YNL285W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL285W / YNL285W

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:-5.03|P-value:3.02E-7 ID:SGTC_370|Compound:0180-0345|FD-Score:4.94|P-value:3.38E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.72|P-value:8.86E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.13|P-value:8.05E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.86|P-value:5.14E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:3.45|P-value:2.51E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.58|P-value:1.54E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.08|P-value:9.46E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:-3.41|P-value:3.76E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.23|P-value:6.98E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.84|P-value:6.98E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.45|P-value:2.54E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.20|P-value:6.29E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.37|P-value:3.37E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-3.54|P-value:2.32E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.35|P-value:4.59E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.50|P-value:2.12E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.99|P-value:3.78E-5 ID:SGTC_1620|Compound:st003704|FD-Score:-3.47|P-value:2.94E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.37|P-value:4.23E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.17|P-value:6.82E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.15|P-value:7.49E-4 ID:SGTC_1990|Compound:st072050|FD-Score:6.21|P-value:2.24E-10 ID:SGTC_2058|Compound:5236698|FD-Score:3.49|P-value:2.21E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.75|P-value:1.03E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.21|P-value:5.93E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:3.43|P-value:2.72E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.15|P-value:7.32E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.64|P-value:1.22E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:5.44|P-value:2.26E-8 ID:SGTC_2780|Compound:5215298|FD-Score:-3.61|P-value:1.74E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-5.08|P-value:2.25E-7 ID:SGTC_2790|Compound:5423970|FD-Score:10.20|P-value:9.14E-25 ID:SGTC_2897|Compound:9048598|FD-Score:3.30|P-value:4.42E-4 ID:SGTC_2898|Compound:9056270|FD-Score:-3.35|P-value:4.53E-4 ID:SGTC_3000|Compound:9075062|FD-Score:5.49|P-value:1.75E-8 ID:SGTC_69|Compound:0096-0274|FD-Score:-5.03|P-value:3.02E-7 ID:SGTC_370|Compound:0180-0345|FD-Score:4.94|P-value:3.38E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.72|P-value:8.86E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.13|P-value:8.05E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.86|P-value:5.14E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:3.45|P-value:2.51E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.58|P-value:1.54E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.08|P-value:9.46E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:-3.41|P-value:3.76E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.23|P-value:6.98E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.84|P-value:6.98E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.45|P-value:2.54E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.20|P-value:6.29E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.37|P-value:3.37E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-3.54|P-value:2.32E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:-3.35|P-value:4.59E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.50|P-value:2.12E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.99|P-value:3.78E-5 ID:SGTC_1620|Compound:st003704|FD-Score:-3.47|P-value:2.94E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.37|P-value:4.23E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.17|P-value:6.82E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.15|P-value:7.49E-4 ID:SGTC_1990|Compound:st072050|FD-Score:6.21|P-value:2.24E-10 ID:SGTC_2058|Compound:5236698|FD-Score:3.49|P-value:2.21E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.75|P-value:1.03E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.21|P-value:5.93E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:3.43|P-value:2.72E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.15|P-value:7.32E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.64|P-value:1.22E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:5.44|P-value:2.26E-8 ID:SGTC_2780|Compound:5215298|FD-Score:-3.61|P-value:1.74E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-5.08|P-value:2.25E-7 ID:SGTC_2790|Compound:5423970|FD-Score:10.20|P-value:9.14E-25 ID:SGTC_2897|Compound:9048598|FD-Score:3.30|P-value:4.42E-4 ID:SGTC_2898|Compound:9056270|FD-Score:-3.35|P-value:4.53E-4 ID:SGTC_3000|Compound:9075062|FD-Score:5.49|P-value:1.75E-8

Top fitness defect scores for YNL285W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2790 5423970 10.20 71.4 µM 9.14E-25 endomembrane recycling 9 1.14E-24
2 SGTC_1990 st072050 6.21 59.8 µM 2.24E-10 1 2.63E-10
3 SGTC_3000 9075062 5.49 71.4 µM 1.75E-8 2 2.03E-8
4 SGTC_2657 nystatin 5.44 74.4 µM 2.26E-8 2 2.62E-8
5 SGTC_370 0180-0345 4.94 38.7 µM 3.38E-7 DNA intercalators 5 3.87E-7
6 SGTC_754 3474-0146 3.86 171.0 µM 5.14E-5 copper-dependent oxidative stress 26 5.75E-5
7 SGTC_449 xestospongin c 3.72 11.2 µM 8.86E-5 NEO1-PIK1 79 9.90E-5
8 SGTC_2654 protoveratrine a 3.64 100.0 µM 1.22E-4 12 1.36E-4
9 SGTC_827 3253-0474 3.58 693.0 µM 1.54E-4 29 1.72E-4
10 SGTC_1606 st000094 3.50 49.2 µM 2.12E-4 60S ribosome export 31 2.36E-4
11 SGTC_2058 5236698 3.49 133.0 µM 2.21E-4 39 2.45E-4
12 SGTC_806 3966-4455 3.45 5.9 µM 2.51E-4 42 2.79E-4
13 SGTC_1013 4112-3890 3.45 241.0 µM 2.54E-4 TSC3-RPN4 56 2.82E-4
14 SGTC_2515 chrysin 3.43 20.8 µM 2.72E-4 RPP1 & pyrimidine depletion 20 3.02E-4
15 SGTC_1199 1638-0010 3.37 4.5 µM 3.37E-4 endomembrane recycling 47 3.73E-4
16 SGTC_2897 9048598 3.30 13.0 µM 4.42E-4 35 4.89E-4
17 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 3.21 54.6 µM 5.93E-4 RPP1 & pyrimidine depletion 53 6.55E-4
18 SGTC_1068 loratadine 3.20 26.9 µM 6.29E-4 58 6.94E-4
19 SGTC_1879 gemcitabine 3.17 100.0 µM 6.82E-4 48 7.52E-4
20 SGTC_2606 farnesol 3.15 9.8 µM 7.32E-4 57 8.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 6.64E-16 YJR050W ISY1 hom Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
0.120 2.77E-12 YIL094C LYS12 hom Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
0.120 3.66E-12 YOR228C YOR228C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.104 1.40E-9 YBR218C PYC2 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication
0.102 3.19E-9 YCL023C_d YCL023C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
0.098 1.18E-8 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.094 4.39E-8 YLR019W PSR2 hom Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
0.088 3.04E-7 YLR449W FPR4 hom Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
0.087 4.38E-7 YLR081W GAL2 hom Galactose permease, required for utilization of galactose; also able to transport glucose
0.083 1.51E-6 YDR178W SDH4 hom Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
0.082 2.06E-6 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.081 2.62E-6 YHR098C SFB3 hom Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p
0.080 3.63E-6 YPR076W_d YPR076W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.077 7.82E-6 YGL104C VPS73 hom Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
0.077 7.89E-6 YOR058C ASE1 hom Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress