YNL284C / MRPL10

Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL284C / MRPL10

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.26|P-value:2.52E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.29|P-value:2.02E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.75|P-value:1.67E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.26|P-value:2.33E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:8.64|P-value:7.82E-17 ID:SGTC_173|Compound:1273-0061|FD-Score:9.02|P-value:3.65E-18 ID:SGTC_211|Compound:3455-0679|FD-Score:4.84|P-value:1.87E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:8.82|P-value:1.81E-17 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.38|P-value:6.10E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.29|P-value:8.23E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.83|P-value:3.61E-14 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.45|P-value:5.08E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.91|P-value:9.40E-5 ID:SGTC_397|Compound:arbidol|FD-Score:3.27|P-value:8.70E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.90|P-value:1.49E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:3.42|P-value:5.43E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.03|P-value:5.87E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:3.34|P-value:6.94E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.35|P-value:6.78E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.68|P-value:2.15E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.40|P-value:5.77E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.25|P-value:9.37E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:9.80|P-value:3.88E-21 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.28|P-value:8.56E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-4.23|P-value:2.75E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.27|P-value:8.92E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.55|P-value:3.40E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.02|P-value:4.78E-9 ID:SGTC_1722|Compound:st034304|FD-Score:4.59|P-value:5.69E-6 ID:SGTC_1742|Compound:st038235|FD-Score:3.54|P-value:3.59E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.25|P-value:2.41E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.68|P-value:2.30E-4 ID:SGTC_1809|Compound:st050081|FD-Score:-3.64|P-value:2.63E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.59|P-value:3.13E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.47|P-value:3.44E-10 ID:SGTC_1854|Compound:st056233|FD-Score:3.90|P-value:9.47E-5 ID:SGTC_1856|Compound:st057054|FD-Score:4.84|P-value:1.90E-6 ID:SGTC_1881|Compound:5652484|FD-Score:3.35|P-value:6.77E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.10|P-value:5.42E-7 ID:SGTC_1913|Compound:st060213|FD-Score:3.54|P-value:3.62E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.08|P-value:4.78E-5 ID:SGTC_1956|Compound:st077085|FD-Score:-3.28|P-value:8.97E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.21|P-value:2.89E-5 ID:SGTC_2032|Compound:5185112|FD-Score:3.36|P-value:6.54E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.94|P-value:8.79E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.49|P-value:4.20E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.49|P-value:2.87E-10 ID:SGTC_2317|Compound:5986382|FD-Score:-3.45|P-value:5.01E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-4.00|P-value:6.94E-5 ID:SGTC_2343|Compound:7990716|FD-Score:-3.60|P-value:3.07E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.52|P-value:3.85E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.99|P-value:9.24E-7 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.19|P-value:3.08E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.33|P-value:1.74E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.86|P-value:1.11E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.79|P-value:1.52E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.45|P-value:5.07E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.17|P-value:2.05E-9 ID:SGTC_2932|Compound:9016711|FD-Score:3.50|P-value:4.06E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.39|P-value:1.35E-5 ID:SGTC_3045|Compound:9092950|FD-Score:3.39|P-value:6.01E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.31|P-value:7.62E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.48|P-value:4.35E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.26|P-value:2.52E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.29|P-value:2.02E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.75|P-value:1.67E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:4.26|P-value:2.33E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:8.64|P-value:7.82E-17 ID:SGTC_173|Compound:1273-0061|FD-Score:9.02|P-value:3.65E-18 ID:SGTC_211|Compound:3455-0679|FD-Score:4.84|P-value:1.87E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:8.82|P-value:1.81E-17 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.38|P-value:6.10E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.29|P-value:8.23E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.83|P-value:3.61E-14 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.45|P-value:5.08E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.91|P-value:9.40E-5 ID:SGTC_397|Compound:arbidol|FD-Score:3.27|P-value:8.70E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.90|P-value:1.49E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:3.42|P-value:5.43E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.03|P-value:5.87E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:3.34|P-value:6.94E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.35|P-value:6.78E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.68|P-value:2.15E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.40|P-value:5.77E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.25|P-value:9.37E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:9.80|P-value:3.88E-21 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.28|P-value:8.56E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-4.23|P-value:2.75E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.27|P-value:8.92E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.55|P-value:3.40E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.02|P-value:4.78E-9 ID:SGTC_1722|Compound:st034304|FD-Score:4.59|P-value:5.69E-6 ID:SGTC_1742|Compound:st038235|FD-Score:3.54|P-value:3.59E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.25|P-value:2.41E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.68|P-value:2.30E-4 ID:SGTC_1809|Compound:st050081|FD-Score:-3.64|P-value:2.63E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.59|P-value:3.13E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.47|P-value:3.44E-10 ID:SGTC_1854|Compound:st056233|FD-Score:3.90|P-value:9.47E-5 ID:SGTC_1856|Compound:st057054|FD-Score:4.84|P-value:1.90E-6 ID:SGTC_1881|Compound:5652484|FD-Score:3.35|P-value:6.77E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.10|P-value:5.42E-7 ID:SGTC_1913|Compound:st060213|FD-Score:3.54|P-value:3.62E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.08|P-value:4.78E-5 ID:SGTC_1956|Compound:st077085|FD-Score:-3.28|P-value:8.97E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.21|P-value:2.89E-5 ID:SGTC_2032|Compound:5185112|FD-Score:3.36|P-value:6.54E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.94|P-value:8.79E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.49|P-value:4.20E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.49|P-value:2.87E-10 ID:SGTC_2317|Compound:5986382|FD-Score:-3.45|P-value:5.01E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-4.00|P-value:6.94E-5 ID:SGTC_2343|Compound:7990716|FD-Score:-3.60|P-value:3.07E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.52|P-value:3.85E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.99|P-value:9.24E-7 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.19|P-value:3.08E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.33|P-value:1.74E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.86|P-value:1.11E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.79|P-value:1.52E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-3.45|P-value:5.07E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.17|P-value:2.05E-9 ID:SGTC_2932|Compound:9016711|FD-Score:3.50|P-value:4.06E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.39|P-value:1.35E-5 ID:SGTC_3045|Compound:9092950|FD-Score:3.39|P-value:6.01E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.31|P-value:7.62E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.48|P-value:4.35E-4

Top fitness defect scores for YNL284C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1227 3909-8010 9.80 46.6 µM 3.88E-21 1 5.41E-23
2 SGTC_173 1273-0061 9.02 2.7 µM 3.65E-18 mitochondrial stress 49 9.83E-20
3 SGTC_236 1509-0011 8.82 5.3 µM 1.81E-17 225 5.67E-19
4 SGTC_70 0141-0289 8.64 43.3 µM 7.82E-17 mitochondrial stress 30 2.82E-18
5 SGTC_310 1273-0058 7.83 1.1 µM 3.61E-14 mitochondrial stress 96 2.35E-15
6 SGTC_2250 alverine citrate 6.49 130.0 µM 2.87E-10 41 4.38E-11
7 SGTC_10 0279-0212 5.26 42.6 µM 2.52E-7 TRP & mitochondrial translation 49 7.26E-8
8 SGTC_1883 5-benzylidenerhodanine 5.10 20.0 µM 5.42E-7 TRP & mitochondrial translation 29 1.68E-7
9 SGTC_2361 9034121 4.99 116.0 µM 9.24E-7 RSC complex & mRNA processing 7 3.01E-7
10 SGTC_211 3455-0679 4.84 143.5 µM 1.87E-6 7 6.51E-7
11 SGTC_1856 st057054 4.84 55.7 µM 1.90E-6 14 6.63E-7
12 SGTC_1722 st034304 4.59 3.6 µM 5.69E-6 mitochondrial processes 14 2.19E-6
13 SGTC_2977 9011197 4.39 71.4 µM 1.35E-5 12 5.62E-6
14 SGTC_2601 securinine 4.33 100.0 µM 1.74E-5 23 7.42E-6
15 SGTC_28 pentachloropyridine N-oxide 4.29 1.6 µM 2.02E-5 TSC3-RPN4 56 8.77E-6
16 SGTC_68 0986-0284 4.26 82.8 µM 2.33E-5 55 1.02E-5
17 SGTC_1765 st044815 4.25 90.4 µM 2.41E-5 18 1.06E-5
18 SGTC_1978 st071761 4.21 42.0 µM 2.89E-5 TSC3-RPN4 11 1.29E-5
19 SGTC_2598 perillyl alcohol 4.19 100.0 µM 3.08E-5 24 1.39E-5
20 SGTC_1921 5740136 4.08 50.0 µM 4.78E-5 TRP & mitochondrial translation 51 2.24E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.437 1.44E-156 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.432 8.95E-152 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.421 1.39E-144 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.421 2.93E-144 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.414 3.35E-139 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.409 2.09E-135 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.408 8.27E-135 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.401 9.75E-130 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.399 2.27E-128 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.396 2.10E-126 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.389 1.05E-121 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.388 6.15E-121 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.383 1.34E-117 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.382 3.36E-117 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.382 5.30E-117 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation