YNL252C / MRPL17

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL252C / MRPL17

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.64|P-value:6.22E-11 ID:SGTC_19|Compound:0279-0214|FD-Score:5.86|P-value:6.51E-9 ID:SGTC_59|Compound:0330-0160|FD-Score:3.26|P-value:7.60E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.37|P-value:1.11E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:4.66|P-value:3.02E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:8.61|P-value:3.93E-17 ID:SGTC_84|Compound:0443-0269|FD-Score:3.55|P-value:2.75E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.09|P-value:3.52E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:5.69|P-value:1.70E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:6.95|P-value:8.26E-12 ID:SGTC_134|Compound:0269-0018|FD-Score:6.98|P-value:7.04E-12 ID:SGTC_173|Compound:1273-0061|FD-Score:10.50|P-value:1.31E-24 ID:SGTC_236|Compound:1509-0011|FD-Score:27.10|P-value:3.96E-151 ID:SGTC_275|Compound:trichlorophene|FD-Score:13.70|P-value:3.12E-40 ID:SGTC_310|Compound:1273-0058|FD-Score:4.73|P-value:2.26E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:3.53|P-value:2.99E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:7.83|P-value:1.76E-14 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.37|P-value:6.29E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.52|P-value:3.71E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.66|P-value:3.02E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:3.49|P-value:3.44E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.75|P-value:1.33E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.44|P-value:4.04E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.54|P-value:2.88E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.82|P-value:1.25E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.30|P-value:6.52E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.72|P-value:1.52E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.21|P-value:8.99E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.50|P-value:4.73E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:9.00|P-value:1.47E-18 ID:SGTC_933|Compound:2914-0560|FD-Score:3.63|P-value:2.12E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.21|P-value:9.03E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:9.38|P-value:5.43E-20 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.33|P-value:1.29E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.36|P-value:5.33E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:5.22|P-value:2.09E-7 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.39|P-value:4.91E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.63|P-value:2.40E-8 ID:SGTC_1547|Compound:harmine|FD-Score:-4.03|P-value:5.56E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.17|P-value:2.56E-5 ID:SGTC_1635|Compound:st007035|FD-Score:14.60|P-value:9.56E-46 ID:SGTC_1658|Compound:st012944|FD-Score:-4.19|P-value:2.96E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.58|P-value:4.34E-6 ID:SGTC_1768|Compound:st044301|FD-Score:4.47|P-value:7.22E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.37|P-value:6.34E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.45|P-value:4.10E-13 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.36|P-value:6.44E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.82|P-value:1.01E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.98|P-value:6.72E-7 ID:SGTC_1898|Compound:st060199|FD-Score:4.04|P-value:4.31E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.80|P-value:1.12E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.20|P-value:9.07E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.59|P-value:2.37E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.21|P-value:8.94E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.80|P-value:1.61E-6 ID:SGTC_2231|Compound:micatex|FD-Score:3.19|P-value:9.40E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.94|P-value:8.33E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.42|P-value:8.98E-6 ID:SGTC_2289|Compound:7946404|FD-Score:4.06|P-value:3.99E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-6.79|P-value:3.45E-11 ID:SGTC_2322|Compound:7413319|FD-Score:-3.93|P-value:8.32E-5 ID:SGTC_2456|Compound:5770359|FD-Score:-3.88|P-value:1.01E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.40|P-value:5.63E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.79|P-value:1.17E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.71|P-value:1.91E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.22|P-value:2.04E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.98|P-value:6.81E-5 ID:SGTC_2669|Compound:eugenol|FD-Score:3.37|P-value:5.24E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.27|P-value:7.42E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.36|P-value:5.43E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.98|P-value:5.40E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.28|P-value:8.54E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.95|P-value:6.08E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.85|P-value:1.12E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.48|P-value:3.60E-4 ID:SGTC_3165|Compound:9101544|FD-Score:4.53|P-value:5.43E-6 ID:SGTC_3180|Compound:9109287|FD-Score:3.51|P-value:3.15E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.48|P-value:3.53E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.64|P-value:6.22E-11 ID:SGTC_19|Compound:0279-0214|FD-Score:5.86|P-value:6.51E-9 ID:SGTC_59|Compound:0330-0160|FD-Score:3.26|P-value:7.60E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.37|P-value:1.11E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:4.66|P-value:3.02E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:8.61|P-value:3.93E-17 ID:SGTC_84|Compound:0443-0269|FD-Score:3.55|P-value:2.75E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:4.09|P-value:3.52E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:5.69|P-value:1.70E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:6.95|P-value:8.26E-12 ID:SGTC_134|Compound:0269-0018|FD-Score:6.98|P-value:7.04E-12 ID:SGTC_173|Compound:1273-0061|FD-Score:10.50|P-value:1.31E-24 ID:SGTC_236|Compound:1509-0011|FD-Score:27.10|P-value:3.96E-151 ID:SGTC_275|Compound:trichlorophene|FD-Score:13.70|P-value:3.12E-40 ID:SGTC_310|Compound:1273-0058|FD-Score:4.73|P-value:2.26E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:3.53|P-value:2.99E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:7.83|P-value:1.76E-14 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.37|P-value:6.29E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.52|P-value:3.71E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:4.66|P-value:3.02E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:3.49|P-value:3.44E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.75|P-value:1.33E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.44|P-value:4.04E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.54|P-value:2.88E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.82|P-value:1.25E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.30|P-value:6.52E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.72|P-value:1.52E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.21|P-value:8.99E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.50|P-value:4.73E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:9.00|P-value:1.47E-18 ID:SGTC_933|Compound:2914-0560|FD-Score:3.63|P-value:2.12E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.21|P-value:9.03E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:9.38|P-value:5.43E-20 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.33|P-value:1.29E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.36|P-value:5.33E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:5.22|P-value:2.09E-7 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.39|P-value:4.91E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.63|P-value:2.40E-8 ID:SGTC_1547|Compound:harmine|FD-Score:-4.03|P-value:5.56E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.17|P-value:2.56E-5 ID:SGTC_1635|Compound:st007035|FD-Score:14.60|P-value:9.56E-46 ID:SGTC_1658|Compound:st012944|FD-Score:-4.19|P-value:2.96E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.58|P-value:4.34E-6 ID:SGTC_1768|Compound:st044301|FD-Score:4.47|P-value:7.22E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.37|P-value:6.34E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.45|P-value:4.10E-13 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.36|P-value:6.44E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.82|P-value:1.01E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.98|P-value:6.72E-7 ID:SGTC_1898|Compound:st060199|FD-Score:4.04|P-value:4.31E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.80|P-value:1.12E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.20|P-value:9.07E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.59|P-value:2.37E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.21|P-value:8.94E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.80|P-value:1.61E-6 ID:SGTC_2231|Compound:micatex|FD-Score:3.19|P-value:9.40E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.94|P-value:8.33E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.42|P-value:8.98E-6 ID:SGTC_2289|Compound:7946404|FD-Score:4.06|P-value:3.99E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-6.79|P-value:3.45E-11 ID:SGTC_2322|Compound:7413319|FD-Score:-3.93|P-value:8.32E-5 ID:SGTC_2456|Compound:5770359|FD-Score:-3.88|P-value:1.01E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.40|P-value:5.63E-4 ID:SGTC_2475|Compound:5812728|FD-Score:3.79|P-value:1.17E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.71|P-value:1.91E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.22|P-value:2.04E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.98|P-value:6.81E-5 ID:SGTC_2669|Compound:eugenol|FD-Score:3.37|P-value:5.24E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.27|P-value:7.42E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.36|P-value:5.43E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.98|P-value:5.40E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.28|P-value:8.54E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.95|P-value:6.08E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-3.85|P-value:1.12E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.48|P-value:3.60E-4 ID:SGTC_3165|Compound:9101544|FD-Score:4.53|P-value:5.43E-6 ID:SGTC_3180|Compound:9109287|FD-Score:3.51|P-value:3.15E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.48|P-value:3.53E-4

Top fitness defect scores for YNL252C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 27.10 5.3 µM 3.96E-151 25 8.07E-162
2 SGTC_1635 st007035 14.60 42.4 µM 9.56E-46 44 8.38E-49
3 SGTC_275 trichlorophene 13.70 5.7 µM 3.12E-40 mitochondrial stress 14 6.79E-43
4 SGTC_173 1273-0061 10.50 2.7 µM 1.31E-24 mitochondrial stress 37 3.67E-26
5 SGTC_1188 1403-0014 9.38 4.6 µM 5.43E-20 mitochondrial stress 2 3.22E-21
6 SGTC_908 3448-7491 9.00 47.7 µM 1.47E-18 mitochondrial stress 13 1.10E-19
7 SGTC_70 0141-0289 8.61 43.3 µM 3.93E-17 mitochondrial stress 31 3.70E-18
8 SGTC_386 1509-0011 7.83 3.1 µM 1.76E-14 67 2.53E-15
9 SGTC_134 0269-0018 6.98 6.9 µM 7.04E-12 68 1.53E-12
10 SGTC_119 0121-0043 6.95 24.8 µM 8.26E-12 mitochondrial stress 16 1.81E-12
11 SGTC_10 0279-0212 6.64 42.6 µM 6.22E-11 TRP & mitochondrial translation 21 1.57E-11
12 SGTC_19 0279-0214 5.86 38.4 µM 6.51E-9 TRP & mitochondrial translation 12 2.25E-9
13 SGTC_116 0155-0182 5.69 31.8 µM 1.70E-8 mitochondrial response to ROS 29 6.28E-9
14 SGTC_1371 2421-0008 5.63 32.7 µM 2.40E-8 mitochondrial processes 7 9.03E-9
15 SGTC_778 3456-2434 5.50 196.0 µM 4.73E-8 mitochondrial response to ROS 31 1.86E-8
16 SGTC_2626 ethyl orsellinate 5.22 100.0 µM 2.04E-7 10 8.85E-8
17 SGTC_1284 0929-0043 5.22 16.0 µM 2.09E-7 12 9.11E-8
18 SGTC_1883 5-benzylidenerhodanine 4.98 20.0 µM 6.72E-7 TRP & mitochondrial translation 33 3.16E-7
19 SGTC_2232 chlorophetanol 4.94 41.5 µM 8.33E-7 TRP & mitochondrial translation 79 3.97E-7
20 SGTC_2183 6420625 4.80 130.5 µM 1.61E-6 mitochondrial processes 33 8.02E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.683 0 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.651 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.644 0 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.643 0 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.639 0 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.637 0 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.630 0 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.627 0 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.615 0 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.603 0 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.594 1.13E-318 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.589 3.14E-313 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.569 1.22E-287 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.569 2.63E-286 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.557 6.82E-273 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator