YNL271C / BNI1

Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL271C / BNI1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.64|P-value:1.84E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.80|P-value:9.21E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-6.74|P-value:1.13E-8 ID:SGTC_132|Compound:0417-1715|FD-Score:-4.36|P-value:1.46E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:19.30|P-value:3.03E-57 ID:SGTC_185|Compound:k048-0037|FD-Score:-4.69|P-value:4.85E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.79|P-value:8.03E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.71|P-value:5.54E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:3.84|P-value:8.22E-4 ID:SGTC_401|Compound:neomycin|FD-Score:4.73|P-value:5.20E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-5.25|P-value:6.62E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:-4.34|P-value:1.54E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.67|P-value:6.39E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:5.55|P-value:2.55E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:5.68|P-value:1.54E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:5.37|P-value:5.22E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:5.31|P-value:6.60E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:7.10|P-value:2.65E-9 ID:SGTC_630|Compound:4356-0227|FD-Score:4.43|P-value:1.41E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:6.02|P-value:3.78E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:10.70|P-value:7.49E-19 ID:SGTC_711|Compound:k292-0785|FD-Score:4.32|P-value:1.99E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.28|P-value:2.24E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.31|P-value:6.62E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:5.95|P-value:5.09E-7 ID:SGTC_899|Compound:1083-0020|FD-Score:5.13|P-value:1.26E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:6.24|P-value:1.49E-7 ID:SGTC_1000|Compound:4048-0884|FD-Score:-4.52|P-value:8.60E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.38|P-value:1.67E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.25|P-value:2.45E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.18|P-value:3.07E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.84|P-value:8.29E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:5.38|P-value:4.99E-6 ID:SGTC_1488|Compound:4013-0813|FD-Score:4.78|P-value:4.40E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.20|P-value:2.91E-4 ID:SGTC_1652|Compound:st011932|FD-Score:9.00|P-value:6.48E-14 ID:SGTC_1709|Compound:st033179|FD-Score:4.57|P-value:8.85E-5 ID:SGTC_1803|Compound:st050068|FD-Score:4.15|P-value:3.30E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.25|P-value:2.45E-4 ID:SGTC_1870|Compound:st057514|FD-Score:4.78|P-value:4.43E-5 ID:SGTC_1985|Compound:st071382|FD-Score:4.31|P-value:2.08E-4 ID:SGTC_1988|Compound:st071872|FD-Score:-4.00|P-value:4.41E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.98|P-value:4.57E-7 ID:SGTC_2192|Compound:5915882|FD-Score:5.46|P-value:3.73E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.78|P-value:9.90E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.94|P-value:6.16E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.79|P-value:7.96E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.90|P-value:6.23E-7 ID:SGTC_2411|Compound:st077133|FD-Score:5.19|P-value:1.02E-5 ID:SGTC_2415|Compound:st077333|FD-Score:7.18|P-value:1.75E-9 ID:SGTC_2453|Compound:5731132|FD-Score:-4.23|P-value:2.20E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.86|P-value:3.31E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.48|P-value:2.71E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.65|P-value:6.82E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.67|P-value:1.59E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.48|P-value:1.21E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.64|P-value:7.16E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.19|P-value:2.99E-4 ID:SGTC_2912|Compound:7964298|FD-Score:9.73|P-value:5.76E-16 ID:SGTC_3097|Compound:9117246|FD-Score:5.00|P-value:2.06E-5 ID:SGTC_3131|Compound:9127911|FD-Score:4.69|P-value:5.92E-5 ID:SGTC_3165|Compound:9101544|FD-Score:-4.00|P-value:4.45E-4 ID:SGTC_3173|Compound:9105693|FD-Score:4.57|P-value:8.91E-5 ID:SGTC_3245|Compound:9134821|FD-Score:4.05|P-value:4.51E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.85|P-value:6.77E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.92|P-value:5.49E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.64|P-value:1.84E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.80|P-value:9.21E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-6.74|P-value:1.13E-8 ID:SGTC_132|Compound:0417-1715|FD-Score:-4.36|P-value:1.46E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:19.30|P-value:3.03E-57 ID:SGTC_185|Compound:k048-0037|FD-Score:-4.69|P-value:4.85E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.79|P-value:8.03E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.71|P-value:5.54E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:3.84|P-value:8.22E-4 ID:SGTC_401|Compound:neomycin|FD-Score:4.73|P-value:5.20E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-5.25|P-value:6.62E-6 ID:SGTC_567|Compound:1080-0542|FD-Score:-4.34|P-value:1.54E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.67|P-value:6.39E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:5.55|P-value:2.55E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:5.68|P-value:1.54E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:5.37|P-value:5.22E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:5.31|P-value:6.60E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:7.10|P-value:2.65E-9 ID:SGTC_630|Compound:4356-0227|FD-Score:4.43|P-value:1.41E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:6.02|P-value:3.78E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:10.70|P-value:7.49E-19 ID:SGTC_711|Compound:k292-0785|FD-Score:4.32|P-value:1.99E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.28|P-value:2.24E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.31|P-value:6.62E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:5.95|P-value:5.09E-7 ID:SGTC_899|Compound:1083-0020|FD-Score:5.13|P-value:1.26E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:6.24|P-value:1.49E-7 ID:SGTC_1000|Compound:4048-0884|FD-Score:-4.52|P-value:8.60E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:4.38|P-value:1.67E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.25|P-value:2.45E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.18|P-value:3.07E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.84|P-value:8.29E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:5.38|P-value:4.99E-6 ID:SGTC_1488|Compound:4013-0813|FD-Score:4.78|P-value:4.40E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.20|P-value:2.91E-4 ID:SGTC_1652|Compound:st011932|FD-Score:9.00|P-value:6.48E-14 ID:SGTC_1709|Compound:st033179|FD-Score:4.57|P-value:8.85E-5 ID:SGTC_1803|Compound:st050068|FD-Score:4.15|P-value:3.30E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.25|P-value:2.45E-4 ID:SGTC_1870|Compound:st057514|FD-Score:4.78|P-value:4.43E-5 ID:SGTC_1985|Compound:st071382|FD-Score:4.31|P-value:2.08E-4 ID:SGTC_1988|Compound:st071872|FD-Score:-4.00|P-value:4.41E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.98|P-value:4.57E-7 ID:SGTC_2192|Compound:5915882|FD-Score:5.46|P-value:3.73E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.78|P-value:9.90E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.94|P-value:6.16E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.79|P-value:7.96E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.90|P-value:6.23E-7 ID:SGTC_2411|Compound:st077133|FD-Score:5.19|P-value:1.02E-5 ID:SGTC_2415|Compound:st077333|FD-Score:7.18|P-value:1.75E-9 ID:SGTC_2453|Compound:5731132|FD-Score:-4.23|P-value:2.20E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.86|P-value:3.31E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.48|P-value:2.71E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.65|P-value:6.82E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:5.67|P-value:1.59E-6 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.48|P-value:1.21E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.64|P-value:7.16E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.19|P-value:2.99E-4 ID:SGTC_2912|Compound:7964298|FD-Score:9.73|P-value:5.76E-16 ID:SGTC_3097|Compound:9117246|FD-Score:5.00|P-value:2.06E-5 ID:SGTC_3131|Compound:9127911|FD-Score:4.69|P-value:5.92E-5 ID:SGTC_3165|Compound:9101544|FD-Score:-4.00|P-value:4.45E-4 ID:SGTC_3173|Compound:9105693|FD-Score:4.57|P-value:8.91E-5 ID:SGTC_3245|Compound:9134821|FD-Score:4.05|P-value:4.51E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.85|P-value:6.77E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-3.92|P-value:5.49E-4

Top fitness defect scores for YNL271C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 19.30 40.9 µM 3.03E-57 cell wall 7 3.18E-83
2 SGTC_673 1082-0474 10.70 110.0 µM 7.49E-19 RSC complex & mRNA processing 7 6.61E-27
3 SGTC_2912 7964298 9.73 10.9 µM 5.76E-16 cell wall 17 1.12E-22
4 SGTC_1652 st011932 9.00 78.0 µM 6.48E-14 RSC complex & mRNA processing 1 1.13E-19
5 SGTC_2415 st077333 7.18 57.7 µM 1.75E-9 7 3.40E-13
6 SGTC_620 0109-0052 7.10 432.0 µM 2.65E-9 2 6.25E-13
7 SGTC_951 1171-0579 6.24 82.7 µM 1.49E-7 cell wall 29 2.25E-10
8 SGTC_631 k072-0230 6.02 41.5 µM 3.78E-7 60S ribosome export 1 8.69E-10
9 SGTC_2021 4019055 5.98 173.0 µM 4.57E-7 endomembrane recycling 39 1.15E-9
10 SGTC_896 0964-0007 5.95 44.5 µM 5.09E-7 2 1.34E-9
11 SGTC_2406 ethylparaben 5.90 405.7 µM 6.23E-7 11 1.80E-9
12 SGTC_576 1073-0113 5.68 22.7 µM 1.54E-6 redox potentiating 24 6.76E-9
13 SGTC_2633 5,7-dihydroxyisoflavone 5.67 100.0 µM 1.59E-6 7 7.04E-9
14 SGTC_58 0957-0393 5.64 9.0 µM 1.84E-6 cell wall 231 8.69E-9
15 SGTC_575 k072-0246 5.55 11.9 µM 2.55E-6 7 1.40E-8
16 SGTC_2192 5915882 5.46 198.5 µM 3.73E-6 RNA processing & uracil transport 17 2.43E-8
17 SGTC_1483 3453-0561 5.38 55.9 µM 4.99E-6 4 3.72E-8
18 SGTC_582 0987-0078 5.37 156.0 µM 5.22E-6 calcium & mitochondrial duress 31 3.97E-8
19 SGTC_586 0957-0265 5.31 8.2 µM 6.60E-6 cell wall 24 5.59E-8
20 SGTC_829 1635-0120 5.31 117.0 µM 6.62E-6 DNA damage response 15 5.61E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.305 4.33E-73 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.278 1.32E-60 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.243 2.13E-46 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.243 2.85E-46 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.239 7.52E-45 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.238 2.12E-44 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.232 3.92E-42 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.230 2.19E-41 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.229 3.66E-41 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.227 2.04E-40 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.223 6.57E-39 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.222 8.45E-39 YBL031W SHE1 hom Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function
0.220 5.40E-38 YDR540C IRC4 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.220 6.34E-38 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.216 8.88E-37 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome