RPP1 & pyrimidine depletion 13 4.88E-5
17 SGTC_580 1123-0028 3.85 41.0 µM 9.16E-5 DNA damage response 41 5.79E-5
18 SGTC_2556 citropten 3.79 84.6 µM 1.18E-4 26 7.58E-5
19 SGTC_3346 9158254 3.79 43.6 µM 1.18E-4 21 7.59E-5
20 SGTC_56 0957-0365 3.68 83.2 µM 1.77E-4 Golgi 59 1.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.333 1.76E-87 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.303 1.82E-72 YJL148W RPA34 hom RNA polymerase I subunit A34.5
0.239 1.11E-44 YBR154C RPB5 het RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.237 4.28E-44 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.212 2.88E-35 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.184 4.62E-27 YDL150W RPC53 het RNA polymerase III subunit C53
0.174 2.74E-24 YDL130W RPP1B hom Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component
0.172 8.84E-24 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.164 9.94E-22 YDL152W_d YDL152W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
0.151 1.14E-18 YPL089C RLM1 hom MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication
0.151 1.46E-18 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.148 5.51E-18 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.148 7.23E-18 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.146 1.49E-17 YPL125W KAP120 hom Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
0.146 1.84E-17 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC