YNL257C / SIP3

Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL257C / SIP3

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.09|P-value:6.39E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:3.59|P-value:4.00E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.50|P-value:1.23E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:5.83|P-value:2.02E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:18.30|P-value:3.96E-68 ID:SGTC_79|Compound:0052-0007|FD-Score:3.52|P-value:5.09E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:5.36|P-value:2.29E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:8.07|P-value:1.17E-14 ID:SGTC_90|Compound:0870-0863|FD-Score:10.30|P-value:1.17E-22 ID:SGTC_96|Compound:0929-0093|FD-Score:3.89|P-value:1.37E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:10.60|P-value:8.00E-24 ID:SGTC_108|Compound:0509-0257|FD-Score:4.19|P-value:4.38E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:4.06|P-value:7.20E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.77|P-value:2.11E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:7.03|P-value:1.61E-11 ID:SGTC_149|Compound:3970-0822|FD-Score:4.36|P-value:2.16E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:4.20|P-value:4.21E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:22.00|P-value:1.20E-97 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.24|P-value:7.89E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.41|P-value:7.29E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.36|P-value:2.19E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.37|P-value:8.27E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-4.17|P-value:2.57E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:3.79|P-value:1.99E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.46|P-value:6.23E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.76|P-value:2.21E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.64|P-value:3.35E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:9.59|P-value:5.72E-20 ID:SGTC_743|Compound:1275-0778|FD-Score:4.35|P-value:2.23E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.73|P-value:2.41E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.33|P-value:9.52E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.18|P-value:9.59E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.78|P-value:2.03E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.55|P-value:9.69E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:4.17|P-value:4.72E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.33|P-value:9.46E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.34|P-value:2.35E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.28|P-value:6.86E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:-3.54|P-value:2.84E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.98|P-value:9.87E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.72|P-value:2.50E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.32|P-value:1.39E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-4.07|P-value:3.75E-5 ID:SGTC_1766|Compound:st045414|FD-Score:3.85|P-value:1.61E-4 ID:SGTC_1804|Compound:st050076|FD-Score:-3.93|P-value:6.65E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.35|P-value:8.84E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.69|P-value:2.87E-4 ID:SGTC_1941|Compound:st076221|FD-Score:12.10|P-value:1.01E-30 ID:SGTC_2119|Compound:5528445|FD-Score:5.81|P-value:2.27E-8 ID:SGTC_2161|Compound:5662504|FD-Score:4.74|P-value:4.37E-6 ID:SGTC_2314|Compound:7727897|FD-Score:4.21|P-value:4.01E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.70|P-value:1.60E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.68|P-value:1.08E-16 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-8.49|P-value:1.47E-16 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.28|P-value:3.37E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.20|P-value:8.98E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.44|P-value:6.69E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.32|P-value:9.97E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.51|P-value:5.26E-4 ID:SGTC_3098|Compound:9119039|FD-Score:4.63|P-value:6.90E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-3.88|P-value:7.91E-5 ID:SGTC_3143|Compound:9086658|FD-Score:6.76|P-value:9.22E-11 ID:SGTC_3311|Compound:9131146|FD-Score:6.45|P-value:5.87E-10 ID:SGTC_3324|Compound:9138759|FD-Score:3.49|P-value:5.69E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.09|P-value:6.39E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:3.59|P-value:4.00E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.50|P-value:1.23E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:5.83|P-value:2.02E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:18.30|P-value:3.96E-68 ID:SGTC_79|Compound:0052-0007|FD-Score:3.52|P-value:5.09E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:5.36|P-value:2.29E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:8.07|P-value:1.17E-14 ID:SGTC_90|Compound:0870-0863|FD-Score:10.30|P-value:1.17E-22 ID:SGTC_96|Compound:0929-0093|FD-Score:3.89|P-value:1.37E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:10.60|P-value:8.00E-24 ID:SGTC_108|Compound:0509-0257|FD-Score:4.19|P-value:4.38E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:4.06|P-value:7.20E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.77|P-value:2.11E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:7.03|P-value:1.61E-11 ID:SGTC_149|Compound:3970-0822|FD-Score:4.36|P-value:2.16E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:4.20|P-value:4.21E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:22.00|P-value:1.20E-97 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.24|P-value:7.89E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.41|P-value:7.29E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.36|P-value:2.19E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.37|P-value:8.27E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:-4.17|P-value:2.57E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:3.79|P-value:1.99E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.46|P-value:6.23E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.76|P-value:2.21E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.64|P-value:3.35E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:9.59|P-value:5.72E-20 ID:SGTC_743|Compound:1275-0778|FD-Score:4.35|P-value:2.23E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.73|P-value:2.41E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.33|P-value:9.52E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.18|P-value:9.59E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:3.78|P-value:2.03E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.55|P-value:9.69E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:4.17|P-value:4.72E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.33|P-value:9.46E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:4.34|P-value:2.35E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.28|P-value:6.86E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:-3.54|P-value:2.84E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.98|P-value:9.87E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.72|P-value:2.50E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.32|P-value:1.39E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-4.07|P-value:3.75E-5 ID:SGTC_1766|Compound:st045414|FD-Score:3.85|P-value:1.61E-4 ID:SGTC_1804|Compound:st050076|FD-Score:-3.93|P-value:6.65E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.35|P-value:8.84E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.69|P-value:2.87E-4 ID:SGTC_1941|Compound:st076221|FD-Score:12.10|P-value:1.01E-30 ID:SGTC_2119|Compound:5528445|FD-Score:5.81|P-value:2.27E-8 ID:SGTC_2161|Compound:5662504|FD-Score:4.74|P-value:4.37E-6 ID:SGTC_2314|Compound:7727897|FD-Score:4.21|P-value:4.01E-5 ID:SGTC_2322|Compound:7413319|FD-Score:-3.70|P-value:1.60E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.68|P-value:1.08E-16 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-8.49|P-value:1.47E-16 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.28|P-value:3.37E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.20|P-value:8.98E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.44|P-value:6.69E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.32|P-value:9.97E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.51|P-value:5.26E-4 ID:SGTC_3098|Compound:9119039|FD-Score:4.63|P-value:6.90E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-3.88|P-value:7.91E-5 ID:SGTC_3143|Compound:9086658|FD-Score:6.76|P-value:9.22E-11 ID:SGTC_3311|Compound:9131146|FD-Score:6.45|P-value:5.87E-10 ID:SGTC_3324|Compound:9138759|FD-Score:3.49|P-value:5.69E-4

Top fitness defect scores for YNL257C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_266 formosanin C 22.00 406.0 nM 1.20E-97 sphingolipid biosynthesis & PDR1 4 8.97E-108
2 SGTC_70 0141-0289 18.30 43.3 µM 3.96E-68 mitochondrial stress 5 3.11E-75
3 SGTC_1941 st076221 12.10 61.8 µM 1.01E-30 sphingolipid biosynthesis & PDR1 11 5.95E-34
4 SGTC_98 0074-0023 10.60 107.7 µM 8.00E-24 Golgi 2 2.49E-26
5 SGTC_90 0870-0863 10.30 4.6 µM 1.17E-22 7 4.82E-25
6 SGTC_683 panaxydol 9.59 45.0 µM 5.72E-20 sphingolipid biosynthesis & PDR1 3 4.54E-22
7 SGTC_2582 agaric acid 8.68 100.0 µM 1.08E-16 redox potentiating 89 1.92E-18
8 SGTC_86 0417-1630 8.07 471.9 µM 1.17E-14 ubiquinone biosynthesis & proteasome 59 3.41E-16
9 SGTC_143 4032-1194 7.03 15.7 µM 1.61E-11 12 1.02E-12
10 SGTC_3143 9086658 6.76 49.5 µM 9.22E-11 5 7.07E-12
11 SGTC_3311 9131146 6.45 2.9 µM 5.87E-10 cell wall 52 5.50E-11
12 SGTC_59 0330-0160 5.83 1.3 µM 2.02E-8 41 2.78E-9
13 SGTC_2119 5528445 5.81 120.6 µM 2.27E-8 3 3.18E-9
14 SGTC_81 0411-0046 5.36 10.0 µM 2.29E-7 12 4.11E-8
15 SGTC_2651 1327-0036 5.28 5.0 µM 3.37E-7 97 6.34E-8
16 SGTC_2161 5662504 4.74 8.5 µM 4.37E-6 tubulin folding & SWR complex 12 1.09E-6
17 SGTC_3098 9119039 4.63 49.5 µM 6.90E-6 Golgi 24 1.81E-6
18 SGTC_929 2805-0021 4.55 398.0 µM 9.69E-6 8 2.64E-6
19 SGTC_58 0957-0393 4.50 9.0 µM 1.23E-5 cell wall 330 3.45E-6
20 SGTC_149 3970-0822 4.36 46.1 µM 2.16E-5 tubulin folding & SWR complex 74 6.42E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.406 1.06E-133 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.385 6.65E-119 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.333 1.15E-87 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.280 2.44E-61 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.273 1.50E-58 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.266 1.34E-55 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.244 1.27E-46 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.243 3.47E-46 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.226 4.64E-40 YPL056C_p LCL1_p hom Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan
0.221 2.99E-38 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.198 3.98E-31 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.198 4.16E-31 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
0.198 5.51E-31 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.196 2.97E-30 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.188 3.82E-28 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family