YNL267W / PIK1

Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL267W / PIK1

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:12.60|P-value:1.01E-26 ID:SGTC_43|Compound:0570-0105|FD-Score:4.99|P-value:1.40E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.28|P-value:1.65E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.29|P-value:1.41E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.63|P-value:5.16E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:12.20|P-value:5.32E-25 ID:SGTC_172|Compound:1112-0046|FD-Score:5.46|P-value:2.26E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:8.79|P-value:7.34E-14 ID:SGTC_181|Compound:1447-1644|FD-Score:6.69|P-value:9.39E-9 ID:SGTC_197|Compound:4544-0043|FD-Score:12.90|P-value:6.42E-28 ID:SGTC_207|Compound:4185-0010|FD-Score:10.40|P-value:1.09E-18 ID:SGTC_221|Compound:trifluoperazine|FD-Score:33.60|P-value:4.27E-176 ID:SGTC_232|Compound:clozapine|FD-Score:3.75|P-value:8.33E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.99|P-value:4.13E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:6.45|P-value:2.99E-8 ID:SGTC_301|Compound:4119-0100|FD-Score:5.64|P-value:1.08E-6 ID:SGTC_308|Compound:4092-1169|FD-Score:4.91|P-value:1.90E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:18.10|P-value:8.31E-53 ID:SGTC_314|Compound:1671-0008|FD-Score:5.39|P-value:3.10E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:5.82|P-value:5.14E-7 ID:SGTC_327|Compound:1273-0057|FD-Score:4.42|P-value:1.06E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.32|P-value:5.64E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.95|P-value:4.16E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:18.10|P-value:1.36E-52 ID:SGTC_445|Compound:e6 berbamine|FD-Score:17.10|P-value:4.87E-47 ID:SGTC_447|Compound:ml7|FD-Score:5.62|P-value:1.21E-6 ID:SGTC_455|Compound:paf C-16|FD-Score:-4.52|P-value:6.48E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:12.50|P-value:4.99E-26 ID:SGTC_528|Compound:3492-0019|FD-Score:8.48|P-value:5.22E-13 ID:SGTC_535|Compound:2293-4129|FD-Score:3.71|P-value:9.41E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.55|P-value:6.79E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:12.80|P-value:3.43E-27 ID:SGTC_658|Compound:3253-0951|FD-Score:3.80|P-value:7.21E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:4.51|P-value:7.79E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:4.34|P-value:1.35E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:10.20|P-value:5.12E-18 ID:SGTC_863|Compound:0466-0191|FD-Score:4.24|P-value:1.86E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:9.71|P-value:1.61E-16 ID:SGTC_986|Compound:1493-0483|FD-Score:5.66|P-value:1.01E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.16|P-value:2.46E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.23|P-value:1.92E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.82|P-value:6.05E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.20|P-value:2.13E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:18.40|P-value:3.38E-54 ID:SGTC_1271|Compound:0832-2808|FD-Score:-4.45|P-value:8.33E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:17.00|P-value:6.42E-47 ID:SGTC_1523|Compound:st012844|FD-Score:-4.36|P-value:1.13E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-5.49|P-value:1.75E-6 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.70|P-value:9.61E-4 ID:SGTC_1665|Compound:st014639|FD-Score:4.53|P-value:7.36E-5 ID:SGTC_1672|Compound:st016598|FD-Score:35.20|P-value:1.47E-193 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.81|P-value:5.33E-7 ID:SGTC_1712|Compound:st032288|FD-Score:8.01|P-value:8.55E-12 ID:SGTC_1750|Compound:st081859|FD-Score:8.87|P-value:4.37E-14 ID:SGTC_1754|Compound:st042065|FD-Score:17.40|P-value:6.61E-49 ID:SGTC_1760|Compound:st045453|FD-Score:30.00|P-value:7.34E-141 ID:SGTC_1781|Compound:st038725|FD-Score:11.10|P-value:7.48E-21 ID:SGTC_1800|Compound:st050079|FD-Score:11.10|P-value:7.38E-21 ID:SGTC_1801|Compound:st050089|FD-Score:24.80|P-value:3.09E-97 ID:SGTC_1803|Compound:st050068|FD-Score:20.80|P-value:4.36E-69 ID:SGTC_1804|Compound:st050076|FD-Score:5.24|P-value:5.46E-6 ID:SGTC_1809|Compound:st050081|FD-Score:4.40|P-value:1.11E-4 ID:SGTC_1818|Compound:st052136|FD-Score:5.26|P-value:4.98E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-3.71|P-value:8.29E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.05|P-value:3.46E-4 ID:SGTC_2006|Compound:4011487|FD-Score:18.70|P-value:2.95E-56 ID:SGTC_2015|Compound:5119600|FD-Score:4.84|P-value:2.44E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.76|P-value:8.04E-4 ID:SGTC_2020|Compound:4017018|FD-Score:5.09|P-value:9.57E-6 ID:SGTC_2021|Compound:4019055|FD-Score:14.90|P-value:3.67E-36 ID:SGTC_2036|Compound:5160441|FD-Score:21.20|P-value:1.39E-71 ID:SGTC_2064|Compound:5220758|FD-Score:3.70|P-value:9.62E-4 ID:SGTC_2090|Compound:5301565|FD-Score:4.43|P-value:1.03E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.24|P-value:1.92E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.49|P-value:8.26E-5 ID:SGTC_2183|Compound:6420625|FD-Score:5.20|P-value:6.51E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:14.40|P-value:6.34E-34 ID:SGTC_2250|Compound:alverine citrate|FD-Score:12.10|P-value:1.74E-24 ID:SGTC_2257|Compound:7960413|FD-Score:14.80|P-value:1.06E-35 ID:SGTC_2373|Compound:9071805|FD-Score:-4.00|P-value:3.50E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.80|P-value:2.87E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.69|P-value:9.96E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.11|P-value:2.89E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.72|P-value:3.29E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.06|P-value:3.36E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:4.29|P-value:1.62E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.02|P-value:3.79E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:5.45|P-value:2.39E-6 ID:SGTC_2790|Compound:5423970|FD-Score:3.91|P-value:5.22E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.96|P-value:3.99E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-5.93|P-value:2.69E-7 ID:SGTC_2852|Compound:9023854|FD-Score:8.84|P-value:5.47E-14 ID:SGTC_2855|Compound:9016525|FD-Score:5.75|P-value:6.87E-7 ID:SGTC_2896|Compound:9052656|FD-Score:6.07|P-value:1.74E-7 ID:SGTC_2902|Compound:5787006|FD-Score:4.00|P-value:4.03E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.80|P-value:6.43E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.99|P-value:3.63E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.86|P-value:5.32E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.91|P-value:5.27E-4 ID:SGTC_3037|Compound:9091026|FD-Score:10.30|P-value:3.34E-18 ID:SGTC_3081|Compound:9117243|FD-Score:5.14|P-value:8.09E-6 ID:SGTC_3100|Compound:9120536|FD-Score:4.04|P-value:3.54E-4 ID:SGTC_3108|Compound:9121785|FD-Score:4.84|P-value:2.48E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-3.91|P-value:4.62E-4 ID:SGTC_3152|Compound:9099253|FD-Score:13.40|P-value:6.99E-30 ID:SGTC_15|Compound:0266-0086|FD-Score:12.60|P-value:1.01E-26 ID:SGTC_43|Compound:0570-0105|FD-Score:4.99|P-value:1.40E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.28|P-value:1.65E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.29|P-value:1.41E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.63|P-value:5.16E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:12.20|P-value:5.32E-25 ID:SGTC_172|Compound:1112-0046|FD-Score:5.46|P-value:2.26E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:8.79|P-value:7.34E-14 ID:SGTC_181|Compound:1447-1644|FD-Score:6.69|P-value:9.39E-9 ID:SGTC_197|Compound:4544-0043|FD-Score:12.90|P-value:6.42E-28 ID:SGTC_207|Compound:4185-0010|FD-Score:10.40|P-value:1.09E-18 ID:SGTC_221|Compound:trifluoperazine|FD-Score:33.60|P-value:4.27E-176 ID:SGTC_232|Compound:clozapine|FD-Score:3.75|P-value:8.33E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.99|P-value:4.13E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:6.45|P-value:2.99E-8 ID:SGTC_301|Compound:4119-0100|FD-Score:5.64|P-value:1.08E-6 ID:SGTC_308|Compound:4092-1169|FD-Score:4.91|P-value:1.90E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:18.10|P-value:8.31E-53 ID:SGTC_314|Compound:1671-0008|FD-Score:5.39|P-value:3.10E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:5.82|P-value:5.14E-7 ID:SGTC_327|Compound:1273-0057|FD-Score:4.42|P-value:1.06E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.32|P-value:5.64E-8 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.95|P-value:4.16E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:18.10|P-value:1.36E-52 ID:SGTC_445|Compound:e6 berbamine|FD-Score:17.10|P-value:4.87E-47 ID:SGTC_447|Compound:ml7|FD-Score:5.62|P-value:1.21E-6 ID:SGTC_455|Compound:paf C-16|FD-Score:-4.52|P-value:6.48E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:12.50|P-value:4.99E-26 ID:SGTC_528|Compound:3492-0019|FD-Score:8.48|P-value:5.22E-13 ID:SGTC_535|Compound:2293-4129|FD-Score:3.71|P-value:9.41E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.55|P-value:6.79E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:12.80|P-value:3.43E-27 ID:SGTC_658|Compound:3253-0951|FD-Score:3.80|P-value:7.21E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:4.51|P-value:7.79E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:4.34|P-value:1.35E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:10.20|P-value:5.12E-18 ID:SGTC_863|Compound:0466-0191|FD-Score:4.24|P-value:1.86E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:9.71|P-value:1.61E-16 ID:SGTC_986|Compound:1493-0483|FD-Score:5.66|P-value:1.01E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.16|P-value:2.46E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.23|P-value:1.92E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:-3.82|P-value:6.05E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.20|P-value:2.13E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:18.40|P-value:3.38E-54 ID:SGTC_1271|Compound:0832-2808|FD-Score:-4.45|P-value:8.33E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:17.00|P-value:6.42E-47 ID:SGTC_1523|Compound:st012844|FD-Score:-4.36|P-value:1.13E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-5.49|P-value:1.75E-6 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.70|P-value:9.61E-4 ID:SGTC_1665|Compound:st014639|FD-Score:4.53|P-value:7.36E-5 ID:SGTC_1672|Compound:st016598|FD-Score:35.20|P-value:1.47E-193 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.81|P-value:5.33E-7 ID:SGTC_1712|Compound:st032288|FD-Score:8.01|P-value:8.55E-12 ID:SGTC_1750|Compound:st081859|FD-Score:8.87|P-value:4.37E-14 ID:SGTC_1754|Compound:st042065|FD-Score:17.40|P-value:6.61E-49 ID:SGTC_1760|Compound:st045453|FD-Score:30.00|P-value:7.34E-141 ID:SGTC_1781|Compound:st038725|FD-Score:11.10|P-value:7.48E-21 ID:SGTC_1800|Compound:st050079|FD-Score:11.10|P-value:7.38E-21 ID:SGTC_1801|Compound:st050089|FD-Score:24.80|P-value:3.09E-97 ID:SGTC_1803|Compound:st050068|FD-Score:20.80|P-value:4.36E-69 ID:SGTC_1804|Compound:st050076|FD-Score:5.24|P-value:5.46E-6 ID:SGTC_1809|Compound:st050081|FD-Score:4.40|P-value:1.11E-4 ID:SGTC_1818|Compound:st052136|FD-Score:5.26|P-value:4.98E-6 ID:SGTC_1904|Compound:st060225|FD-Score:-3.71|P-value:8.29E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.05|P-value:3.46E-4 ID:SGTC_2006|Compound:4011487|FD-Score:18.70|P-value:2.95E-56 ID:SGTC_2015|Compound:5119600|FD-Score:4.84|P-value:2.44E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.76|P-value:8.04E-4 ID:SGTC_2020|Compound:4017018|FD-Score:5.09|P-value:9.57E-6 ID:SGTC_2021|Compound:4019055|FD-Score:14.90|P-value:3.67E-36 ID:SGTC_2036|Compound:5160441|FD-Score:21.20|P-value:1.39E-71 ID:SGTC_2064|Compound:5220758|FD-Score:3.70|P-value:9.62E-4 ID:SGTC_2090|Compound:5301565|FD-Score:4.43|P-value:1.03E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.24|P-value:1.92E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.49|P-value:8.26E-5 ID:SGTC_2183|Compound:6420625|FD-Score:5.20|P-value:6.51E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:14.40|P-value:6.34E-34 ID:SGTC_2250|Compound:alverine citrate|FD-Score:12.10|P-value:1.74E-24 ID:SGTC_2257|Compound:7960413|FD-Score:14.80|P-value:1.06E-35 ID:SGTC_2373|Compound:9071805|FD-Score:-4.00|P-value:3.50E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.80|P-value:2.87E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.69|P-value:9.96E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:4.11|P-value:2.89E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.72|P-value:3.29E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.06|P-value:3.36E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:4.29|P-value:1.62E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.02|P-value:3.79E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:5.45|P-value:2.39E-6 ID:SGTC_2790|Compound:5423970|FD-Score:3.91|P-value:5.22E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.96|P-value:3.99E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-5.93|P-value:2.69E-7 ID:SGTC_2852|Compound:9023854|FD-Score:8.84|P-value:5.47E-14 ID:SGTC_2855|Compound:9016525|FD-Score:5.75|P-value:6.87E-7 ID:SGTC_2896|Compound:9052656|FD-Score:6.07|P-value:1.74E-7 ID:SGTC_2902|Compound:5787006|FD-Score:4.00|P-value:4.03E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.80|P-value:6.43E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.99|P-value:3.63E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.86|P-value:5.32E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.91|P-value:5.27E-4 ID:SGTC_3037|Compound:9091026|FD-Score:10.30|P-value:3.34E-18 ID:SGTC_3081|Compound:9117243|FD-Score:5.14|P-value:8.09E-6 ID:SGTC_3100|Compound:9120536|FD-Score:4.04|P-value:3.54E-4 ID:SGTC_3108|Compound:9121785|FD-Score:4.84|P-value:2.48E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-3.91|P-value:4.62E-4 ID:SGTC_3152|Compound:9099253|FD-Score:13.40|P-value:6.99E-30

Top fitness defect scores for YNL267W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1672 st016598 35.20 6.5 µM 1.47E-193 endomembrane recycling 1 4.87E-272 25.70
2 SGTC_221 trifluoperazine 33.60 10.3 µM 4.27E-176 NEO1-PIK1 2 1.99E-247 15.00
3 SGTC_1760 st045453 30.00 10.4 µM 7.34E-141 NEO1-PIK1 2 8.99E-198 23.20
4 SGTC_1801 st050089 24.80 28.4 µM 3.09E-97 NEO1-PIK1 2 2.70E-136 14.30
5 SGTC_2036 5160441 21.20 105.0 µM 1.39E-71 NEO1 2 3.78E-100 8.32
6 SGTC_1803 st050068 20.80 52.4 µM 4.36E-69 NEO1-PIK1 2 1.25E-96 10.40
7 SGTC_2006 4011487 18.70 200.0 µM 2.95E-56 endomembrane recycling 2 1.49E-78 4.22
8 SGTC_1230 0170-0365 18.40 3.8 µM 3.38E-54 endomembrane recycling 4 1.18E-75 7.46
9 SGTC_313 3474-0040 18.10 5.0 µM 8.31E-53 NEO1-PIK1 2 1.08E-73 12.70
10 SGTC_439 amiodarone 18.10 34.4 µM 1.36E-52 NEO1-PIK1 2 2.17E-73 12.50
11 SGTC_1754 st042065 17.40 16.1 µM 6.61E-49 NEO1-PIK1 2 3.38E-68 4.67
12 SGTC_445 e6 berbamine 17.10 66.0 µM 4.87E-47 NEO1-PIK1 2 1.44E-65 0.49
13 SGTC_1282 0886-0010 17.00 32.4 µM 6.42E-47 endomembrane recycling 1 2.13E-65 8.13
14 SGTC_2021 4019055 14.90 173.0 µM 3.67E-36 endomembrane recycling 2 3.02E-50 1.68
15 SGTC_2257 7960413 14.80 200.0 µM 1.06E-35 NEO1-PIK1 2 1.34E-49 4.00
16 SGTC_2249 haloperidol 14.40 116.4 µM 6.34E-34 ergosterol depletion effects on membrane 5 4.27E-47 1.61
17 SGTC_3152 9099253 13.40 49.5 µM 6.99E-30 NEO1-PIK1 2 2.10E-41 0.55
18 SGTC_197 4544-0043 12.90 41.6 µM 6.42E-28 endomembrane recycling 3 1.22E-38 1.88
19 SGTC_649 1123-0311 12.80 367.0 µM 3.43E-27 endomembrane recycling 2 1.29E-37 3.91
20 SGTC_15 0266-0086 12.60 27.1 µM 1.01E-26 endomembrane recycling 2 5.94E-37 5.43

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.603 0 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.591 7.55E-314 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.590 1.39E-312 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.576 4.26E-295 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.552 9.33E-267 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.520 1.58E-231 YGL161C YIP5 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.520 8.56E-231 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.518 6.26E-229 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.487 3.39E-199 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.484 3.02E-196 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.473 1.06E-185 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.472 4.96E-185 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.466 6.29E-180 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.465 1.35E-178 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.463 4.14E-176 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit