YNL286W / CUS2

Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL286W / CUS2

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.72|P-value:1.19E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.79|P-value:9.08E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.40|P-value:3.84E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.98|P-value:4.15E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:4.08|P-value:2.69E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:4.19|P-value:1.70E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:3.16|P-value:8.85E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.18|P-value:8.42E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.20|P-value:7.74E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.39|P-value:3.87E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.43|P-value:3.44E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.15|P-value:9.35E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.42|P-value:3.61E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.66|P-value:1.48E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.17|P-value:8.71E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.25|P-value:6.31E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.43|P-value:3.46E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.72|P-value:1.17E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.67|P-value:1.46E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:-4.11|P-value:2.32E-5 ID:SGTC_1706|Compound:st031321|FD-Score:-3.37|P-value:4.23E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.73|P-value:1.08E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.46|P-value:3.19E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.83|P-value:7.77E-5 ID:SGTC_1812|Compound:st052057|FD-Score:-3.51|P-value:2.54E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.94|P-value:4.75E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.96|P-value:4.56E-5 ID:SGTC_1942|Compound:st076330|FD-Score:4.37|P-value:7.75E-6 ID:SGTC_2125|Compound:5246583|FD-Score:3.44|P-value:3.36E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.16|P-value:8.66E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.51|P-value:2.59E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.63|P-value:1.68E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.75|P-value:1.06E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.31|P-value:5.12E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-4.85|P-value:7.56E-7 ID:SGTC_2483|Compound:5729050|FD-Score:4.25|P-value:1.34E-5 ID:SGTC_2486|Compound:5283202|FD-Score:4.30|P-value:1.06E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.82|P-value:7.82E-5 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.11|P-value:2.39E-5 ID:SGTC_2537|Compound:larixol|FD-Score:-3.21|P-value:7.23E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.04|P-value:3.26E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.76|P-value:9.94E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.25|P-value:1.33E-5 ID:SGTC_2942|Compound:9052777|FD-Score:3.92|P-value:5.29E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.70|P-value:1.27E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.18|P-value:8.21E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.49|P-value:2.71E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.39|P-value:3.88E-4 ID:SGTC_3297|Compound:9117502|FD-Score:-6.43|P-value:9.77E-11 ID:SGTC_24|Compound:0417-1663|FD-Score:3.72|P-value:1.19E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.79|P-value:9.08E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.40|P-value:3.84E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.98|P-value:4.15E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:4.08|P-value:2.69E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:4.19|P-value:1.70E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:3.16|P-value:8.85E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.18|P-value:8.42E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.20|P-value:7.74E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.39|P-value:3.87E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.43|P-value:3.44E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.15|P-value:9.35E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.42|P-value:3.61E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.66|P-value:1.48E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.17|P-value:8.71E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.25|P-value:6.31E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.43|P-value:3.46E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.72|P-value:1.17E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.67|P-value:1.46E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:-4.11|P-value:2.32E-5 ID:SGTC_1706|Compound:st031321|FD-Score:-3.37|P-value:4.23E-4 ID:SGTC_1711|Compound:st032263|FD-Score:-3.73|P-value:1.08E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.46|P-value:3.19E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.83|P-value:7.77E-5 ID:SGTC_1812|Compound:st052057|FD-Score:-3.51|P-value:2.54E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.94|P-value:4.75E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.96|P-value:4.56E-5 ID:SGTC_1942|Compound:st076330|FD-Score:4.37|P-value:7.75E-6 ID:SGTC_2125|Compound:5246583|FD-Score:3.44|P-value:3.36E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.16|P-value:8.66E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.51|P-value:2.59E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.63|P-value:1.68E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.75|P-value:1.06E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.31|P-value:5.12E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-4.85|P-value:7.56E-7 ID:SGTC_2483|Compound:5729050|FD-Score:4.25|P-value:1.34E-5 ID:SGTC_2486|Compound:5283202|FD-Score:4.30|P-value:1.06E-5 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.82|P-value:7.82E-5 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.11|P-value:2.39E-5 ID:SGTC_2537|Compound:larixol|FD-Score:-3.21|P-value:7.23E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.04|P-value:3.26E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.76|P-value:9.94E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.25|P-value:1.33E-5 ID:SGTC_2942|Compound:9052777|FD-Score:3.92|P-value:5.29E-5 ID:SGTC_3043|Compound:9092303|FD-Score:3.70|P-value:1.27E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.18|P-value:8.21E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.49|P-value:2.71E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.39|P-value:3.88E-4 ID:SGTC_3297|Compound:9117502|FD-Score:-6.43|P-value:9.77E-11

Top fitness defect scores for YNL286W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1942 st076330 4.37 65.2 µM 7.75E-6 20 6.18E-6
2 SGTC_2486 5283202 4.30 22.4 µM 1.06E-5 30 8.48E-6
3 SGTC_2837 9008476 4.25 45.5 µM 1.33E-5 26 1.07E-5
4 SGTC_2483 5729050 4.25 27.2 µM 1.34E-5 19 1.08E-5
5 SGTC_259 usnic acid 4.19 108.9 µM 1.70E-5 13 1.38E-5
6 SGTC_2512 diallyl trisulfide 4.11 49.2 µM 2.39E-5 5 1.95E-5
7 SGTC_184 1494-0393 4.08 24.7 µM 2.69E-5 55 2.20E-5
8 SGTC_2604 4'-hydroxychalcone 4.04 11.3 µM 3.26E-5 33 2.68E-5
9 SGTC_178 4092-0806 3.98 87.5 µM 4.15E-5 ergosterol depletion effects on membrane 98 3.43E-5
10 SGTC_1876 myriocin 3.96 605.0 nM 4.56E-5 32 3.77E-5
11 SGTC_2942 9052777 3.92 62.2 µM 5.29E-5 34 4.40E-5
12 SGTC_1811 st050069 3.83 61.5 µM 7.77E-5 5 6.51E-5
13 SGTC_2500 5-alpha-androstan-3,17-dione 3.82 61.4 µM 7.82E-5 43 6.55E-5
14 SGTC_49 0717-0965 3.79 32.1 µM 9.08E-5 60S ribosome export 24 7.63E-5
15 SGTC_2778 tioconazole 3.76 65.1 nM 9.94E-5 ergosterol depletion effects on membrane 68 8.37E-5
16 SGTC_2405 ticlatone 3.75 3.5 µM 1.06E-4 74 8.95E-5
17 SGTC_1468 k284-1086 3.72 134.0 µM 1.17E-4 DNA intercalators 47 9.85E-5
18 SGTC_24 0417-1663 3.72 219.0 µM 1.19E-4 23 1.01E-4
19 SGTC_3043 9092303 3.70 49.5 µM 1.27E-4 27 1.08E-4
20 SGTC_1470 k295-0292 3.67 231.0 µM 1.46E-4 21 1.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.39E-14 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.120 3.56E-12 YMR030W RSF1 hom Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes
0.108 4.29E-10 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.106 7.64E-10 YBR182C-A_p YBR182C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.105 9.30E-10 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.098 1.33E-8 YBR043C QDR3 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin
0.093 6.59E-8 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
0.091 1.52E-7 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.087 3.99E-7 YFL007W BLM10 hom Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
0.081 2.72E-6 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.080 3.20E-6 YBL050W SEC17 het Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP
0.080 3.89E-6 YBR242W_p YBR242W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
0.079 4.14E-6 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.078 6.84E-6 YDR267C CIA1 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein
0.076 1.10E-5 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W