YNL276C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL276C / YNL276C

Click on Significant Values for Screen Details ID:SGTC_205|Compound:1486-1330|FD-Score:-3.65|P-value:6.07E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:-2.98|P-value:8.21E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:5.17|P-value:4.18E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:3.61|P-value:9.32E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:3.36|P-value:2.60E-4 ID:SGTC_448|Compound:monastrol|FD-Score:3.31|P-value:3.08E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.24|P-value:3.17E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:4.83|P-value:2.77E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:3.11|P-value:6.69E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-2.97|P-value:8.66E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.07|P-value:7.77E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.53|P-value:1.32E-6 ID:SGTC_929|Compound:2805-0021|FD-Score:3.20|P-value:4.70E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-4.51|P-value:1.06E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.89|P-value:2.89E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.63|P-value:8.84E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.46|P-value:1.75E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.31|P-value:2.43E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.06|P-value:6.20E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.88|P-value:3.00E-5 ID:SGTC_1625|Compound:st003711|FD-Score:3.83|P-value:3.64E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.48|P-value:1.62E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.98|P-value:1.88E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.10|P-value:5.28E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.13|P-value:4.75E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.50|P-value:1.51E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.32|P-value:2.33E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.33|P-value:2.85E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-4.36|P-value:2.24E-6 ID:SGTC_2069|Compound:5228469|FD-Score:3.04|P-value:8.44E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-2.93|P-value:9.81E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.13|P-value:6.14E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.84|P-value:3.52E-5 ID:SGTC_2398|Compound:5228213|FD-Score:6.04|P-value:1.74E-10 ID:SGTC_2436|Compound:5633522|FD-Score:4.03|P-value:1.53E-5 ID:SGTC_2451|Compound:5856223|FD-Score:5.65|P-value:2.27E-9 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-2.99|P-value:7.90E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.14|P-value:5.82E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.22|P-value:3.08E-8 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.16|P-value:5.47E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.06|P-value:6.25E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.38|P-value:2.34E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-2.95|P-value:9.20E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.25|P-value:3.96E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.34|P-value:2.14E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.50|P-value:1.59E-6 ID:SGTC_205|Compound:1486-1330|FD-Score:-3.65|P-value:6.07E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:-2.98|P-value:8.21E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:5.17|P-value:4.18E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:3.61|P-value:9.32E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:3.36|P-value:2.60E-4 ID:SGTC_448|Compound:monastrol|FD-Score:3.31|P-value:3.08E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.24|P-value:3.17E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:4.83|P-value:2.77E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:3.11|P-value:6.69E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-2.97|P-value:8.66E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.07|P-value:7.77E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.53|P-value:1.32E-6 ID:SGTC_929|Compound:2805-0021|FD-Score:3.20|P-value:4.70E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-4.51|P-value:1.06E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.89|P-value:2.89E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.63|P-value:8.84E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.46|P-value:1.75E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.31|P-value:2.43E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.06|P-value:6.20E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.88|P-value:3.00E-5 ID:SGTC_1625|Compound:st003711|FD-Score:3.83|P-value:3.64E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.48|P-value:1.62E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.98|P-value:1.88E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.10|P-value:5.28E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.13|P-value:4.75E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.50|P-value:1.51E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.32|P-value:2.33E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.33|P-value:2.85E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-4.36|P-value:2.24E-6 ID:SGTC_2069|Compound:5228469|FD-Score:3.04|P-value:8.44E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-2.93|P-value:9.81E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.13|P-value:6.14E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.84|P-value:3.52E-5 ID:SGTC_2398|Compound:5228213|FD-Score:6.04|P-value:1.74E-10 ID:SGTC_2436|Compound:5633522|FD-Score:4.03|P-value:1.53E-5 ID:SGTC_2451|Compound:5856223|FD-Score:5.65|P-value:2.27E-9 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-2.99|P-value:7.90E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.14|P-value:5.82E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.22|P-value:3.08E-8 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.16|P-value:5.47E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.06|P-value:6.25E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.38|P-value:2.34E-4 ID:SGTC_2974|Compound:9094440|FD-Score:-2.95|P-value:9.20E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.25|P-value:3.96E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.34|P-value:2.14E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.50|P-value:1.59E-6

Top fitness defect scores for YNL276C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2398 5228213 6.04 48.8 µM 1.74E-10 iron homeostasis 7 7.48E-10
2 SGTC_2451 5856223 5.65 45.7 µM 2.27E-9 3 8.04E-9
3 SGTC_2688 kanamycin b 5.22 96.7 µM 3.08E-8 calcium & mitochondrial duress 226 8.95E-8
4 SGTC_302 1094-0063 5.17 18.9 µM 4.18E-8 1 1.19E-7
5 SGTC_461 N-acetylfarnesylcysteine 4.83 136.0 µM 2.77E-7 1 6.84E-7
6 SGTC_922 1866-0035 4.53 480.0 µM 1.32E-6 excess fatty acid 33 2.90E-6
7 SGTC_3280 9140961 4.50 49.5 µM 1.59E-6 60S ribosome export 9 3.46E-6
8 SGTC_2436 5633522 4.03 8.1 µM 1.53E-5 13 2.83E-5
9 SGTC_1713 st033146 3.98 12.8 µM 1.88E-5 26 3.41E-5
10 SGTC_1227 3909-8010 3.89 46.6 µM 2.89E-5 21 5.09E-5
11 SGTC_1568 digitonin 3.88 820.0 nM 3.00E-5 sphingolipid biosynthesis & PDR1 35 5.28E-5
12 SGTC_2348 9022543 3.84 33.4 µM 3.52E-5 mitochondrial processes 28 6.13E-5
13 SGTC_1625 st003711 3.83 30.1 µM 3.64E-5 calcium & mitochondrial duress 39 6.31E-5
14 SGTC_1339 1486-1321 3.63 22.7 µM 8.84E-5 ERG2 33 1.44E-4
15 SGTC_310 1273-0058 3.61 1.1 µM 9.32E-5 mitochondrial stress 272 1.51E-4
16 SGTC_1920 st075728 3.50 45.7 µM 1.51E-4 43 2.36E-4
17 SGTC_1635 st007035 3.48 42.4 µM 1.62E-4 253 2.53E-4
18 SGTC_1453 4237-0541 3.46 195.0 µM 1.75E-4 heme biosynthesis & mitochondrial translocase 40 2.71E-4
19 SGTC_2926 9010726 3.38 65.2 µM 2.34E-4 46 3.56E-4
20 SGTC_380 3970-0968 3.36 6.0 µM 2.60E-4 28 3.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 2.21E-17 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.143 7.22E-17 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.134 5.25E-15 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.119 4.74E-12 YNR020C ATP23 hom Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p
0.116 1.36E-11 YEL005C VAB2 hom Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter
0.116 1.57E-11 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.109 2.28E-10 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.108 3.19E-10 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.108 3.22E-10 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.107 5.35E-10 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.105 1.02E-9 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.103 1.88E-9 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.103 1.91E-9 YNL284C MRPL10 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
0.102 2.87E-9 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.102 3.07E-9 YGR237C_p YGR237C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm