YNL278W / CAF120

Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL278W / CAF120

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:-3.39|P-value:2.63E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.09|P-value:6.90E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.71|P-value:5.92E-7 ID:SGTC_71|Compound:0417-1750|FD-Score:3.74|P-value:5.56E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:3.89|P-value:2.98E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.44|P-value:1.88E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.60|P-value:9.77E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.38|P-value:2.39E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.87|P-value:3.25E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:3.46|P-value:1.72E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.29|P-value:3.93E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:4.35|P-value:3.59E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.28|P-value:4.03E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.92|P-value:2.50E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.42|P-value:2.05E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.00|P-value:9.48E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.00|P-value:1.79E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.11|P-value:6.37E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.04|P-value:8.24E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.02|P-value:8.85E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.16|P-value:5.50E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.14|P-value:5.81E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.84|P-value:3.63E-5 ID:SGTC_1870|Compound:st057514|FD-Score:3.04|P-value:8.27E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.53|P-value:1.31E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.51|P-value:1.44E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:4.01|P-value:1.68E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-3.04|P-value:9.46E-4 ID:SGTC_2069|Compound:5228469|FD-Score:4.34|P-value:3.69E-6 ID:SGTC_2143|Compound:5623677|FD-Score:3.39|P-value:2.25E-4 ID:SGTC_2148|Compound:5546263|FD-Score:-3.61|P-value:1.11E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.13|P-value:1.01E-5 ID:SGTC_2162|Compound:5663267|FD-Score:3.32|P-value:3.00E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.04|P-value:8.22E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.16|P-value:5.49E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.13|P-value:6.89E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.44|P-value:1.89E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.57|P-value:1.33E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.17|P-value:5.24E-4 ID:SGTC_2781|Compound:5567276|FD-Score:5.43|P-value:1.05E-8 ID:SGTC_2788|Compound:5282734|FD-Score:3.93|P-value:2.45E-5 ID:SGTC_2789|Compound:5281112|FD-Score:3.12|P-value:6.27E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.22|P-value:4.29E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.27|P-value:4.15E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-4.78|P-value:4.81E-7 ID:SGTC_3180|Compound:9109287|FD-Score:3.19|P-value:4.92E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.72|P-value:7.02E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:-3.39|P-value:2.63E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.09|P-value:6.90E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.71|P-value:5.92E-7 ID:SGTC_71|Compound:0417-1750|FD-Score:3.74|P-value:5.56E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:3.89|P-value:2.98E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.44|P-value:1.88E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.60|P-value:9.77E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.38|P-value:2.39E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:3.87|P-value:3.25E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:3.46|P-value:1.72E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.29|P-value:3.93E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:4.35|P-value:3.59E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.28|P-value:4.03E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.92|P-value:2.50E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.42|P-value:2.05E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.00|P-value:9.48E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.00|P-value:1.79E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.11|P-value:6.37E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.04|P-value:8.24E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.02|P-value:8.85E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.16|P-value:5.50E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.14|P-value:5.81E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.84|P-value:3.63E-5 ID:SGTC_1870|Compound:st057514|FD-Score:3.04|P-value:8.27E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.53|P-value:1.31E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.51|P-value:1.44E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:4.01|P-value:1.68E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-3.04|P-value:9.46E-4 ID:SGTC_2069|Compound:5228469|FD-Score:4.34|P-value:3.69E-6 ID:SGTC_2143|Compound:5623677|FD-Score:3.39|P-value:2.25E-4 ID:SGTC_2148|Compound:5546263|FD-Score:-3.61|P-value:1.11E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.13|P-value:1.01E-5 ID:SGTC_2162|Compound:5663267|FD-Score:3.32|P-value:3.00E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.04|P-value:8.22E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.16|P-value:5.49E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.13|P-value:6.89E-4 ID:SGTC_2556|Compound:citropten|FD-Score:3.44|P-value:1.89E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.57|P-value:1.33E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.17|P-value:5.24E-4 ID:SGTC_2781|Compound:5567276|FD-Score:5.43|P-value:1.05E-8 ID:SGTC_2788|Compound:5282734|FD-Score:3.93|P-value:2.45E-5 ID:SGTC_2789|Compound:5281112|FD-Score:3.12|P-value:6.27E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.22|P-value:4.29E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.27|P-value:4.15E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-4.78|P-value:4.81E-7 ID:SGTC_3180|Compound:9109287|FD-Score:3.19|P-value:4.92E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.72|P-value:7.02E-5

Top fitness defect scores for YNL278W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2781 5567276 5.43 71.4 µM 1.05E-8 17 2.80E-8
2 SGTC_70 0141-0289 4.71 43.3 µM 5.92E-7 mitochondrial stress 123 1.26E-6
3 SGTC_689 0833-0039 4.35 98.0 µM 3.59E-6 ergosterol depletion effects on membrane 27 6.92E-6
4 SGTC_2069 5228469 4.34 200.0 µM 3.69E-6 8 7.11E-6
5 SGTC_2149 5554786 4.13 194.8 µM 1.01E-5 cell wall signaling 31 1.84E-5
6 SGTC_1955 wogonin 4.01 32.4 µM 1.68E-5 18 2.97E-5
7 SGTC_1217 1183-1422 4.00 255.0 µM 1.79E-5 10 3.16E-5
8 SGTC_2788 5282734 3.93 71.4 µM 2.45E-5 48 4.25E-5
9 SGTC_1031 k035-0009 3.92 16.0 µM 2.50E-5 33 4.34E-5
10 SGTC_178 4092-0806 3.89 87.5 µM 2.98E-5 ergosterol depletion effects on membrane 102 5.11E-5
11 SGTC_602 3130-1533 3.87 38.1 µM 3.25E-5 19 5.55E-5
12 SGTC_1679 4130-1276 3.84 6.7 µM 3.63E-5 Golgi 66 6.16E-5
13 SGTC_71 0417-1750 3.74 47.8 µM 5.56E-5 Golgi 51 9.21E-5
14 SGTC_253 dyclonine 3.60 31.2 µM 9.77E-5 amide catabolism 36 1.57E-4
15 SGTC_1879 gemcitabine 3.53 100.0 µM 1.31E-4 24 2.07E-4
16 SGTC_1893 st059353 3.51 36.1 µM 1.44E-4 39 2.27E-4
17 SGTC_612 0302-0167 3.46 22.4 µM 1.72E-4 copper-dependent oxidative stress 57 2.67E-4
18 SGTC_217 ketoconazole 3.44 989.0 nM 1.88E-4 ergosterol depletion effects on membrane 43 2.91E-4
19 SGTC_2556 citropten 3.44 84.6 µM 1.89E-4 47 2.92E-4
20 SGTC_1040 k898-0338 3.42 155.0 µM 2.05E-4 33 3.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 7.44E-10 YDR451C YHP1 hom Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication
0.101 4.73E-9 YBR102C EXO84 het Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
0.098 1.11E-8 YGR289C MAL11 hom Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization
0.097 1.92E-8 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.092 8.01E-8 YJL078C PRY3 hom Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
0.092 8.68E-8 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.092 8.68E-8 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.47E-7 YOR204W DED1 het ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility
0.085 7.68E-7 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.085 8.14E-7 YCL031C RRP7 het Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress
0.083 1.56E-6 YNL299W TRF5 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p
0.082 2.03E-6 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.081 2.95E-6 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.078 5.41E-6 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.078 5.69E-6 YDR439W LRS4 hom Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation