YNL277W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL277W-A / YNL277W-A

Click on Significant Values for Screen Details ID:SGTC_236|Compound:1509-0011|FD-Score:3.37|P-value:5.56E-5 ID:SGTC_280|Compound:3448-3607|FD-Score:2.95|P-value:3.62E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:2.91|P-value:4.15E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:2.73|P-value:8.50E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.47|P-value:3.37E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:5.42|P-value:2.59E-10 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.06|P-value:2.24E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.68|P-value:1.22E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.27|P-value:8.59E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.21|P-value:1.17E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.04|P-value:2.57E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.51|P-value:2.83E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.83|P-value:5.90E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.77|P-value:7.62E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.02|P-value:2.69E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.23|P-value:1.05E-4 ID:SGTC_1735|Compound:st034310|FD-Score:2.73|P-value:8.78E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.40|P-value:4.83E-5 ID:SGTC_1977|Compound:st070720|FD-Score:3.62|P-value:1.61E-5 ID:SGTC_2097|Compound:5376186|FD-Score:3.17|P-value:1.35E-4 ID:SGTC_2111|Compound:5486399|FD-Score:-3.52|P-value:2.81E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-2.71|P-value:9.70E-4 ID:SGTC_2255|Compound:7941087|FD-Score:2.69|P-value:9.99E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.05|P-value:2.32E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.89|P-value:4.64E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.87|P-value:5.10E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.72|P-value:9.69E-6 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.61|P-value:1.77E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-5.88|P-value:8.31E-12 ID:SGTC_2586|Compound:curcumin|FD-Score:2.78|P-value:7.13E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.68|P-value:3.96E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.31|P-value:7.46E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-2.91|P-value:4.35E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.19|P-value:1.23E-4 ID:SGTC_2808|Compound:7946468|FD-Score:5.42|P-value:2.55E-10 ID:SGTC_2883|Compound:9059145|FD-Score:-3.60|P-value:1.94E-5 ID:SGTC_2886|Compound:9058944|FD-Score:3.19|P-value:1.29E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.38|P-value:5.31E-5 ID:SGTC_2891|Compound:9063876|FD-Score:4.49|P-value:1.26E-7 ID:SGTC_2894|Compound:9048625|FD-Score:3.51|P-value:2.85E-5 ID:SGTC_2898|Compound:9056270|FD-Score:4.59|P-value:7.22E-8 ID:SGTC_2899|Compound:9053889|FD-Score:4.99|P-value:5.19E-9 ID:SGTC_2979|Compound:9012552|FD-Score:-4.02|P-value:2.08E-6 ID:SGTC_2984|Compound:9022109|FD-Score:-2.91|P-value:4.33E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.24|P-value:9.90E-5 ID:SGTC_2987|Compound:9018338|FD-Score:-2.91|P-value:4.35E-4 ID:SGTC_2995|Compound:9067767|FD-Score:2.69|P-value:9.92E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.37|P-value:5.56E-5 ID:SGTC_280|Compound:3448-3607|FD-Score:2.95|P-value:3.62E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:2.91|P-value:4.15E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:2.73|P-value:8.50E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.47|P-value:3.37E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:5.42|P-value:2.59E-10 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.06|P-value:2.24E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.68|P-value:1.22E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.27|P-value:8.59E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.21|P-value:1.17E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.04|P-value:2.57E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.51|P-value:2.83E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.83|P-value:5.90E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.77|P-value:7.62E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.02|P-value:2.69E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.23|P-value:1.05E-4 ID:SGTC_1735|Compound:st034310|FD-Score:2.73|P-value:8.78E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.40|P-value:4.83E-5 ID:SGTC_1977|Compound:st070720|FD-Score:3.62|P-value:1.61E-5 ID:SGTC_2097|Compound:5376186|FD-Score:3.17|P-value:1.35E-4 ID:SGTC_2111|Compound:5486399|FD-Score:-3.52|P-value:2.81E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-2.71|P-value:9.70E-4 ID:SGTC_2255|Compound:7941087|FD-Score:2.69|P-value:9.99E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.05|P-value:2.32E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.89|P-value:4.64E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.87|P-value:5.10E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.72|P-value:9.69E-6 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.61|P-value:1.77E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-5.88|P-value:8.31E-12 ID:SGTC_2586|Compound:curcumin|FD-Score:2.78|P-value:7.13E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.68|P-value:3.96E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.31|P-value:7.46E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-2.91|P-value:4.35E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.19|P-value:1.23E-4 ID:SGTC_2808|Compound:7946468|FD-Score:5.42|P-value:2.55E-10 ID:SGTC_2883|Compound:9059145|FD-Score:-3.60|P-value:1.94E-5 ID:SGTC_2886|Compound:9058944|FD-Score:3.19|P-value:1.29E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.38|P-value:5.31E-5 ID:SGTC_2891|Compound:9063876|FD-Score:4.49|P-value:1.26E-7 ID:SGTC_2894|Compound:9048625|FD-Score:3.51|P-value:2.85E-5 ID:SGTC_2898|Compound:9056270|FD-Score:4.59|P-value:7.22E-8 ID:SGTC_2899|Compound:9053889|FD-Score:4.99|P-value:5.19E-9 ID:SGTC_2979|Compound:9012552|FD-Score:-4.02|P-value:2.08E-6 ID:SGTC_2984|Compound:9022109|FD-Score:-2.91|P-value:4.33E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.24|P-value:9.90E-5 ID:SGTC_2987|Compound:9018338|FD-Score:-2.91|P-value:4.35E-4 ID:SGTC_2995|Compound:9067767|FD-Score:2.69|P-value:9.92E-4

Top fitness defect scores for YNL277W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2808 7946468 5.42 45.5 µM 2.55E-10 10 2.97E-8
2 SGTC_769 0302-0231 5.42 76.0 µM 2.59E-10 11 3.02E-8
3 SGTC_2899 9053889 4.99 58.4 µM 5.19E-9 2 3.00E-7
4 SGTC_2592 piperlongumine 4.68 83.3 µM 3.96E-8 TSC3-RPN4 16 1.43E-6
5 SGTC_2898 9056270 4.59 58.4 µM 7.22E-8 3 2.26E-6
6 SGTC_2891 9063876 4.49 19.5 µM 1.26E-7 3 3.48E-6
7 SGTC_2576 guaiol 3.72 23.1 µM 9.69E-6 27 9.82E-5
8 SGTC_1081 sertraline 3.68 6.0 µM 1.22E-5 60S ribosome export 39 1.17E-4
9 SGTC_1977 st070720 3.62 65.3 µM 1.61E-5 16 1.45E-4
10 SGTC_1388 3346-4487 3.51 254.0 µM 2.83E-5 38 2.24E-4
11 SGTC_2894 9048625 3.51 32.5 µM 2.85E-5 24 2.26E-4
12 SGTC_740 k014-0057 3.47 261.0 µM 3.37E-5 42 2.57E-4
13 SGTC_1938 st074717 3.40 56.4 µM 4.83E-5 20 3.39E-4
14 SGTC_2890 9046729 3.38 58.4 µM 5.31E-5 Golgi 37 3.65E-4
15 SGTC_236 1509-0011 3.37 5.3 µM 5.56E-5 430 3.78E-4
16 SGTC_2752 diclazuril 3.31 33.1 µM 7.46E-5 173 4.74E-4
17 SGTC_1087 pterostilbene 3.27 9.1 µM 8.59E-5 58 5.29E-4
18 SGTC_2986 9022445 3.24 71.4 µM 9.90E-5 36 5.90E-4
19 SGTC_1635 st007035 3.23 42.4 µM 1.05E-4 268 6.16E-4
20 SGTC_1214 0358-0031 3.21 63.7 µM 1.17E-4 45 6.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 1.77E-29 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.183 1.44E-26 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.182 1.61E-26 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.178 2.10E-25 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.172 7.85E-24 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.167 2.26E-22 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.167 2.63E-22 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.166 3.76E-22 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.166 4.64E-22 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.165 6.59E-22 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.165 8.71E-22 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.162 4.91E-21 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.161 7.34E-21 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.161 8.31E-21 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.158 2.80E-20 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding