YNL262W / POL2

Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL262W / POL2

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:-2.69|P-value:7.67E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.09|P-value:1.35E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.13|P-value:1.15E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.55|P-value:1.47E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.59|P-value:1.21E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:2.80|P-value:4.67E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:2.84|P-value:4.02E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.96|P-value:1.43E-6 ID:SGTC_404|Compound:fumagillin|FD-Score:2.79|P-value:4.97E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.83|P-value:3.05E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:3.04|P-value:1.61E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:2.74|P-value:6.04E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.29|P-value:5.15E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-2.80|P-value:4.95E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.33|P-value:4.25E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:-2.74|P-value:6.20E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:2.87|P-value:3.44E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.69|P-value:1.51E-8 ID:SGTC_974|Compound:1326-0144|FD-Score:3.63|P-value:9.16E-6 ID:SGTC_1143|Compound:3454-2408|FD-Score:2.71|P-value:6.84E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.94|P-value:1.63E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.27|P-value:5.85E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:2.80|P-value:4.73E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:2.80|P-value:4.71E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.22|P-value:3.09E-7 ID:SGTC_1376|Compound:2910-0861|FD-Score:2.87|P-value:3.53E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:4.18|P-value:3.86E-7 ID:SGTC_1567|Compound:st069303|FD-Score:2.88|P-value:3.28E-4 ID:SGTC_1614|Compound:st002383|FD-Score:2.99|P-value:2.03E-4 ID:SGTC_1672|Compound:st016598|FD-Score:2.66|P-value:8.26E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.61|P-value:1.09E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-2.98|P-value:2.26E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.30|P-value:4.77E-5 ID:SGTC_2432|Compound:5630864|FD-Score:2.75|P-value:5.80E-4 ID:SGTC_2447|Compound:5741742|FD-Score:2.93|P-value:2.69E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.79|P-value:3.78E-6 ID:SGTC_2517|Compound:totarol|FD-Score:-3.81|P-value:3.65E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.70|P-value:7.20E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.31|P-value:1.75E-7 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.38|P-value:3.41E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.03|P-value:1.75E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.38|P-value:3.28E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-2.73|P-value:6.45E-4 ID:SGTC_2804|Compound:7954240|FD-Score:9.19|P-value:9.92E-28 ID:SGTC_2808|Compound:7946468|FD-Score:4.42|P-value:9.00E-8 ID:SGTC_2968|Compound:9090663|FD-Score:3.23|P-value:6.65E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-2.93|P-value:2.85E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-2.82|P-value:4.56E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-2.69|P-value:7.67E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.09|P-value:1.35E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.13|P-value:1.15E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.55|P-value:1.47E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.59|P-value:1.21E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:2.80|P-value:4.67E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:2.84|P-value:4.02E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.96|P-value:1.43E-6 ID:SGTC_404|Compound:fumagillin|FD-Score:2.79|P-value:4.97E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.83|P-value:3.05E-6 ID:SGTC_551|Compound:k048-0028|FD-Score:3.04|P-value:1.61E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:2.74|P-value:6.04E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.29|P-value:5.15E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-2.80|P-value:4.95E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.33|P-value:4.25E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:-2.74|P-value:6.20E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:2.87|P-value:3.44E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.69|P-value:1.51E-8 ID:SGTC_974|Compound:1326-0144|FD-Score:3.63|P-value:9.16E-6 ID:SGTC_1143|Compound:3454-2408|FD-Score:2.71|P-value:6.84E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.94|P-value:1.63E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.27|P-value:5.85E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:2.80|P-value:4.73E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:2.80|P-value:4.71E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.22|P-value:3.09E-7 ID:SGTC_1376|Compound:2910-0861|FD-Score:2.87|P-value:3.53E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:4.18|P-value:3.86E-7 ID:SGTC_1567|Compound:st069303|FD-Score:2.88|P-value:3.28E-4 ID:SGTC_1614|Compound:st002383|FD-Score:2.99|P-value:2.03E-4 ID:SGTC_1672|Compound:st016598|FD-Score:2.66|P-value:8.26E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.61|P-value:1.09E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-2.98|P-value:2.26E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.30|P-value:4.77E-5 ID:SGTC_2432|Compound:5630864|FD-Score:2.75|P-value:5.80E-4 ID:SGTC_2447|Compound:5741742|FD-Score:2.93|P-value:2.69E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.79|P-value:3.78E-6 ID:SGTC_2517|Compound:totarol|FD-Score:-3.81|P-value:3.65E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:2.70|P-value:7.20E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.31|P-value:1.75E-7 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.38|P-value:3.41E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.03|P-value:1.75E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.38|P-value:3.28E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-2.73|P-value:6.45E-4 ID:SGTC_2804|Compound:7954240|FD-Score:9.19|P-value:9.92E-28 ID:SGTC_2808|Compound:7946468|FD-Score:4.42|P-value:9.00E-8 ID:SGTC_2968|Compound:9090663|FD-Score:3.23|P-value:6.65E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-2.93|P-value:2.85E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-2.82|P-value:4.56E-4

Top fitness defect scores for YNL262W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2804 7954240 9.19 19.5 µM 9.92E-28 1 1.89E-20 2.45
2 SGTC_929 2805-0021 4.69 398.0 µM 1.51E-8 2 1.35E-6 0.87
3 SGTC_2808 7946468 4.42 45.5 µM 9.00E-8 3 4.95E-6 0.21
4 SGTC_2533 agelasine 4.31 13.7 µM 1.75E-7 ERG2 10 8.04E-6 0.18
5 SGTC_1332 1480-0653 4.22 17.5 µM 3.09E-7 TSC3-RPN4 2 1.21E-5 0.04
6 SGTC_1529 apigenin 4.18 74.0 µM 3.86E-7 3 1.43E-5 0.06
7 SGTC_357 1325-0123 3.96 420.0 µM 1.43E-6 3 3.69E-5 0.37
8 SGTC_1151 3909-8316 3.94 15.3 µM 1.63E-6 6 4.08E-5 0.10
9 SGTC_537 1334-0398 3.83 209.0 µM 3.05E-6 5 6.43E-5 0.00
10 SGTC_2500 5-alpha-androstan-3,17-dione 3.79 61.4 µM 3.78E-6 4 7.52E-5 0.17
11 SGTC_974 1326-0144 3.63 138.0 µM 9.16E-6 ERG2 10 1.43E-4 0.05
12 SGTC_2541 muurolladie-3-one 3.38 83.1 µM 3.28E-5 excess fatty acid 26 3.64E-4 0.03
13 SGTC_665 3914-0008 3.33 307.0 µM 4.25E-5 8 4.40E-4 0.22
14 SGTC_1906 st060206 3.30 94.7 µM 4.77E-5 6 4.78E-4 0.17
15 SGTC_651 3253-0966 3.29 34.4 µM 5.15E-5 calcium & mitochondrial duress 7 5.06E-4 0.00
16 SGTC_2968 9090663 3.23 33.4 µM 6.65E-5 21 6.10E-4 0.09
17 SGTC_551 k048-0028 3.04 34.9 µM 1.61E-4 20 0.00117 0.14
18 SGTC_2539 epi(13)torulosol 3.03 80.0 µM 1.75E-4 15 0.00124 0.04
19 SGTC_1614 st002383 2.99 48.6 µM 2.03E-4 cell wall signaling 8 0.00138 0.10
20 SGTC_2447 5741742 2.93 33.8 µM 2.69E-4 22 0.00170 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.22E-18 YIL088C AVT7 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.144 4.85E-17 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.134 7.95E-15 YPL095C EEB1 hom Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication
0.133 8.54E-15 YDR235W PRP42 het U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.126 2.39E-13 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.125 3.12E-13 YHR113W APE4 hom Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family
0.122 1.34E-12 YNL304W YPT11 hom Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells
0.121 2.32E-12 YNL151C RPC31 het RNA polymerase III subunit C31
0.114 3.25E-11 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.110 1.94E-10 YKL181W PRS1 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
0.109 2.35E-10 YMR281W GPI12 het ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
0.106 8.26E-10 YDL154W MSH5 hom Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
0.105 1.14E-9 YOR314W_d YOR314W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.103 2.19E-9 YPR019W MCM4 het Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p
0.098 1.50E-8 YNL160W YGP1 hom Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p