YNL269W / BSC4

Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL269W / BSC4

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:3.46|P-value:1.27E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.17|P-value:4.06E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.62|P-value:4.94E-7 ID:SGTC_296|Compound:1222-0039|FD-Score:3.36|P-value:1.94E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.12|P-value:4.85E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.68|P-value:5.02E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.19|P-value:3.06E-4 ID:SGTC_442|Compound:cape|FD-Score:-3.76|P-value:2.73E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.82|P-value:2.66E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:3.85|P-value:2.29E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.91|P-value:1.37E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:4.04|P-value:9.37E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.17|P-value:3.98E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.18|P-value:3.82E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-2.91|P-value:8.76E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.52|P-value:1.00E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.94|P-value:8.02E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.08|P-value:5.78E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.11|P-value:5.00E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.79|P-value:3.06E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.77|P-value:3.37E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.93|P-value:1.63E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.48|P-value:1.18E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.02|P-value:5.85E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:-2.95|P-value:7.70E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.49|P-value:1.13E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.04|P-value:6.56E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-3.09|P-value:4.50E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.20|P-value:4.35E-6 ID:SGTC_1915|Compound:st067105|FD-Score:3.15|P-value:4.32E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.31|P-value:2.31E-4 ID:SGTC_2241|Compound:6772625|FD-Score:2.93|P-value:9.72E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-3.82|P-value:2.09E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-3.00|P-value:6.30E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.35|P-value:1.59E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.60|P-value:5.44E-7 ID:SGTC_2366|Compound:9070441|FD-Score:4.76|P-value:2.32E-7 ID:SGTC_2368|Compound:9071271|FD-Score:-3.06|P-value:5.14E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.18|P-value:3.89E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.23|P-value:2.60E-4 ID:SGTC_2625|Compound:euphol|FD-Score:4.33|P-value:2.32E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-3.20|P-value:2.92E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.07|P-value:5.91E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-2.99|P-value:6.53E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.18|P-value:3.93E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.56|P-value:6.98E-7 ID:SGTC_2844|Compound:9010103|FD-Score:3.10|P-value:5.23E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.96|P-value:1.40E-5 ID:SGTC_2889|Compound:9059656|FD-Score:4.03|P-value:1.00E-5 ID:SGTC_2898|Compound:9056270|FD-Score:3.20|P-value:3.62E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.53|P-value:9.36E-5 ID:SGTC_2947|Compound:9072639|FD-Score:4.58|P-value:6.00E-7 ID:SGTC_2964|Compound:9083345|FD-Score:3.13|P-value:4.64E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.67|P-value:5.09E-5 ID:SGTC_2995|Compound:9067767|FD-Score:3.23|P-value:3.23E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.50|P-value:1.08E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-2.88|P-value:9.91E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-5.59|P-value:1.10E-9 ID:SGTC_3136|Compound:9095672|FD-Score:3.49|P-value:1.13E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.39|P-value:1.66E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.08|P-value:4.62E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.06|P-value:6.07E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.11|P-value:5.15E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.46|P-value:1.27E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:3.17|P-value:4.06E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.62|P-value:4.94E-7 ID:SGTC_296|Compound:1222-0039|FD-Score:3.36|P-value:1.94E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.12|P-value:4.85E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.68|P-value:5.02E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.19|P-value:3.06E-4 ID:SGTC_442|Compound:cape|FD-Score:-3.76|P-value:2.73E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.82|P-value:2.66E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:3.85|P-value:2.29E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.91|P-value:1.37E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:4.04|P-value:9.37E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.17|P-value:3.98E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:3.18|P-value:3.82E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-2.91|P-value:8.76E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.52|P-value:1.00E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.94|P-value:8.02E-4 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.08|P-value:5.78E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.11|P-value:5.00E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.79|P-value:3.06E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.77|P-value:3.37E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.93|P-value:1.63E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.48|P-value:1.18E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.02|P-value:5.85E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:-2.95|P-value:7.70E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.49|P-value:1.13E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.04|P-value:6.56E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-3.09|P-value:4.50E-4 ID:SGTC_1856|Compound:st057054|FD-Score:4.20|P-value:4.35E-6 ID:SGTC_1915|Compound:st067105|FD-Score:3.15|P-value:4.32E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.31|P-value:2.31E-4 ID:SGTC_2241|Compound:6772625|FD-Score:2.93|P-value:9.72E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-3.82|P-value:2.09E-5 ID:SGTC_2289|Compound:7946404|FD-Score:-3.00|P-value:6.30E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.35|P-value:1.59E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.60|P-value:5.44E-7 ID:SGTC_2366|Compound:9070441|FD-Score:4.76|P-value:2.32E-7 ID:SGTC_2368|Compound:9071271|FD-Score:-3.06|P-value:5.14E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.18|P-value:3.89E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.23|P-value:2.60E-4 ID:SGTC_2625|Compound:euphol|FD-Score:4.33|P-value:2.32E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-3.20|P-value:2.92E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.07|P-value:5.91E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-2.99|P-value:6.53E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.18|P-value:3.93E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.56|P-value:6.98E-7 ID:SGTC_2844|Compound:9010103|FD-Score:3.10|P-value:5.23E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.96|P-value:1.40E-5 ID:SGTC_2889|Compound:9059656|FD-Score:4.03|P-value:1.00E-5 ID:SGTC_2898|Compound:9056270|FD-Score:3.20|P-value:3.62E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.53|P-value:9.36E-5 ID:SGTC_2947|Compound:9072639|FD-Score:4.58|P-value:6.00E-7 ID:SGTC_2964|Compound:9083345|FD-Score:3.13|P-value:4.64E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.67|P-value:5.09E-5 ID:SGTC_2995|Compound:9067767|FD-Score:3.23|P-value:3.23E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.50|P-value:1.08E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-2.88|P-value:9.91E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-5.59|P-value:1.10E-9 ID:SGTC_3136|Compound:9095672|FD-Score:3.49|P-value:1.13E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.39|P-value:1.66E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.08|P-value:4.62E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.06|P-value:6.07E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.11|P-value:5.15E-4

Top fitness defect scores for YNL269W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2366 9070441 4.76 60.6 µM 2.32E-7 15 9.79E-7
2 SGTC_180 1486-1293 4.62 102.8 µM 4.94E-7 28 1.92E-6
3 SGTC_2331 7980721 4.60 200.0 µM 5.44E-7 12 2.09E-6
4 SGTC_2947 9072639 4.58 7.7 µM 6.00E-7 tubulin folding & SWR complex 26 2.28E-6
5 SGTC_2812 7970281 4.56 58.4 µM 6.98E-7 11 2.61E-6
6 SGTC_2625 euphol 4.33 100.0 µM 2.32E-6 24 7.60E-6
7 SGTC_1856 st057054 4.20 55.7 µM 4.35E-6 23 1.33E-5
8 SGTC_769 0302-0231 4.04 76.0 µM 9.37E-6 37 2.64E-5
9 SGTC_2889 9059656 4.03 52.0 µM 1.00E-5 8 2.81E-5
10 SGTC_2845 9003024 3.96 43.0 µM 1.40E-5 amide catabolism 45 3.78E-5
11 SGTC_1453 4237-0541 3.93 195.0 µM 1.63E-5 heme biosynthesis & mitochondrial translocase 27 4.33E-5
12 SGTC_726 3448-4391 3.85 34.2 µM 2.29E-5 14 5.86E-5
13 SGTC_706 4262-0057 3.82 46.9 µM 2.66E-5 fatty acid desaturase (OLE1) 37 6.69E-5
14 SGTC_1203 3992-3522 3.79 103.0 µM 3.06E-5 43 7.59E-5
15 SGTC_1248 0469-0687 3.77 58.6 µM 3.37E-5 33 8.26E-5
16 SGTC_342 k048-0088 3.68 23.3 µM 5.02E-5 RSC & ERG11 26 1.18E-4
17 SGTC_2976 9009005 3.67 19.5 µM 5.09E-5 35 1.19E-4
18 SGTC_2910 7948405 3.53 26.0 µM 9.36E-5 plasma membrane duress 34 2.06E-4
19 SGTC_1114 scopoletin 3.52 1.7 µM 1.00E-4 28 2.19E-4
20 SGTC_3012 9080433 3.50 71.4 µM 1.08E-4 21 2.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.02E-11 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.114 3.22E-11 YDR250C_d YDR250C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.088 3.32E-7 YGL010W_p YGL010W_p hom Putative protein of unknown function; YGL010W is not an essential gene
0.087 4.23E-7 YMR178W YMR178W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress
0.084 9.93E-7 YLR007W NSE1 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.083 1.54E-6 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.080 3.77E-6 YPL126W NAN1 het U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA
0.079 4.06E-6 YML086C ALO1 hom D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
0.078 5.53E-6 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.076 1.01E-5 YGL021W ALK1 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins
0.074 1.64E-5 YNL261W ORC5 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.074 1.69E-5 YJL131C AIM23 hom Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss
0.074 1.83E-5 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.073 2.22E-5 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.072 2.63E-5 YOR166C SWT1 hom RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain