HIPHOP chemogenomics database

YNL268W / LYP1

Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL268W / LYP1

Click on Significant Values for Screen Details

Top fitness defect scores for YNL268W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_451	chloral hydrate	22.60	100.0 µM	1.24E-112		1	7.08E-114
2	SGTC_359	0081-0058	10.00	15.9 µM	1.30E-23	60S ribosome export	3	6.40E-24
3	SGTC_1718	roemerine	8.86	11.9 µM	7.39E-19	redox potentiating	3	4.14E-19
4	SGTC_2759	disulfiram	8.49	3.4 µM	1.77E-17		2	1.03E-17
5	SGTC_3	0833-0587	7.34	95.6 µM	1.68E-13	redox potentiating	4	1.09E-13
6	SGTC_674	0498-0004	7.15	451.0 µM	6.48E-13	heme requiring	2	4.27E-13
7	SGTC_123	0083-0120	6.64	66.7 µM	2.22E-11		16	1.53E-11
8	SGTC_1968	st069590	6.46	43.6 µM	7.70E-11		1	5.38E-11
9	SGTC_1656	st012921	6.45	11.0 µM	7.75E-11		14	5.42E-11
10	SGTC_103	0844-0104	6.04	51.8 µM	1.05E-9	ERAD & cell cycle	76	7.62E-10
11	SGTC_824	1304-0008	5.37	100.0 µM	5.12E-8	DNA damage response	14	3.90E-8
12	SGTC_3141	9094609	5.37	49.5 µM	5.31E-8	iron homeostasis	13	4.04E-8
13	SGTC_688	0527-0193	5.27	473.0 µM	9.14E-8	fatty acid desaturase (OLE1)	5	7.01E-8
14	SGTC_2968	9090663	5.06	33.4 µM	2.68E-7		14	2.08E-7
15	SGTC_1240	0356-0016	4.80	42.1 µM	1.02E-6	mitochondrial response to ROS	18	8.07E-7
16	SGTC_120	rhodamine 6G	4.78	52.3 µM	1.08E-6	mitochondrial processes	15	8.56E-7
17	SGTC_818	4072-2707	4.76	53.5 µM	1.22E-6		4	9.71E-7
18	SGTC_2941	9056145	4.69	11.2 µM	1.69E-6		10	1.35E-6
19	SGTC_2778	tioconazole	4.57	65.1 nM	3.09E-6	ergosterol depletion effects on membrane	45	2.48E-6
20	SGTC_95	0471-0001	4.45	561.1 µM	5.33E-6		17	4.32E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.240	2.55E-45	YPL028W	ERG10	het	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.217	5.85E-37	YIL039W	TED1	hom	Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.170	3.82E-23	YBR024W	SCO2	hom	Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication
0.162	3.28E-21	YDR186C	YDR186C	hom	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.152	7.81E-19	YBR204C	LDH1	hom	Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.123	6.95E-13	YDL217C	TIM22	het	Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.123	7.25E-13	YLR153C	ACS2	het	Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.121	1.72E-12	YGL068W	MNP1	het	Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
0.120	3.10E-12	YFL056C	AAD6	hom	Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.115	3.16E-11	YMR088C	VBA1	hom	Permease of basic amino acids in the vacuolar membrane
0.113	4.67E-11	YAL066W_d	YAL066W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.110	1.41E-10	YML081W	TDA9	hom	DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
0.110	1.80E-10	YIL017C	VID28	hom	GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
0.109	2.60E-10	YMR170C	ALD2	hom	Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
0.107	4.30E-10	YCR024C-A	PMP1	hom	Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication