YNL282W / POP3

Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL282W / POP3

Click on Significant Values for Screen Details ID:SGTC_175|Compound:3793-3120|FD-Score:3.00|P-value:8.32E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.01|P-value:7.92E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.13|P-value:5.25E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:7.50|P-value:1.81E-15 ID:SGTC_542|Compound:3381-0244|FD-Score:3.32|P-value:2.52E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.52|P-value:1.05E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.30|P-value:2.63E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.09|P-value:5.98E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.33|P-value:2.39E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:-4.24|P-value:4.13E-6 ID:SGTC_782|Compound:0083-0095|FD-Score:4.40|P-value:1.97E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:3.19|P-value:4.20E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.19|P-value:4.14E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.29|P-value:2.78E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.37|P-value:1.98E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.30|P-value:2.61E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.59|P-value:8.48E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:2.96|P-value:9.53E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.23|P-value:3.59E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.61|P-value:6.78E-7 ID:SGTC_1486|Compound:3970-0793|FD-Score:-3.20|P-value:3.81E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.12|P-value:5.46E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.58|P-value:8.66E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.71|P-value:5.08E-5 ID:SGTC_1657|Compound:st012939|FD-Score:-3.34|P-value:2.21E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-3.07|P-value:6.22E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.26|P-value:3.04E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.22|P-value:4.74E-6 ID:SGTC_1798|Compound:st045719|FD-Score:3.58|P-value:8.90E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:7.51|P-value:1.60E-15 ID:SGTC_1927|Compound:st060202|FD-Score:3.21|P-value:3.82E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.46|P-value:1.45E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.01|P-value:7.96E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.15|P-value:4.87E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.05|P-value:6.89E-4 ID:SGTC_2455|Compound:5377712|FD-Score:2.97|P-value:9.33E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.02|P-value:7.50E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:-4.51|P-value:1.08E-6 ID:SGTC_2691|Compound:st077356|FD-Score:3.43|P-value:1.59E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.04|P-value:7.24E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:5.81|P-value:5.50E-10 ID:SGTC_2780|Compound:5215298|FD-Score:3.14|P-value:4.98E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-2.98|P-value:8.59E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.69|P-value:5.49E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.01|P-value:8.15E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.37|P-value:2.08E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.38|P-value:1.93E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.61|P-value:7.58E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.06|P-value:6.61E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.00|P-value:8.32E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.01|P-value:7.92E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.13|P-value:5.25E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:7.50|P-value:1.81E-15 ID:SGTC_542|Compound:3381-0244|FD-Score:3.32|P-value:2.52E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.52|P-value:1.05E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.30|P-value:2.63E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.09|P-value:5.98E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.33|P-value:2.39E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:-4.24|P-value:4.13E-6 ID:SGTC_782|Compound:0083-0095|FD-Score:4.40|P-value:1.97E-6 ID:SGTC_841|Compound:0251-0215|FD-Score:3.19|P-value:4.20E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.19|P-value:4.14E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.29|P-value:2.78E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.37|P-value:1.98E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-3.30|P-value:2.61E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.59|P-value:8.48E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:2.96|P-value:9.53E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.23|P-value:3.59E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:4.61|P-value:6.78E-7 ID:SGTC_1486|Compound:3970-0793|FD-Score:-3.20|P-value:3.81E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.12|P-value:5.46E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.58|P-value:8.66E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.71|P-value:5.08E-5 ID:SGTC_1657|Compound:st012939|FD-Score:-3.34|P-value:2.21E-4 ID:SGTC_1659|Compound:st012954|FD-Score:-3.07|P-value:6.22E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.26|P-value:3.04E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.22|P-value:4.74E-6 ID:SGTC_1798|Compound:st045719|FD-Score:3.58|P-value:8.90E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:7.51|P-value:1.60E-15 ID:SGTC_1927|Compound:st060202|FD-Score:3.21|P-value:3.82E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.46|P-value:1.45E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.01|P-value:7.96E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.15|P-value:4.87E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.05|P-value:6.89E-4 ID:SGTC_2455|Compound:5377712|FD-Score:2.97|P-value:9.33E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.02|P-value:7.50E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:-4.51|P-value:1.08E-6 ID:SGTC_2691|Compound:st077356|FD-Score:3.43|P-value:1.59E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.04|P-value:7.24E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:5.81|P-value:5.50E-10 ID:SGTC_2780|Compound:5215298|FD-Score:3.14|P-value:4.98E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-2.98|P-value:8.59E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.69|P-value:5.49E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.01|P-value:8.15E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.37|P-value:2.08E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.38|P-value:1.93E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.61|P-value:7.58E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.06|P-value:6.61E-4

Top fitness defect scores for YNL282W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1872 amphotericin b 7.51 148.0 nM 1.60E-15 RNA pol III & RNase P/MRP 9 2.88E-14 0.12
2 SGTC_539 4859-0462 7.50 2.5 µM 1.81E-15 RNA pol III & RNase P/MRP 7 3.23E-14 0.47
3 SGTC_2758 dehydroepiandrosterone 5.81 69.3 µM 5.50E-10 2 3.14E-9 0.96
4 SGTC_1148 3909-7663 4.61 27.7 µM 6.78E-7 1 2.05E-6 0.51
5 SGTC_782 0083-0095 4.40 30.5 µM 1.97E-6 3 5.40E-6 1.10
6 SGTC_1781 st038725 4.22 66.3 µM 4.74E-6 NEO1 10 1.21E-5 0.19
7 SGTC_1601 4'-hydroxyflavanone 3.71 55.5 µM 5.08E-5 RPP1 & pyrimidine depletion 8 1.05E-4 0.09
8 SGTC_2845 9003024 3.69 43.0 µM 5.49E-5 amide catabolism 16 1.13E-4 0.02
9 SGTC_3031 9088762 3.61 49.5 µM 7.58E-5 7 1.51E-4 0.10
10 SGTC_1003 4049-0218 3.59 100.0 µM 8.48E-5 11 1.68E-4 0.02
11 SGTC_1589 2',5'-dimethoxyflavone 3.58 47.2 µM 8.66E-5 8 1.71E-4 0.20
12 SGTC_1798 st045719 3.58 61.0 µM 8.90E-5 7 1.75E-4 0.07
13 SGTC_1932 st074806 3.46 40.9 µM 1.45E-4 13 2.74E-4 0.10
14 SGTC_2691 st077356 3.43 60.2 µM 1.59E-4 13 2.98E-4 0.20
15 SGTC_2888 9058547 3.37 13.0 µM 2.08E-4 3 3.80E-4 0.18
16 SGTC_737 1950-0117 3.33 57.9 µM 2.39E-4 9 4.31E-4 0.08
17 SGTC_542 3381-0244 3.32 89.3 µM 2.52E-4 11 4.53E-4 0.06
18 SGTC_931 2812-0076 3.29 566.0 µM 2.78E-4 14 4.96E-4 0.06
19 SGTC_1105 epirubicin 3.23 18.1 µM 3.59E-4 anthracycline transcription coupled DNA repair 17 6.27E-4 0.05
20 SGTC_1927 st060202 3.21 13.8 µM 3.82E-4 13 6.63E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.311 3.00E-76 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.195 4.25E-30 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.162 2.80E-21 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.118 5.89E-12 YER048C CAJ1 hom Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
0.110 1.54E-10 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.110 1.81E-10 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.102 2.90E-9 YNR035C ARC35 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin
0.098 1.14E-8 YNR029C_p YNR029C_p hom Putative protein of unknown function, deletion confers reduced fitness in saline
0.098 1.35E-8 YDR276C PMP3 hom Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
0.092 8.56E-8 YBR296C-A_p YBR296C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.092 8.65E-8 YPL111W CAR1 hom Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
0.090 1.97E-7 YKR106W GEX2 hom Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway
0.083 1.31E-6 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.082 1.82E-6 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.082 2.00E-6 YGL053W PRM8 hom Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family