YNL259C / ATX1

Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL259C / ATX1

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-4.99|P-value:4.60E-7 ID:SGTC_112|Compound:phenothiazine|FD-Score:-4.17|P-value:2.00E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:12.80|P-value:5.17E-36 ID:SGTC_197|Compound:4544-0043|FD-Score:3.97|P-value:5.51E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:3.57|P-value:2.56E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:4.00|P-value:4.89E-5 ID:SGTC_263|Compound:alizarin|FD-Score:8.38|P-value:1.24E-16 ID:SGTC_286|Compound:k060-0067|FD-Score:3.64|P-value:1.92E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.21|P-value:8.77E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.32|P-value:5.44E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:5.59|P-value:2.44E-8 ID:SGTC_374|Compound:0880-0231|FD-Score:3.94|P-value:6.16E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.94|P-value:6.19E-5 ID:SGTC_444|Compound:curcumin|FD-Score:5.77|P-value:8.75E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.54|P-value:4.77E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.80|P-value:1.05E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:4.61|P-value:3.37E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:3.33|P-value:5.95E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.15|P-value:2.54E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.26|P-value:7.53E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.21|P-value:8.92E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.82|P-value:9.90E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.48|P-value:3.49E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.54|P-value:8.56E-11 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.32|P-value:5.37E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.49|P-value:3.31E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.48|P-value:3.07E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.16|P-value:9.10E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.23|P-value:1.86E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.41|P-value:4.42E-4 ID:SGTC_1608|Compound:st001473|FD-Score:5.31|P-value:1.10E-7 ID:SGTC_1616|Compound:st002734|FD-Score:6.35|P-value:2.83E-10 ID:SGTC_1725|Compound:st036284|FD-Score:-4.67|P-value:2.21E-6 ID:SGTC_1756|Compound:st041558|FD-Score:-3.24|P-value:6.93E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.55|P-value:2.66E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.91|P-value:6.76E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.51|P-value:3.11E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.64|P-value:1.96E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-3.87|P-value:7.06E-5 ID:SGTC_2133|Compound:5320837|FD-Score:4.17|P-value:2.39E-5 ID:SGTC_2146|Compound:5545642|FD-Score:3.44|P-value:4.02E-4 ID:SGTC_2153|Compound:5569715|FD-Score:6.42|P-value:1.74E-10 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.41|P-value:4.43E-4 ID:SGTC_2203|Compound:7227154|FD-Score:-3.43|P-value:3.59E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.21|P-value:8.71E-4 ID:SGTC_2275|Compound:7947463|FD-Score:5.80|P-value:7.39E-9 ID:SGTC_2291|Compound:7917025|FD-Score:8.01|P-value:2.53E-15 ID:SGTC_2351|Compound:9026858|FD-Score:3.94|P-value:6.10E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.28|P-value:7.01E-4 ID:SGTC_2395|Compound:5646831|FD-Score:4.68|P-value:2.47E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.58|P-value:2.46E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:4.67|P-value:2.64E-6 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.81|P-value:8.71E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.44|P-value:3.97E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.81|P-value:7.03E-9 ID:SGTC_2586|Compound:curcumin|FD-Score:3.64|P-value:1.92E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:7.20|P-value:9.88E-13 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.63|P-value:3.12E-6 ID:SGTC_2601|Compound:securinine|FD-Score:6.72|P-value:2.63E-11 ID:SGTC_2602|Compound:kawain|FD-Score:4.15|P-value:2.62E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.25|P-value:1.67E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.50|P-value:2.86E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.32|P-value:5.29E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.74|P-value:1.35E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.82|P-value:9.87E-5 ID:SGTC_2928|Compound:9011484|FD-Score:4.62|P-value:3.30E-6 ID:SGTC_3016|Compound:9080866|FD-Score:-3.39|P-value:4.21E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.34|P-value:5.69E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.84|P-value:9.14E-5 ID:SGTC_3090|Compound:9117696|FD-Score:3.53|P-value:2.90E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.63|P-value:1.99E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-4.99|P-value:4.60E-7 ID:SGTC_112|Compound:phenothiazine|FD-Score:-4.17|P-value:2.00E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:12.80|P-value:5.17E-36 ID:SGTC_197|Compound:4544-0043|FD-Score:3.97|P-value:5.51E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:3.57|P-value:2.56E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:4.00|P-value:4.89E-5 ID:SGTC_263|Compound:alizarin|FD-Score:8.38|P-value:1.24E-16 ID:SGTC_286|Compound:k060-0067|FD-Score:3.64|P-value:1.92E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.21|P-value:8.77E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.32|P-value:5.44E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:5.59|P-value:2.44E-8 ID:SGTC_374|Compound:0880-0231|FD-Score:3.94|P-value:6.16E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:3.94|P-value:6.19E-5 ID:SGTC_444|Compound:curcumin|FD-Score:5.77|P-value:8.75E-9 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.54|P-value:4.77E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.80|P-value:1.05E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:4.61|P-value:3.37E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:3.33|P-value:5.95E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.15|P-value:2.54E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.26|P-value:7.53E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.21|P-value:8.92E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.82|P-value:9.90E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.48|P-value:3.49E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.54|P-value:8.56E-11 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.32|P-value:5.37E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.49|P-value:3.31E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.48|P-value:3.07E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.16|P-value:9.10E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:4.23|P-value:1.86E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.41|P-value:4.42E-4 ID:SGTC_1608|Compound:st001473|FD-Score:5.31|P-value:1.10E-7 ID:SGTC_1616|Compound:st002734|FD-Score:6.35|P-value:2.83E-10 ID:SGTC_1725|Compound:st036284|FD-Score:-4.67|P-value:2.21E-6 ID:SGTC_1756|Compound:st041558|FD-Score:-3.24|P-value:6.93E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.55|P-value:2.66E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.91|P-value:6.76E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.51|P-value:3.11E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.64|P-value:1.96E-4 ID:SGTC_2015|Compound:5119600|FD-Score:-3.87|P-value:7.06E-5 ID:SGTC_2133|Compound:5320837|FD-Score:4.17|P-value:2.39E-5 ID:SGTC_2146|Compound:5545642|FD-Score:3.44|P-value:4.02E-4 ID:SGTC_2153|Compound:5569715|FD-Score:6.42|P-value:1.74E-10 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.41|P-value:4.43E-4 ID:SGTC_2203|Compound:7227154|FD-Score:-3.43|P-value:3.59E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.21|P-value:8.71E-4 ID:SGTC_2275|Compound:7947463|FD-Score:5.80|P-value:7.39E-9 ID:SGTC_2291|Compound:7917025|FD-Score:8.01|P-value:2.53E-15 ID:SGTC_2351|Compound:9026858|FD-Score:3.94|P-value:6.10E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.28|P-value:7.01E-4 ID:SGTC_2395|Compound:5646831|FD-Score:4.68|P-value:2.47E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.58|P-value:2.46E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:4.67|P-value:2.64E-6 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.81|P-value:8.71E-5 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.44|P-value:3.97E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.81|P-value:7.03E-9 ID:SGTC_2586|Compound:curcumin|FD-Score:3.64|P-value:1.92E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:7.20|P-value:9.88E-13 ID:SGTC_2600|Compound:tangeritin|FD-Score:4.63|P-value:3.12E-6 ID:SGTC_2601|Compound:securinine|FD-Score:6.72|P-value:2.63E-11 ID:SGTC_2602|Compound:kawain|FD-Score:4.15|P-value:2.62E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.25|P-value:1.67E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.50|P-value:2.86E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.32|P-value:5.29E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.74|P-value:1.35E-4 ID:SGTC_2927|Compound:9011802|FD-Score:3.82|P-value:9.87E-5 ID:SGTC_2928|Compound:9011484|FD-Score:4.62|P-value:3.30E-6 ID:SGTC_3016|Compound:9080866|FD-Score:-3.39|P-value:4.21E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.34|P-value:5.69E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.84|P-value:9.14E-5 ID:SGTC_3090|Compound:9117696|FD-Score:3.53|P-value:2.90E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.63|P-value:1.99E-4

Top fitness defect scores for YNL259C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_157 1348-1695 12.80 65.8 µM 5.17E-36 iron homeostasis 8 1.54E-37
2 SGTC_263 alizarin 8.38 107.9 µM 1.24E-16 iron homeostasis 9 2.55E-17
3 SGTC_2291 7917025 8.01 104.3 µM 2.53E-15 iron homeostasis 16 5.92E-16
4 SGTC_2597 laccaic acid a 7.20 100.0 µM 9.88E-13 5 3.00E-13
5 SGTC_2601 securinine 6.72 100.0 µM 2.63E-11 2 9.21E-12
6 SGTC_1110 3-hydroxy-3'-methoxyflavone 6.54 1.2 µM 8.56E-11 iron homeostasis 9 3.16E-11
7 SGTC_2153 5569715 6.42 200.0 µM 1.74E-10 iron homeostasis 5 6.62E-11
8 SGTC_1616 st002734 6.35 56.1 µM 2.83E-10 7 1.10E-10
9 SGTC_2582 agaric acid 5.81 100.0 µM 7.03E-9 redox potentiating 170 3.14E-9
10 SGTC_2275 7947463 5.80 200.0 µM 7.39E-9 iron homeostasis 13 3.31E-9
11 SGTC_444 curcumin 5.77 90.4 µM 8.75E-9 iron homeostasis 7 3.95E-9
12 SGTC_339 3091-4833 5.59 71.4 µM 2.44E-8 iron homeostasis 5 1.15E-8
13 SGTC_1608 st001473 5.31 40.5 µM 1.10E-7 20 5.53E-8
14 SGTC_2395 5646831 4.68 180.2 µM 2.47E-6 14 1.43E-6
15 SGTC_2490 carminic acid 4.67 95.4 µM 2.64E-6 2 1.53E-6
16 SGTC_2600 tangeritin 4.63 88.0 µM 3.12E-6 19 1.83E-6
17 SGTC_2928 9011484 4.62 9.8 µM 3.30E-6 heme biosynthesis & mitochondrial translocase 27 1.93E-6
18 SGTC_565 1418-0001 4.61 44.5 µM 3.37E-6 6 1.98E-6
19 SGTC_453 enantio-paf c16 4.54 10.0 µM 4.77E-6 108 2.84E-6
20 SGTC_2675 theaflavin digallate 4.25 100.0 µM 1.67E-5 iron homeostasis 24 1.05E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.501 1.17E-212 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.440 1.86E-158 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.388 1.45E-120 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.384 1.64E-118 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.383 1.31E-117 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.324 1.21E-82 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.266 2.91E-55 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.192 4.09E-29 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.182 1.84E-26 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.177 7.28E-25 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.163 2.18E-21 YMR057C_d YMR057C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
0.162 3.09E-21 YML028W TSA1 hom Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.160 1.07E-20 YDR202C RAV2 hom Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
0.140 3.29E-16 YOR310C NOP58 het Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
0.127 1.54E-13 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc