YNL264C / PDR17

Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL264C / PDR17

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:6.41|P-value:1.05E-10 ID:SGTC_4|Compound:0960-0234|FD-Score:5.00|P-value:3.53E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:3.99|P-value:3.88E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:4.60|P-value:2.55E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:3.85|P-value:6.82E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:8.46|P-value:2.52E-17 ID:SGTC_145|Compound:3737-0113|FD-Score:10.60|P-value:3.66E-26 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:5.83|P-value:3.64E-9 ID:SGTC_264|Compound:promethazine|FD-Score:5.94|P-value:1.94E-9 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.21|P-value:7.14E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.67|P-value:1.40E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.97|P-value:2.37E-12 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.60|P-value:1.83E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.28|P-value:5.84E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:6.17|P-value:4.65E-10 ID:SGTC_528|Compound:3492-0019|FD-Score:15.40|P-value:3.17E-53 ID:SGTC_536|Compound:3852-0578|FD-Score:-4.17|P-value:1.68E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:4.14|P-value:2.03E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.96|P-value:4.38E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.92|P-value:5.03E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.28|P-value:5.57E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.80|P-value:8.26E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.45|P-value:3.21E-8 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.67|P-value:1.38E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.38|P-value:4.01E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.33|P-value:4.90E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.11|P-value:9.80E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.62|P-value:1.67E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-4.67|P-value:1.76E-6 ID:SGTC_2111|Compound:5486399|FD-Score:-3.21|P-value:7.13E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-3.39|P-value:3.77E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-3.82|P-value:7.18E-5 ID:SGTC_2349|Compound:9023730|FD-Score:-3.76|P-value:9.29E-5 ID:SGTC_2467|Compound:5474540|FD-Score:3.36|P-value:4.44E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.48|P-value:2.85E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.87|P-value:6.17E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:3.45|P-value:3.10E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.23|P-value:1.29E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-3.40|P-value:3.66E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.48|P-value:2.80E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.54|P-value:2.19E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-4.27|P-value:1.09E-5 ID:SGTC_2896|Compound:9052656|FD-Score:5.34|P-value:6.02E-8 ID:SGTC_3203|Compound:9113543|FD-Score:8.29|P-value:1.03E-16 ID:SGTC_3210|Compound:9128157|FD-Score:-3.84|P-value:6.85E-5 ID:SGTC_3214|Compound:9129694|FD-Score:4.37|P-value:7.41E-6 ID:SGTC_3231|Compound:9132313|FD-Score:3.18|P-value:8.20E-4 ID:SGTC_3253|Compound:9135987|FD-Score:-3.83|P-value:7.14E-5 ID:SGTC_3263|Compound:9137018|FD-Score:3.53|P-value:2.35E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:6.41|P-value:1.05E-10 ID:SGTC_4|Compound:0960-0234|FD-Score:5.00|P-value:3.53E-7 ID:SGTC_22|Compound:0964-0034|FD-Score:3.99|P-value:3.88E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:4.60|P-value:2.55E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:3.85|P-value:6.82E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:8.46|P-value:2.52E-17 ID:SGTC_145|Compound:3737-0113|FD-Score:10.60|P-value:3.66E-26 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:5.83|P-value:3.64E-9 ID:SGTC_264|Compound:promethazine|FD-Score:5.94|P-value:1.94E-9 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.21|P-value:7.14E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.67|P-value:1.40E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.97|P-value:2.37E-12 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.60|P-value:1.83E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.28|P-value:5.84E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:6.17|P-value:4.65E-10 ID:SGTC_528|Compound:3492-0019|FD-Score:15.40|P-value:3.17E-53 ID:SGTC_536|Compound:3852-0578|FD-Score:-4.17|P-value:1.68E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:4.14|P-value:2.03E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.96|P-value:4.38E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:3.92|P-value:5.03E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:-3.28|P-value:5.57E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.80|P-value:8.26E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.45|P-value:3.21E-8 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.67|P-value:1.38E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.38|P-value:4.01E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.33|P-value:4.90E-4 ID:SGTC_1800|Compound:st050079|FD-Score:-3.11|P-value:9.80E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.62|P-value:1.67E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-4.67|P-value:1.76E-6 ID:SGTC_2111|Compound:5486399|FD-Score:-3.21|P-value:7.13E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-3.39|P-value:3.77E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-3.82|P-value:7.18E-5 ID:SGTC_2349|Compound:9023730|FD-Score:-3.76|P-value:9.29E-5 ID:SGTC_2467|Compound:5474540|FD-Score:3.36|P-value:4.44E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.48|P-value:2.85E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.87|P-value:6.17E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:3.45|P-value:3.10E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.23|P-value:1.29E-5 ID:SGTC_2790|Compound:5423970|FD-Score:-3.40|P-value:3.66E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.48|P-value:2.80E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.54|P-value:2.19E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-4.27|P-value:1.09E-5 ID:SGTC_2896|Compound:9052656|FD-Score:5.34|P-value:6.02E-8 ID:SGTC_3203|Compound:9113543|FD-Score:8.29|P-value:1.03E-16 ID:SGTC_3210|Compound:9128157|FD-Score:-3.84|P-value:6.85E-5 ID:SGTC_3214|Compound:9129694|FD-Score:4.37|P-value:7.41E-6 ID:SGTC_3231|Compound:9132313|FD-Score:3.18|P-value:8.20E-4 ID:SGTC_3253|Compound:9135987|FD-Score:-3.83|P-value:7.14E-5 ID:SGTC_3263|Compound:9137018|FD-Score:3.53|P-value:2.35E-4

Top fitness defect scores for YNL264C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_528 3492-0019 15.40 172.0 µM 3.17E-53 calcium & mitochondrial duress 14 4.76E-54
2 SGTC_145 3737-0113 10.60 38.4 µM 3.66E-26 DNA intercalators 5 1.46E-26
3 SGTC_144 4161-2749 8.46 112.4 µM 2.52E-17 DNA intercalators 5 1.39E-17
4 SGTC_3203 9113543 8.29 49.5 µM 1.03E-16 1 5.78E-17
5 SGTC_363 0455-0021 6.97 3.1 µM 2.37E-12 azole & statin 25 1.56E-12
6 SGTC_3 0833-0587 6.41 95.6 µM 1.05E-10 redox potentiating 6 7.32E-11
7 SGTC_526 4469-0568 6.17 170.0 µM 4.65E-10 azole & statin 14 3.33E-10
8 SGTC_264 promethazine 5.94 12.5 mM 1.94E-9 DNA intercalators 20 1.43E-9
9 SGTC_219 mitoxanthrone 5.83 164.4 µM 3.64E-9 DNA intercalators 19 2.69E-9
10 SGTC_1468 k284-1086 5.45 134.0 µM 3.21E-8 DNA intercalators 7 2.46E-8
11 SGTC_2896 9052656 5.34 71.4 µM 6.02E-8 endomembrane recycling 49 4.66E-8
12 SGTC_4 0960-0234 5.00 25.7 µM 3.53E-7 Golgi 4 2.81E-7
13 SGTC_42 0133-0086 4.60 60.6 µM 2.55E-6 12 2.09E-6
14 SGTC_3214 9129694 4.37 49.5 µM 7.41E-6 17 6.20E-6
15 SGTC_797 k781-0471 4.14 270.0 µM 2.03E-5 RPP1 & pyrimidine depletion 16 1.73E-5
16 SGTC_22 0964-0034 3.99 14.5 µM 3.88E-5 unfolded protein response 46 3.33E-5
17 SGTC_817 1391-0715 3.96 46.0 µM 4.38E-5 19 3.77E-5
18 SGTC_867 0518-0118 3.92 155.0 µM 5.03E-5 DNA intercalators 21 4.34E-5
19 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.87 70.0 µM 6.17E-5 redox potentiating 77 5.34E-5
20 SGTC_143 4032-1194 3.85 15.7 µM 6.82E-5 71 5.91E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.359 7.89E-103 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.323 1.83E-82 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.315 3.60E-78 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.291 1.27E-66 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.284 1.90E-63 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.270 2.58E-57 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.258 4.67E-52 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.257 7.08E-52 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.252 9.60E-50 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.245 6.20E-47 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.219 1.08E-37 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.200 1.38E-31 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.194 7.12E-30 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.193 2.13E-29 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.192 3.18E-29 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry