YNL283C / WSC2

Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL283C / WSC2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:7.39|P-value:2.17E-11 ID:SGTC_121|Compound:0557-0495|FD-Score:4.08|P-value:1.41E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.50|P-value:9.36E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:14.00|P-value:5.46E-36 ID:SGTC_304|Compound:1310-0298|FD-Score:4.57|P-value:2.39E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.70|P-value:1.46E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:-4.00|P-value:1.59E-4 ID:SGTC_389|Compound:tpck|FD-Score:6.83|P-value:5.52E-10 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.84|P-value:2.67E-4 ID:SGTC_393|Compound:acivicin|FD-Score:6.95|P-value:2.82E-10 ID:SGTC_430|Compound:0958-0115|FD-Score:-5.60|P-value:2.35E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:8.37|P-value:3.97E-14 ID:SGTC_528|Compound:3492-0019|FD-Score:3.49|P-value:9.54E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:-3.46|P-value:9.12E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:5.28|P-value:1.27E-6 ID:SGTC_610|Compound:4215-0184|FD-Score:3.56|P-value:7.74E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.81|P-value:3.55E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:-3.67|P-value:4.68E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.66|P-value:5.71E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.03|P-value:1.72E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.55|P-value:8.04E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.26|P-value:1.41E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.78|P-value:3.26E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.52|P-value:8.78E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:4.11|P-value:1.30E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:7.34|P-value:2.95E-11 ID:SGTC_978|Compound:1416-0512|FD-Score:4.93|P-value:5.57E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.18|P-value:1.01E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.31|P-value:6.32E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.48|P-value:9.90E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.80|P-value:3.71E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.27|P-value:7.37E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.92|P-value:2.47E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:5.54|P-value:3.96E-7 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.33|P-value:5.91E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.65|P-value:5.94E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:6.35|P-value:7.69E-9 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.03|P-value:1.71E-4 ID:SGTC_1627|Compound:st003713|FD-Score:5.86|P-value:8.70E-8 ID:SGTC_1634|Compound:st006576|FD-Score:7.28|P-value:4.21E-11 ID:SGTC_1642|Compound:st009582|FD-Score:4.94|P-value:5.40E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.55|P-value:2.59E-5 ID:SGTC_1745|Compound:st081495|FD-Score:5.35|P-value:9.60E-7 ID:SGTC_1774|Compound:st048371|FD-Score:7.10|P-value:1.21E-10 ID:SGTC_1781|Compound:st038725|FD-Score:3.53|P-value:8.65E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.69|P-value:5.25E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.38|P-value:8.38E-7 ID:SGTC_1800|Compound:st050079|FD-Score:3.61|P-value:6.71E-4 ID:SGTC_1902|Compound:st060212|FD-Score:4.85|P-value:8.03E-6 ID:SGTC_1980|Compound:st071811|FD-Score:3.79|P-value:3.77E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.98|P-value:2.01E-4 ID:SGTC_2147|Compound:5545932|FD-Score:4.14|P-value:1.16E-4 ID:SGTC_2163|Compound:5671233|FD-Score:7.07|P-value:1.46E-10 ID:SGTC_2225|Compound:6654152|FD-Score:3.66|P-value:5.77E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.65|P-value:5.96E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.88|P-value:2.77E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.08|P-value:1.43E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.76|P-value:4.14E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-4.25|P-value:6.37E-5 ID:SGTC_2349|Compound:9023730|FD-Score:-6.15|P-value:1.61E-8 ID:SGTC_2370|Compound:9071495|FD-Score:3.99|P-value:1.95E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.56|P-value:7.80E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.93|P-value:2.34E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.74|P-value:4.45E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.82|P-value:1.09E-7 ID:SGTC_2433|Compound:5607874|FD-Score:4.36|P-value:5.33E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:3.75|P-value:4.26E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.82|P-value:3.42E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.40|P-value:4.53E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:7.09|P-value:1.29E-10 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.11|P-value:1.26E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-4.68|P-value:1.24E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:5.37|P-value:8.73E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.83|P-value:3.31E-4 ID:SGTC_2706|Compound:st078239|FD-Score:4.45|P-value:3.80E-5 ID:SGTC_2710|Compound:st078562|FD-Score:5.69|P-value:2.03E-7 ID:SGTC_2912|Compound:7964298|FD-Score:5.75|P-value:1.49E-7 ID:SGTC_2960|Compound:9079389|FD-Score:3.69|P-value:5.21E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.84|P-value:3.26E-4 ID:SGTC_3130|Compound:9127414|FD-Score:4.53|P-value:2.73E-5 ID:SGTC_3196|Compound:9111891|FD-Score:4.40|P-value:4.54E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.83|P-value:3.26E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.38|P-value:8.10E-7 ID:SGTC_3311|Compound:9131146|FD-Score:8.24|P-value:9.57E-14 ID:SGTC_3321|Compound:9137793|FD-Score:4.69|P-value:1.51E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:7.39|P-value:2.17E-11 ID:SGTC_121|Compound:0557-0495|FD-Score:4.08|P-value:1.41E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.50|P-value:9.36E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:14.00|P-value:5.46E-36 ID:SGTC_304|Compound:1310-0298|FD-Score:4.57|P-value:2.39E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.70|P-value:1.46E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:-4.00|P-value:1.59E-4 ID:SGTC_389|Compound:tpck|FD-Score:6.83|P-value:5.52E-10 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.84|P-value:2.67E-4 ID:SGTC_393|Compound:acivicin|FD-Score:6.95|P-value:2.82E-10 ID:SGTC_430|Compound:0958-0115|FD-Score:-5.60|P-value:2.35E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:8.37|P-value:3.97E-14 ID:SGTC_528|Compound:3492-0019|FD-Score:3.49|P-value:9.54E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:-3.46|P-value:9.12E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:5.28|P-value:1.27E-6 ID:SGTC_610|Compound:4215-0184|FD-Score:3.56|P-value:7.74E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:3.81|P-value:3.55E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:-3.67|P-value:4.68E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.66|P-value:5.71E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.03|P-value:1.72E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.55|P-value:8.04E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.26|P-value:1.41E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.78|P-value:3.26E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.52|P-value:8.78E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:4.11|P-value:1.30E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:7.34|P-value:2.95E-11 ID:SGTC_978|Compound:1416-0512|FD-Score:4.93|P-value:5.57E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.18|P-value:1.01E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.31|P-value:6.32E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.48|P-value:9.90E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.80|P-value:3.71E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.27|P-value:7.37E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.92|P-value:2.47E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:5.54|P-value:3.96E-7 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.33|P-value:5.91E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.65|P-value:5.94E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:6.35|P-value:7.69E-9 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.03|P-value:1.71E-4 ID:SGTC_1627|Compound:st003713|FD-Score:5.86|P-value:8.70E-8 ID:SGTC_1634|Compound:st006576|FD-Score:7.28|P-value:4.21E-11 ID:SGTC_1642|Compound:st009582|FD-Score:4.94|P-value:5.40E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.55|P-value:2.59E-5 ID:SGTC_1745|Compound:st081495|FD-Score:5.35|P-value:9.60E-7 ID:SGTC_1774|Compound:st048371|FD-Score:7.10|P-value:1.21E-10 ID:SGTC_1781|Compound:st038725|FD-Score:3.53|P-value:8.65E-4 ID:SGTC_1786|Compound:berberine|FD-Score:3.69|P-value:5.25E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:5.38|P-value:8.38E-7 ID:SGTC_1800|Compound:st050079|FD-Score:3.61|P-value:6.71E-4 ID:SGTC_1902|Compound:st060212|FD-Score:4.85|P-value:8.03E-6 ID:SGTC_1980|Compound:st071811|FD-Score:3.79|P-value:3.77E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.98|P-value:2.01E-4 ID:SGTC_2147|Compound:5545932|FD-Score:4.14|P-value:1.16E-4 ID:SGTC_2163|Compound:5671233|FD-Score:7.07|P-value:1.46E-10 ID:SGTC_2225|Compound:6654152|FD-Score:3.66|P-value:5.77E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.65|P-value:5.96E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.88|P-value:2.77E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.08|P-value:1.43E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.76|P-value:4.14E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-4.25|P-value:6.37E-5 ID:SGTC_2349|Compound:9023730|FD-Score:-6.15|P-value:1.61E-8 ID:SGTC_2370|Compound:9071495|FD-Score:3.99|P-value:1.95E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.56|P-value:7.80E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.93|P-value:2.34E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.74|P-value:4.45E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.82|P-value:1.09E-7 ID:SGTC_2433|Compound:5607874|FD-Score:4.36|P-value:5.33E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:3.75|P-value:4.26E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.82|P-value:3.42E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.40|P-value:4.53E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:7.09|P-value:1.29E-10 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.11|P-value:1.26E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-4.68|P-value:1.24E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:5.37|P-value:8.73E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.83|P-value:3.31E-4 ID:SGTC_2706|Compound:st078239|FD-Score:4.45|P-value:3.80E-5 ID:SGTC_2710|Compound:st078562|FD-Score:5.69|P-value:2.03E-7 ID:SGTC_2912|Compound:7964298|FD-Score:5.75|P-value:1.49E-7 ID:SGTC_2960|Compound:9079389|FD-Score:3.69|P-value:5.21E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.84|P-value:3.26E-4 ID:SGTC_3130|Compound:9127414|FD-Score:4.53|P-value:2.73E-5 ID:SGTC_3196|Compound:9111891|FD-Score:4.40|P-value:4.54E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.83|P-value:3.26E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.38|P-value:8.10E-7 ID:SGTC_3311|Compound:9131146|FD-Score:8.24|P-value:9.57E-14 ID:SGTC_3321|Compound:9137793|FD-Score:4.69|P-value:1.51E-5

Top fitness defect scores for YNL283C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 14.00 40.9 µM 5.46E-36 cell wall 20 1.42E-44
2 SGTC_514 4466-0038 8.37 2.6 nM 3.97E-14 cell wall 32 2.81E-17
3 SGTC_3311 9131146 8.24 2.9 µM 9.57E-14 cell wall 31 8.42E-17
4 SGTC_58 0957-0393 7.39 9.0 µM 2.17E-11 cell wall 148 7.30E-14
5 SGTC_928 2764-0428 7.34 58.7 µM 2.95E-11 cell wall 8 1.07E-13
6 SGTC_1634 st006576 7.28 41.0 µM 4.21E-11 TSC3-RPN4 2 1.67E-13
7 SGTC_1774 st048371 7.10 48.5 µM 1.21E-10 RNA processing & uracil transport 3 6.23E-13
8 SGTC_2571 chrysanthemic acid 7.09 100.0 µM 1.29E-10 2 6.73E-13
9 SGTC_2163 5671233 7.07 125.0 µM 1.46E-10 4 7.86E-13
10 SGTC_393 acivicin 6.95 6.2 µM 2.82E-10 4 1.79E-12
11 SGTC_389 tpck 6.83 16.7 µM 5.52E-10 7 4.13E-12
12 SGTC_1393 3470-5649 6.35 58.2 µM 7.69E-9 60S ribosome export 1 1.10E-10
13 SGTC_1627 st003713 5.86 25.6 µM 8.70E-8 calcium & mitochondrial duress 32 2.27E-9
14 SGTC_2405 ticlatone 5.82 3.5 µM 1.09E-7 32 2.99E-9
15 SGTC_2912 7964298 5.75 10.9 µM 1.49E-7 cell wall 52 4.42E-9
16 SGTC_2710 st078562 5.69 53.7 µM 2.03E-7 2 6.49E-9
17 SGTC_1302 1159-0335 5.54 255.0 µM 3.96E-7 2 1.49E-8
18 SGTC_3266 9136860 5.38 49.5 µM 8.10E-7 cell wall 23 3.64E-8
19 SGTC_1787 fluconazole 5.38 80.0 µM 8.38E-7 iron homeostasis 6 3.80E-8
20 SGTC_2584 androsterone 5.37 48.7 µM 8.73E-7 cell wall 70 4.00E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.350 5.58E-97 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.345 2.48E-94 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.328 3.11E-85 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.321 4.91E-81 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.298 5.22E-70 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.291 1.96E-66 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.288 2.98E-65 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.287 1.13E-64 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.287 1.16E-64 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.285 9.79E-64 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.284 3.28E-63 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.282 3.68E-62 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.278 1.97E-60 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.278 2.19E-60 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.270 4.01E-57 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins