YNL270C / ALP1

Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL270C / ALP1

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:-3.08|P-value:6.35E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:5.32|P-value:1.22E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.08|P-value:6.34E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.97|P-value:1.59E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:3.63|P-value:7.13E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:2.96|P-value:9.47E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.48|P-value:1.30E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.58|P-value:8.73E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.38|P-value:1.94E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.24|P-value:3.36E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.61|P-value:7.77E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:-3.28|P-value:2.96E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:2.96|P-value:9.42E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.95|P-value:9.89E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.16|P-value:4.66E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.24|P-value:4.40E-6 ID:SGTC_1612|Compound:st002233|FD-Score:3.04|P-value:7.11E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.02|P-value:1.25E-5 ID:SGTC_2003|Compound:4023581|FD-Score:4.92|P-value:1.23E-7 ID:SGTC_2079|Compound:5212404|FD-Score:-3.70|P-value:5.33E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.99|P-value:1.43E-5 ID:SGTC_2334|Compound:9017922|FD-Score:4.75|P-value:3.25E-7 ID:SGTC_2359|Compound:9039622|FD-Score:-3.06|P-value:6.87E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.14|P-value:4.96E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.91|P-value:2.07E-5 ID:SGTC_2363|Compound:9053361|FD-Score:5.94|P-value:2.35E-10 ID:SGTC_2366|Compound:9070441|FD-Score:3.17|P-value:4.41E-4 ID:SGTC_2372|Compound:9071633|FD-Score:-3.15|P-value:4.90E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.37|P-value:2.02E-4 ID:SGTC_2787|Compound:5284540|FD-Score:6.13|P-value:6.42E-11 ID:SGTC_2983|Compound:9022671|FD-Score:3.77|P-value:3.83E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.07|P-value:6.36E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.90|P-value:2.18E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:-3.08|P-value:6.35E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:5.32|P-value:1.22E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.08|P-value:6.34E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.97|P-value:1.59E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:3.63|P-value:7.13E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:2.96|P-value:9.47E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.48|P-value:1.30E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.58|P-value:8.73E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.38|P-value:1.94E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.24|P-value:3.36E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.61|P-value:7.77E-5 ID:SGTC_1114|Compound:scopoletin|FD-Score:-3.28|P-value:2.96E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:2.96|P-value:9.42E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.95|P-value:9.89E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.16|P-value:4.66E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:4.24|P-value:4.40E-6 ID:SGTC_1612|Compound:st002233|FD-Score:3.04|P-value:7.11E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.02|P-value:1.25E-5 ID:SGTC_2003|Compound:4023581|FD-Score:4.92|P-value:1.23E-7 ID:SGTC_2079|Compound:5212404|FD-Score:-3.70|P-value:5.33E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.99|P-value:1.43E-5 ID:SGTC_2334|Compound:9017922|FD-Score:4.75|P-value:3.25E-7 ID:SGTC_2359|Compound:9039622|FD-Score:-3.06|P-value:6.87E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.14|P-value:4.96E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.91|P-value:2.07E-5 ID:SGTC_2363|Compound:9053361|FD-Score:5.94|P-value:2.35E-10 ID:SGTC_2366|Compound:9070441|FD-Score:3.17|P-value:4.41E-4 ID:SGTC_2372|Compound:9071633|FD-Score:-3.15|P-value:4.90E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.37|P-value:2.02E-4 ID:SGTC_2787|Compound:5284540|FD-Score:6.13|P-value:6.42E-11 ID:SGTC_2983|Compound:9022671|FD-Score:3.77|P-value:3.83E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.07|P-value:6.36E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.90|P-value:2.18E-5

Top fitness defect scores for YNL270C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2787 5284540 6.13 71.4 µM 6.42E-11 5 4.29E-10
2 SGTC_2363 9053361 5.94 176.0 µM 2.35E-10 Golgi 7 1.40E-9
3 SGTC_26 0302-0163 5.32 425.2 µM 1.22E-8 heme biosynthesis & mitochondrial translocase 1 5.16E-8
4 SGTC_2003 4023581 4.92 200.0 µM 1.23E-7 cell wall signaling 22 4.27E-7
5 SGTC_2334 9017922 4.75 200.0 µM 3.25E-7 10 1.03E-6
6 SGTC_1301 naphtanilide LB 4.24 4.8 µM 4.40E-6 heme requiring 7 1.12E-5
7 SGTC_1945 st075991 4.02 56.6 µM 1.25E-5 60S ribosome export 16 2.91E-5
8 SGTC_2114 5491910 3.99 81.2 µM 1.43E-5 10 3.28E-5
9 SGTC_50 0929-0078 3.97 56.4 µM 1.59E-5 45 3.62E-5
10 SGTC_2361 9034121 3.91 116.0 µM 2.07E-5 RSC complex & mRNA processing 22 4.61E-5
11 SGTC_2999 9069765 3.90 71.4 µM 2.18E-5 amide catabolism 25 4.82E-5
12 SGTC_2983 9022671 3.77 13.0 µM 3.83E-5 60S ribosome export 14 8.08E-5
13 SGTC_196 k015-0023 3.63 18.1 µM 7.13E-5 PDR1 33 1.43E-4
14 SGTC_403 arphamenine a 3.58 50.0 µM 8.73E-5 60S ribosome export 22 1.72E-4
15 SGTC_275 trichlorophene 3.48 5.7 µM 1.30E-4 mitochondrial stress 256 2.48E-4
16 SGTC_791 1348-1292 3.38 225.0 µM 1.94E-4 60 3.56E-4
17 SGTC_2662 daunorubicin 3.37 22.4 µM 2.02E-4 anthracycline transcription coupled DNA repair 32 3.71E-4
18 SGTC_1029 k015-0030 3.24 64.7 µM 3.36E-4 65 5.90E-4
19 SGTC_2366 9070441 3.17 60.6 µM 4.41E-4 70 7.58E-4
20 SGTC_1223 0764-0573 3.16 147.0 µM 4.66E-4 50 7.96E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 5.04E-14 YLR449W FPR4 hom Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
0.122 1.12E-12 YGR129W SYF2 hom Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest
0.120 3.00E-12 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.108 4.00E-10 YNL007C SIS1 het Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; has similarity to bacterial DnaJ proteins; protein abundance increases in response to DNA replication stress
0.102 3.04E-9 YPL119C DBP1 hom Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress
0.093 5.97E-8 YER022W SRB4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
0.092 8.23E-8 YPL208W RKM1 hom SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp)
0.090 1.79E-7 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.090 1.95E-7 YER075C PTP3 hom Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
0.089 2.58E-7 YDL179W PCL9 hom Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
0.088 3.72E-7 YHR162W MPC2 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium
0.086 6.20E-7 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.084 1.15E-6 YOR242C SSP2 hom Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis
0.081 2.78E-6 YLR409C UTP21 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma
0.080 4.10E-6 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene