Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YNL260C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.188 | 3.80E-28 | YKL072W | STB6 | hom | Protein that binds Sin3p in a two-hybrid assay |
0.156 | 9.21E-20 | YOR087W | YVC1 | hom | Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock |
0.130 | 3.97E-14 | YER065C | ICL1 | hom | Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose |
0.130 | 5.14E-14 | YMR111C | YMR111C | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress |
0.126 | 2.07E-13 | YNL076W | MKS1 | hom | Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling |
0.125 | 3.85E-13 | YDR180W | SCC2 | het | Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin |
0.122 | 1.39E-12 | YPL064C | CWC27 | hom | Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress |
0.121 | 2.21E-12 | YLR307C-A_p | YLR307C-A_p | hom | Putative protein of unknown function |
0.121 | 2.19E-12 | YLR365W_d | YLR365W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene |
0.106 | 7.04E-10 | YGR185C | TYS1 | het | Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress |
0.105 | 9.21E-10 | YKL131W_d | YKL131W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.101 | 4.65E-9 | YLR363W-A | YLR363W-A | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress |
0.099 | 7.67E-9 | YDR441C | APT2 | hom | Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication |
0.099 | 9.95E-9 | YPR010C | RPA135 | het | RNA polymerase I second largest subunit A135 |
0.098 | 1.49E-8 | YLR290C_p | YLR290C_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene |