YNL263C / YIF1

Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL263C / YIF1

Click on Significant Values for Screen Details ID:SGTC_143|Compound:4032-1194|FD-Score:3.67|P-value:6.75E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.76|P-value:5.16E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:3.46|P-value:1.63E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.09|P-value:7.04E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.43|P-value:2.00E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.24|P-value:4.06E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:-3.08|P-value:7.32E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.44|P-value:1.88E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.38|P-value:2.24E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.38|P-value:2.26E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.44|P-value:1.89E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.06|P-value:7.31E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.83|P-value:3.44E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:-3.50|P-value:1.48E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:-3.29|P-value:3.38E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.67|P-value:7.03E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.13|P-value:6.09E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-4.85|P-value:2.69E-7 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.43|P-value:1.99E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.18|P-value:5.02E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.18|P-value:5.15E-4 ID:SGTC_1607|Compound:st000305|FD-Score:-3.10|P-value:6.92E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.00|P-value:9.01E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.01|P-value:8.83E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.86|P-value:3.27E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-3.30|P-value:3.24E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.41|P-value:1.98E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-3.16|P-value:5.48E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.53|P-value:1.33E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.03|P-value:8.18E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.04|P-value:8.03E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.33|P-value:2.88E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.09|P-value:6.54E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.42|P-value:1.90E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.98|P-value:1.79E-5 ID:SGTC_3084|Compound:9116877|FD-Score:3.06|P-value:7.30E-4 ID:SGTC_3177|Compound:9107506|FD-Score:2.99|P-value:9.40E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.01|P-value:8.74E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.28|P-value:3.32E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.67|P-value:6.75E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.76|P-value:5.16E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:3.46|P-value:1.63E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.09|P-value:7.04E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:-3.43|P-value:2.00E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.24|P-value:4.06E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:-3.08|P-value:7.32E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:-3.44|P-value:1.88E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.38|P-value:2.24E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.38|P-value:2.26E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.44|P-value:1.89E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.06|P-value:7.31E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.83|P-value:3.44E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:-3.50|P-value:1.48E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:-3.29|P-value:3.38E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.67|P-value:7.03E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.13|P-value:6.09E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:-4.85|P-value:2.69E-7 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.43|P-value:1.99E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.18|P-value:5.02E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.18|P-value:5.15E-4 ID:SGTC_1607|Compound:st000305|FD-Score:-3.10|P-value:6.92E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.00|P-value:9.01E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.01|P-value:8.83E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.86|P-value:3.27E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-3.30|P-value:3.24E-4 ID:SGTC_1941|Compound:st076221|FD-Score:3.41|P-value:1.98E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-3.16|P-value:5.48E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.53|P-value:1.33E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.03|P-value:8.18E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.04|P-value:8.03E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.33|P-value:2.88E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.09|P-value:6.54E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.42|P-value:1.90E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.98|P-value:1.79E-5 ID:SGTC_3084|Compound:9116877|FD-Score:3.06|P-value:7.30E-4 ID:SGTC_3177|Compound:9107506|FD-Score:2.99|P-value:9.40E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.01|P-value:8.74E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.28|P-value:3.32E-4

Top fitness defect scores for YNL263C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3083 9117465 3.98 49.5 µM 1.79E-5 5 3.44E-5 0.09
2 SGTC_1406 3909-7906 3.83 11.9 µM 3.44E-5 60S ribosome export 5 6.34E-5 0.03
3 SGTC_143 4032-1194 3.67 15.7 µM 6.75E-5 21 1.19E-4 0.03
4 SGTC_1440 4100-1550 3.67 40.0 µM 7.03E-5 1 1.23E-4 0.23
5 SGTC_292 k038-0015 3.46 474.0 µM 1.63E-4 3 2.70E-4 0.04
6 SGTC_2973 9094665 3.42 18.0 µM 1.90E-4 NEO1 23 3.12E-4 0.04
7 SGTC_1941 st076221 3.41 61.8 µM 1.98E-4 sphingolipid biosynthesis & PDR1 13 3.25E-4 0.02
8 SGTC_1335 1486-0900 3.38 202.0 µM 2.24E-4 8 3.65E-4 0.09
9 SGTC_1369 1866-0067 3.38 208.0 µM 2.26E-4 RPP1 & pyrimidine depletion 12 3.67E-4 0.11
10 SGTC_3253 9135987 3.28 49.5 µM 3.32E-4 60S ribosome export 5 5.26E-4 0.14
11 SGTC_2968 9090663 3.09 33.4 µM 6.54E-4 25 9.91E-4 0.03
12 SGTC_3084 9116877 3.06 49.5 µM 7.30E-4 3 0.00110 0.10
13 SGTC_1381 2324-0066 3.06 62.1 µM 7.31E-4 18 0.00110 0.02
14 SGTC_2750 bromebric acid 3.04 70.2 µM 8.03E-4 17 0.00120 0.10
15 SGTC_2692 st077426 3.03 47.7 µM 8.18E-4 17 0.00122 0.04
16 SGTC_3242 9133940 3.01 49.5 µM 8.74E-4 12 0.00130 0.14
17 SGTC_1646 st011709 3.01 75.6 µM 8.83E-4 16 0.00131 0.06
18 SGTC_1631 benzylvanillin 3.00 81.9 µM 9.01E-4 Golgi 16 0.00134 0.17
19 SGTC_3177 9107506 2.99 49.5 µM 9.40E-4 ERG2 5 0.00139 0.08
20 SGTC_58 0957-0393 2.96 9.0 µM 0.00104 cell wall 71 0.00153 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.95E-12 YBR212W NGR1 hom RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase
0.110 1.65E-10 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.091 1.20E-7 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.090 1.90E-7 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.089 2.78E-7 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.087 4.07E-7 YPL025C_d YPL025C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.083 1.43E-6 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.083 1.45E-6 YDR304C CPR5 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
0.076 1.15E-5 YDL095W PMT1 hom Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
0.074 1.93E-5 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.070 4.52E-5 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.070 5.51E-5 YDR319C_p YFT2_p hom Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens
0.069 6.35E-5 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.068 8.06E-5 YNL128W TEP1 hom PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1
0.065 1.48E-4 YGL010W_p YGL010W_p hom Putative protein of unknown function; YGL010W is not an essential gene