YNL279W / PRM1

Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL279W / PRM1

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:4.62|P-value:1.77E-6 ID:SGTC_23|Compound:0213-0011|FD-Score:3.38|P-value:3.48E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.07|P-value:1.92E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.89|P-value:4.24E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:4.41|P-value:4.90E-6 ID:SGTC_218|Compound:alverine citrate|FD-Score:5.50|P-value:1.69E-8 ID:SGTC_284|Compound:0988-0104|FD-Score:3.82|P-value:6.55E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.09|P-value:8.96E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.06|P-value:9.71E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.43|P-value:2.93E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.18|P-value:6.41E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.33|P-value:4.31E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.86|P-value:5.42E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.37|P-value:3.23E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.23|P-value:6.03E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.15|P-value:7.90E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.15|P-value:8.13E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.23|P-value:6.08E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.03|P-value:2.26E-7 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.37|P-value:5.92E-6 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.42|P-value:3.06E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.36|P-value:6.16E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.89|P-value:4.23E-5 ID:SGTC_1814|Compound:st052110|FD-Score:3.36|P-value:3.84E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.15|P-value:8.10E-4 ID:SGTC_1992|Compound:st073643|FD-Score:5.13|P-value:1.28E-7 ID:SGTC_2159|Compound:5658611|FD-Score:4.10|P-value:1.94E-5 ID:SGTC_2176|Compound:5809774|FD-Score:3.17|P-value:7.56E-4 ID:SGTC_2187|Compound:6125751|FD-Score:4.84|P-value:5.98E-7 ID:SGTC_2299|Compound:7976368|FD-Score:4.11|P-value:1.88E-5 ID:SGTC_2351|Compound:9026858|FD-Score:3.17|P-value:7.38E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.57|P-value:1.74E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.37|P-value:3.63E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.21|P-value:6.63E-4 ID:SGTC_2470|Compound:5664817|FD-Score:6.06|P-value:5.67E-10 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.59|P-value:1.73E-6 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.12|P-value:8.83E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.46|P-value:2.68E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.45|P-value:3.98E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:7.55|P-value:1.73E-14 ID:SGTC_2791|Compound:5663188|FD-Score:3.64|P-value:1.30E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.20|P-value:1.28E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-3.09|P-value:8.68E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.54|P-value:1.92E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.22|P-value:6.29E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:4.62|P-value:1.77E-6 ID:SGTC_23|Compound:0213-0011|FD-Score:3.38|P-value:3.48E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.07|P-value:1.92E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.89|P-value:4.24E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:4.41|P-value:4.90E-6 ID:SGTC_218|Compound:alverine citrate|FD-Score:5.50|P-value:1.69E-8 ID:SGTC_284|Compound:0988-0104|FD-Score:3.82|P-value:6.55E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.09|P-value:8.96E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.06|P-value:9.71E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.43|P-value:2.93E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:-3.18|P-value:6.41E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:3.33|P-value:4.31E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.86|P-value:5.42E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.37|P-value:3.23E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.23|P-value:6.03E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.15|P-value:7.90E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.15|P-value:8.13E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.23|P-value:6.08E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.03|P-value:2.26E-7 ID:SGTC_1405|Compound:3909-7894|FD-Score:4.37|P-value:5.92E-6 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.42|P-value:3.06E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.36|P-value:6.16E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.89|P-value:4.23E-5 ID:SGTC_1814|Compound:st052110|FD-Score:3.36|P-value:3.84E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.15|P-value:8.10E-4 ID:SGTC_1992|Compound:st073643|FD-Score:5.13|P-value:1.28E-7 ID:SGTC_2159|Compound:5658611|FD-Score:4.10|P-value:1.94E-5 ID:SGTC_2176|Compound:5809774|FD-Score:3.17|P-value:7.56E-4 ID:SGTC_2187|Compound:6125751|FD-Score:4.84|P-value:5.98E-7 ID:SGTC_2299|Compound:7976368|FD-Score:4.11|P-value:1.88E-5 ID:SGTC_2351|Compound:9026858|FD-Score:3.17|P-value:7.38E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.57|P-value:1.74E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.37|P-value:3.63E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.21|P-value:6.63E-4 ID:SGTC_2470|Compound:5664817|FD-Score:6.06|P-value:5.67E-10 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.59|P-value:1.73E-6 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.12|P-value:8.83E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.46|P-value:2.68E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.45|P-value:3.98E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:7.55|P-value:1.73E-14 ID:SGTC_2791|Compound:5663188|FD-Score:3.64|P-value:1.30E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.20|P-value:1.28E-5 ID:SGTC_2854|Compound:9024559|FD-Score:-3.09|P-value:8.68E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.54|P-value:1.92E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.22|P-value:6.29E-4

Top fitness defect scores for YNL279W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2627 acetyl isogambogic acid 7.55 100.0 µM 1.73E-14 TSC3-RPN4 6 2.25E-14
2 SGTC_2470 5664817 6.06 21.7 µM 5.67E-10 2 6.61E-10
3 SGTC_218 alverine citrate 5.50 93.8 µM 1.69E-8 fatty acid desaturase (OLE1) 16 1.90E-8
4 SGTC_1992 st073643 5.13 23.3 µM 1.28E-7 mitochondrial processes 3 1.42E-7
5 SGTC_1279 0874-0590 5.03 65.2 µM 2.26E-7 16 2.48E-7
6 SGTC_2187 6125751 4.84 200.0 µM 5.98E-7 RSC complex & mRNA processing 5 6.49E-7
7 SGTC_19 0279-0214 4.62 38.4 µM 1.77E-6 TRP & mitochondrial translation 26 1.90E-6
8 SGTC_2588 indole-3-carbinol 4.45 100.0 µM 3.98E-6 26 4.24E-6
9 SGTC_139 0099-0334 4.41 718.6 µM 4.90E-6 16 5.21E-6
10 SGTC_1405 3909-7894 4.37 12.0 µM 5.92E-6 60S ribosome export 9 6.29E-6
11 SGTC_1559 coumarin 343 4.36 70.1 µM 6.16E-6 7 6.54E-6
12 SGTC_2825 7998094 4.20 58.4 µM 1.28E-5 fatty acid desaturase (OLE1) 26 1.35E-5
13 SGTC_2299 7976368 4.11 114.9 µM 1.88E-5 26 1.97E-5
14 SGTC_2159 5658611 4.10 73.8 µM 1.94E-5 9 2.03E-5
15 SGTC_751 0833-0568 3.86 350.0 µM 5.42E-5 23 5.63E-5
16 SGTC_284 0988-0104 3.82 32.6 µM 6.55E-5 heme requiring 13 6.80E-5
17 SGTC_2791 5663188 3.64 71.4 µM 1.30E-4 RPP1 & pyrimidine depletion 28 1.35E-4
18 SGTC_2368 9071271 3.57 200.0 µM 1.74E-4 48 1.79E-4
19 SGTC_2921 7974240 3.54 10.7 µM 1.92E-4 71 1.98E-4
20 SGTC_2584 androsterone 3.46 48.7 µM 2.68E-4 cell wall 161 2.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.61E-16 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.128 9.77E-14 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.126 2.64E-13 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.121 2.09E-12 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.109 2.15E-10 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.108 3.94E-10 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.105 1.23E-9 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.102 2.99E-9 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.102 3.01E-9 YOR099W KTR1 hom Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.095 3.35E-8 YGL232W TAN1 hom Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
0.090 1.51E-7 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.088 3.33E-7 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.087 4.20E-7 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.086 5.35E-7 YGL229C SAP4 hom Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
0.086 5.55E-7 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery