YNL249C / MPA43

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL249C / MPA43

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-4.34|P-value:1.25E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.51|P-value:3.46E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.78|P-value:1.28E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.32|P-value:6.62E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:4.19|P-value:2.55E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:3.49|P-value:3.68E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.92|P-value:7.66E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.05|P-value:4.31E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.34|P-value:6.17E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-5.02|P-value:5.62E-7 ID:SGTC_726|Compound:3448-4391|FD-Score:3.52|P-value:3.39E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:-3.78|P-value:1.20E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.97|P-value:5.73E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:4.70|P-value:2.72E-6 ID:SGTC_938|Compound:3126-1755|FD-Score:3.35|P-value:6.02E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.36|P-value:1.26E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.45|P-value:4.00E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.69|P-value:1.81E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-4.91|P-value:9.65E-7 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.84|P-value:1.05E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.31|P-value:1.53E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.45|P-value:4.28E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.30|P-value:1.59E-5 ID:SGTC_1554|Compound:st069299|FD-Score:3.82|P-value:1.11E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.38|P-value:5.40E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.61|P-value:2.44E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-3.77|P-value:1.28E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.12|P-value:3.39E-5 ID:SGTC_1766|Compound:st045414|FD-Score:3.49|P-value:3.79E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.58|P-value:2.68E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-4.11|P-value:3.38E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-4.68|P-value:2.82E-6 ID:SGTC_2074|Compound:5212007|FD-Score:3.91|P-value:7.88E-5 ID:SGTC_2089|Compound:5281248|FD-Score:3.21|P-value:9.64E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.38|P-value:5.57E-4 ID:SGTC_2203|Compound:7227154|FD-Score:-3.45|P-value:4.06E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.22|P-value:9.27E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.22|P-value:9.50E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.81|P-value:1.17E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.30|P-value:7.26E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.87|P-value:8.49E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.85|P-value:1.00E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:6.09|P-value:1.92E-9 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.46|P-value:4.16E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.28|P-value:1.74E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:6.30|P-value:5.54E-10 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:6.22|P-value:8.84E-10 ID:SGTC_2671|Compound:danthron|FD-Score:3.38|P-value:5.39E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-5.18|P-value:2.46E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-4.06|P-value:4.03E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.57|P-value:2.63E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.81|P-value:1.17E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.43|P-value:4.60E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.39|P-value:1.09E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.34|P-value:1.25E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.51|P-value:3.46E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.78|P-value:1.28E-4 ID:SGTC_224|Compound:benfluorex|FD-Score:3.32|P-value:6.62E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:4.19|P-value:2.55E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:3.49|P-value:3.68E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.92|P-value:7.66E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.05|P-value:4.31E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.34|P-value:6.17E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-5.02|P-value:5.62E-7 ID:SGTC_726|Compound:3448-4391|FD-Score:3.52|P-value:3.39E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:-3.78|P-value:1.20E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.97|P-value:5.73E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:4.70|P-value:2.72E-6 ID:SGTC_938|Compound:3126-1755|FD-Score:3.35|P-value:6.02E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.36|P-value:1.26E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.45|P-value:4.00E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.69|P-value:1.81E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:-4.91|P-value:9.65E-7 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.84|P-value:1.05E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.31|P-value:1.53E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.45|P-value:4.28E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:4.30|P-value:1.59E-5 ID:SGTC_1554|Compound:st069299|FD-Score:3.82|P-value:1.11E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.38|P-value:5.40E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.61|P-value:2.44E-4 ID:SGTC_1704|Compound:st028805|FD-Score:-3.77|P-value:1.28E-4 ID:SGTC_1762|Compound:st045503|FD-Score:4.12|P-value:3.39E-5 ID:SGTC_1766|Compound:st045414|FD-Score:3.49|P-value:3.79E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.58|P-value:2.68E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-4.11|P-value:3.38E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-4.68|P-value:2.82E-6 ID:SGTC_2074|Compound:5212007|FD-Score:3.91|P-value:7.88E-5 ID:SGTC_2089|Compound:5281248|FD-Score:3.21|P-value:9.64E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.38|P-value:5.57E-4 ID:SGTC_2203|Compound:7227154|FD-Score:-3.45|P-value:4.06E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.22|P-value:9.27E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.22|P-value:9.50E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.81|P-value:1.17E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.30|P-value:7.26E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.87|P-value:8.49E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.85|P-value:1.00E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:6.09|P-value:1.92E-9 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.46|P-value:4.16E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.28|P-value:1.74E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:6.30|P-value:5.54E-10 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:6.22|P-value:8.84E-10 ID:SGTC_2671|Compound:danthron|FD-Score:3.38|P-value:5.39E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-5.18|P-value:2.46E-7 ID:SGTC_2833|Compound:9001315|FD-Score:-4.06|P-value:4.03E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.57|P-value:2.63E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.81|P-value:1.17E-4 ID:SGTC_3156|Compound:9099931|FD-Score:3.43|P-value:4.60E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.39|P-value:1.09E-5

Top fitness defect scores for YNL249C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 6.30 100.0 µM 5.54E-10 3 1.48E-10
2 SGTC_2636 apigenin dimethyl ether 6.22 100.0 µM 8.84E-10 9 2.44E-10
3 SGTC_2610 ononetin 6.09 44.2 µM 1.92E-9 6 5.59E-10
4 SGTC_925 2064-1272 4.70 59.6 µM 2.72E-6 10 1.27E-6
5 SGTC_3217 9129673 4.39 49.5 µM 1.09E-5 24 5.61E-6
6 SGTC_960 1222-0186 4.36 7.7 µM 1.26E-5 23 6.52E-6
7 SGTC_1457 k015-0032 4.31 57.3 µM 1.53E-5 29 8.01E-6
8 SGTC_1501 4491-0275 4.30 38.4 µM 1.59E-5 5 8.36E-6
9 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 4.28 100.0 µM 1.74E-5 28 9.22E-6
10 SGTC_292 k038-0015 4.19 474.0 µM 2.55E-5 4 1.38E-5
11 SGTC_1762 st045503 4.12 25.5 µM 3.39E-5 24 1.87E-5
12 SGTC_365 0121-0052 3.92 13.6 µM 7.66E-5 mitochondrial response to ROS 58 4.46E-5
13 SGTC_2074 5212007 3.91 75.4 µM 7.88E-5 11 4.60E-5
14 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 3.85 100.0 µM 1.00E-4 37 5.96E-5
15 SGTC_1226 3909-7979 3.84 35.4 µM 1.05E-4 42 6.24E-5
16 SGTC_1554 st069299 3.82 38.7 µM 1.11E-4 25 6.63E-5
17 SGTC_3128 9127691 3.81 49.5 µM 1.17E-4 24 6.99E-5
18 SGTC_2361 9034121 3.81 116.0 µM 1.17E-4 RSC complex & mRNA processing 23 7.01E-5
19 SGTC_217 ketoconazole 3.78 989.0 nM 1.28E-4 ergosterol depletion effects on membrane 28 7.73E-5
20 SGTC_992 3909-8734 3.69 162.0 µM 1.81E-4 26 1.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.42E-10 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.102 3.41E-9 YOR280C FSH3 hom Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2
0.101 4.98E-9 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.41E-7 YPR183W DPM1 het Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
0.088 2.93E-7 YBR135W CKS1 het Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
0.086 5.57E-7 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.084 1.14E-6 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.082 2.22E-6 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.080 3.93E-6 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.075 1.38E-5 YGR235C MOS2 hom Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.074 1.57E-5 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.073 2.55E-5 YIR001C SGN1 hom Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
0.071 3.50E-5 YDR182W CDC1 het Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution
0.071 3.77E-5 YLR078C BOS1 het v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
0.071 4.02E-5 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway